Tetraethyleneglycol monododecyl ether supplier

Name
Tetraethyleneglycol monododecyl ether
EINECS 226-097-1
CAS No. 5274-68-0
Article Data17
CAS DataBase
Density 0.95 g/cm³
Solubility
Melting Point 14°C
Formula C₂₀H₄₂O₅
Boiling Point 450.3 °C at 760 mmHg
Molecular Weight 362.55
Flash Point 226.1 °C
Transport Information UN 3082 9/PG 3
Appearance white solid or colourless liquid
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Dodecyl tetraethylene glycolether;Ethanol, 2-[2-[2-[2-(dodecyloxy)ethoxy]ethoxy]ethoxy]-;Tetraethylene glycol dodecyl ether;Tetraoxyethylene glycol dodecyl ether;n-Dodecyl tetraethylene glycolether;
PSA 57.15000
LogP 3.96600

Synthetic route

: 112-53-8
1-dodecyl alcohol

: 1,3,6,9,12-pentaoxa-2-thiacyclotetradecane 2,2-dioxide

: 5274-68-0
tetraethylene glycol monododecyl ether

Conditions

Conditions	Yield
Stage #1: 1-dodecyl alcohol With sodium hydride In tetrahydrofuran; mineral oil for 0.5h; Inert atmosphere; Stage #2: 1,3,6,9,12-pentaoxa-2-thiacyclotetradecane 2,2-dioxide In tetrahydrofuran; water; mineral oil pH=2; Inert atmosphere; Stage #3: With sulfuric acid In tetrahydrofuran; water; mineral oil at 80℃; for 2h; Inert atmosphere;	86%

: 112-60-7
Tetraethylene glycol

: 143-15-7
1-dodecylbromide

: 5274-68-0
tetraethylene glycol monododecyl ether

Conditions

Conditions	Yield
With sodium hydride In dimethyl sulfoxide at 90℃; Substitution;	57%
With sodium hydride In dimethyl sulfoxide at 90℃; Dehydrobromination; overnight; under nitrogen;	57%
With sodium
With sodium hydroxide In water
With sodium hydroxide at 90 - 100℃; for 24h; Temperature; Inert atmosphere;

: 75-21-8
oxirane

: 3055-94-5
2-[2-(2-Dodecyloxy-ethoxy)-ethoxy]-ethanol

: 5274-68-0
tetraethylene glycol monododecyl ether

Conditions

Conditions	Yield
With borontrifluoride acetic acid

: 112-53-8
1-dodecyl alcohol

: 5274-68-0
tetraethylene glycol monododecyl ether

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: boron fluorid-acetic acid adduct 2: boron fluorid-acetic acid adduct 3: boron fluorid-acetic acid adduct 4: boron fluorid-acetic acid adduct View Scheme

: 4536-30-5
ethylene glycol mono-n-dodecyl ether

: 5274-68-0
tetraethylene glycol monododecyl ether

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: boron fluorid-acetic acid adduct 2: boron fluorid-acetic acid adduct 3: boron fluorid-acetic acid adduct View Scheme

: 3055-93-4
diethylene glycol monododecyl ether

: 5274-68-0
tetraethylene glycol monododecyl ether

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: boron fluorid-acetic acid adduct 2: boron fluorid-acetic acid adduct View Scheme

: 112-60-7
Tetraethylene glycol

: 5274-68-0
tetraethylene glycol monododecyl ether

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: triethylamine; dmap; thionyl chloride / dichloromethane / 0 - 25 °C 2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere 2.2: pH 2 / Inert atmosphere 2.3: 2 h / 80 °C / Inert atmosphere View Scheme

: 108-30-5
succinic acid anhydride

: 5274-68-0
tetraethylene glycol monododecyl ether

: 1421487-17-3
C24H46O8

Conditions

Conditions	Yield
In neat (no solvent) at 130℃; for 3h;	100%
With pyridine In dichloromethane at 20℃; for 18h;	95%
With pyridine at 20℃; for 18h;	95%

: 5274-68-0
tetraethylene glycol monododecyl ether

: 92600-11-8
1-Chloro-2-Methylpropyl Chloroformate

: 1421487-05-9
MR24

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 18h; Inert atmosphere;	96%
With pyridine In dichloromethane at 20℃; for 18h; Inert atmosphere;	2.58 g

: 5274-68-0
tetraethylene glycol monododecyl ether

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: 1421487-03-7
MR17

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 18h; Inert atmosphere;	92%
With pyridine In dichloromethane at 20℃; for 18h; Inert atmosphere;	2.26 g

: 50893-53-3
carbonochloridic acid 1-chloro-ethyl ester

: 5274-68-0
tetraethylene glycol monododecyl ether

: 1421487-04-8
MR23

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 18h; Inert atmosphere;	92%
With pyridine In dichloromethane at 20℃; for 18h; Inert atmosphere;	2.33 g

: 5274-68-0
tetraethylene glycol monododecyl ether

: C6H12O6S

: 3055-97-8
heptaethylene glycol monododecyl ether

Conditions

Conditions	Yield
Stage #1: tetraethylene glycol monododecyl ether With sodium hydride In tetrahydrofuran; mineral oil for 0.5h; Inert atmosphere; Stage #2: C6H12O6S In tetrahydrofuran; mineral oil pH=2; Inert atmosphere; Stage #3: With sulfuric acid In tetrahydrofuran; water; mineral oil at 80℃; for 2h; Inert atmosphere;	88%

: 5274-68-0
tetraethylene glycol monododecyl ether

: 1,3,6,9,12-pentaoxa-2-thiacyclotetradecane 2,2-dioxide

: 3055-98-9
Octa(ethylene oxide) dodecyl ether

Conditions

Conditions	Yield
Stage #1: tetraethylene glycol monododecyl ether With sodium hydride In tetrahydrofuran; mineral oil for 0.5h; Inert atmosphere; Stage #2: 1,3,6,9,12-pentaoxa-2-thiacyclotetradecane 2,2-dioxide In tetrahydrofuran; mineral oil pH=2; Inert atmosphere; Stage #3: With sulfuric acid In tetrahydrofuran; water; mineral oil at 80℃; for 2h; Inert atmosphere;	87%

: 5274-68-0
tetraethylene glycol monododecyl ether

: C6H12O6S

: C26H53O11S(1-)*Na(1+)

Conditions

Conditions	Yield
Stage #1: tetraethylene glycol monododecyl ether With sodium hydride In tetrahydrofuran; mineral oil for 0.5h; Inert atmosphere; Stage #2: C6H12O6S In tetrahydrofuran; mineral oil Inert atmosphere;	86%

: 5274-68-0
tetraethylene glycol monododecyl ether

: 98-59-9
p-toluenesulfonyl chloride

: 121043-71-8
tetraethylene glycol monododecyl ether tosylate

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran; water at 0℃; for 4h;	80%
With sodium hydroxide In tetrahydrofuran; water at 0℃; for 2h;	61%
With pyridine at 4℃; for 24h;

: 64-18-6
formic acid

: 5274-68-0
tetraethylene glycol monododecyl ether

: formic acid 2-{2-[2-(2-dodecyloxy-ethoxy)-ethoxy]-ethoxy}-ethyl ester

Conditions

Conditions	Yield
toluene-4-sulfonic acid at 85℃; for 4h; Esterification;	80%

: 5274-68-0
tetraethylene glycol monododecyl ether

: hexakiscyclophosphazene

Conditions

Conditions	Yield
With 2,2,4,4,6,6-hexachloro-1,3,5-triaza-2,4,6-triphosphorine; sodium hydride In tetrahydrofuran for 48h; Heating;	61%
With 2,2,4,4,6,6-hexachloro-1,3,5-triaza-2,4,6-triphosphorine; sodium hydride; tetrabutylammomium bromide In tetrahydrofuran for 48h; Heating;
With 2,2,4,4,6,6-hexachloro-1,3,5-triaza-2,4,6-triphosphorine; tetrabutylammomium bromide; sodium hydride In tetrahydrofuran Yield given;

: 5274-68-0
tetraethylene glycol monododecyl ether

: 1,3,6,9,12-pentaoxa-2-thiacyclotetradecane 2,2-dioxide

: sodium polyoxyethylene (8) lauryl sulfate

Conditions

Conditions	Yield
Stage #1: tetraethylene glycol monododecyl ether With sodium hydride In tetrahydrofuran; mineral oil for 0.5h; Inert atmosphere; Stage #2: 1,3,6,9,12-pentaoxa-2-thiacyclotetradecane 2,2-dioxide In tetrahydrofuran; mineral oil Inert atmosphere;	52%

: 5274-68-0
tetraethylene glycol monododecyl ether

: {2-[2-(2-dodecyloxy-ethoxy)-ethoxy]-ethoxy}-acetaldehyde

Conditions

Conditions	Yield
With pyridinium trifluroacetate; dimethyl sulfoxide; dicyclohexyl-carbodiimide In toluene at 20℃; for 48h; Oxidation;	40%

: 5274-68-0
tetraethylene glycol monododecyl ether

: 3926-62-3
sodium monochloroacetic acid

: 21127-45-7
(2-{2-[2-(2-Dodecyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-acetic acid

Conditions

Conditions	Yield
With sodium In xylene at 110 - 130℃; for 16h;	35%

: 5274-68-0
tetraethylene glycol monododecyl ether

: 2032-35-1
Bromoacetaldehyde diethyl acetal

: 202408-17-1
dodecyltetraoxyethyleneoxyacetaldehyde diethyl acetal

Conditions

Conditions	Yield
With sodium hydride In dimethyl sulfoxide at 20℃; for 48h; Substitution;	30%

: 5274-68-0
tetraethylene glycol monododecyl ether

: 107-07-3
2-chloro-ethanol

: 3055-95-6
pentaethylene glycol mono-n-dodecyl ether

Conditions

Conditions	Yield
With sodium

: 108-77-0
1,3,5-trichloro-2,4,6-triazine

: 5274-68-0
tetraethylene glycol monododecyl ether

: 145820-12-8
2,4,6-tris(1,4,7,10,13-pentaoxapentacosyl)-1,3,5-triazine

Conditions

Conditions	Yield
With sodium hydride 1.) benzene, toluene, 6 h, 2.a) toluene, r.t., 1 h, b) 45 deg C, 1 h, c) reflux, overnight; Yield given. Multistep reaction;

: 5274-68-0
tetraethylene glycol monododecyl ether

: octakiscyclotetraphosphazatetraene

Conditions

Conditions	Yield
With octachlorocyclotetraphosphazene; tetrabutylammomium bromide; sodium hydride 1.) THF, reflux, 6 h, 2.) THF, reflux, 2 days; Yield given. Multistep reaction;

: 115-21-9
ethyltrichlorosilane

: 5274-68-0
tetraethylene glycol monododecyl ether

: C2H5Si(OCH2(C2H4O)3CH2OC12H25)3

Conditions

Conditions	Yield
for 8h; Heating;

: 5274-68-0
tetraethylene glycol monododecyl ether

: 98-13-5
Phenyltrichlorosilane

: C6H5Si(OCH2(C2H4O)3CH2OC12H25)3

Conditions

Conditions	Yield
for 8h; Heating;

: 5274-68-0
tetraethylene glycol monododecyl ether

: dodecyltetraoxyethyleneoxyacetaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 30 percent / NaH / dimethylsulfoxide / 48 h / 20 °C 2: 80 percent / aq. CF3CO2H / CH2Cl2 / 2 h / 20 °C View Scheme

: 5274-68-0
tetraethylene glycol monododecyl ether

: N-(2-hydroxyethylene)bis(3,6,9,12,15-pentaoxaheptacosyl)amine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 80 percent / sodium hydroxide / H2O; tetrahydrofuran / 4 h / 0 °C 2: 39 percent / sodium hydride / tetrahydrofuran / 49 h / Ambient temperature 3: 98 percent / aqueous hydrochloric acid / methanol / 2 h / Ambient temperature View Scheme

: 5274-68-0
tetraethylene glycol monododecyl ether

: 174091-94-2
N-bis(3,6,9,12,15-pentaoxaheptacosyl)amine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 80 percent / sodium hydroxide / H2O; tetrahydrofuran / 4 h / 0 °C 2: 39 percent / sodium hydride / tetrahydrofuran / 49 h / Ambient temperature View Scheme

: 5274-68-0
tetraethylene glycol monododecyl ether

: 148433-39-0
tetraethylene glycol monododecyl monophthalimide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: pyridine / 24 h / 4 °C 2: dimethylformamide / 72 h / 60 °C View Scheme

: 5274-68-0
tetraethylene glycol monododecyl ether

: 2,7,12,18-tetramethyl-3,8-divinyl-13-(((3',6',9',12'-tetraoxatetraeicosyl)carbamoyl)ethyl)-17-(carboxyethyl)porphyrin

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: pyridine / 24 h / 4 °C 2: dimethylformamide / 72 h / 60 °C 3: 68 percent / hydrazine monohydrate / ethanol / 2.5 h / Heating 4: 60 percent / diethoxyphosphinyl cyanide / tetrahydrofuran / 96 h / Ambient temperature 5: 94 percent / 1N aq. NaOH / tetrahydrofuran; methanol / 24 h / Ambient temperature View Scheme

: 5274-68-0
tetraethylene glycol monododecyl ether

: 2,7,12,18-tetramethyl-3,8-divinyl-13-(((3',6',9',12'-tetraoxatetraeicosyl)carbamoyl)ethyl)-17-((ethoxycarbonyl)ethyl)porphyrin

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: pyridine / 24 h / 4 °C 2: dimethylformamide / 72 h / 60 °C 3: 68 percent / hydrazine monohydrate / ethanol / 2.5 h / Heating 4: 60 percent / diethoxyphosphinyl cyanide / tetrahydrofuran / 96 h / Ambient temperature View Scheme

: 5274-68-0
tetraethylene glycol monododecyl ether

: 148433-34-5
3,6,9,12-tetraoxatetraeicosylamine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: pyridine / 24 h / 4 °C 2: dimethylformamide / 72 h / 60 °C 3: 68 percent / hydrazine monohydrate / ethanol / 2.5 h / Heating View Scheme

Tetraethyleneglycol monododecyl ether Specification

The IUPAC name of 3,6,9,12-Tetraoxatetracosan-1-ol is 2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethanol. With the CAS registry number 5274-68-0, it is also named as Dodecyltetraethylene glycol monoether. The product's categories are Ether Type (Surfactants); Ethylene Glycols & Monofunctional Ethylene Glycols; Functional Materials; Monofunctional Ethylene Glycols; Nonionic Surfactants; Surfactants. Besides, it is white solid or colourless liquid, which should be sealed in dark, cool and dry place at 2-8 °C. It is used as an emulsifier. In addition, its molecular formula is C₂₀H₄₂O₅ and molecular weight is 362.54.

The other characteristics of 3,6,9,12-Tetraoxatetracosan-1-ol can be summarized as: (1)EINECS: 226-097-1; (2)ACD/LogP: 3.97; (3)# of Rule of 5 Violations: 0; (4)ACD/LogD (pH 5.5): 3.97; (5)ACD/LogD (pH 7.4): 3.97; (6)ACD/BCF (pH 5.5): 615.87; (7)ACD/BCF (pH 7.4): 615.87; (8)ACD/KOC (pH 5.5): 3453.96; (9)ACD/KOC (pH 7.4): 3453.96; (10)#H bond acceptors: 5; (11)#H bond donors: 1; (12)#Freely Rotating Bonds: 23; (13)Polar Surface Area: 46.15 Å²; (14)Index of Refraction: 1.453; (15)Molar Refractivity: 103.22 cm³; (16)Molar Volume: 381.6 cm³; (17)Polarizability: 40.92×10^-24cm³; (18)Surface Tension: 34.2 dyne/cm; (19)Density: 0.949 g/cm³; (20)Flash Point: 226.1 °C; (21)Enthalpy of Vaporization: 81.82 kJ/mol; (22)Boiling Point: 450.3 °C at 760 mmHg; (23)Vapour Pressure: 5.31E-10 mmHg at 25 °C.

When you are using this chemical, please be cautious about it as the following: it is irritating to eyes, respiratory system and skin. In case of contact with eyes, please rinse immediately with plenty of water and seek medical advice. And you should wear suitable protective clothing.

People can use the following data to convert to the molecule structure.
(1)Canonical SMILES: CCCCCCCCCCCCOCCOCCOCCOCCO
(2)InChI: InChI=1S/C20H42O5/c1-2-3-4-5-6-7-8-9-10-11-13-22-15-17-24-19-20-25-18-16-23-14-12-21/h21H,2-20H2,1H3
(3)InChIKey: WPMWEFXCIYCJSA-UHFFFAOYSA-N

Product Name

Tetraethyleneglycol monododecyl ether

Synthetic route

Tetraethyleneglycol monododecyl ether Specification

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