Spermine supplier | CasNO.71-44-3

Name
Spermine
EINECS 200-754-2
CAS No. 71-44-3
Article Data27
CAS DataBase
Density 0.925 g/cm³
Solubility 1 M at 20 °C, clear, colorless
Melting Point 310-311 °C (dec.)(lit.)
Formula C₁₀H₂₆N₄
Boiling Point 308.4 °C at 760 mmHg
Molecular Weight 202.343
Flash Point 175.6 °C
Transport Information UN 3259 8/PG 2
Appearance white to slightly off-white powder crystal
Safety 26-36-45-36/37/39-27
Risk Codes 36/38-34
Molecular Structure
Hazard Symbols Xi,C
Synonyms 1,4-Butanediamine,N,N'-bis(3-aminopropyl)- (8CI,9CI);Spermine (6CI);1,5,10,14-Tetraazatetradecane;4,9-Diazadodecane-1,12-diamine;Gerontine;Musculamine;N,N'-Bis(3-aminopropyl)-1,4-butanediamine;N,N'-Bis(3-aminopropyl)-1,4-tetramethylenediamine;NSC 268508;Neuridine;
PSA 76.10000
LogP 1.82580

Synthetic route

: 14209-32-6
3-(4-[(2-cyanoethyl)amino]butylamino)propanenitrile

: 71-44-3
Spermine

Conditions

Conditions	Yield
With sodium; butan-1-ol
With diethyl ether; ammonia; nickel at 140℃; under 250073 Torr; Hydrogenation;
With hydrogenchloride; platinum Hydrogenation;

: 78706-92-0
1,2-bis(1,4,5,6-tetrahydropyrimidin-2-yl)ethane

: 71-44-3
Spermine

Conditions

Conditions	Yield
With sulfuric acid; diisobutylaluminium hydride; 1,1,1,3,3,3-hexamethyl-disilazane 1.) reflux, 12 h, 2.) xylene, reflux, 3 d; Yield given. Multistep reaction;

: 525-79-1
kinetin

A: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

B: 71-44-3
Spermine

C: 110-60-1
1,4-diaminobutane

Conditions

Conditions	Yield
at 30℃; for 24h; effect on poliamine content and ratio in rice embryos of Oryza sativa;

...Expand

: 14398-53-9
(R)-(-)-abscisic acid

A: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

B: 71-44-3
Spermine

C: 110-60-1
1,4-diaminobutane

Conditions

Conditions	Yield
at 30℃; for 24h; effect on poliamine content and ratio in rice embryos of Oryza sativa;

...Expand

: 12651-38-6
(-)-Verbaskine

A: 71-44-3
Spermine

B: 140-10-3
(E)-3-phenylacrylic acid

Conditions

Conditions	Yield
With hydrogenchloride at 150℃; for 18h; sealed tube;

: 73397-39-4
1-(4-Amino-butyl)-tetrahydro-pyrimidin-2-one

: 107-13-1
acrylonitrile

: 71-44-3
Spermine

Conditions

Conditions	Yield
Yield given. Multistep reaction;

: 77485-28-0
N'-(4-(N'-hexahydropyrimidyl) butyl)-hexahydro-pyrimidine

A: 50-00-0
formaldehyd

B: 71-44-3
Spermine

Conditions

Conditions	Yield
With hydrogenchloride Heating;

: 185250-13-9
1,1'-(butane-1,4-diyl)-2,2'-diphenylbis(hexahydropyrimidine)

A: 71-44-3
Spermine

B: 100-52-7
benzaldehyde

Conditions

Conditions	Yield
With hydrogenchloride at 20℃;

1.4-bis-<γ-bromo-propylamino>-butane dihydrobromide: 1.4-bis-<γ-bromo-propylamino>-butane dihydrobromide

: 71-44-3
Spermine

Conditions

Conditions	Yield
With ethanol; ammonia at 100℃;

: 110-60-1
1,4-diaminobutane

N-<γ-iodo-propyl>-phthalimide: N-<γ-iodo-propyl>-phthalimide

: 71-44-3
Spermine

Conditions

Conditions	Yield
at 100℃; anschl. mit wss. KOH, anschl. Erhitzen mit HCl auf 100grad;

: N,N'-Bis(3-brompropyl)-1,4-diaminobutan

potassium-: potassium-

: 71-44-3
Spermine

Conditions

Conditions	Yield
With pentan-1-ol Erwaermen des Reaktionsprodukts mit Hydrazin-hydrat in Aethanol;

: (Z)-1-{N-[3-aminopropyl]-N-[4-(3-aminopropyl-ammonio)butyl]-amino}-diazen-1-ium-1,2-diolate

: 71-44-3
Spermine

Conditions

Conditions	Yield
With sodium hydroxide; phosphate buffer at 37℃; pH=5.60 - 8.50; Kinetics; Further Variations:; pH-values;

: 477808-25-6
3,10-dioxo-4,9-diazadodecanediamide

: 71-44-3
Spermine

Conditions

Conditions	Yield
With borane-THF In tetrahydrofuran for 7h; Heating;

: 477808-23-4
N-[4-(2-methoxycarbonyl-acetylamino)-butyl]-malonamic acid methyl ester

: 71-44-3
Spermine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NH3 / methanol / 7 °C 2: BH3*THF / tetrahydrofuran / 7 h / Heating View Scheme

: 78707-11-6
C24H30N4O4S2

: 71-44-3
Spermine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 97 percent / sodium methoxide / methanol / 0.33 h / 0 °C 2: 1.) hexamethyldisilazane, fuming sulfuric acid, 2.) diisobutylaluminum hydride / 1.) reflux, 12 h, 2.) xylene, reflux, 3 d View Scheme

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

: 71-44-3
Spermine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 2) Ba(OH)2 View Scheme

: N-(3-aminopropyl)-N'-(3-ethylaminopropyl)butane-1,4-diamine

A: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

B: 71-44-3
Spermine

C: 10563-23-2
N-ethyl-1,3-diaminopropane

D: N1-(3-ethylaminopropyl)butane-1,4-diamine

Conditions

Conditions	Yield
With recombinant human polyamine oxidase pH=9.5; Kinetics; pH-value; Reagent/catalyst; Enzymatic reaction;

...Expand

: N1-(3-aminopropyl)-N4-(3-(benzylamino)propyl)butane-1,4-diamine

A: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

B: 71-44-3
Spermine

C: 100-46-9
benzylamine

D: N-{3-[(4-aminobutyl)amino]propyl}(phenylmethyl)amine

Conditions

Conditions	Yield
With recombinant human polyamine oxidase pH=9.5; Kinetics; pH-value; Reagent/catalyst; Enzymatic reaction;

...Expand

: 1111644-29-1
N-(3-benzylaminopropyl)-N'-(3-ethylaminopropyl)butane-1,4-diamine

A: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

B: 71-44-3
Spermine

C: 10563-23-2
N-ethyl-1,3-diaminopropane

D: N1-(3-ethylaminopropyl)butane-1,4-diamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: spermine oxidase / pH 9.5 / Enzymatic reaction 2: recombinant human polyamine oxidase / pH 9.5 / Enzymatic reaction View Scheme
Multi-step reaction with 2 steps 1: recombinant human polyamine oxidase / pH 9.5 / Enzymatic reaction 2: recombinant human polyamine oxidase / pH 9.5 / Enzymatic reaction View Scheme

...Expand

: 117654-79-2
1,14-bis(phenylmethyl)-1,5,10,14-tetraazatetradecane tetrahydrochloride

A: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

B: 71-44-3
Spermine

C: 100-46-9
benzylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: recombinant human polyamine oxidase / pH 9.5 / Enzymatic reaction 2: recombinant human polyamine oxidase / pH 9.5 / Enzymatic reaction View Scheme

...Expand

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

: C15H25N6O3S(1+)

A: 71-44-3
Spermine

B: 5'-methylthioadenosine

Conditions

Conditions	Yield
With Thermus thermophilus triamine/agmatine aminopropyltransferase; diothiothreitol at 37℃; pH=9; Kinetics; aq. buffer; Enzymatic reaction;

...Expand

: 3,3′,3″,3′″-(butane-1,4-diylbis(azanetriyl))tetrapropanenitrile

A: 71-44-3
Spermine

B: 120239-63-6
N,N,N',N'-tetra(3-aminopropyl)-1,4-butanediamine

C: N,N,N'-tris(3-aminopropyl)-1,4-butanediamine

Conditions

Conditions	Yield
With ammonia; hydrogen In tetrahydrofuran at 50℃; under 33753.4 Torr; Autoclave;

...Expand

: C32H48N6O12S2

: 71-44-3
Spermine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: thionyl chloride; methanol / 2 h / 0 - 20 °C / Inert atmosphere 2.1: N-ethyl-N,N-diisopropylamine; dmap / N,N-dimethyl-formamide / 24 h / 20 °C 2.2: 24 h / 0 - 20 °C / Inert atmosphere View Scheme

: C22H32N6O8S2

: 71-44-3
Spermine

Conditions

Conditions	Yield
Stage #1: C22H32N6O8S2 With dmap; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 24h; Stage #2: With 1,8-diazabicyclo[5.4.0]undec-7-ene; 2-hydroxyethanethiol In N,N-dimethyl-formamide at 0 - 20℃; for 24h; Inert atmosphere; Stage #3: With trifluoroacetic acid In dichloromethane	30 mg

: 71-44-3
Spermine

: 22509-74-6
N-ethoxycarbonylphthalimide

: 104435-59-8
1,12-diphthalimido-4,9-diazadodecane

Conditions

Conditions	Yield
In chloroform at 20℃; for 1h;	100%
In dichloromethane Ambient temperature;	86%
In chloroform Ambient temperature;	70%

: 71-44-3
Spermine

: 63867-00-5
3-(4'-acetoxyphenyl)propionyl chloride

: N1,N5,N10,N14-tertakis[3-(4-acetoxyphenyl)propanoyl]-1,5,10,14-tetraazatetradecane

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃;	100%

: 1477-49-2
3-indolylglyoxylic acid

: 71-44-3
Spermine

: 76-05-1
trifluoroacetic acid

: N1,N4-bis(3-(2-(1H-indol-3-yl)-2-oxoacetamido)propyl)butane-1,4-diaminium 2,2,2-trifluoroacetate

Conditions

Conditions	Yield
Stage #1: 3-indolylglyoxylic acid; Spermine With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 20℃; for 23h; Inert atmosphere; Stage #2: trifluoroacetic acid In methanol; water	100%

...Expand

: 71-44-3
Spermine

: 13710-19-5
tolfenamic Acid

: tolfenamic acid spermine salt

Conditions

Conditions	Yield
In methanol at 20℃; for 0.5h;	99%

: 71-44-3
Spermine

: C10H26N6O2

Conditions

Conditions	Yield
With nitrogen(II) oxide In acetonitrile under 3800 Torr; for 20h; Ambient temperature;	98%

: 71-44-3
Spermine

: 383-63-1
ethyl trifluoroacetate,

: 168788-09-8
N1,N12-di(trifluoroacetyl)-1,12-diamino-4,9-diazadodecane

Conditions

Conditions	Yield
With water In methanol Heating;	98%
In water; acetonitrile at 100℃;	95%
In water; acetonitrile	94%

: 71-44-3
Spermine

: 402598-52-1
(E)-3-(4-hydroxyphenyl)-2-methyl-2-propenoyl chloride

: 402598-61-2
N1,N5,N10,N14-tertakis[3-(4-acetoxyphenyl)-2-methyl-2-propenoyl]-1,5,10,14-tetraazatetradecane

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃;	98%

: 71-44-3
Spermine

: 16308-68-2
allyl phenyl carbonate

: N1,N8-bis(allyloxycarbonyl)spermine

Conditions

Conditions	Yield
In dichloromethane at 20℃;	98%

: 71-44-3
Spermine

: 110-17-8
(2E)-but-2-enedioic acid

: spermine fumarate

Conditions

Conditions	Yield
In water for 0.25h;	98%

: 71-44-3
Spermine

: 244639-79-0
9-(5-O-dimethoxytrityl-2-deoxy-β-D-erythro-pentofuranose)-6-(1,2,4-triazol-4-yl)purine

: 259141-08-7
5'-O-dimethoxytrityl-6-N-(4,9,13-triazatridecane-1-yl)-2'-deoxyadenosine

Conditions

Conditions	Yield
With pyridine at 70℃; for 8h; Substitution;	97%
In pyridine at 70℃; Substitution;

: 71-44-3
Spermine

: 1114539-81-9
succinimidyl (E)-3-(trioxsalen-4'-yl)propenoate

: N1,N12-bis[(E)-3-(trioxsalen-4'-yl)propenoyl]spermine bishydroxysuccinimidate salt

Conditions

Conditions	Yield
In dichloromethane at 25℃; for 1h;	96%

: 50-00-0
formaldehyd

: 71-44-3
Spermine

: 77485-28-0
N'-(4-(N'-hexahydropyrimidyl) butyl)-hexahydro-pyrimidine

Conditions

Conditions	Yield
In water at 0℃; for 0.833333h;	95%
In water at 20℃; for 20h;

: 71-44-3
Spermine

: 100-52-7
benzaldehyde

: 185250-13-9
1,1'-(butane-1,4-diyl)-2,2'-diphenylbis(hexahydropyrimidine)

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane at -78 - 23℃;	95%
In benzene Heating;

: 71-44-3
Spermine

: 383-63-1
ethyl trifluoroacetate,

: 24424-99-5
di-tert-butyl dicarbonate

: 201984-66-9
1-trifluoroacetyl-5,10,14-tris-Boc-spermine

Conditions

Conditions	Yield
Stage #1: Spermine; ethyl trifluoroacetate, In methanol at -78 - 0℃; for 1h; Stage #2: di-tert-butyl dicarbonate In methanol at 0 - 25℃; for 15h;	95%
Stage #1: Spermine; ethyl trifluoroacetate, In methanol at -78 - 4℃; Inert atmosphere; Stage #2: di-tert-butyl dicarbonate In methanol at 4℃; Inert atmosphere;	82.9%
Stage #1: Spermine; ethyl trifluoroacetate, In methanol at -78℃; for 1h; Inert atmosphere; Stage #2: di-tert-butyl dicarbonate In methanol at 0 - 25℃; for 24h; Inert atmosphere;	49%
1) MeOH, 78 deg C, 1 h then 0 deg C, 1 h, 2) MeOH, 0 to 25 deg C, 1 h; Multistep reaction;
Stage #1: Spermine; ethyl trifluoroacetate, In methanol at -78 - 0℃; Inert atmosphere; Stage #2: di-tert-butyl dicarbonate In methanol at 0 - 20℃; for 18h; Inert atmosphere;

...Expand

: 71-44-3
Spermine

: 566-88-1
dihydrocholesterone

: 177745-14-1
3β-(12-amino-4,9-diaza-dodecyl)amino-cholestane

Conditions

Conditions	Yield
Stage #1: Spermine; dihydrocholesterone With titanium(IV) isopropylate In methanol at 20℃; for 12h; Stage #2: With sodium tetrahydroborate In methanol at -78℃; for 2h; Further stages.;	95%

: 71-44-3
Spermine

: 383-63-1
ethyl trifluoroacetate,

: N1,N14-bis(trifluoroacetyl)spermine ditrifluoroacetate

Conditions

Conditions	Yield
In water; acetonitrile Heating;	94%
With water In acetonitrile Heating;	93%
In acetonitrile Reflux;	93%
With water In acetonitrile Reflux;	93%
With water In acetonitrile Reflux;

: 71-44-3
Spermine

: 5-benzoyl-3-(cyclopent-1-en-1-yl)-5-phenyl-1,5-dihydro-4H-pyrazol-4-one

: 220221-33-0
C17H30N4O

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 0.5h; regioselective reaction;	93%

: 71-44-3
Spermine

: 76-05-1
trifluoroacetic acid

: 501-52-0
3-Phenylpropionic acid

: N1,N4-bis(3-(3-phenylpropanamido)propyl)butane-1,4-diaminium 2,2,2-trifluoroacetate

Conditions

Conditions	Yield
Stage #1: Spermine; 3-Phenylpropionic acid With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 20℃; for 23h; Inert atmosphere; Stage #2: trifluoroacetic acid In N,N-dimethyl-formamide Inert atmosphere;	92%

...Expand

: 613-90-1
benzoyl cyanide

: 71-44-3
Spermine

: 111574-87-9
N1,N12-dibenzoylspermine

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 3h;	91%
In dichloromethane for 15h; Ambient temperature;	91%
In dichloromethane Ambient temperature;	91%

: 71-44-3
Spermine

: 358-23-6
trifluoromethylsulfonic anhydride

: 144534-70-3
C,C,C-Trifluoro-N-(3-trifluoromethanesulfonylamino-propyl)-N-{4-[trifluoromethanesulfonyl-(3-trifluoromethanesulfonylamino-propyl)-amino]-butyl}-methanesulfonamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 1h; Ambient temperature; -30 deg C up to r.t.;	90%

: 71-44-3
Spermine

: 2212-69-3
N2-benzyloxycarbonyl-N6-t-butoxycarbonyl-L-lysine 4-nitrophenyl ester

: 199340-70-0
((S)-5-{3-[4-(3-Amino-propylamino)-butylamino]-propylcarbamoyl}-5-benzyloxycarbonylamino-pentyl)-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran for 2.5h; Ambient temperature;	90%

: 54888-42-5
2,2-diphenyl-benzo[1,3]dioxole-4-carbonyl chloride

: 71-44-3
Spermine

: C90H74N4O12

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 50℃;	90%

: 71-44-3
Spermine

: 10381-82-5
8-bromocaffeine

: 8-(3-(4-(3-aminopropylamino)butylamino)propylamino)caffeine

Conditions

Conditions	Yield
In ethanol for 40h; Reflux;	90%
In ethanol

: 71-44-3
Spermine

: 125802-80-4
(E)-3-(4-Nitro-phenyl)-acrylic acid 2,5-dioxo-pyrrolidin-1-yl ester

: (E)-3-(4-Nitro-phenyl)-N-[3-(4-{3-[(E)-3-(4-nitro-phenyl)-acryloylamino]-propylamino}-butylamino)-propyl]-acrylamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃;	89%

: 71-44-3
Spermine

: 2094-72-6
1-Adamantanecarbonyl chloride

: C54H82N4O4

Conditions

Conditions	Yield
With sodium hydroxide In dichloromethane	88%

: 71-44-3
Spermine

: 383-63-1
ethyl trifluoroacetate,

: 2,2,2-trifluoro-N-(3-{4-[3-(2,2,2-trifluoro-acetylamino)-propylamino]-butylamino}-propyl)-acetamide trifluoroacetate

Conditions

Conditions	Yield
With water In acetonitrile for 18h; Heating / reflux;	88%

: 71-44-3
Spermine

: 22509-74-6
N-ethoxycarbonylphthalimide

: N-(12-phthalimido-4,9-diazadodecyl)phthalimide*2HCl

Conditions

Conditions	Yield
In tetrahydrofuran at 23℃; for 2h;	87%

: 71-44-3
Spermine

: 82592-68-5, 98631-72-2
(E)-3,4-di-O-acetylcaffeoyl chloride

: N1,N5,N10,N14-tertakis[3-(3,4-diacetoxyphenyl)-2-propenoyl]-1,5,10,14-tetraazatetradecane

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃;	87%

: 71-44-3
Spermine

: 24424-99-5
di-tert-butyl dicarbonate

: 177213-61-5
di-tert-butyl butane-1,4-diylbis((3-aminopropyl)carbamate)

Conditions

Conditions	Yield
Stage #1: Spermine With ethyl trifluoroacetate, In methanol at 0℃; for 0.5h; Stage #2: di-tert-butyl dicarbonate In methanol at 20℃; Stage #3: With sodium hydroxide In methanol at 20℃; for 4h;	87%
Stage #1: Spermine With ethyl trifluoroacetate, In methanol at -78℃; for 16h; Stage #2: di-tert-butyl dicarbonate In dichloromethane at 20℃; for 12h; Stage #3: With sodium hydroxide In methanol at 20℃; for 12h;

: 71-44-3
Spermine

: C10H22Cl2N7P3

Conditions

Conditions	Yield
With 2,2,4,4,6,6-hexachloro-1,3,5-triaza-2,4,6-triphosphorine In chloroform for 48h; Ambient temperature;	86.3%
With 2,2,4,4,6,6-hexachloro-1,3,5-triaza-2,4,6-triphosphorine In chloroform at 20℃; Inert atmosphere;
With 2,2,4,4,6,6-hexachloro-1,3,5-triaza-2,4,6-triphosphorine In chloroform at 20℃; Inert atmosphere;

Spermine Chemical Properties

Product Name: Diaminopropyltetramethylenediamine (CAS NO.71-44-3)

Empirical Formula: C₁₀H₂₆N₄
Molecular Weight: 202.3402
EINECS: 206-189-8
Melting point: 310-311 °C (dec.)(lit.)
Appearance: Clear colorless liquid
Storage temp.: 2-8°C
Solubility: H₂O: 1 M at 20 °C, clear, colorless
Form: Powder
Sensitive: Air Sensitive & Hygroscopic
Stable: Stable. Reacts with water.
Index of Refraction: 1.484
Density: 0.925 g/cm³
Flash Point: 175.6 °C
Enthalpy of Vaporization: 54.91 kJ/mol
Boiling Point: 308.4 °C at 760 mmHg
Vapour Pressure: 0.000683 mmHg at 25 °C
Surface Tension: 38.3 dyne/cm
Index of Refraction: 1.484
Molar Refractivity: 62.63 cm³
Molar Volume: 218.5 cm³
XLogP3-AA: -1.1
H-Bond Donor: 4
H-Bond Acceptor: 4
Structure Descriptors of Diaminopropyltetramethylenediamine (CAS NO.71-44-3):
IUPAC Name: N,N'-bis(3-aminopropyl)butane-1,4-diamine
Canonical SMILES: C(CCNCCCN)CNCCCN
InChI: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2
InChIKey: PFNFFQXMRSDOHW-UHFFFAOYSA-N
Product Categories: Aliphatics; Amines

Spermine Uses

Diaminopropyltetramethylenediamine (CAS NO.71-44-3) can be used as an organic phosphorus pesticide intermediats. At the same time, it is a typical anionic surfactant with good penetration, emulsification, foam and decontamination capabilities, so it is widely used in chemical, pesticide, fiber, electric crossing, mineral and other industries, especiallily for cosmetics, toothpaste, shampoo and other manufacturings. In the textile industry, it is used for washing wool and silk.

Spermine Production

Take coconut oil as the raw material and then with Sulfuric acid by sulfonation to get: Diaminopropyltetramethylenediamine (CAS NO.71-44-3).

Spermine Toxicity Data With Reference

1.	mmo-sat 100 µmol/L	AMACCQ Antimicrobial Agents and Chemotherapy. 9 (1976),77.
2.	cyt-hmn:hla 2 mmol/L	JCLLAX Journal of Cellular Physiology. 78 (1971),217.
3.	dni-rat:lvr 100 µmol/L	BIJOAK Biochemical Journal. 146 (1975),697.
4.	ipr-rat LD50:33 mg/kg	TXAPA9 Toxicology and Applied Pharmacology. 88 (1987),433.
5.	ivn-rat LD50:65 mg/kg	AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 165 (1967),374.
6.	orl-mus LD30:650 mg/kg	AGACBH Agents and Actions, A Swiss Journal of Pharmacology. 14 (1984),228.
7.	ipr-mus LDLo:8 mg/kg	TXAPA9 Toxicology and Applied Pharmacology. 23 (1972),288.
8.	scu-mus LD30:280 mg/kg	AGACBH Agents and Actions, A Swiss Journal of Pharmacology. 14 (1984),228.
9.	ivn-mus LD50:56 mg/kg	CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) NX#00641 .

Spermine Consensus Reports

Reported in EPA TSCA Inventory.

Spermine Safety Profile

Poison by intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by ingestion. Human mutation data reported. When heated to decomposition it emits toxic fumes of NO_x. See also AMINES.
Safety Information of Diaminopropyltetramethylenediamine (CAS NO.71-44-3):
Hazard Codes: Irritant Xi, Corrosive C
Risk Statements: 36/38-34
R34:Causes burns.
R36/38:Irritating to eyes and skin.
Safety Statements: 26-36-45-36/37/39-27
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S27:Take off immediately all contaminated clothing.
S36:Wear suitable protective clothing.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

Spermine Specification

Diaminopropyltetramethylenediamine , its cas register number is 71-44-3. It also can be called N,N'-Bis(3-aminopropyl)-1,4-butandiamin ; N,N'-Bis(3-aminopropyl)tetramethylenediamine ; 4,9-Diazadodecamethylenediamine ; and 1,4-Butanediamine, N1,N4-bis(3-aminopropyl)- .

Product Name

Spermine

Synthetic route

Spermine Chemical Properties

Spermine Uses

Spermine Production

Spermine Toxicity Data With Reference

Spermine Consensus Reports

Spermine Safety Profile

Spermine Specification

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