Thiophenethiol supplier | CasNO.7774-74-5

Name
Thiophenethiol
EINECS 231-881-1
CAS No. 7774-74-5
Article Data40
CAS DataBase
Density 1.269 g/cm³
Solubility
Melting Point
Formula C₄H₄S₂
Boiling Point 166.9 °C at 760 mmHg
Molecular Weight 116.208
Flash Point 54.7 °C
Transport Information UN 3334
Appearance Clear yellowish to orange liquid
Safety 26-36-36/37/39
Risk Codes 36/37/38-36/38-21/22-20/22
Molecular Structure
Hazard Symbols Xn, Xi
Synonyms 2-Thiophenethiol(6CI,7CI,8CI,9CI);2-Mercaptothiophene;2-Thienylmercaptan;a-Thienyl mercaptan;2-Thienyl mercaptan;2-Thiophenethiol(7774-74-5 );Thiophene-2-thiol;2-Thiophenethiol;
PSA 67.04000
LogP 2.03680

Synthetic route

: 1227941-25-4
3-(thiophen-2-ylsulfanyl)propionic acid 2-ethylhexyl ester

: 7774-74-5
Thiophene-2-thiol

Conditions

Conditions	Yield
Stage #1: 3-(thiophen-2-ylsulfanyl)propionic acid 2-ethylhexyl ester With sodium methylate In methanol at 20℃; for 1h; Reflux; Stage #2: With hydrogenchloride In water at 20℃; pH=1 - 2;	87.3%

: 16629-19-9
thiophene-2-sulfonyl chloride

: 7774-74-5
Thiophene-2-thiol

Conditions

Conditions	Yield
With triphenylphosphine In toluene for 0.166667h; Inert atmosphere; chemoselective reaction;	85%

: 188290-36-0
thiophene

: 7774-74-5
Thiophene-2-thiol

Conditions

Conditions	Yield
With n-butyllithium; water; sulfur	70%
With n-butyllithium; sulfur 1.) hexane/THF, -20 - -30 deg C, 0.5 h, 2.) hexane/THF, -70 deg C, 1 h; Yield given. Multistep reaction;
With n-butyllithium; sulfur In tetrahydrofuran; hexane at 0 - 5℃; for 2h;

: 96-43-5
2-thienyl chloride

A: 188290-36-0
thiophene

B: 7774-74-5
Thiophene-2-thiol

C: 7774-73-4
thiophene-3-thiol

D: 3807-38-3
sulfure de dithienyle-3,3'

E: 3807-37-2
2-thienyl 3-thienyl sulfide

F: 3988-99-6
bis(thien-2-yl)sulfide

Conditions

Conditions	Yield
With dimethylselenide; hydrogen sulfide In gas at 500℃; Product distribution; Mechanism; effect of dimethyl selenide on reaction; various temperatures;	A 46% B 10% C 3% D n/a E n/a F 1.8%

...Expand

: 1227941-25-4
3-(thiophen-2-ylsulfanyl)propionic acid 2-ethylhexyl ester

: 7774-74-5
Thiophene-2-thiol

Conditions

Conditions	Yield
Stage #1: 3-(thiophen-2-ylsulfanyl)propionic acid 2-ethylhexyl ester With sodium methylate In methanol at 20℃; for 1h; Reflux; Stage #2: With hydrogenchloride In water at 20℃; pH=1 - 2;	87.3%

: 16629-19-9
thiophene-2-sulfonyl chloride

: 7774-74-5
Thiophene-2-thiol

Conditions

Conditions	Yield
With triphenylphosphine In toluene for 0.166667h; Inert atmosphere; chemoselective reaction;	85%

: 188290-36-0
thiophene

: 7774-74-5
Thiophene-2-thiol

Conditions

Conditions	Yield
With n-butyllithium; water; sulfur	70%
With n-butyllithium; sulfur 1.) hexane/THF, -20 - -30 deg C, 0.5 h, 2.) hexane/THF, -70 deg C, 1 h; Yield given. Multistep reaction;
With n-butyllithium; sulfur In tetrahydrofuran; hexane at 0 - 5℃; for 2h;

: 96-43-5
2-thienyl chloride

A: 188290-36-0
thiophene

B: 7774-74-5
Thiophene-2-thiol

C: 7774-73-4
thiophene-3-thiol

D: 3807-38-3
sulfure de dithienyle-3,3'

E: 3807-37-2
2-thienyl 3-thienyl sulfide

F: 3988-99-6
bis(thien-2-yl)sulfide

Conditions

Conditions	Yield
With dimethylselenide; hydrogen sulfide In gas at 500℃; Product distribution; Mechanism; effect of dimethyl selenide on reaction; various temperatures;	A 46% B 10% C 3% D n/a E n/a F 1.8%

...Expand

: 96-43-5
2-thienyl chloride

: 110-81-6
Diethyl disulfide

A: 188290-36-0
thiophene

B: 7774-74-5
Thiophene-2-thiol

C: 250-84-0
thieno[2,3-b]thiophene

D: 3988-99-6
bis(thien-2-yl)sulfide

Conditions

Conditions	Yield
at 550℃; for 0.0141667h; Product distribution; gas phase copyrolysis;	A 18.4% B 36.4% C 3.4% D 14.3%

...Expand

: 3988-99-6
bis(thien-2-yl)sulfide

A: 188290-36-0
thiophene

B: 7774-74-5
Thiophene-2-thiol

C: 7774-73-4
thiophene-3-thiol

D: 3807-37-2
2-thienyl 3-thienyl sulfide

E: 3593-75-7
dithieno[3,2-b;2',3'-d]thiophene

F: 492-97-7
2,2'-Bithiophene

Conditions

Conditions	Yield
With hydrogen sulfide at 450 - 600℃; Product distribution;	A 31.8% B 6% C 5% D 4.7% E n/a F 15.2%
at 500 - 600℃; Product distribution;	A 17.6% B 13.1% C 1.4% D 0.5% E n/a F 3%

...Expand

: 3988-99-6
bis(thien-2-yl)sulfide

A: 7774-74-5
Thiophene-2-thiol

B: 7774-73-4
thiophene-3-thiol

C: 2404-89-9
2,3'-bithienyl

D: 3807-37-2
2-thienyl 3-thienyl sulfide

E: 492-97-7
2,2'-Bithiophene

Conditions

Conditions	Yield
With hydrogen sulfide; sulfur at 180℃; for 8h; Product distribution;	A 29.9% B 12.6% C 5.7% D 16.6% E 7.7%

...Expand

: 540-59-0
1,2-Dichloroethylene

A: 188290-36-0
thiophene

B: 7774-74-5
Thiophene-2-thiol

C: 7774-73-4
thiophene-3-thiol

D: 250-84-0
thieno[2,3-b]thiophene

E: β-chlorovinyl hydrosulfide

F: 74121-39-4
cis-2-thienyl β-chlorovinyl sulfide

Conditions

Conditions	Yield
With hydrogen sulfide In neat (no solvent) at 480℃; for 0.0125h; Product distribution; var. temp., var. ratio of reagents, var. contact time;	A 13.5% B 5.47% C 3.95% D n/a E 5.91% F 5.45%

...Expand

: 96-43-5
2-thienyl chloride

: 110-81-6
Diethyl disulfide

: 51639-98-6
ethyldisulfanyl

A: 188290-36-0
thiophene

B: 7774-74-5
Thiophene-2-thiol

C: 250-84-0
thieno[2,3-b]thiophene

D: 251-41-2
thieno[3,2-b]thiophene

E: 3988-99-6
bis(thien-2-yl)sulfide

Conditions

Conditions	Yield
at 560℃; for 0.0166667h; Product distribution; Mechanism; different ratio;

...Expand

: 96-43-5
2-thienyl chloride

: 110-81-6
Diethyl disulfide

A: 188290-36-0
thiophene

B: 7774-74-5
Thiophene-2-thiol

C: 250-84-0
thieno[2,3-b]thiophene

D: 251-41-2
thieno[3,2-b]thiophene

E: 3988-99-6
bis(thien-2-yl)sulfide

Conditions

Conditions	Yield
at 560℃; for 0.0166667h; Product distribution; Mechanism;

...Expand

: 96-43-5
2-thienyl chloride

: 352-93-2
diethyl sulphide

A: 188290-36-0
thiophene

B: 7774-74-5
Thiophene-2-thiol

C: 250-84-0
thieno[2,3-b]thiophene

D: 251-41-2
thieno[3,2-b]thiophene

E: 3988-99-6
bis(thien-2-yl)sulfide

Conditions

Conditions	Yield
at 560℃; for 0.0166667h; Product distribution; Mechanism;

...Expand

: 96-43-5
2-thienyl chloride

: 3600-24-6
diethyltrisulfane

A: 188290-36-0
thiophene

B: 7774-74-5
Thiophene-2-thiol

C: 250-84-0
thieno[2,3-b]thiophene

D: 251-41-2
thieno[3,2-b]thiophene

E: 3988-99-6
bis(thien-2-yl)sulfide

Conditions

Conditions	Yield
at 560℃; for 0.0166667h; Product distribution; Mechanism;

...Expand

: 96-43-5
2-thienyl chloride

: 75-33-2
2-propanethiol

A: 188290-36-0
thiophene

B: 7774-74-5
Thiophene-2-thiol

C: 250-84-0
thieno[2,3-b]thiophene

D: 3988-99-6
bis(thien-2-yl)sulfide

Conditions

Conditions	Yield
at 540℃; for 0.0152778h; Product distribution;	A 2.4 % Chromat. B 20.0 % Chromat. C 1.7 % Chromat. D 32.0 % Chromat.

...Expand

: 96-43-5
2-thienyl chloride

: 75-08-1
ethanethiol

A: 7774-74-5
Thiophene-2-thiol

B: 250-84-0
thieno[2,3-b]thiophene

C: 251-41-2
thieno[3,2-b]thiophene

D: 3988-99-6
bis(thien-2-yl)sulfide

Conditions

Conditions	Yield
at 560℃; for 0.0166667h; Product distribution; Mechanism;

...Expand

: 1003-09-4
2-bromothiophene

: 7774-74-5
Thiophene-2-thiol

Conditions

Conditions	Yield
With mesna Yield given. Multistep reaction;
Stage #1: 2-bromothiophene With n-butyllithium In diethyl ether; hexane at -70℃; for 2.5h; Inert atmosphere; Stage #2: With sulfur In diethyl ether; hexane at -70℃; for 2h; Inert atmosphere;

: 6911-35-9
2-ethylthiophene

: 250-84-0
thieno[2,3-b]thiophene

A: 188290-36-0
thiophene

B: 7774-74-5
Thiophene-2-thiol

C: 251-41-2
thieno[3,2-b]thiophene

D: 3988-99-6
bis(thien-2-yl)sulfide

Conditions

Conditions	Yield
at 560℃; Product distribution; thermolysis;	A 10 % Chromat. B 11.5 % Chromat. C n/a D 17 % Chromat.

...Expand

: 3988-99-6
bis(thien-2-yl)sulfide

A: 7774-74-5
Thiophene-2-thiol

B: 7774-73-4
thiophene-3-thiol

C: 3172-56-3
3,3'-bithiophene

D: 2404-89-9
2,3'-bithienyl

E: 3807-37-2
2-thienyl 3-thienyl sulfide

F: 492-97-7
2,2'-Bithiophene

Conditions

Conditions	Yield
With hydrogen sulfide at 180℃; for 10h; Product distribution; other reagent, reaction time;	A 1.0 % Turnov. B 0.5 % Turnov. C 8.5 % Turnov. D 10.7 % Turnov. E 37.8 % Turnov. F 8.0 % Turnov.

...Expand

: 33892-56-7
allyl(2-thiophene)sulfide

A: 188290-36-0
thiophene

B: 7774-74-5
Thiophene-2-thiol

C: 3988-99-6
bis(thien-2-yl)sulfide

D: 26238-22-2
2-methylthieno<2,3-b>thiophene

Conditions

Conditions	Yield
In gas thermolysis above 380 deg C;

...Expand

: 6911-51-9
2-thienyl disulfide

A: 7774-74-5
Thiophene-2-thiol

B: 7774-73-4
thiophene-3-thiol

C: 3807-37-2
2-thienyl 3-thienyl sulfide

D: 3988-99-6
bis(thien-2-yl)sulfide

Conditions

Conditions	Yield
With hydrogen sulfide at 130℃; for 7h; Product distribution; other temperatures, reaction time;	A 12.5 % Turnov. B 3.8 % Turnov. C 19.6 % Turnov. D 61.6 % Turnov.

...Expand

: 120665-65-8
4-(2-thienylthio)tetrahydrothiophene-2-thione

: 7774-74-5
Thiophene-2-thiol

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran Product distribution;

: 5713-61-1
thiophen-2-yl magnesium bromide

: 288-39-1, 23091-39-6
1,2,5-thiadiazole

A: 7774-74-5
Thiophene-2-thiol

B: 3988-99-6
bis(thien-2-yl)sulfide

C: 112633-32-6
3-(2-thienyl)-1,2,5-selenadiazole

Conditions

Conditions	Yield
With sulenium monochloride 1.) tetrahydrofuran, reflux, 2 h, 2.) tetrahydrofuran, 3 h; Yield given. Multistep reaction;

...Expand

: 33892-56-7
allyl(2-thiophene)sulfide

: 74-86-2
acetylene

A: 188290-36-0
thiophene

B: 7774-74-5
Thiophene-2-thiol

C: 250-84-0
thieno[2,3-b]thiophene

D: 3988-99-6
bis(thien-2-yl)sulfide

E: 26238-22-2
2-methylthieno<2,3-b>thiophene

Conditions

Conditions	Yield
In gas at 460℃; Product distribution; Mechanism; other allyl 2-thieno selenide, with or without acetylene, var. temperatures;	A 5 % Chromat. B 14 % Chromat. C 25 % Chromat. D 17 % Chromat. E 10 % Chromat.

...Expand

: 33892-56-7
allyl(2-thiophene)sulfide

: 74-86-2
acetylene

A: 7774-74-5
Thiophene-2-thiol

B: 250-84-0
thieno[2,3-b]thiophene

C: 3988-99-6
bis(thien-2-yl)sulfide

D: 26238-22-2
2-methylthieno<2,3-b>thiophene

Conditions

Conditions	Yield
In gas at 460℃; thermolysis; Further byproducts given;	A 14 % Chromat. B 25 % Chromat. C 17 % Chromat. D 10 % Chromat.

...Expand

: 2786-07-4
2-thienyl lithium

: 7774-74-5
Thiophene-2-thiol

Conditions

Conditions	Yield
With sulfur

: 3988-99-6
bis(thien-2-yl)sulfide

A: 188290-36-0
thiophene

B: 7774-74-5
Thiophene-2-thiol

C: 7774-73-4
thiophene-3-thiol

D: 236-63-5
dithieno[2,3-b:3',2'-d]thiophene

E isomeric dithienyls: isomeric dithienyls

Conditions

Conditions	Yield
With hydrogen sulfide In gas at 500 - 600℃; Product distribution;

...Expand

: 96-43-5
2-thienyl chloride

A: 7774-74-5
Thiophene-2-thiol

B: 7774-73-4
thiophene-3-thiol

C: 3807-37-2
2-thienyl 3-thienyl sulfide

D: 3988-99-6
bis(thien-2-yl)sulfide

Conditions

Conditions	Yield
With methanol; hydrogen sulfide at 610℃; Product distribution; Further Variations:; Reagents; Temperatures;

...Expand

: 87947-35-1
S-thiophen-2-yl ethanethioate

: 7774-74-5
Thiophene-2-thiol

Conditions

Conditions	Yield
With potassium hydroxide In methanol

: 14660-52-7
ethyl 5-bromovalerate

A: 7774-74-5
Thiophene-2-thiol

B: 5-(thien-2-ylsulfanyl)-valeric acid

: 96-43-5
2-thienyl chloride

: 7783-06-4
hydrogen sulfide

A: 7774-74-5
Thiophene-2-thiol

B: 3988-99-6
bis(thien-2-yl)sulfide

Conditions

Conditions	Yield
Kinetics; byproducts: HCl; at 500-600°C;

...Expand

: 7774-74-5
Thiophene-2-thiol

: 3354-32-3
2,5-dihydro-2H-2-oxothiophene

: 120638-04-2
4-(Thiophen-2-ylsulfanyl)-dihydro-thiophen-2-one

Conditions

Conditions	Yield
In neat (no solvent) at 25℃; for 18h; Product distribution;	100%
In neat (no solvent) at 25℃; for 18h;	100%

: 7774-74-5
Thiophene-2-thiol

: 100-63-0
phenylhydrazine

: 135922-87-1
4-(2-thienylthio)-2-phenylhydrazonotetrahydrothiophene

Conditions

Conditions	Yield
at 18 - 20℃; for 240h;	99%

: 7774-74-5
Thiophene-2-thiol

: 6911-51-9
2-thienyl disulfide

Conditions

Conditions	Yield
With oxygen In water at 45℃; under 1500.15 Torr; Reagent/catalyst; Temperature; Pressure;	99%
With cobalt(II)phthalocyanine-tetra-sodium sulfonate In water at 60℃; for 6h; Schlenk technique;	91%
With (bis(2,1-phenylene)bis(azanediyl)bis(methylene)diphenol)diselenide In acetonitrile at 20℃; for 7h;	89%

: 7774-74-5
Thiophene-2-thiol

: 541-47-9
3-Methylbutenoic acid

: 111190-17-1
3-methyl-3-(thiophene-2-thio)butyric acid

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran for 21h; Heating;	98%
With triethylamine In tetrahydrofuran for 20h; Reflux; Inert atmosphere;	63.35%
With triethylamine In tetrahydrofuran for 20h; Reflux; Inert atmosphere;	63.35%
With triethylamine In tetrahydrofuran for 20h; Inert atmosphere; Reflux;	63.35%
With triethylamine In tetrahydrofuran for 20h; Inert atmosphere; Reflux;	63.4%

: 7774-74-5
Thiophene-2-thiol

: 628-48-8
glutaconic acid

: 138302-56-4
3-(thien-2-ylthio)-glutaric acid

Conditions

Conditions	Yield
With sodium chloride; triethylamine In tetrahydrofuran	98%

: 7774-74-5
Thiophene-2-thiol

: 7252-83-7
1-bromo-2,2-dimethoxyethane

: 98558-44-2
2-(2,2-dimethoxy-ethylsulfanyl)-thiophene

Conditions

Conditions	Yield
With potassium carbonate In acetone	97%
With ethanol; sodium ethanolate

: 7774-74-5
Thiophene-2-thiol

: 78324-12-6
tert-butyldimethylsilyl p-methoxycinnamate

: 111190-20-6
3-(4-Methoxy-phenyl)-3-(thiophen-2-ylsulfanyl)-propionic acid

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran for 21h; Heating;	97%

: 7774-74-5
Thiophene-2-thiol

: 600-00-0
ethyl 2-bromoisobutyrate

: 70060-29-6
ethyl 2-methyl-2-(thien-2-ylthio)propanoate

Conditions

Conditions	Yield
With sodium ethanolate In ethanol Heating;	97%

: 7774-74-5
Thiophene-2-thiol

: 1004770-54-0
2-bromo-N-(5-tert-butyl-isoxazol-3-yl)-2-methyl-propionamide

: N-(5-tert-butyl-isoxazol-3-yl)-2-methyl-2-(thiophen-2-ylsulfanyl)-propionamide

Conditions

Conditions	Yield
With potassium hydroxide In ethanol for 18h; Heating / reflux;	97%

: 7774-74-5
Thiophene-2-thiol

: 65060-93-7
N-methyl bromomaleimide

: N-methyl-3-(thiophen-2-ylthio)-maleimide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 0.166667h;	97%

: 7774-74-5
Thiophene-2-thiol

: 155170-47-1
(Z)-3-(pyridin-3-yl)acrylic acid

: 111190-22-8
3-Pyridin-3-yl-3-(thiophen-2-ylsulfanyl)-propionic acid

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran for 21h; Heating;	96%

: 7774-74-5
Thiophene-2-thiol

: 79-41-4
poly(methacrylic acid)

: 111190-16-0
2-Methyl-3-(thiophen-2-ylsulfanyl)-propionic acid

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran for 21h; Heating;	95%

: 7774-74-5
Thiophene-2-thiol

: 140-10-3, 621-82-9, 102-94-3
cis-cinnamic acid

: 111190-18-2
3-(2-mercaptothiopheneyl)-3-phenyl propionic acid

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran for 21h; Heating;	95%

: 7774-74-5
Thiophene-2-thiol

: 5676-64-2
(Z)-3-(4-methoxyphenyl)acrylic acid

: 111190-20-6
3-(4-Methoxy-phenyl)-3-(thiophen-2-ylsulfanyl)-propionic acid

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran for 21h; Heating;	95%

: 7774-74-5
Thiophene-2-thiol

: 89761-18-2
(Z)-3-(2-nitrophenyl)acrylic acid

: 111190-24-0
3-(2-thienylthio)-3-(o-nitrophenyl)-propionic acid

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran for 21h; Heating;	95%

: 7774-74-5
Thiophene-2-thiol

: 109-70-6
1,3-chlorobromopropane

: 81577-85-7
2-(3-Chloropropylsulfanyl)thiophene

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In isopropyl alcohol at 100℃; for 1h;	95%
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 0 - 20℃;

: 7774-74-5
Thiophene-2-thiol

: 106-93-4
ethylene dibromide

: 55697-88-6
2-(2-bromoethylthio)-thiophene

Conditions

Conditions	Yield
With potassium carbonate at 20 - 78℃; Inert atmosphere;	95%
With potassium carbonate at 78℃; for 3h; Inert atmosphere;	95%
With potassium carbonate; potassium iodide In acetone at 20℃;	32.9%

: 7774-74-5
Thiophene-2-thiol

: 1394285-00-7
1,9-dichloro-5-phenyldipyrromethene

: C23H16N2S4

Conditions

Conditions	Yield
With triethylamine In acetonitrile at 76℃; for 6.5h; Inert atmosphere;	95%

: 7774-74-5
Thiophene-2-thiol

: 6339-87-3
2-thiophensulfonamide

Conditions

Conditions	Yield
With [bis(acetoxy)iodo]benzene; ammonium carbamate In methanol at 25℃; for 24h; Inert atmosphere; chemoselective reaction;	95%
With ammonium hydroxide; manganese(IV) oxide; oxygen In water; N,N-dimethyl-formamide at 90℃; under 7500.75 Torr; for 20h; Autoclave;	59%

: 7774-74-5
Thiophene-2-thiol

: 31930-36-6
ethyl (Z)-3-iodopropenoate

: 1234562-79-8
(Z)-3-(thiophen-2-ylthio)-acrylic acid ethyl ester

Conditions

Conditions	Yield
With potassium phosphate; copper(l) iodide; cis-1,2-cyclohexane In N,N-dimethyl-formamide at 40 - 50℃; for 2h; Inert atmosphere;	94%

: 7774-74-5
Thiophene-2-thiol

: 5061-21-2
α-bromo-γ-butyrolactone

: α-[(thiophen-2-yl)thio]-γ-butyrolactone

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃;	94%

: 7774-74-5
Thiophene-2-thiol

: 110-16-7
maleic acid

: 3807-43-0
2-thienylthiosuccinic acid

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran	93%
With triethylamine In tetrahydrofuran	93%
With triethylamine In tetrahydrofuran	93%
In 1,4-dioxane at 70 - 80℃;	92%

: 7774-74-5
Thiophene-2-thiol

A: 6911-51-9
2-thienyl disulfide

B: 120665-65-8
4-(2-thienylthio)tetrahydrothiophene-2-thione

Conditions

Conditions	Yield
Product distribution; Mechanism;	A n/a B 93%

: 280-57-9
1,4-diaza-bicyclo[2.2.2]octane

: 7774-74-5
Thiophene-2-thiol

: 88284-48-4
2-(trimethylsilyl)phenyl trifluoromethanesulfonate

: 1-phenyl-4-(2-(thiophen-2-ylthio)ethyl)piperazine

Conditions

Conditions	Yield
Stage #1: 1,4-diaza-bicyclo[2.2.2]octane; 2-(trimethylsilyl)phenyl trifluoromethanesulfonate With cesium fluoride In acetonitrile at 20℃; Stage #2: Thiophene-2-thiol In acetonitrile at 100℃; for 18h;	93%

...Expand

: 7774-74-5
Thiophene-2-thiol

: 99440-99-0
2-hydroxycyclobutanone

: 1-(thiophen-2-ylsulfanyl)cyclopropanecarbaldehyde

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In dichloromethane at 20℃;	93%

: 7774-74-5
Thiophene-2-thiol

: 20013-15-4
2-((4-((4-aminophenyl)sulfonyl)phenyl)amino)-3-chloronaphthalene-1,4-dione

: C26H18N2O4S3

Conditions

Conditions	Yield
In ethanol for 2h; Reflux;	93%

: 7774-74-5
Thiophene-2-thiol

: 111-83-1
1-bromo-octane

: 55191-03-2
2-octyl 2-thiophenyl sulfide

Conditions

Conditions	Yield
Stage #1: Thiophene-2-thiol With potassium tert-butylate In ethanol at 0℃; for 0.5h; Inert atmosphere; Stage #2: 1-bromo-octane In ethanol at 80℃; for 12h; Inert atmosphere;	92.4%
With potassium hydroxide; hydrazine hydrate for 1h; Ambient temperature;	63%
With potassium tert-butylate In ethanol; dichloromethane for 2h; Heating;	60%
With potassium hydroxide
With potassium carbonate

Thiophenethiol Chemical Properties

Molecular Structure of 2-Thiophenethiol (CAS NO.7774-74-5):

IUPAC Name: Thiophene-2-thiol
Canonical SMILES: C1=CSC(=C1)S
InChI: InChI=1S/C4H4S2/c5-4-2-1-3-6-4/h1-3,5H
InChIKey: SWEDAZLCYJDAGW-UHFFFAOYSA-N
Molecular Weight: 116.20456 [g/mol]
Molecular Formula: C₄H₄S₂
XLogP3: 2.2
EINECS: 231-881-1
Appearance: Clear yellowish to orange liquid
Index of Refraction: 1.636
Molar Refractivity: 32.81 cm³
Molar Volume: 91.5 cm³
Surface Tension: 46.4 dyne/cm
Density: 1.269 g/cm³
Flash Point: 54.7 °C
Enthalpy of Vaporization: 38.68 kJ/mol
Boiling Point: 166.9 °C at 760 mmHg
Vapour Pressure: 2.3 mmHg at 25 °C
storage temp.: Store under inert gas
Sensitive: Air Sensitive
Product Categories: THIOL;Thiophene & Benzothiophene; thiol Flavor

Thiophenethiol Uses

2-Thiophenethiol (CAS NO.7774-74-5) is used to deploy flavor for candy and baking food.

Thiophenethiol Safety Profile

Safety Information of 2-Thiophenethiol (CAS NO.7774-74-5):
Hazard Codes: Irritant Xi, Harmful Xn
Risk Statements:36/37/38-36/38-21/22-20/22
36/37/38:Irritating to eyes, respiratory system and skin
36/38:Irritating to eyes and skin
21/22:Harmful in contact with skin and if swallowed
20/22:Harmful by inhalation and if swallowed
Safety Statements:26-36-36/37/39
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:Wear suitable protective clothing
36/37/39:Wear suitable protective clothing, gloves and eye/face protection
RIDADR:UN3334
WGK Germany:3
F:10-13-23
Hazard Note:Irritant

Thiophenethiol Specification

2-Thiophenethiol (CAS NO.7774-74-5), its Synonyms are 2-Mercaptothiophene ; 2-Thienyl mercaptan ; FEMA No. 3062 ; alpha-Thienyl mercaptan ; Thiophene-2-thiol .

Product Name

Thiophenethiol

Synthetic route

Thiophenethiol Chemical Properties

Thiophenethiol Uses

Thiophenethiol Safety Profile

Thiophenethiol Specification

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