Trimethylmethoxysilane supplier

Name
METHOXYTRIMETHYLSILANE
EINECS 217-369-0
CAS No. 1825-61-2
Article Data183
CAS DataBase
Density 0.762 g/cm³
Solubility
Melting Point
Formula C₄H₁₂OSi
Boiling Point 57.5 °C at 760 mmHg
Molecular Weight 104.224
Flash Point -11°C
Transport Information UN 1993 3/PG 2
Appearance Clear colorless liquid
Safety 16-26
Risk Codes 11-36
Molecular Structure
Hazard Symbols Xi, F
Synonyms LS 510;Methoxytrimethylsilane;Methyl trimethylsilyl ether;NSC 139858;SS 2010;TSL8111;Trimethylsilyl methyl ether;Z 6013;
PSA 9.23000
LogP 1.46770

Synthetic route

: 13368-42-8
4-(trimethylsilyl)morpholine

: 2623-87-2
bromobutyric acid

A: 1825-61-2
Methoxytrimethylsilane

B: 6377-82-8
morpholinium hydrobromide

C: trimethylsilyl 4-morpholinobutyrate

Conditions

Conditions	Yield
With methanol at 20℃; for 24h;	A n/a B 99.1% C 71%

...Expand

: 67-56-1
methanol

: 82340-08-7, 82340-09-8
1,2-Diphenyl-1,2-bis<1-(trimethylsiloxy)ethenyl>diphosphan

A: 1825-61-2
Methoxytrimethylsilane

B: 79-20-9
acetic acid methyl ester

C: 34478-62-1
1,2-diphenyldiphosphane

Conditions

Conditions	Yield
for 1h; Product distribution; Ambient temperature;	A n/a B n/a C 99%

...Expand

: 80631-66-9
1-cyclopropyl-1-methoxytetramethyldisilane

A: 1825-61-2
Methoxytrimethylsilane

B: 22053-38-9
1,3-dimethyl-1,3-divinyl-1,3-disilacyclobutane

Conditions

Conditions	Yield
at 680℃; under 4E-05 Torr;	A 99% B 42%

: 67-56-1
methanol

: 91482-61-0
2,5-dimethyl-4-acetyl-5-trimethylsiloxy-1,3,4-oxadiazoline-2

A: 1825-61-2
Methoxytrimethylsilane

B: 91482-60-9
trisacetylhydrazine

Conditions

Conditions	Yield
In dichloromethane at 24℃; for 0.5h; Product distribution;	A n/a B 98%

...Expand

: 18243-41-9
(bromomethyl)trimethylsilane

: 124-41-4
sodium methylate

A: 1825-61-2
Methoxytrimethylsilane

B: 14704-14-4
(methoxymethyl)trimethylsilane

Conditions

Conditions	Yield
In methanol for 19h; Heating;	A 0.5% B 98%

...Expand

: 107-46-0
Hexamethyldisiloxane

: 616-38-6
carbonic acid dimethyl ester

: 1825-61-2
Methoxytrimethylsilane

Conditions

Conditions	Yield
With methanol; aluminum oxide; potassium fluoride at 400℃;	98%

: 4656-04-6
bis(trimethylsilyl)mercury

: 1067-52-3
tributyltin methoxide

A: 1825-61-2
Methoxytrimethylsilane

B: 813-19-4
bis(tri-n-butyltin)

C: mercury

Conditions

Conditions	Yield
In benzene 25°C; 0.1 h;	A 95% B 98% C 96%

...Expand

: 67-56-1
methanol

: 80395-65-9
(2-Trimethylsilanyl-1-trimethylsilanyloxy-cyclopropyl)-phosphonic acid diethyl ester

A: 1825-61-2
Methoxytrimethylsilane

B: 80406-85-5
diethyl <1-hydroxy-2-(trimethylsilyl)cyclopropyl>phosphonate

Conditions

Conditions	Yield
for 120h; Ambient temperature;	A 97% B 85%

...Expand

: 80395-65-9
(2-Trimethylsilanyl-1-trimethylsilanyloxy-cyclopropyl)-phosphonic acid diethyl ester

A: 1825-61-2
Methoxytrimethylsilane

B: 80406-85-5
diethyl <1-hydroxy-2-(trimethylsilyl)cyclopropyl>phosphonate

Conditions

Conditions	Yield
With methanol for 120h; Ambient temperature;	A 97% B 85%

: 7677-24-9
trimethylsilyl cyanide

: potassium (pentafluoroethyl)trimethoxyborate

A: 1825-61-2
Methoxytrimethylsilane

B: potassium cyano-dimethoxypentafluoroethylborate

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 4h; Inert atmosphere;	A n/a B 97%

...Expand

: 18243-41-9
(bromomethyl)trimethylsilane

: 124-41-4
sodium methylate

A: 1825-61-2
Methoxytrimethylsilane

B: 14704-14-4
(methoxymethyl)trimethylsilane

C: 52686-75-6
ethyl(methoxy)dimethylsilane

Conditions

Conditions	Yield
In 1,4-dioxane; methanol for 21h; Product distribution; Mechanism; Heating; variation of solvents and reaction time;	A 1.2% B 96% C 0.3%
In 1,4-dioxane for 7h; Heating;	A 6% B 1% C 80%
In 1,4-dioxane; methanol for 18h; Heating;	A 9% B 24% C 60%

...Expand

: 7677-24-9
trimethylsilyl cyanide

: 2751-90-8
tetraphenylphosphonium bromide

: potassium trimethoxy(trifluoromethyl)boranuide

A: 1825-61-2
Methoxytrimethylsilane

B: tetraphenylphosphonium dicyanomethoxytrifluoromethylborate

Conditions

Conditions	Yield
Stage #1: trimethylsilyl cyanide; potassium trimethoxy(trifluoromethyl)boranuide at 70℃; for 2.5h; Stage #2: tetraphenylphosphonium bromide In water	A n/a B 96%

...Expand

: 67-56-1
methanol

: 43112-38-5
3-(trimethylsilyl)-2-oxazolidinone

: 1825-61-2
Methoxytrimethylsilane

Conditions

Conditions	Yield
chloro-trimethyl-silane at 0℃; for 0.0166667h;	95%

: 124-41-4
sodium methylate

: 333361-87-8
bis(trimethylsilyl) [2-(2-furyl)-1-(trimethylsilyloxycarbonyl)ethyl]phosphonite

A: 1825-61-2
Methoxytrimethylsilane

B: sodium [2-(2-furyl)-1-(sodiooxycarbonyl)ethyl]phosphonite

Conditions

Conditions	Yield
In methanol Heating;	A n/a B 95%

...Expand

: 124-41-4
sodium methylate

: 333364-16-2
bis(trimethylsilyl) 2-(2-furyl)ethylphosphonite

A: 1825-61-2
Methoxytrimethylsilane

B: sodium 2-(2-furyl)ethylphosphonite

Conditions

Conditions	Yield
In methanol Heating;	A n/a B 94%

...Expand

: 124-41-4
sodium methylate

: 333364-17-3
bis(trimethylsilyl) 2,4-bis(2-furyl)butylphosphonite

A: 1825-61-2
Methoxytrimethylsilane

B: sodium 2,4-bis(2-furyl)butylphosphonite

Conditions

Conditions	Yield
In methanol Heating;	A n/a B 93%

...Expand

: 67-56-1
methanol

: N-Trimethylsilyl-trifluormethansulfonimidoyl-Ethylester

A: 540-67-0
ethyl methyl ether

B: 1825-61-2
Methoxytrimethylsilane

C: 421-85-2
Trifluoromethanesulfonamide

Conditions

Conditions	Yield
Heating;	A n/a B n/a C 92%

...Expand

: 7677-24-9
trimethylsilyl cyanide

: 87802-71-9, 85217-69-2
(E)-methyl cinnamyl carbonate

A: 1825-61-2
Methoxytrimethylsilane

B: 20068-10-4
(E)-4-phenyl-3-butenenitrile

Conditions

Conditions	Yield
tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran for 16h; Heating;	A n/a B 92%

...Expand

: 7677-24-9
trimethylsilyl cyanide

: methyl mirtenyl carbonate

A: 1825-61-2
Methoxytrimethylsilane

B: (6,6-Dimethyl-bicyclo[3.1.1]hept-2-en-2-yl)-acetonitrile

Conditions

Conditions	Yield
tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran for 15h; Heating;	A n/a B 92%

...Expand

: 116889-36-2
C--N-(trimethylsilyl)nitrilimine

A: 1825-61-2
Methoxytrimethylsilane

B: 113597-81-2
(diazo)methane

Conditions

Conditions	Yield
With methanol Yields of byproduct given;	A n/a B 92%

: 7677-24-9
trimethylsilyl cyanide

: 18024-69-6
sodium tetramethoxyborate

A: 1825-61-2
Methoxytrimethylsilane

B: C4H3BN3O(1-)*Na(1+)

Conditions

Conditions	Yield
at 60℃; for 48h;	A n/a B 92%

...Expand

: 7677-24-9
trimethylsilyl cyanide

: potassium (pentafluoroethyl)trimethoxyborate

A: 1825-61-2
Methoxytrimethylsilane

B: potassium dicyanomethoxypentafluoroethylborate

Conditions

Conditions	Yield
Stage #1: trimethylsilyl cyanide; potassium (pentafluoroethyl)trimethoxyborate at 20℃; for 20h; Inert atmosphere; Stage #2: With dihydrogen peroxide; potassium carbonate In water at 20℃; for 2h;	A n/a B 92%

...Expand

: 67-56-1
methanol

: 114099-91-1
trimethyl(phenanthren-9-ylmethyl)silane

A: 1825-61-2
Methoxytrimethylsilane

B: 57741-37-4
9-(methoxymethyl)phenanthrene

Conditions

Conditions	Yield
With copper(II) bis(tetrafluoroborate) In acetonitrile for 40h; Irradiation;	A n/a B 91%

...Expand

: 67-56-1
methanol

: 999-97-3
1,1,1,3,3,3-hexamethyl-disilazane

: 1825-61-2
Methoxytrimethylsilane

Conditions

Conditions	Yield
Stage #1: 1,1,1,3,3,3-hexamethyl-disilazane With C12H24KO6(1+)*Br3H(1-) In acetonitrile at 20℃; for 0.0166667h; Stage #2: methanol In acetonitrile at 20℃; for 0.333333h;	90%

: cis-Re(CO)4(PPh3)CH2OCH3

: 16029-98-4
trimethylsilyl iodide

: cis-Re(CO)4(PPh3)(iodomethyl)

B: 1825-61-2
Methoxytrimethylsilane

Conditions

Conditions	Yield
In dichloromethane under N2, addn. at -78°C, allowed to warm to room temp.; removal of solvent in vac., dissolved in CH2Cl2/hexane, cooled to -5°C, filtered; elem. anal.;	A 90% B n/a

...Expand

: 40633-36-1
1,1-dimethoxy-1-phenyl-2,2,2-trimethyldisilane

: 513-81-5
2,3-dimethyl-buta-1,3-diene

A: 1825-61-2
Methoxytrimethylsilane

B: 145431-92-1
1-methoxy-1-phenyl-3,4-dimethyl-1-silacyclopent-3-ene

Conditions

Conditions	Yield
at 500℃; under 0.001 Torr;	A n/a B 89%

...Expand

: 2-Diethylamino-4-phenyl-3-trimethylsilyl-1,3-butadien-1,1-dicarbonsaeuredimethylester

A: 1825-61-2
Methoxytrimethylsilane

B: (Z)-3-Benzyliden-2-diethylamino-4-oxo-1-cyclobuten-1-carbonsaeuremethylester

Conditions

Conditions	Yield
at 200℃; under 0.1 Torr;	A n/a B 89%

: 67-56-1
methanol

: 75-77-4
chloro-trimethyl-silane

: 1825-61-2
Methoxytrimethylsilane

Conditions

Conditions	Yield
With urea at 20℃; for 4h;	88.1%
With triethylamine at 20℃; for 0.05h; Inert atmosphere;	85%
With aniline 1.) 20 deg C, 15 min, 2.) boiling water bath, 20 min;	23%

: 67-56-1
methanol

: 18410-58-7
1-<(trimethylsilyl)methyl>naphthalene

A: 1825-61-2
Methoxytrimethylsilane

B: 5903-23-1
1-(methoxymethyl)naphthalene

Conditions

Conditions	Yield
With copper(II) bis(tetrafluoroborate) In acetonitrile for 43h; Irradiation;	A n/a B 88%

...Expand

: 7677-24-9
trimethylsilyl cyanide

: 58329-99-0
cyclohex-2-enyl methyl carbonate

A: 1825-61-2
Methoxytrimethylsilane

B: 13048-17-4
cyclohex-2-enecarbonitrile

Conditions

Conditions	Yield
tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran for 18h; Heating;	A n/a B 88%

...Expand

: 1825-61-2
Methoxytrimethylsilane

: 1-O-trimethylsilyl-2,3,5-tri-O-benzyl-D-ribofuranose

A: 64363-77-5, 79083-29-7, 79083-32-2, 79083-33-3, 79083-40-2, 79083-41-3, 79083-43-5, 79083-44-6, 85549-73-1, 85610-74-8, 89824-86-2, 131615-65-1, 131896-99-6, 135910-14-4, 135911-60-3, 55725-85-4
methyl 2,3,5-tri-O-benzyl-β-D-ribofuranoside

B: 79083-29-7
(2R,3R,4R,5S)-3,4-bis(benzyloxy)-2-((benzyloxy)methyl)-5-methoxytetrahydrofuran

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate; diphenyltin sulfide In dichloromethane for 2h; Ambient temperature;	A 99% B 1%
With trimethylsilyl trifluoromethanesulfonate; lithium perchlorate; diphenyltin sulfide In dichloromethane for 2h; Ambient temperature;	A 5% B 95%

...Expand

: 1825-61-2
Methoxytrimethylsilane

: 210486-69-4
2,3-Dimethoxy-4-[(triisopropylsilanyl)-ethynyl]-4-trimethylsilanyloxy-cyclobut-2-enone

: 210486-72-9
3,4,4-Trimethoxy-2-[(triisopropylsilanyl)-ethynyl]-cyclobut-2-enone

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate In tetrahydrofuran at 25℃; for 0.5h;	99%

: 1825-61-2
Methoxytrimethylsilane

: 1460-57-7
trans-1,2-cyclohexandiol

: 134-81-6
benzil

: (2R,3R,4aS,8aS)-2,3-Dimethoxy-2,3-diphenyl-octahydro-benzo[1,4]dioxine

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at 0℃; for 3h;	99%

...Expand

: 1825-61-2
Methoxytrimethylsilane

: C15H17O2Pol

: 1148107-24-7
C18H27NO5

: C35H48NO7Pol

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate at 0 - 20℃; solid phase reaction;	99%

...Expand

: 1825-61-2
Methoxytrimethylsilane

: C15H17O2Pol

: 1148107-25-8
C20H45NO5Si3

: C28H42NO7Pol

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate at 0 - 20℃; solid phase reaction;	99%

...Expand

: 13811-71-7
diethyl (2S,3S)-tartrate

: 1825-61-2
Methoxytrimethylsilane

: C15H17O2Pol

: C25H35O8Pol

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate at 0 - 20℃; solid phase reaction;	99%

...Expand

: 1825-61-2
Methoxytrimethylsilane

: C15H17O2Pol

: 1460-57-7
trans-1,2-cyclohexandiol

: C23H33O4Pol

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate at 0 - 20℃; solid phase reaction;	99%

...Expand

: 1825-61-2
Methoxytrimethylsilane

: 7677-24-9
trimethylsilyl cyanide

A: 420-56-4
trimethylsilyl fluoride

B: C4H3BN3O(1-)*Li(1+)

Conditions

Conditions	Yield
With lithium tetrafluoroborate at 20℃; for 48h; Product distribution / selectivity;	A n/a B 99%

...Expand

: 1825-61-2
Methoxytrimethylsilane

: 7677-24-9
trimethylsilyl cyanide

: 6630-33-7
ortho-bromobenzaldehyde

: 1415388-63-4
2-(2-bromophenyl)-2-methoxyacetonitrile

Conditions

Conditions	Yield
Stage #1: Trimethylmethoxysilane; ortho-bromobenzaldehyde With iron(III) chloride at 0℃; for 2h; Inert atmosphere; Schlenk technique; Stage #2: trimethylsilyl cyanide at 0℃; for 1.33333h; Inert atmosphere; Schlenk technique;	99%
Stage #1: Trimethylmethoxysilane; ortho-bromobenzaldehyde With iron(III) chloride In neat (no solvent) at 0℃; for 2h; Inert atmosphere; Stage #2: trimethylsilyl cyanide In neat (no solvent) at 0℃; for 1.33333h; Inert atmosphere;	88%

...Expand

: 16838-89-4
2,3,5-tri-O-benzyl-D-ribofuranose

: 1825-61-2
Methoxytrimethylsilane

: 64363-77-5, 79083-29-7, 79083-32-2, 79083-33-3, 79083-40-2, 79083-41-3, 79083-43-5, 79083-44-6, 85549-73-1, 85610-74-8, 89824-86-2, 131615-65-1, 131896-99-6, 135910-14-4, 135911-60-3, 55725-85-4
methyl 2,3,5-tri-O-benzyl-β-D-ribofuranoside

Conditions

Conditions	Yield
With trifluoromethylsulfonic anhydride; diphenyltin sulfide; cesium fluoride In diethyl ether	98%

: 1825-61-2
Methoxytrimethylsilane

: 194232-63-8
2''-(tert-Butyl-diphenyl-silanyloxymethyl)-[2,4';2',4'']teroxazole-4-carbaldehyde

: 213738-68-2
2''-(tert-Butyl-diphenyl-silanyloxymethyl)-4-dimethoxymethyl-[2,4';2',4'']teroxazole

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at -40℃;	98%

: 1,1'-bis(dibromoboryl)ferrocene

: 1825-61-2
Methoxytrimethylsilane

: 934672-99-8
[Fe(C5H4B(OCH3)Br)2]

Conditions

Conditions	Yield
In pentane (N2); Schlenk technique; soln. of MeOSiMe3 in pentane was added to suspn. of Fe complex in pentane at -78°C; mixt. was slowly warmed to room temp.; stirred overnight; volatiles removed (vac.); recrystd. (hexane);	98%

: 1825-61-2
Methoxytrimethylsilane

: 7727-18-6
vanadium(V) oxychloride

: 62449-99-4
VOCl(methoxide)2

Conditions

Conditions	Yield
In dichloromethane byproducts: (CH3)3SiCl; (N2); addn. of 5 equiv. of silane deriv. to CH2Cl2 soln. of vanadium compd. at room temp., stirring for 16 h at room temp.; evapn., elem. anal.;	98%

: 1825-61-2
Methoxytrimethylsilane

: 114956-74-0
2,3,8-trioxocephalotaxane

: 114942-83-5
2-methoxy-3,8-dioxocephalotax-1-ene

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid In dichloromethane for 24h;	97%

: 600-14-6
2,3-Pentanedione

: 1825-61-2
Methoxytrimethylsilane

: 1460-57-7
trans-1,2-cyclohexandiol

: (2R,3R,4aS,8aS)-2-Ethyl-2,3-dimethoxy-3-methyl-octahydro-benzo[1,4]dioxine

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at 0℃; for 3h;	97%

...Expand

: 1825-61-2
Methoxytrimethylsilane

: 1460-57-7
trans-1,2-cyclohexandiol

: 431-03-8
dimethylglyoxal

: (2R,3R,4aS,8aS)-2,3-Dimethoxy-2,3-dimethyl-octahydro-benzo[1,4]dioxine

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at 0℃; for 3h;	97%

...Expand

: 1825-61-2
Methoxytrimethylsilane

: 10026-12-7
niobium pentachloride

: 91846-25-2
trichlorodimethoxyniobium(V)

Conditions

Conditions	Yield
In dichloromethane byproducts: trimethylchlorosilane; reaction at -78°C, then was allowed to warm to room temp., concentreting under reduced pressure, hexane was added to give a white crist. solid (all in an inert atmosphere); washing with hexane, dried under vac., elem.anal.;	97%

: 1825-61-2
Methoxytrimethylsilane

: 38848-25-8
(±)-demethylcephalotaxinone

: 38750-57-1, 38848-26-9
(±)-cephalotaxinone

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid In dichloromethane at 0 - 40℃; Inert atmosphere;	97%

: 1825-61-2
Methoxytrimethylsilane

: 118813-73-3
1-Trimethylsilanylmethyl-cyclododecanecarbaldehyde

: 113541-76-7
1-Methoxy-2-methylene-cyclotridecane

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate In dichloromethane Ambient temperature;	96%

Trimethylmethoxysilane Specification

The Silane,methoxytrimethyl-, with the CAS registry number 1825-61-2 and EINECS registry number 217-369-0, has the systematic name of methoxy(trimethyl)silane. It is a kind of clear colorless liquid, and belongs to the following product categories: Monoalkoxysilanes; Si (Classes of Silicon Compounds); Si-O Compounds. And the molecular formula of the chemical is C₄H₁₂OSi.

The characteristics of Silane,methoxytrimethyl- are as followings: (1)ACD/LogP: 1.62; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.62; (4)ACD/LogD (pH 7.4): 1.62; (5)ACD/BCF (pH 5.5): 10.01; (6)ACD/BCF (pH 7.4): 10.01; (7)ACD/KOC (pH 5.5): 181.02; (8)ACD/KOC (pH 7.4): 181.02; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 9.23 Å²; (13)Index of Refraction: 1.371; (14)Molar Refractivity: 31.04 cm³; (15)Molar Volume: 136.6 cm³; (16)Polarizability: 12.3×10^-24cm³; (17)Surface Tension: 15.2 dyne/cm; (18)Density: 0.762 g/cm³; (19)Enthalpy of Vaporization: 28.78 kJ/mol; (20)Boiling Point: 57.5 °C at 760 mmHg; (21)Vapour Pressure: 230 mmHg at 25°C.

Preparation of Silane,methoxytrimethyl-: This chemical can be prepared by methanol and chloro-trimethyl-silane. The reaction will need reagent pyridine and toluene.

Uses of Silane,methoxytrimethyl-: It can react with vinylbenzene to produce 2-fluoro-1-methoxy-1-phenylethane. This reaction will need reagent N-fluoropentachloropyridinium triflate. The reaction time is 5 days with ambient temperature, and the yield is about 54%.

You should be cautious while dealing with this chemical. It is a kind of flammable chemical which irritates to eyes. Therefore, you had better take the following instructions: Keep away from sources of ignition, and if in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

Addtionally, the following datas could be converted into the molecular structure:
(1)SMILES: O(C)[Si](C)(C)C
(2)InChI: InChI=1/C4H12OSi/c1-5-6(2,3)4/h1-4H3
(3)InChIKey: POPACFLNWGUDSR-UHFFFAOYAM

Product Name

METHOXYTRIMETHYLSILANE

Synthetic route

Trimethylmethoxysilane Specification

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