Sulfadiazine supplier | CasNO.68-35-9

Name
Sulfadiazine
EINECS 200-685-8
CAS No. 68-35-9
Article Data29
CAS DataBase
Density 1.496 g/cm³
Solubility Very slightly soluble in cold water
Melting Point 254 °C
Formula C₁₀H₁₀N₄O₂S
Boiling Point 512.6 °C at 760 mmHg
Molecular Weight 250.281
Flash Point 263.8 °C
Transport Information
Appearance White to slightly yellow crystalline powder
Safety 26-36
Risk Codes 22-36/37/38-42/43
Molecular Structure
Hazard Symbols Xn,Xi
Synonyms Sulfanilamide,N1-2(1H)-pyrimidinylidene- (6CI);Sulfanilamide, N1-2-pyrimidinyl- (8CI);2-(4-Aminobenzenesulfonylamino)pyrimidine;2-(p-Aminobenzenesulfonamido)pyrimidin;4-Amino-N-(2-pyrimidinyl)benzenesulfonamide;4-[[(Pyrimidin-2-yl)amino]sulfonyl]aniline;Adiazine;Cremodiazine;Debenal;Deltazina;Di-Azo-Mul;Diazin;Diazovit;Diazyl;Lipo-Levazine;Liquadiazine;N1-2-Pyrimidylsulfanilamide;Neazine;Pirimal;Pyrimal;RP 2616;Spofadrizine;Sterazine;Sulfadiazine;Sulfapirimidin;Sulfazin (Russian pharmaceutical);Sulfazine;Sulfolex;Sulphadiazine E;Sulfadiazine (SD);
PSA 106.35000
LogP 2.59460

Synthetic route

: 109-12-6
2-aminopyrimidine

: 121-60-8
p-acetylaminobenzenesulfonyl chloride

: 68-35-9
sulfadiazine

Conditions

Conditions	Yield
Stage #1: 2-aminopyrimidine; p-acetylaminobenzenesulfonyl chloride With calcium carbonate In toluene at 20 - 65℃; Stage #2: With water; sodium hydroxide In toluene at 100 - 115℃; Stage #3: With acetic acid pH=5 - 5.5; Reagent/catalyst;	98.5%
Stage #1: 2-aminopyrimidine; p-acetylaminobenzenesulfonyl chloride With pyridine In tetrahydrofuran at 20℃; for 6h; Inert atmosphere; Stage #2: With sodium hydroxide for 2h; Inert atmosphere; Reflux;	65%
Stage #1: 2-aminopyrimidine; p-acetylaminobenzenesulfonyl chloride With pyridine In tetrahydrofuran at 20℃; for 6h; Stage #2: With sodium hydroxide for 2h; Reflux;

: 77218-33-8
N-benzylidene-sulfanilic acid pyrimidin-2-ylamide

: 68-35-9
sulfadiazine

Conditions

Conditions	Yield
With water In acetone at 20℃; for 0.666667h; Irradiation;	98%

: 57-67-0
4-amino-N-(diaminomethylene) benzenesulfonamide

: 19060-08-3
3-ethoxyacrolein

: 68-35-9
sulfadiazine

Conditions

Conditions	Yield
In ethanol at 100℃; for 4h; Green chemistry;	91%

: 4652-39-5
3-butoxyacrolein

: 57-67-0
4-amino-N-(diaminomethylene) benzenesulfonamide

: 68-35-9
sulfadiazine

Conditions

Conditions	Yield
In butan-1-ol at 100℃; for 4h; Green chemistry;	90.8%

: 542-78-9
Malondialdehyde

: 57-67-0
1-amino-4-({[amino(imino)methyl]amino}sulfonyl)benzene

: 68-35-9
sulfadiazine

Conditions

Conditions	Yield
With sodium methylate In methanol at 65℃; for 2h; Temperature;	89%

: 4652-35-1
3-methoxyacrolein

: 57-67-0
4-amino-N-(diaminomethylene) benzenesulfonamide

: 68-35-9
sulfadiazine

Conditions

Conditions	Yield
In methanol at 100℃; for 4h; Temperature; Green chemistry;	87%

: 109-12-6
2-aminopyrimidine

: 101570-35-8
3-(4-acetylamino-benzenesulfonyl)-2-benzenesulfonylimino-2,3-dihydro-thiazole

: 68-35-9
sulfadiazine

Conditions

Conditions	Yield
und anschliessenden Erhitzen mit wss. NaOH;

: 109-12-6
2-aminopyrimidine

: phenyl-methanesulfonic acid-[3-(N-acetyl-sulfanilyl)-3H-thiazol-2-ylidenamide]

: 68-35-9
sulfadiazine

Conditions

Conditions	Yield
und anschliessenden Erhitzen mit wss. NaOH;

: 1722-12-9
2-chloropyrimidine

: 63-74-1
sulfanilamide

: 68-35-9
sulfadiazine

Conditions

Conditions	Yield
With potassium carbonate

: 18213-90-6
2-phenoxypyrimidine

: 63-74-1
sulfanilamide

: 68-35-9
sulfadiazine

Conditions

Conditions	Yield
With potassium carbonate

: 24265-24-5
4-nitro-N-pyrimidin-2-ylbenzenesulfonamide

: 68-35-9
sulfadiazine

Conditions

Conditions	Yield
With hydrogenchloride; iron
With palladium 10% on activated carbon In tetrahydrofuran; methanol; ethyl acetate at 50℃; under 37503.8 Torr;
With hydrogenchloride; iron

: 127-74-2
4'-(pyrimidin-2-ylsulfamoyl)acetanilide

: 68-35-9
sulfadiazine

Conditions

Conditions	Yield
With calcium hydroxide
With hydrogenchloride
With sodium hydroxide
With sodium hydroxide In methanol; 1,2-dimethoxyethane at 120℃; for 16h;
With sodium hydroxide

<35S>sulfanilic acid pyrimidin-2-ylamide: <35S>sulfanilic acid pyrimidin-2-ylamide

: 68-35-9
sulfadiazine

: 121-60-8
p-acetylaminobenzenesulfonyl chloride

: 68-35-9
sulfadiazine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 2: aq. NaOH solution View Scheme
Multi-step reaction with 2 steps 1: pyridine / acetonitrile / 3.08 h / 60 °C 2: sodium hydroxide / methanol; 1,2-dimethoxyethane / 16 h / 120 °C View Scheme

: AgC10H9N4O2S*2(1-(3-hydroxy-phenyl)-2-methylamino-ethanol)

: 68-35-9
sulfadiazine

Conditions

Conditions	Yield
With mineral acids byproducts: amin-salt; dild. acids;
With mineral acids byproducts: Ag-salt; concd. acids;
With mineral acids byproducts: Ag-salt; concd. acids;
With mineral acids byproducts: amin-salt; dild. acids;

: AgC10H9N4O2S*2ethylamine

: 68-35-9
sulfadiazine

Conditions

Conditions	Yield
With mineral acids byproducts: Ag-salt; concd. acids;
With mineral acids byproducts: Ag-salt; concd. acids;
Multi-step reaction with 3 steps 1: mineral acids 3: mineral acids View Scheme

: AgC10H9N4O2S*2benzylamine

: 68-35-9
sulfadiazine

Conditions

Conditions	Yield
With mineral acids byproducts: Ag-salt; concd. acids;
With mineral acids byproducts: Ag-salt; concd. acids;
Multi-step reaction with 3 steps 1: mineral acids 3: mineral acids View Scheme

: AgC10H9N4O2S*2morpholine

: 68-35-9
sulfadiazine

Conditions

Conditions	Yield
With mineral acids byproducts: Ag-salt; dild. acids;
With mineral acids byproducts: Ag-salt; concd. acids;
With mineral acids byproducts: Ag-salt; concd. acids;

: AgC10H9N4O2S*2ethylenediamine

: 68-35-9
sulfadiazine

Conditions

Conditions	Yield
With mineral acids byproducts: Ag-salt; concd. acids;
With mineral acids byproducts: Ag-salt; concd. acids;
Multi-step reaction with 3 steps 1: mineral acids 3: mineral acids View Scheme

: Ag(1+)*C10H9N4O2S(1-)*2NH3=AgC10H9N4O2S*2NH3

: 68-35-9
sulfadiazine

Conditions

Conditions	Yield
With mineral acids byproducts: Ag-salt; concd. acids;
With mineral acids byproducts: Ag-salt; concd. acids;
Multi-step reaction with 3 steps 1: mineral acids 3: mineral acids View Scheme

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 68-35-9
sulfadiazine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: pyridine / 100 °C 2: palladium 10% on activated carbon / methanol; ethyl acetate; tetrahydrofuran / 50 °C / 37503.8 Torr View Scheme

: 22199-08-2
silver sulfadiazine

: 68-35-9
sulfadiazine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 2: mineral acids View Scheme
Multi-step reaction with 2 steps 2: mineral acids View Scheme
Multi-step reaction with 2 steps 2: mineral acids View Scheme

: 68-35-9
sulfadiazine

: 920-46-7
Methacryloyl chloride

: 52205-02-4
methacrylate sulfadiazine

Conditions

Conditions	Yield
With sodium hydroxide In water; acetone for 3h; Darkness;	97%

: 68-35-9
sulfadiazine

: 708-06-5
2-hydroxynaphthalene-1-carbaldehyde

: (E)-4-(((2-hydroxynaphthalen-1-yl)methylene)amino)-N-(pyrimidin-2-yl)benzenesulfonamide

Conditions

Conditions	Yield
With acetic acid In ethanol for 4h; Reflux;	96.3%
In ethanol for 2.5h; Schiff Reaction; Reflux;	62%

: 68-35-9
sulfadiazine

: 7732-18-5
water

: 6147-53-1
cobalt(II) diacetate tetrahydrate

: 905593-88-6
[cobalt(II)(sulfadiazine(-1H))2(H2O)2]

Conditions

Conditions	Yield
In water byproducts: Na acetate; Na salt of ligand dissolved in H2O; Co salt in H2O added dropwise with stirring at 40°C for 1 h; filtered; ppt. washed with H2O, MeOH and Et2O successively; dried under vac.; elem. anal.;	96%

...Expand

: cobalt(II) chloride hexahydrate

: 68-35-9
sulfadiazine

: 7732-18-5
water

: 905593-88-6
[cobalt(II)(sulfadiazine(-1H))2(H2O)2]

Conditions

Conditions	Yield
In water byproducts: NaCl; Na salt of ligand dissolved in H2O; Co salt in H2O added dropwise with stirring at 40°C for 1 h; filtered; ppt. washed with H2O, MeOH and Et2O successively; dried under vac.; elem. anal.;	96%

...Expand

: 68-35-9
sulfadiazine

: 141-97-9
ethyl acetoacetate

: 134477-88-6
3-oxo-N-{4-[(pyrimidin-2-ylamino)sulphonyl]phenyl}butanamide

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide for 3h;	95%
at 140℃; for 0.25h;	75%

: 67-56-1
methanol

: 68-35-9
sulfadiazine

: 6147-53-1
cobalt(II) diacetate tetrahydrate

: 905593-87-5
[cobalt(II)(sulfadiazine(-1H))2(methanol)2]

Conditions

Conditions	Yield
In methanol byproducts: Na acetate; Na salt of ligand dissolved in MeOH; Co salt in MeOH added dropwise withstirring at 40°C for 1 h; filtered; ppt. washed with H2O, MeOH and Et2O successively; dried under vac.; elem. anal.;	95%

...Expand

: 67-56-1
methanol

: cobalt(II) chloride hexahydrate

: 68-35-9
sulfadiazine

: 905593-87-5
[cobalt(II)(sulfadiazine(-1H))2(methanol)2]

Conditions

Conditions	Yield
In methanol byproducts: NaCl; Na salt of ligand dissolved in MeOH; Co salt in MeOH added dropwise withstirring at 40°C for 1 h; filtered; ppt. washed with H2O, MeOH and Et2O successively; dried under vac.; elem. anal.;	95%

...Expand

: 176-29-4
1-oxa-4-aza-spiro[4.4]nonane

: 50-00-0
formaldehyd

: 68-35-9
sulfadiazine

: 1208127-45-0
C18H23N5O3S

Conditions

Conditions	Yield
In ethanol; water for 4h; Reflux;	95%

...Expand

: 68-35-9
sulfadiazine

: 85100-77-2
1-n-butyl-3-methylimidazolim bromide

: 1676076-90-6
C8H15N2(1+)*C10H9N4O2S(1-)

Conditions

Conditions	Yield
Stage #1: 1-n-butyl-3-methylimidazolim bromide With Merck ion exchange resin III In water Stage #2: sulfadiazine In water at 20℃; for 2h;	95%

: 68-35-9
sulfadiazine

: 1239-31-2
3β-acetoxy-5α-androstan-17-one

: 1346667-31-9
C31H40N4O4S

Conditions

Conditions	Yield
With acetic acid at 120℃; for 0.166667h;	94%

: 68-35-9
sulfadiazine

: (E)-N-[(2-chloroquinolin-3-yl)methylene]-4-phenylthiazol-2-amine

: 4-[{(Z)-(2-chloroquinolin-3-yl)(4-phenylthiazol-2-ylimino)methyl}diazenyl]-N-(pyrimidin-2-yl)benzenesulfonamide

Conditions

Conditions	Yield
Stage #1: sulfadiazine With sulfuric acid; sodium nitrite In water at 0 - 5℃; for 0.25h; Stage #2: (E)-N-[(2-chloroquinolin-3-yl)methylene]-4-phenylthiazol-2-amine With sodium hydroxide In ethanol; water for 1h; pH=5 - 6; Cooling with ice;	93%

: 68-35-9
sulfadiazine

: 112-67-4
n-hexadecanoyl chloride

: 103350-72-7
N-palmitoyl-sulfanilic acid pyrimidin-2-ylamide

Conditions

Conditions	Yield
With pyridine for 48h; Ambient temperature;	92%

: 68-35-9
sulfadiazine

: 149-30-4
2-Mercaptobenzothiazole

: C17H12N6O2S3

Conditions

Conditions	Yield
Stage #1: sulfadiazine With hydrogenchloride; sodium nitrite In ethanol at 0 - 5℃; Stage #2: 2-Mercaptobenzothiazole With sodium hydroxide In ethanol at 5 - 20℃; for 6h;	92%

: 444731-74-2
N-(2-chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine

: 68-35-9
sulfadiazine

: 1572439-08-7
4-((4-((2,3-dimethyl-2H-indazol-6-yl)amino)pyrimidin-2-yl)amino)-N-(pyrimidin-2-yl)benzenesulfonamide

Conditions

Conditions	Yield
With hydrogenchloride In water; isopropyl alcohol at 85℃;	92%

: 68-35-9
sulfadiazine

: 1-octyl-3-methyl-imidazolium bromide

: 1676076-97-3
C12H23N2(1+)*C10H9N4O2S(1-)

Conditions

Conditions	Yield
Stage #1: 1-octyl-3-methyl-imidazolium bromide With Merck ion exchange resin III In water Stage #2: sulfadiazine In water at 20℃; for 2h;	92%

: 1200-07-3
3-(4-bromophenyl)acrylic acid

: 68-35-9
sulfadiazine

: N-[4-(pyrimidin-2-yl-sulfamoyl)phenyl]4-bromocinnamamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane Reflux;	91%

: 68-35-9
sulfadiazine

: O,O‐diethyl 2-iodoethoxymethylphosphonate

: diethyl (2-(4-(N-pyrimidin-2-ylsulfamoyl)phenylamino)ethoxy)methylphosphonate

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 10 - 50℃; for 3h;	91%

: trans-chloroaquabis(dimethylglyoximato(1-))cobalt(III)

: 68-35-9
sulfadiazine

: trans-chlorobis(dimethylglyoximato)(2-sulfanilamidopyrimidine)cobalt(III) monohydrate

Conditions

Conditions	Yield
With water In acetone react. at 75°C for 1 h; ppt.; elem. anal.;	90%
With water In methanol react. at 75°C for 1 h; ppt.; elem. anal.;	90%

: trans-{Co(ONC(CH3)C(CH3)NOH)2(I)(H2O)}

: 68-35-9
sulfadiazine

: trans-iodobis(dimethylglyoximato)(2-sulfanilamidopyrimidine)cobalt(III) trihydrate

Conditions

Conditions	Yield
With water In methanol react. at 60°C; pptn. after several hours; filtration (glass filter); washing of the ppt. with MeOH, H2O, EtOH and ether; elem. anal.;	90%

: 68-35-9
sulfadiazine

: 127-79-7
sulfamerazina

: 7664-41-7
ammonia

: copper(II) ion

: [Cu(sulfadiazine(1-))1.34(sulfamerazine)0.66(H2O)(NH3)]

Conditions

Conditions	Yield
In methanol; water mixt. Cu(2+) salt and ligand was dissolved in MeOH, concd. ammonia soln.was added dropwise and stirred for 10 min; slow evapn. at room temp.; elem. anal.;	90%

...Expand

: 68-35-9
sulfadiazine

: 7664-41-7
ammonia

: copper(II) ion

: [Cu(sulfadiazine(1-))2(H2O)(NH3)]

Conditions

Conditions	Yield
In methanol; water mixt. Cu(2+) salt and ligand was dissolved in MeOH, concd. ammonia soln.was added dropwise and stirred for 10 min; slow evapn. at room temp.; elem. anal.;	90%

...Expand

: 459-32-5, 14290-66-5, 14290-86-9
4-fluorocinnamic acid

: 68-35-9
sulfadiazine

: N-[4-(pyrimidin-2-yl-sulfamoyl)phenyl]4-fluorocinnamamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane Reflux;	90%

: 68-35-9
sulfadiazine

: 123-54-6
acetylacetone

: 41095-18-5
4-{2-[2,4-dioxopentan-3-ylidene]hydrazinyl}-N-(pyrimidin-2-yl)benzenesulfonamide

Conditions

Conditions	Yield
Stage #1: sulfadiazine With hydrogenchloride; sodium nitrite In water; acetic acid at 0 - 5℃; Stage #2: acetylacetone With sodium acetate In ethanol; water; acetic acid at 0 - 20℃; for 2h;	90%

: 68-35-9
sulfadiazine

: 74467-58-6
3-methyl-1-tosyl-1H-pyrazol-5(4H)-one

: 4-(2-(3-methyl-5-oxo-1-tosyl-1H-pyrazol-4(5H)- ylidene)hydrazinyl)-N-(pyrimidin-2-yl)benzenesulfonamide

Conditions

Conditions	Yield
With hydrogenchloride; sodium acetate; sodium nitrite In ethanol; water at 0 - 5℃; for 1h;	90%

: 4414-88-4
1H-benzimidazol-2-acetonitrile

: 68-35-9
sulfadiazine

: N-(4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)-1H-benzo[d]imidazole-2-carbohydrazonoyl cyanide

Conditions

Conditions	Yield
Stage #1: sulfadiazine With hydrogenchloride; sodium nitrite In water at 0 - 70℃; for 0.0833333h; Stage #2: 1H-benzimidazol-2-acetonitrile With sodium acetate In ethanol at 0 - 5℃;	90%

: 109-12-6
2-aminopyrimidine

: 68-35-9
sulfadiazine

: 4-amino-N-(pyrimidine-2-yl)-3-(pyrimidine-2-yldiazenyl)benzene sulfonamide

Conditions

Conditions	Yield
Stage #1: 2-aminopyrimidine With hydrogenchloride; sodium nitrite In water at 0 - 5℃; Stage #2: sulfadiazine With sodium hydroxide In water at 0 - 5℃; pH=7;	89.5%

Sulfadiazine Consensus Reports

Reported in EPA TSCA Inventory.

Sulfadiazine Specification

The Sulfadiazine, with the CAS registry number 68-35-9, is also known as Benzenesulfonamide, 4-amino-N-2-pyrimidinyl-. It belongs to the product categories of Antibiotics for Research and Experimental Use; Biochemistry; Sulfonamides (Antibiotics for Research and Experimental Use). Its EINECS registry number is 200-685-8. This chemical's molecular formula is C₁₀H₁₀N₄O₂S and molecular weight is 250.277. Its IUPAC name is called 4-amino-N-pyrimidin-2-ylbenzenesulfonamide. Side effects reported for sulfadiazine include: nausea, upset stomach, loss of appetite, and dizziness. This chemical's classification codes are Anti-infective Agents; Antibacterial; Antiparasitic Agents; Antiprotozoal agents; Coccidiostats; Drug / Therapeutic Agent; Human Data; Reproductive Effect.

Physical properties of Sulfadiazine: (1)ACD/LogP: -0.12; (2)ACD/LogD (pH 5.5): -0.13; (3)ACD/LogD (pH 7.4): -0.66; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 19.93; (7)ACD/KOC (pH 7.4): 5.87; (8)#H bond acceptors: 6; (9)#H bond donors: 3; (10)#Freely Rotating Bonds: 2; (11)Index of Refraction: 1.679; (12)Molar Refractivity: 63.14 cm³; (13)Molar Volume: 167.2 cm³; (14)Surface Tension: 82.6 dyne/cm; (15)Density: 1.496 g/cm³; (16)Flash Point: 263.8 °C; (17)Enthalpy of Vaporization: 78.38 kJ/mol; (18)Boiling Point: 512.6 °C at 760 mmHg; (19)Vapour Pressure: 1.28E-10 mmHg at 25°C.

Preparation of Sulfadiazine: this chemical can be prepared by chaff iodate and nitro metformin. This reaction will need reagents acetyl groups benzene sulfo-chloride and pyridine.

Uses of Sulfadiazine: It eliminates bacteria that cause infections by stopping the production of folic acid inside the bacterial cell, and is commonly used to treat urinary tract infections (UTIs). In combination, sulfadiazine and pyrimethamine, can be used to treat toxoplasmosis, a disease caused by Toxoplasma gondii.

When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C1=CN=C(N=C1)NS(=O)(=O)C2=CC=C(C=C2)N
(2)InChI: InChI=1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,; (3)16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14)
(4)InChIKey: SEEPANYCNGTZFQ-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	oral	1800mg/kg/5D- (1800mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: HEMATURIA ENDOCRINE: HYPOGLYCEMIA	Postgraduate Medical Journal. Vol. 53, Pg. 103, 1977.
child	TDLo	unreported	138mg/kg (138mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC KIDNEY, URETER, AND BLADDER: HEMATURIA KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED	Postgraduate Medical Journal. Vol. 53, Pg. 103, 1977.
dog	LD	oral	> 5gm/kg (5000mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 79, Pg. 354, 1943.
man	TDLo	oral	229mg/kg/8D-I (229mg/kg)	GASTROINTESTINAL: OTHER CHANGES KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED	Israel Journal of Medical Sciences. Vol. 6, Pg. 561, 1970.
mouse	LD50	intraperitoneal	750mg/kg (750mg/kg)		"Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 109, 1969.
mouse	LD50	intravenous	180mg/kg (180mg/kg)		U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03347,
mouse	LD50	oral	1500mg/kg (1500mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 571, 1971.
mouse	LD50	subcutaneous	1600mg/kg (1600mg/kg)		Drugs in Japan Vol. 6, Pg. 386, 1982.
rat	LD50	intravenous	880mg/kg (880mg/kg)		Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 211, Pg. 367, 1950.
rat	LDLo	intraperitoneal	446mg/kg (446mg/kg)		Klinische Wochenscrift. Vol. 27, Pg. 449, 1949

Product Name

Sulfadiazine

Synthetic route

Sulfadiazine Consensus Reports

Sulfadiazine Specification

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