Product Name

  • Name

    Triethyl orthoacetate

  • EINECS 201-112-4
  • CAS No. 78-39-7
  • Article Data40
  • CAS DataBase
  • Density 0.902 g/cm3
  • Solubility slightly soluble in water
  • Melting Point
  • Formula C8H18O3
  • Boiling Point 145 °C at 760 mmHg
  • Molecular Weight 162.229
  • Flash Point 36.1 °C
  • Transport Information UN 3272 3/PG 3
  • Appearance clear colourless liquid
  • Safety 26-37/39-16
  • Risk Codes 10-36/38
  • Molecular Structure Molecular Structure of 78-39-7 (Triethyl orthoacetate)
  • Hazard Symbols IrritantXi
  • Synonyms Orthoaceticacid, triethyl ester (6CI,7CI,8CI);1,1,1-Triethoxyethane;Ethyl orthoacetate;NSC 5596;
  • PSA 27.69000
  • LogP 1.76960

Synthetic route

diethyl ether
60-29-7

diethyl ether

ethyl acetate
141-78-6

ethyl acetate

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

Conditions
ConditionsYield
With boron trifluoride In Hexadecane at 110℃; for 12h; Autoclave;90%
ketene diethyl acetal
2678-54-8

ketene diethyl acetal

dimethylglyoxal
431-03-8

dimethylglyoxal

A

3-hydroxy-3-methyl-levulinic acid ethylester
67079-92-9

3-hydroxy-3-methyl-levulinic acid ethylester

B

2,2-diethoxy-4-acetyl-4-methyl-oxetane
93183-68-7

2,2-diethoxy-4-acetyl-4-methyl-oxetane

C

ethyl acetate
141-78-6

ethyl acetate

D

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

Conditions
ConditionsYield
In acetonitrile Ambient temperature; thermal reaction;A n/a
B 34%
C n/a
D n/a
ethanol
64-17-5

ethanol

C7H14NO2(1+)*CH3O4S(1-)

C7H14NO2(1+)*CH3O4S(1-)

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

Conditions
ConditionsYield
With ethyl acetate 1) 16h, 2) 4h, 40 deg C;27%
piperidine
110-89-4

piperidine

ketene diethyl acetal
2678-54-8

ketene diethyl acetal

A

orthoacetic acid tripiperidide

orthoacetic acid tripiperidide

B

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

diethyl ether
60-29-7

diethyl ether

1,1,1-trichloroethane
71-55-6

1,1,1-trichloroethane

sodium ethanolate
141-52-6

sodium ethanolate

A

3-chloro-but-3-en-2-ol
6498-47-1

3-chloro-but-3-en-2-ol

B

sodium acetate
127-09-3

sodium acetate

C

ethyl acetate
141-78-6

ethyl acetate

D

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

Conditions
ConditionsYield
at 100℃;
ethanol
64-17-5

ethanol

1,1-dichloroethyl ethyl ether
50966-31-9

1,1-dichloroethyl ethyl ether

sodium ethanolate
141-52-6

sodium ethanolate

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

ethanol
64-17-5

ethanol

1-ethoxy-1,1-diazido-ethane
98071-92-2

1-ethoxy-1,1-diazido-ethane

sodium ethanolate
141-52-6

sodium ethanolate

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

ethanol
64-17-5

ethanol

ethyl acetimidate hydrochloride
2208-07-3

ethyl acetimidate hydrochloride

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

triethyl bromoorthoacetate
40070-39-1

triethyl bromoorthoacetate

potassium ethoxide
917-58-8

potassium ethoxide

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

dibromo-orthoacetic acid triethyl ester
408529-13-5

dibromo-orthoacetic acid triethyl ester

potassium ethoxide
917-58-8

potassium ethoxide

A

triethyl bromoorthoacetate
40070-39-1

triethyl bromoorthoacetate

B

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

ethanol
64-17-5

ethanol

ketene diethyl acetal
2678-54-8

ketene diethyl acetal

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

ketene diethyl acetal
2678-54-8

ketene diethyl acetal

ethyl iodide
75-03-6

ethyl iodide

A

3,3-diethoxy-hexanoic acid ethyl ester

3,3-diethoxy-hexanoic acid ethyl ester

B

ethyl acetate
141-78-6

ethyl acetate

C

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

D

butanoic acid ethyl ester
105-54-4

butanoic acid ethyl ester

Conditions
ConditionsYield
at 170℃;
diethyl ether
60-29-7

diethyl ether

ketene diethyl acetal
2678-54-8

ketene diethyl acetal

acetic acid
64-19-7

acetic acid

A

ethyl 3-ethoxy-2-butenoate
998-91-4

ethyl 3-ethoxy-2-butenoate

B

ethyl acetate
141-78-6

ethyl acetate

C

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

Conditions
ConditionsYield
at 25℃;
ketene diethyl acetal
2678-54-8

ketene diethyl acetal

N-ethyl-N-phenylamine
103-69-5

N-ethyl-N-phenylamine

A

N-ethyl-N-(1-ethoxy-vinyl)-aniline

N-ethyl-N-(1-ethoxy-vinyl)-aniline

B

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

ketene diethyl acetal
2678-54-8

ketene diethyl acetal

acetyl chloride
75-36-5

acetyl chloride

A

4,4-diethoxy-but-3-en-2-one
39690-38-5

4,4-diethoxy-but-3-en-2-one

B

chloroethane
75-00-3

chloroethane

C

ethyl acetate
141-78-6

ethyl acetate

D

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

Conditions
ConditionsYield
Produkt 5: 3-Aethoxy-crotonsaeure-aethylester;
diethyl ether
60-29-7

diethyl ether

ketene diethyl acetal
2678-54-8

ketene diethyl acetal

chloroacetic acid
79-11-8

chloroacetic acid

A

ethyl 3-ethoxy-2-butenoate
998-91-4

ethyl 3-ethoxy-2-butenoate

B

ethyl acetate
141-78-6

ethyl acetate

C

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

D

chloroacetic acid ethyl ester
105-39-5

chloroacetic acid ethyl ester

Conditions
ConditionsYield
at 25℃;
ketene diethyl acetal
2678-54-8

ketene diethyl acetal

p-benzoquinone
106-51-4

p-benzoquinone

benzene
71-43-2

benzene

A

2-ethoxy-benzofuran-5-ol
860183-06-8

2-ethoxy-benzofuran-5-ol

B

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

sodium ethanolate
141-52-6

sodium ethanolate

ketene diethyl acetal
2678-54-8

ketene diethyl acetal

diethyl malonate
105-53-3

diethyl malonate

A

(1-ethoxy-vinyl)-malonic acid diethyl ester
854838-42-9

(1-ethoxy-vinyl)-malonic acid diethyl ester

B

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

C

diethyl 2-(1-ethoxyethylidene)malonate
3044-06-2

diethyl 2-(1-ethoxyethylidene)malonate

Conditions
ConditionsYield
at 125 - 130℃;
ketene diethyl acetal
2678-54-8

ketene diethyl acetal

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

sodium ethanolate
141-52-6

sodium ethanolate

1,1-diethoxy-2-iodoethane
51806-20-3

1,1-diethoxy-2-iodoethane

A

ethyl acetate
141-78-6

ethyl acetate

B

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

C

1,1,2-triethoxyethane
4819-77-6

1,1,2-triethoxyethane

Conditions
ConditionsYield
at 100℃;
sodium ethanolate
141-52-6

sodium ethanolate

ethyl acetoacetate
141-97-9

ethyl acetoacetate

ketene diethyl acetal
2678-54-8

ketene diethyl acetal

A

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

B

2-<1-ethoxy-ethyliden>-acetoacetic acid ester

2-<1-ethoxy-ethyliden>-acetoacetic acid ester

Conditions
ConditionsYield
at 85℃;
ammonia
7664-41-7

ammonia

ketene diethyl acetal
2678-54-8

ketene diethyl acetal

A

ethanol
64-17-5

ethanol

B

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

C

acetamidine
143-37-3

acetamidine

D

acetonitrile
75-05-8

acetonitrile

Conditions
ConditionsYield
at 110℃;
diethyl ether
60-29-7

diethyl ether

ketene diethyl acetal
2678-54-8

ketene diethyl acetal

acetic acid
64-19-7

acetic acid

A

ethyl acetate
141-78-6

ethyl acetate

B

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

C

O-ethyl-acetoacetic acid ester

O-ethyl-acetoacetic acid ester

Conditions
ConditionsYield
at 25℃;
ketene diethyl acetal
2678-54-8

ketene diethyl acetal

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

A

Ethyl benzenesulfonate
515-46-8

Ethyl benzenesulfonate

B

ethyl acetate
141-78-6

ethyl acetate

C

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

D

O-ethyl-acetoacetic acid ester

O-ethyl-acetoacetic acid ester

Conditions
ConditionsYield
at 125℃;
sodium ethanolate
141-52-6

sodium ethanolate

1-ethoxy-1,1-diazo-ethane

1-ethoxy-1,1-diazo-ethane

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

Conditions
ConditionsYield
With ethanol
ethanol
64-17-5

ethanol

acetimidic acid ethyl ester hydrochloride

acetimidic acid ethyl ester hydrochloride

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

ethanol
64-17-5

ethanol

acetimino ether-hydrochloride

acetimino ether-hydrochloride

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

1,1,1-trichloroethane
71-55-6

1,1,1-trichloroethane

sodium ethanolate
141-52-6

sodium ethanolate

A

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

B

C2H2Cl(OC2H5)

C2H2Cl(OC2H5)

Conditions
ConditionsYield
at 100 - 120℃;
1,1-diethoxy-2-iodoethane
51806-20-3

1,1-diethoxy-2-iodoethane

alcoholic KOH

alcoholic KOH

A

ethyl acetate
141-78-6

ethyl acetate

B

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

C

glycoaldehyde diethyl acetal
621-63-6

glycoaldehyde diethyl acetal

Conditions
ConditionsYield
at 100℃;
pentadec-1-en-3-ol
99814-65-0

pentadec-1-en-3-ol

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

trans ethyl heptadec-4-enoate
145285-55-8

trans ethyl heptadec-4-enoate

Conditions
ConditionsYield
With propionic acid100%
propionic acid Heating;92%
With phenol at 120℃; Johnson Claisen rearrangement;92%
With propionic acid Johnson-Claisen rearrangement;86%
at 135℃;
2-cycloheptenol
79605-67-7, 4096-38-2

2-cycloheptenol

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

2-Cycloheptene-1-acetic acid ethyl ester
143682-19-3

2-Cycloheptene-1-acetic acid ethyl ester

Conditions
ConditionsYield
Montmorillonite KSF clay In N,N-dimethyl-formamide for 0.15h; microwave irradiation, other substrates;100%
montmorillonite KSF In N,N-dimethyl-formamide for 0.166667h; Irradiation;100%
Montmorillonite KSF clay In N,N-dimethyl-formamide for 0.15h; microwave irradiation;100%
2-amino-4,5-dimethoxybenzonitrile
26961-27-3

2-amino-4,5-dimethoxybenzonitrile

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

ethyl N-(2-cyano-4,5-dimethoxyphenyl)acetimidate
90402-53-2

ethyl N-(2-cyano-4,5-dimethoxyphenyl)acetimidate

Conditions
ConditionsYield
at 150℃; for 1h;100%
hydrogen cation at 150℃; Yield given;
methyl 3,4-di-O-benzyl-2-O-<2-O-benzyl-α-L-fucopyranosyl>-α-L-fucopyranoside
131524-31-7

methyl 3,4-di-O-benzyl-2-O-<2-O-benzyl-α-L-fucopyranosyl>-α-L-fucopyranoside

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

(3aR,4S,6S,7S,7aR)-7-Benzyloxy-6-((2R,3S,4R,5R,6S)-4,5-bis-benzyloxy-2-methoxy-6-methyl-tetrahydro-pyran-3-yloxy)-2-ethoxy-2,4-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran

(3aR,4S,6S,7S,7aR)-7-Benzyloxy-6-((2R,3S,4R,5R,6S)-4,5-bis-benzyloxy-2-methoxy-6-methyl-tetrahydro-pyran-3-yloxy)-2-ethoxy-2,4-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran

Conditions
ConditionsYield
With p-toluenesulfonic acid monohydrate In benzene for 1.5h; Ambient temperature;100%
3-<(Diethylamino)sulfonyl>benzoic Acid Hydrazide
96134-80-4

3-<(Diethylamino)sulfonyl>benzoic Acid Hydrazide

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

N,N-Diethyl-3-(5-methyl-[1,3,4]oxadiazol-2-yl)-benzenesulfonamide
96134-58-6

N,N-Diethyl-3-(5-methyl-[1,3,4]oxadiazol-2-yl)-benzenesulfonamide

Conditions
ConditionsYield
100%
2-(5-Methyl-1,3,4-oxadiazol-2-yl)benzenamine
96134-65-5

2-(5-Methyl-1,3,4-oxadiazol-2-yl)benzenamine

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

N-<2-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl>ethanimidic Acid Ethyl Ester
96134-69-9

N-<2-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl>ethanimidic Acid Ethyl Ester

Conditions
ConditionsYield
for 24h; Product distribution; Heating;100%
for 24h; Heating; Yield given;
Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

1,6-anhydro-2-O-benzyl-β-D-galactopyranose
55287-63-3

1,6-anhydro-2-O-benzyl-β-D-galactopyranose

1,6-Anhydro-2-O-benzyl-3,4-O-(1-ethoxyethyliden)-β-D-galactopyranose
79705-26-3

1,6-Anhydro-2-O-benzyl-3,4-O-(1-ethoxyethyliden)-β-D-galactopyranose

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene100%
Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

4-nitrophenyl O-(2,6-di-O-acetyl-β-D-galactopyranosyl)-(1-3)-2-acetamido-4,6-di-O-acetyl-2-deoxy-β-D-glucopyranoside
148704-98-7

4-nitrophenyl O-(2,6-di-O-acetyl-β-D-galactopyranosyl)-(1-3)-2-acetamido-4,6-di-O-acetyl-2-deoxy-β-D-glucopyranoside

Acetic acid (3aS,4R,6R,7R,7aS)-6-[(2R,3S,4R,5R,6S)-3-acetoxy-2-acetoxymethyl-5-acetylamino-6-(4-nitro-phenoxy)-tetrahydro-pyran-4-yloxy]-4-acetoxymethyl-2-ethoxy-2-methyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yl ester

Acetic acid (3aS,4R,6R,7R,7aS)-6-[(2R,3S,4R,5R,6S)-3-acetoxy-2-acetoxymethyl-5-acetylamino-6-(4-nitro-phenoxy)-tetrahydro-pyran-4-yloxy]-4-acetoxymethyl-2-ethoxy-2-methyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yl ester

Conditions
ConditionsYield
With p-toluenesulfonic acid monohydrate In benzene for 2h; Ambient temperature;100%
Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

3-hydroxy-2-methyl-1-propene
513-42-8

3-hydroxy-2-methyl-1-propene

ethyl 4-methyl-4-pentenoate
4911-54-0

ethyl 4-methyl-4-pentenoate

Conditions
ConditionsYield
With propionic acid for 8h; Reflux;100%
With propionic acid at 118℃; for 6h; Johnson orthoester Claisen rearrangement;98%
With acetic acid at 150 - 170℃; Inert atmosphere;87%
benzyl O-(2,6-di-O-acetyl-β-D-galactopyranosyl)-(1<*>4)-3,6-di-O-acetyl-2-deoxy-2-phthalimido-β-D-glucopyranoside
114262-31-6

benzyl O-(2,6-di-O-acetyl-β-D-galactopyranosyl)-(1<*>4)-3,6-di-O-acetyl-2-deoxy-2-phthalimido-β-D-glucopyranoside

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

Acetic acid (2R,3S,4R,5R,6R)-3-((3aS,4R,6S,7R,7aS)-7-acetoxy-4-acetoxymethyl-2-ethoxy-2-methyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yloxy)-2-acetoxymethyl-6-benzyloxy-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-tetrahydro-pyran-4-yl ester

Acetic acid (2R,3S,4R,5R,6R)-3-((3aS,4R,6S,7R,7aS)-7-acetoxy-4-acetoxymethyl-2-ethoxy-2-methyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yloxy)-2-acetoxymethyl-6-benzyloxy-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-tetrahydro-pyran-4-yl ester

Conditions
ConditionsYield
With p-toluenesulfonic acid monohydrate In benzene for 2h; Ambient temperature;100%
Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

4-Chloro-1,2-phenylenediamine
95-83-0

4-Chloro-1,2-phenylenediamine

5-chloro-2-methyl-1H-benzimidazole
2818-69-1

5-chloro-2-methyl-1H-benzimidazole

Conditions
ConditionsYield
With zirconium(IV) chloride In methanol at 20℃; for 3h;100%
With ammonium chloride In ethanol Inert atmosphere; Reflux; Green chemistry;96%
With gallium(III) triflate at 20℃; for 0.416667h;86%
With zirconium(IV) oxychloride octahydrate for 0.116667h; Microwave irradiation;84%
With H-Y-zeolite In ethanol for 10h; Heating;74%
Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

ethyl 4,6-di-O-acetyl-1-thio-α-D-mannopyranoside
362520-16-9

ethyl 4,6-di-O-acetyl-1-thio-α-D-mannopyranoside

ethyl 4,6-di-O-acetyl-2,3-O-ethoxyethylidene-1-thio-α-D-mannopyranoside
362520-17-0

ethyl 4,6-di-O-acetyl-2,3-O-ethoxyethylidene-1-thio-α-D-mannopyranoside

Conditions
ConditionsYield
With toluene-4-sulfonic acid In N,N-dimethyl-formamide at 20℃;100%
Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

(4S,5S)-4,5-dihydroxyocta-1,7-diene
189445-44-1

(4S,5S)-4,5-dihydroxyocta-1,7-diene

acetic acid (1S,5S)-1-allyl-2-hydroxypent-4-enyl ester
951698-29-6

acetic acid (1S,5S)-1-allyl-2-hydroxypent-4-enyl ester

Conditions
ConditionsYield
Stage #1: Triethyl orthoacetate; (4S,5S)-4,5-dihydroxyocta-1,7-diene With toluene-4-sulfonic acid In tetrahydrofuran at 20℃; for 20h;
Stage #2: With acetic acid In water at 20℃; for 1h; Further stages.;
100%
methyl [1-(2-chlorophenyl)-5-hydroxy-1H-pyrazol-3-yl]acetate
1158233-60-3

methyl [1-(2-chlorophenyl)-5-hydroxy-1H-pyrazol-3-yl]acetate

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

methyl [(4E)-1-(2-chlorophenyl)-4-(1-ethoxyethylidene)-5-oxo-4,5-dihydro-1H-pyrazol-3-yl]acetate
1217799-18-2

methyl [(4E)-1-(2-chlorophenyl)-4-(1-ethoxyethylidene)-5-oxo-4,5-dihydro-1H-pyrazol-3-yl]acetate

Conditions
ConditionsYield
With acetic acid at 60℃; for 1.25h;100%
acetic acid at 60℃;100%
methyl (1-benzyl-5-hydroxy-1H-pyrazol-3-yl)acetate
1217487-94-9

methyl (1-benzyl-5-hydroxy-1H-pyrazol-3-yl)acetate

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

methyl [(4E)-1-benzyl-4-(1-ethoxyethylidene)-5-oxo-4,5-dihydro-1H-pyrazol-3-yl]acetate
1217487-95-0

methyl [(4E)-1-benzyl-4-(1-ethoxyethylidene)-5-oxo-4,5-dihydro-1H-pyrazol-3-yl]acetate

Conditions
ConditionsYield
acetic acid at 75℃;100%
(L)-phenylalanine ethyl ester hydrochloride
3182-93-2

(L)-phenylalanine ethyl ester hydrochloride

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

ethyl N-acetyl-(L)-phenylalaninate
2361-96-8

ethyl N-acetyl-(L)-phenylalaninate

Conditions
ConditionsYield
In toluene at 110℃; for 24h;100%
C17H29NO6Si
1315455-07-2

C17H29NO6Si

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

C19H31NO7Si
1315455-08-3

C19H31NO7Si

Conditions
ConditionsYield
Stage #1: C17H29NO6Si; Triethyl orthoacetate With pyridinium p-toluenesulfonate In water; benzene at 20℃; for 0.166667h; Inert atmosphere;
Stage #2: With acetic acid In water; benzene at 20℃; for 0.166667h; Inert atmosphere;
100%
Conditions
ConditionsYield
With toluene-4-sulfonic acid In N,N-dimethyl-formamide for 2h;100%
allyl 4-O-benzyl-6-O-tert-butyldiphenylsilyl-α-D-mannopyranoside

allyl 4-O-benzyl-6-O-tert-butyldiphenylsilyl-α-D-mannopyranoside

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

allyl 2-O-acetyl-4-O-benzyl-6-O-tert-butyldiphenylsilyl-α-D-mannopyranoside
1430237-14-1

allyl 2-O-acetyl-4-O-benzyl-6-O-tert-butyldiphenylsilyl-α-D-mannopyranoside

Conditions
ConditionsYield
With camphor-10-sulfonic acid In acetonitrile at 20℃; for 2h; Inert atmosphere;100%
C15H24FN3O2

C15H24FN3O2

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

C17H24FN3O2

C17H24FN3O2

Conditions
ConditionsYield
at 120℃; for 1h;100%
1-octen-3-ol
3391-86-4

1-octen-3-ol

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

ethyl trans-4-decenoate
76649-16-6

ethyl trans-4-decenoate

Conditions
ConditionsYield
With propionic acid at 150℃; for 3h; Temperature; Claisen Rearrangement;99.9%
C14H22FN3O2

C14H22FN3O2

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

C16H22FN3O2

C16H22FN3O2

Conditions
ConditionsYield
at 80℃; for 1h;99.3%
Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

malononitrile
109-77-3

malononitrile

(1-ethoxyethylidene)malononitrile
5417-82-3

(1-ethoxyethylidene)malononitrile

Conditions
ConditionsYield
at 90 - 95℃; for 0.75h;99%
at 95℃; for 1.5h; Neat (no solvent);99%
at 95℃; for 1.5h;99%
3-Phenylpropenol
104-54-1

3-Phenylpropenol

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

ethyl 3-phenyl-4-pentenoate
60066-61-7

ethyl 3-phenyl-4-pentenoate

Conditions
ConditionsYield
With propionic acid In toluene at 150℃; for 15h;99%
In water; toluene at 265℃; under 37503.8 Torr; for 0.0788889h; Johnson-Claisen rearrangement; Supercritical conditions; Flow reactor;95%
With acetic acid In toluene at 220℃; under 75007.5 Torr; for 0.0666667h; Temperature; Johnson-Claisen Rearrangement;93%
3-Acetyl-8-hydroxy-5-isopropyl-cyclohepta[b]furan-2-one
134919-93-0

3-Acetyl-8-hydroxy-5-isopropyl-cyclohepta[b]furan-2-one

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

1-(2,4-Diethoxy-7-isopropyl-azulen-1-yl)-ethanone
134920-04-0

1-(2,4-Diethoxy-7-isopropyl-azulen-1-yl)-ethanone

Conditions
ConditionsYield
Heating;99%
Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

7-chloro-2-methyl-6-(tetrahydro-2H-pyran-2-yloxy)-1-hepten-3-ol
83235-34-1

7-chloro-2-methyl-6-(tetrahydro-2H-pyran-2-yloxy)-1-hepten-3-ol

ethyl (E)-9-chloro-4-methyl-8-(tetrahydro-2H-pyran-2-yloxy)-4-nonenoate
83235-35-2

ethyl (E)-9-chloro-4-methyl-8-(tetrahydro-2H-pyran-2-yloxy)-4-nonenoate

Conditions
ConditionsYield
With propionic acid at 140℃; for 1h;99%
2-(2'-aminophenyl)-4(3H)-quinazolinone
27259-73-0

2-(2'-aminophenyl)-4(3H)-quinazolinone

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

6-methyl-8H-quinazolino[4,3-b]quinazolin-8-one
109981-24-0

6-methyl-8H-quinazolino[4,3-b]quinazolin-8-one

Conditions
ConditionsYield
for 0.05h; microwave irradiation;99%
Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

2,5-dimethylbenzimidazole
1792-41-2

2,5-dimethylbenzimidazole

Conditions
ConditionsYield
With nano-Ni(II)/Y zeolite catalyst In neat (no solvent) at 60℃; for 0.766667h; Green chemistry;99%
With [PVP-SO3H] HSO4 at 60℃; for 0.0666667h;96%
With ammonium chloride In water Inert atmosphere; Reflux; Green chemistry;95%
Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

benzene-1,2-dicarboxylic acid
88-99-3

benzene-1,2-dicarboxylic acid

Diethyl phthalate
84-66-2

Diethyl phthalate

Conditions
ConditionsYield
In various solvent(s) at 80℃; for 2h;99%
Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

phenylpropyolic acid
637-44-5

phenylpropyolic acid

phenylpropynoic acid ethyl ester
2216-94-6

phenylpropynoic acid ethyl ester

Conditions
ConditionsYield
In various solvent(s) at 80℃; for 0.5h;99%

Triethyl orthoacetate Chemical Properties

Molecular Structure of Triethyl orthoacetate (CAS No.78-39-7):

Molecular Formula: C8H18O3
Molecular Weight: 162.23
IUPAC Name: 1,1,1-Triethoxyethane
CAS No: 78-39-7
EINECS: 201-112-4
H bond acceptors: 3
H bond donors: 0
Freely Rotating Bonds: 6
Polar Surface Area: 27.69 Å2
Index of Refraction: 1.407
Molar Refractivity: 44.31 cm3
Molar Volume: 179.7 cm3
Surface Tension: 25.6 dyne/cm
Density: 0.902 g/cm3
Flash Point: 36.1 °C
Enthalpy of Vaporization: 36.63 kJ/mol
Boiling Point: 145 °C at 760 mmHg
Vapour Pressure: 6.25 mmHg at 25°C
Storage Temp.: Flammables area
Water Solubility : Slightly soluble
Refractive index: 1.395-1.398
Appearance: Colorless transparent liquid
Canonical SMILES: CCOC(C)(OCC)OCC
InChI: InChI=1S/C8H18O3/c1-5-9-8(4,10-6-2)11-7-3/h5-7H2,1-4H3
InChIKey: NDQXKKFRNOPRDW-UHFFFAOYSA-N
Product Categories: Intermediates of Dyes and Pigments;Orthoesters

Triethyl orthoacetate Uses

  Triethyl orthoacetate (CAS No.78-39-7) have such uses as following:
 1.  It can be used as pharmaceutical and water scavenger.
 2. It also can be used in organic synthesis for the introduction of the acetate group to an alcohol. 
 3.It also can be used in the Johnson-Claisen rearrangement.

Triethyl orthoacetate Safety Profile

Safety Information of Triethyl orthoacetate (CAS No.78-39-7):
Hazard Codes: IrritantXi
Risk Statements: 10-36/38 
R10:Flammable. 
R36/38:Irritating to eyes and skin.
Safety Statements: 26-37/39-16 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S37/39:Wear suitable gloves and eye/face protection. 
S16:Keep away from sources of ignition.
RIDADR: UN 3272 3/PG 3
WGK Germany: 1
HazardClass: 3
PackingGroup: III
HS Code: 29159080

Triethyl orthoacetate Standards and Recommendations

Content: 98.5% min
Water: 0.05% max

Triethyl orthoacetate Specification

   Triethyl orthoacetate (CAS No.78-39-7), it also can be called Orthoaceticacid, triethyl ester (6CI,7CI,8CI) ; 1,1,1-Triethoxyethane ; Ethyl orthoacetate ; NSC 5596 . It should be stored away from oxidizing agents,store away from water/moisture, store away from oxidizing agents, store in cool, dry conditions in well sealed containers. Triethyl orthoacetate (CAS No.78-39-7) is moisture sensitive, keep container tightly sealed, and protect from humidity and water.
   Triethyl orthoacetate is the ethyl orthoacetate of acetic acid. It is also known as 1,1,1-triethoxyethane, and is an oily liquid with a colour that is anywhere from yellow to colorless. It is also known for its pungent odour.

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