Tosyl azide supplier | CasNO.941-55-9

Name
Tosyl azide
EINECS 213-381-5
CAS No. 941-55-9
Article Data39
CAS DataBase
Density ~0.90 g/mL at 20 °C
Solubility Dissolved in most organic solvents
Melting Point 22 °C
Formula C₇H₇N₃O₂S
Boiling Point
Molecular Weight 197.217
Flash Point 4℃
Transport Information
Appearance white crystal
Safety 16-35
Risk Codes 5
Molecular Structure
Hazard Symbols F
Synonyms p-Toluenesulfonylazide (6CI,7CI,8CI);4-Methylbenzenesulfonyl azide;Azido-p-toluenesulfonic acid;NSC 138649;Tosylazide;p-Methylphenylsulfonyl azide;p-Toluenesulfonazide;p-Toluenesulfonic acid azide;p-Tolylsulfonyl azide;p-Tosyl azide;
PSA 92.27000
LogP 2.52756

Synthetic route

: 98-59-9
p-toluenesulfonyl chloride

: 941-55-9
4-toluenesulfonyl azide

Conditions

Conditions	Yield
With sodium azide In water; isopropyl alcohol at 20℃; for 1h;	100%
With sodium azide In water; acetone at 0 - 23℃; for 17h; Inert atmosphere;	100%
With sodium azide In water; acetone at 0 - 23℃; for 17h; Inert atmosphere;	100%

: 455-16-3
p-toluenesulfonyl fluoride

: 941-55-9
4-toluenesulfonyl azide

Conditions

Conditions	Yield
With trimethylsilylazide; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 50℃; for 1.5h;	98%

: 104-15-4
toluene-4-sulfonic acid

: 941-55-9
4-toluenesulfonyl azide

Conditions

Conditions	Yield
Stage #1: toluene-4-sulfonic acid With trichloroisocyanuric acid; triphenylphosphine In tetrahydrofuran at 0 - 5℃; for 0.25h; Stage #2: With sodium azide In tetrahydrofuran at 5 - 20℃; for 0.0166667h; Solvent;	97%
With sodium azide; trichloroacetonitrile; triphenylphosphine In acetonitrile at 20℃; for 3h;	95%
Stage #1: toluene-4-sulfonic acid With 1-ethyl-3-methylimidazolium tetrafluoroborate; triethylamine at 0℃; for 0.0833333h; Stage #2: With sodium azide; bis(trichloromethyl) carbonate at 0 - 25℃; for 1.5h;	89%
With sodium azide; trichloroisocyanuric acid; triphenylphosphine In tetrahydrofuran at 20℃;

: 1576-35-8
toluene-4-sulfonic acid hydrazide

: 941-55-9
4-toluenesulfonyl azide

Conditions

Conditions	Yield
With SHNC In water for 0.75h; Ambient temperature;	96%
With dinitrogen tetraoxide In tetrachloromethane; acetonitrile at -20℃; for 0.166667h; Product distribution; other t;	95%
With dinitrogen tetraoxide In tetrachloromethane; acetonitrile at -20℃; for 0.166667h;	95%

: 70-55-3
toluene-4-sulfonamide

: 941-55-9
4-toluenesulfonyl azide

Conditions

Conditions	Yield
With 3-azidosulfonyl-3H-imidazole-1-ium hydrogen sulfate; potassium carbonate In water; isopropyl alcohol at 20℃; for 18h; Solvent; Concentration;	90%
With sodium azide In water; acetone at 20℃; for 2h;	87%
With copper(ll) sulfate pentahydrate; sodium hydrogencarbonate; perfluorobutanesulfonyl azide In methanol; diethyl ether; water at 20℃; for 6h;	81%

: (η5-cyclopentadienyl)(p-toluenesulfonylimido-kN-thio-kS-ethene-2-thiolato-kS)cobalt(III)

A: 941-55-9
4-toluenesulfonyl azide

B: 86543-67-1
(η(5)-cyclopentadienyl)[1,2-bis(methoxycarbonyl)ethenethiolato-κS]cobalt(III)

Conditions

Conditions	Yield
In neat (no solvent) 177-178°C;	A 43% B 88%

: 1028-19-9
1-(4'-methylbenzenesulfonyl)-1H-benzo[d][1.2.3]triazole

: 941-55-9
4-toluenesulfonyl azide

Conditions

Conditions	Yield
With sodium azide; water In acetonitrile for 4h; Heating;	88%

: 153718-76-4
7-Methoxy-1-<(4-methylphenyl)sulfonyl>-3,4-dihydropyrrolo<4,3,2-de>quinolin-8(1H)-one

A: 941-55-9
4-toluenesulfonyl azide

B: 160208-44-6
7-Methoxy-2,4-dihydropyrrolo<4,3,2-de>quinolin-8(1H)-one

Conditions

Conditions	Yield
With sodium azide; N,N-dimethyl-formamide at 25℃; for 4h;	A n/a B 84%

: 263765-02-2
toluene-4-sulfonic acid 4-methyl-5-oxo-2,5-dihydro-furan-3-yl ester

A: 941-55-9
4-toluenesulfonyl azide

B: 516-09-6
4-hydroxy-3-methyl-5H-furan-2-one

C: 4-azido-3-methyl-5H-furan-2-one

Conditions

Conditions	Yield
With sodium azide In methanol at 20℃; Substitution;	A n/a B n/a C 20%

...Expand

: 263765-03-3
toluene-4-sulfonic acid 4-(3,4-dimethoxy-phenyl)-5-oxo-2,5-dihydro-furan-3-yl ester

A: 941-55-9
4-toluenesulfonyl azide

B: 263764-91-6
3-(3,4-dimethoxyphenyl)-4-hydroxy-5H-furan-2-one

C: 4-azido-3-(3,4-dimethoxyphenyl)-5H-furan-2-one

Conditions

Conditions	Yield
With sodium azide In methanol at 20℃; Substitution;	A n/a B n/a C 20%

...Expand

: 76227-58-2
N-tosyl dimethylketenimine

A: 941-55-9
4-toluenesulfonyl azide

B: 78-82-0
Isobutyronitrile

C: 86439-37-4
N-[1-Amino-2-methyl-prop-2-en-(Z)-ylidene]-4-methyl-benzenesulfonamide

D: 86439-38-5
C22H28N2O5S2

Conditions

Conditions	Yield
With tris-(2-chloro-ethyl)-amine In diethyl ether Product distribution;	A n/a B n/a C 14% D 3%
With tris-(2-chloro-ethyl)-amine In diethyl ether	A n/a B n/a C 14% D 3%

...Expand

: 86439-36-3
N-[1-Chloro-2-methyl-prop-(Z)-ylidene]-4-methyl-benzenesulfonamide

A: 941-55-9
4-toluenesulfonyl azide

B: 78-82-0
Isobutyronitrile

Conditions

Conditions	Yield
With lithium azide In diethyl ether; N,N-dimethyl-formamide at -20 - 20℃; Product distribution;

p-toluenesulfonic acid hydrazide: p-toluenesulfonic acid hydrazide

: 941-55-9
4-toluenesulfonyl azide

Conditions

Conditions	Yield
With acetic acid; sodium nitrite

: 98-59-9
p-toluenesulfonyl chloride

CH2=CMeCHMeCH2X, X=Br or tosyl: CH2=CMeCHMeCH2X, X=Br or tosyl

: 941-55-9
4-toluenesulfonyl azide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 70 percent / K2CO3 / acetone / 20 °C 2: NaN3 / methanol / 20 °C View Scheme

: 200055-89-6
4-(4-toluenesulfonyloxy)coumarin

: 941-55-9
4-toluenesulfonyl azide

Conditions

Conditions	Yield
With sodium azide In dimethyl sulfoxide for 1h;

: 106-45-6
para-thiocresol

: 941-55-9
4-toluenesulfonyl azide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: N-chloro-succinimide; tetrabutyl-ammonium chloride; water / acetonitrile / 0 °C 2: sodium azide / acetonitrile / 0.75 h / 20 °C View Scheme
Multi-step reaction with 2 steps 1: tetrabutyl-ammonium chloride; water; N-chloro-4-methylbenzenesulfonamide / acetonitrile / 0.5 h / 0 °C 2: sodium azide / acetonitrile / 0.75 h / 0 - 20 °C View Scheme

: 51-28-5
2,4-Dinitrophenol

: 98-59-9
p-toluenesulfonyl chloride

A: 941-55-9
4-toluenesulfonyl azide

B: 4096-88-2
1-azido-2,4-dinitrobenzene

C: 104-15-4
toluene-4-sulfonic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine / diethyl ether 2: sodium azide / dimethyl sulfoxide; water; acetonitrile / 25 °C View Scheme

...Expand

: 742-25-6
2,4-dinitrophenyl 4-methylbenzenesulfonate

A: 941-55-9
4-toluenesulfonyl azide

B: 51-28-5
2,4-Dinitrophenol

C: 4096-88-2
1-azido-2,4-dinitrobenzene

D: 104-15-4
toluene-4-sulfonic acid

Conditions

Conditions	Yield
With sodium azide In water; dimethyl sulfoxide; acetonitrile at 25℃; Kinetics; Mechanism; regioselective reaction;

...Expand

: 941-55-9
4-toluenesulfonyl azide

: 70-55-3
toluene-4-sulfonamide

Conditions

Conditions	Yield
With C36H55N2Pd(2+)C7H7NO2S(2-); hydrogen In benzene-d6 at 75℃; for 12h; Temperature; Time;	100%
With iron(III) oxide; hydrazine hydrate In water at 120℃; for 1.5h; Inert atmosphere;	99%
With D-glucose; potassium hydroxide In water at 85℃; for 0.0833333h; Green chemistry; chemoselective reaction;	99%

: 941-55-9
4-toluenesulfonyl azide

: (1S,3aS,6aR,9aR)-1,8,8-Trimethyl-4,7-dioxo-decahydro-cyclopenta[d]indene-5-carbaldehyde

: C16H21N2O3(1+)*C7H8NO2S(1-)

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 18℃;	100%

: 941-55-9
4-toluenesulfonyl azide

: C24H30O2P2

: 11,17-di-tert-butyl-2-tosyltiazenyliden-3,2-12-oxadiphosphapentacyclo<11.5.1.02,11.04,10.012,16>nonadeca-4(10),5,8,14,17-pentaen-19-one

Conditions

Conditions	Yield
In dichloromethane-d2 at -78℃; for 144h;	100%

: 54986-16-2
1,4-Dihydro-1,4-dimethyl-5-(2,2-dimethylpropyliden)-5H-tetrazol

: 941-55-9
4-toluenesulfonyl azide

: 5-{2,2-dimethyl-1-{3-[(4-methylphenyl)sulfonyl]triaz-1-enyl}propyl}-1,4-dimethyl-1H-tetrazolium inner salt

Conditions

Conditions	Yield
In toluene at 20℃; for 1h;	100%

: 941-55-9
4-toluenesulfonyl azide

: 3194-60-3
thiolane-2,5-dione

: 100-46-9
benzylamine

: 104816-53-7
N-(4-methylphenylsulfonyl)-N'-(phenylmethyl)-butanediamide

Conditions

Conditions	Yield
Stage #1: thiolane-2,5-dione; benzylamine In methanol for 0.5h; Stage #2: 4-toluenesulfonyl azide With 2,6-dimethylpyridine In methanol for 0.5h; Further stages.;	100%

...Expand

: 909103-59-9
methyl 5-acetamido-2,6-anhydro-3,5-dideoxy-8,9-O-isopropylidene-4-O-(2-propynyl)-D-glycero-D-galacto-non-2-enonate

: 941-55-9
4-toluenesulfonyl azide

: 108-18-9
diisopropylamine

: 1304780-03-7
methyl 5-acetamido-2,6-anhydro-3,5-dideoxy-8,9-O-isopropylidene-4-O-[3-(diisopropylamino)-3-(4-methylbenzenesulfonylimino)propoxy]-D-glycero-D-galacto-non-2-enonate

Conditions

Conditions	Yield
With copper(l) iodide In dichloromethane at 20℃; for 1h; Inert atmosphere;	100%

...Expand

: 941-55-9
4-toluenesulfonyl azide

: methyl 3-oxo-4-phenylhexanoate

: methyl 2-diazo-3-oxo-4-phenylhexanoate

Conditions

Conditions	Yield
With triethylamine In acetonitrile at 20℃; for 16h;	100%

: 941-55-9
4-toluenesulfonyl azide

: benzyl(3S,4S)-4-(2-(4-bromophenyl)-2-oxoethyl)-3-ethynyl-1-(mesitylsulfonyl)-1,2,3,4-tetrahydroquinoline-3-carboxylate

: benzyl(3R,4S)-4-(2-(4-bromophenyl)-2-oxoethyl)-1-(mesitylsulfonyl)-3-(1-tosyl-1H-1,2,3-triazol-4-yl)-1,2,3,4-tetrahydroquinoline-3-carboxylate

Conditions

Conditions	Yield
With copper(I) thiophene-2-carboxylate In dichloromethane at 20℃; for 3h;	99.2%

: 941-55-9
4-toluenesulfonyl azide

: 316380-13-9
ethyl 5-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-3-oxohept-6-enoate

: 316380-15-1
ethyl 5-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-2-diazo-3-oxohept-6-enoate

Conditions

Conditions	Yield
With triethylamine In acetonitrile Diazotization;	99%

: 941-55-9
4-toluenesulfonyl azide

: 1079-66-9
chloro-diphenylphosphine

: C26H24N2O4PS2(1-)*Na(1+)

Conditions

Conditions	Yield
Stage #1: chloro-diphenylphosphine With sodium In tetrahydrofuran for 18h; Heating; Stage #2: 4-toluenesulfonyl azide In tetrahydrofuran; acetone at 20℃; for 48h; Staudinger reaction;	99%

: 941-55-9
4-toluenesulfonyl azide

: 701-57-5
1-methylthio-4-nitro-benzene

: C14H14N2O4S2

Conditions

Conditions	Yield
With 4 A molecular sieve; chiral (CO)Ru(II)(salen) In dichloromethane at 20℃; for 24h;	99%

: 941-55-9
4-toluenesulfonyl azide

: 100-68-5
methyl-phenyl-thioether

: 205581-06-2, 543681-35-2, 543681-36-3
S-methyl-S-phenyl-N-(p-tolylsulfonyl)sulfimide

Conditions

Conditions	Yield
With MS 4 Angstroem; bis(salicylaldehyde)ethylenediiminatocarbonylruthenium(II) In dichloromethane at 20℃;	99%
With (5,10,15,20-tetrakis(pentafluorophenyl)porphyrinato)iron(III) chloride In 1,2-dichloro-ethane for 24h; Molecular sieve; Inert atmosphere; Reflux;	94%
With D-glucose; cytochrome P-I263F A328V variant; NADPH In aq. phosphate buffer; dimethyl sulfoxide at 20℃; for 20h; pH=8; Reagent/catalyst; Enzymatic reaction;	63%

: 941-55-9
4-toluenesulfonyl azide

: 705-31-7
4-trifluoromethylphenylacetylene

: 108-18-9
diisopropylamine

: N1,N1-diisopropyl-N2-(4-methylbenzenesulfonyl)-2-(4-trifluoromethylphenyl)acetamidine

Conditions

Conditions	Yield
With copper(l) iodide In tetrahydrofuran at 20℃; for 1h;	99%

...Expand

: 941-55-9
4-toluenesulfonyl azide

: 536-74-3
phenylacetylene

: 884866-01-7
1-(4-methylbenzensulfonyl)-4-phenyl-1H-1,2,3-triazole

Conditions

Conditions	Yield
With copper(I) thiophene-2-carboxylate; benzoic acid In benzene at 60℃; for 0.05h; Flow reactor;	99%
With (N,N’-bis-{2,6-(di-iso-propyl)phenyl}imidazole-2-ylidene)tri-tert-butylphosphinetetrafluoroborate copper (I) In toluene at 20℃; for 15h; Reagent/catalyst; Solvent; Temperature;	97%
With copper(II) acetate monohydrate; 2-amino-phenol In acetonitrile at 20℃; for 0.333333h; regioselective reaction;	95%

: C10H16O4

: 941-55-9
4-toluenesulfonyl azide

: C17H25NO7S

Conditions

Conditions	Yield
With copper(l) iodide; water; triethylamine at 25℃; for 1h;	99%

: 941-55-9
4-toluenesulfonyl azide

: 16433-96-8
2-ethynyl-1-nitrobenzene

: 1215090-01-9
1-(4-methylbenzensulfonyl)-4-(2-nitrophenyl)-1H-1,2,3-triazole

Conditions

Conditions	Yield
With [Tpm*,BrCu(NCMe)]BF4 In chloroform at 40℃; for 72h; Inert atmosphere;	99%

: 941-55-9
4-toluenesulfonyl azide

: 10147-11-2
propargyl benzene

: 1078739-21-5
4-benzyl-1-(p-tosyl)-1H-1,2,3-triazole

Conditions

Conditions	Yield
With copper(I) thiophene-2-carboxylate; benzoic acid In benzene at 60℃; for 0.05h; Flow reactor;	99%
With copper(I) thiophene-2-carboxylate In toluene at 20℃; for 3h;	75%

: 941-55-9
4-toluenesulfonyl azide

: 17356-19-3
1-ethynylcyclopentanol

: 1253966-26-5
1-(1-(p-tosyl)-1H-1,2,3-triazol-4-yl)cyclopentan-1-ol

Conditions

Conditions	Yield
With copper(I) thiophene-2-carboxylate; benzoic acid In benzene at 60℃; for 0.05h; Flow reactor;	99%
With copper(I) thiophene-2-carboxylate In toluene at 20℃; for 3h;	90%
With copper(I) thiophene-2-carboxylate In toluene at 20℃; for 2h;	83%

: 941-55-9
4-toluenesulfonyl azide

: 7196-01-2
4-(1-phenylvinyl)morpholine

: 17260-48-9
4-methyl-N-[morpholino(phenyl)methylene]benzenesulfonamide

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 0.333333h;	99%

: 941-55-9
4-toluenesulfonyl azide

: 768-60-5
4-methoxyphenylacetylen

: 1078739-24-8
4-(4-methoxyphenyl)-1-tosyl-1H-1,2,3-triazole

Conditions

Conditions	Yield
With copper(I) thiophene-2-carboxylate; benzoic acid In benzene at 60℃; for 0.05h; Flow reactor;	99%
With copper(II) acetate monohydrate; 2-amino-phenol In acetonitrile at 20℃; for 0.5h; regioselective reaction;	96%
With (N,N’-bis-{2,6-(di-iso-propyl)phenyl}imidazole-2-ylidene)tri-tert-butylphosphinetetrafluoroborate copper (I) In toluene at 20℃; for 15h;	93%

: 941-55-9
4-toluenesulfonyl azide

: 99-90-1
para-bromoacetophenone

: 1438400-32-8
N-(2-acetyl-5-bromophenyl)-4-methylbenzenesulfonamide

Conditions

Conditions	Yield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; lithium carbonate; acetic acid; silver(I) triflimide In 1,2-dichloro-ethane at 25℃; for 12h; Inert atmosphere;	99%
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; sodium acetate; silver(I) triflimide In 1,2-dichloro-ethane at 80℃; for 12h;	71%
With silver hexafluoroantimonate; [RhCl2(p-cymene)]2; copper(II) acetate monohydrate In 1,2-dichloro-ethane at 100℃; for 24h; Inert atmosphere; Schlenk technique;	70%
With silver hexafluoroantimonate; dichloro(p-cymene)ruthenium(II) dimer; copper diacetate In 1,2-dichloro-ethane at 80℃; for 48h; Inert atmosphere;	46%

: 941-55-9
4-toluenesulfonyl azide

: 98-86-2
acetophenone

: 1859-70-7
N-(2-acetylphenyl)-4-methylbenzenesulfonamide

Conditions

Conditions	Yield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; lithium carbonate; acetic acid; silver(I) triflimide In 1,2-dichloro-ethane at 25℃; for 12h; Inert atmosphere;	99%
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; sodium acetate; silver(I) triflimide In 1,2-dichloro-ethane at 80℃; for 12h; Reagent/catalyst; Temperature; Time;	97%
With bromopentacarbonylmanganese(I); dimethyl zinc(II); copper diacetate In 1,4-dioxane; toluene at 0 - 80℃; for 6h; Schlenk technique; Inert atmosphere; regioselective reaction;	90%
With silver hexafluoroantimonate; dichloro(p-cymene)ruthenium(II) dimer; copper diacetate In 1,2-dichloro-ethane at 80℃; for 24h; Inert atmosphere;	75%
With silver hexafluoroantimonate; [RhCl2(p-cymene)]2; copper(II) acetate monohydrate In 1,2-dichloro-ethane at 100℃; for 24h; Solvent; Reagent/catalyst; Inert atmosphere; Schlenk technique;	72%

: 941-55-9
4-toluenesulfonyl azide

: 93-89-0
benzoic acid ethyl ester

: 223526-78-1
ethyl 2-(4-methylphenylsulfonamido)benzoate

Conditions

Conditions	Yield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; lithium carbonate; acetic acid; silver(I) triflimide In 1,2-dichloro-ethane at 50℃; for 12h; Temperature; Reagent/catalyst; Solvent; Inert atmosphere;	99%

: 941-55-9
4-toluenesulfonyl azide

: 22190-38-1
5-bromo-N-acetylindoline

: 1612872-73-7
N-(1-acetyl-5-bromoindolin-7-yl)-4-methylbenzenesulfonamide

Conditions

Conditions	Yield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; silver(I) triflimide In 1,2-dichloro-ethane at 20℃; for 3h;	99%
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; sodium acetate; silver(I) triflimide In 1,2-dichloro-ethane at 25℃; for 6h; Inert atmosphere; regioselective reaction;	95%
With silver hexafluoroantimonate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; silver(I) acetate In 1,2-dichloro-ethane at 80℃; for 10h; Schlenk technique;	75%

: 941-55-9
4-toluenesulfonyl azide

: 5720-05-8
4-methylphenylboronic acid

: 599-86-0
4-methyl-N-(4-methylphenyl)benzenesulfonamide

Conditions

Conditions	Yield
With copper(l) chloride In methanol at 20℃; for 0.5h; Chan-Lam Coupling;	99%
With L-proline-functionalized MCM-41-immobilized-CuCl; air In methanol at 20℃; for 2h;	97%
With Copper(II) immobilized into prolinamide-modified polyacrylonitrile fiber In methanol at 60℃; for 0.5h; Chan-Lam Coupling;	94%
With air; Graphene supported-1-N-ferrocenylmethylimidazole-Copper complex In ethanol at 70℃; for 0.75h; Catalytic behavior;	92%

: 941-55-9
4-toluenesulfonyl azide

: 579-75-9
2-Methoxybenzoic acid

: 2-methoxy-6-[(4-methylphenyl)sulfonamido]benzoic acid

Conditions

Conditions	Yield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; lithium carbonate; acetic acid; silver(I) triflimide In 1,2-dichloro-ethane at 80℃; for 12h; Inert atmosphere;	99%
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; sodium acetate; silver(I) triflimide In 1,2-dichloro-ethane at 80℃; for 16h; Catalytic behavior; Reagent/catalyst; Solvent; Sealed tube;	92%
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; lithium acetate; silver(I) triflimide In 1,2-dichloro-ethane at 50℃; for 24h;	88%

: 941-55-9
4-toluenesulfonyl azide

: C16H14O

: 4-(2-((2-methylbenzyl)oxy)phenyl)-1-tosyl-1H-1,2,3-triazole

Conditions

Conditions	Yield
With copper(I) thiophene-2-carboxylate In toluene at 20℃; Schlenk technique; Inert atmosphere;	99%

: 941-55-9
4-toluenesulfonyl azide

: C13H14ClNO

: N-(4-chloro-1-pivaloyl-1H-indol-7-yl)-4-methylbenzenesulfonamide

Conditions

Conditions	Yield
With [Cp*Ir(OCOCH3)2]; silver(I) triflimide In 1,2-dichloro-ethane at 25℃; for 12h; regioselective reaction;	99%
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; silver(I) acetate; silver(I) triflimide In 1,2-dichloro-ethane at 80℃; Sealed tube; Inert atmosphere; regioselective reaction;	78%
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; lithium acetate; silver(I) triflimide In 1,2-dichloro-ethane at 120℃; for 1h; regioselective reaction;	76%

: 941-55-9
4-toluenesulfonyl azide

: ((2S,3S)-3-ethynyl-1-tosylindolin-2-yl)(phenyl)methanone

: C31H26N4O5S2

Conditions

Conditions	Yield
With copper(I) thiophene-2-carboxylate In toluene at 0 - 20℃; for 1h; Inert atmosphere; Schlenk technique;	99%

Tosyl azide Specification

The Tosyl azide, with the CAS registry number 941-55-9, is also known as p-Methylphenylsulfonyl azide. Its EINECS number is 213-381-5. This chemical's molecular formula is C₇H₇N₃O₂S and molecular weight is 197.21. What's more, its systematic name is 4-Methylbenzenesulfonyl azide. It is stable at common pressure and temperature. When heating, it may cause an explosion, so you should keep it away from sources of ignition - No smoking. This material and its container must be disposed of in a safe way. Tosyl azide is a reagent used in organic synthesis. This chemical is used for the introduction of azide and diazo functional groups. It is also used as a nitrene source and as a substrate for cycloaddition reactions. It can be prepared by the reaction of tosyl chloride with sodium azide in aqueous acetone.

Physical properties of Tosyl azide are: (1)ACD/LogP: 0.918; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.92; (4)ACD/LogD (pH 7.4): 0.92; (5)ACD/BCF (pH 5.5): 2.94; (6)ACD/BCF (pH 7.4): 2.94; (7)ACD/KOC (pH 5.5): 75.23; (8)ACD/KOC (pH 7.4): 75.23; (9)#H bond acceptors: 5; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 70.67 Å².

You can still convert the following datas into molecular structure:
(1)SMILES: O=S(=O)([N-][N+]#N)c1ccc(cc1)C
(2)Std. InChI: InChI=1S/C7H7N3O2S/c1-6-2-4-7(5-3-6)13(11,12)10-9-8/h2-5H,1H3
(3)Std. InChIKey: NDLIRBZKZSDGSO-UHFFFAOYSA-N

Product Name

Tosyl azide

Synthetic route

Tosyl azide Specification

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