Tryptophol supplier | CasNO.526-55-6

Name
Tryptophol
EINECS 208-393-2
CAS No. 526-55-6
Article Data99
CAS DataBase
Density 1.219 g/cm³
Solubility 10 g/L (20 °C) in water
Melting Point 56-59 °C(lit.)
Formula C₁₀H₁₁NO
Boiling Point 357.803 °C at 760 mmHg
Molecular Weight 161.203
Flash Point 170.193 °C
Transport Information
Appearance off-white to brown crystalline mass
Safety 24/25
Risk Codes Xi:;
Molecular Structure
Hazard Symbols Xi
Synonyms Indole-3-ethanol(8CI);1H-Indole-3-ethanol;2-(1H-Indol-3-yl)ethanol;2-(3-Indolyl)ethanol;3-(2-Hydroxyethyl)-1H-indole;3-(2-Hydroxyethyl)indole;3-(b-Hydroxyethyl)indole;IEA;NSC 3884;b-(3-Indole)ethanol;3-Indoleethanol;
PSA 36.02000
LogP 1.70270

Synthetic route

: 87-51-4
indole-3-acetic acid

: 526-55-6
2-(3-indole)-ethanol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran for 3h; Reflux;	100%
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 10h; Inert atmosphere;	96%
Stage #1: indole-3-acetic acid With 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane at 20℃; for 12h; Inert atmosphere; Stage #2: With silica gel In methanol at 50℃; for 3h;	92%

: 18372-22-0
2-(3-indolyl)oxoacetic acid methyl ester

: 526-55-6
2-(3-indole)-ethanol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; for 12h;	100%
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 70℃; for 5h; Inert atmosphere;	80%
With sodium borohydrid In isopropyl alcohol

: 101079-48-5
3-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1H-indole

: 526-55-6
2-(3-indole)-ethanol

Conditions

Conditions	Yield
With aluminium(III) chloride hexahydrate In methanol at 100℃; for 0.25h; Solvent; Temperature; Microwave irradiation; Sealed tube; chemoselective reaction;	98%
With cerium (IV) sulfate tetrahydrate In methanol at 130℃; for 0.333333h; Microwave irradiation;	90%

: 1912-33-0
Indole-3-acetic acid methyl ester

: 526-55-6
2-(3-indole)-ethanol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran	96%
With isopropyl alcohol In hexane at 0 - 20℃; for 0.583333h; Bouveault-Blanc Reduction; Inert atmosphere;	81%
With tetrabutylammonium borohydride In dichloromethane for 10h; Heating;	69%

: 778-82-5
ethyl 3-indoleacetate

: 526-55-6
2-(3-indole)-ethanol

Conditions

Conditions	Yield
With methanol; Na/SiO2 In tetrahydrofuran at 0 - 25℃; Bouveault-Blanc reduction; Inert atmosphere;	95%
With samarium diiodide; water; triethylamine In tetrahydrofuran at 20℃; for 20h; Inert atmosphere;	81%
Stage #1: ethyl 3-indoleacetate With polyethylsiloxane; LiTi(OPr-i)4 at 100℃; for 24h; Stage #2: With sodium hydroxide In tetrahydrofuran for 3h; Heating;	49%
With lithium aluminium tetrahydride; diethyl ether
With samarium diiodide; water; triethylamine In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;	99 %Spectr.

: 1191-99-7
2,3-dihydro-2H-furan

: 59-88-1
phenylhydrazine hydrochloride

: 526-55-6
2-(3-indole)-ethanol

Conditions

Conditions	Yield
With sulfuric acid In N,N-dimethyl acetamide; water at 100℃;	92%
With L-(+)-tartaric acid-urea melt at 70℃; for 1h; Fischer Indole Synthesis;	90%
With montmorillonite K-10 In N,N-dimethyl acetamide; water at 80℃; for 2h;	75%

: 160194-28-5
1-triethylsilanyl-4-(triethylsilanyloxy)but-1-yne

: 615-36-1
2-bromoaniline

: 526-55-6
2-(3-indole)-ethanol

Conditions

Conditions	Yield
Stage #1: 1-triethylsilanyl-4-(triethylsilanyloxy)but-1-yne; 2-bromoaniline With 2 mol% Pd/C; sodium carbonate In N,N-dimethyl-formamide at 120℃; for 18h; Larock heteroannulation; Inert atmosphere; Stage #2: With hydrogenchloride In water regioselective reaction;	87%

: 40118-09-0
2,3-dihydro-1H-indole-3-ethanol

: 526-55-6
2-(3-indole)-ethanol

Conditions

Conditions	Yield
With dichloro[1,3-bis(2-methylphenyl)-2-imidazolidinylidene](benzylidene) (tricyclohexylphosphine) ruthenium(II); oxygen In ethyl acetate at 70℃; under 760.051 Torr; for 46h; Sealed tube;	85%

: 879-37-8
3-indolylacetamide

: 526-55-6
2-(3-indole)-ethanol

Conditions

Conditions	Yield
With samarium diiodide; water; triethylamine In tetrahydrofuran at 23℃; for 18h; Inert atmosphere; chemoselective reaction;	82%
Multi-step reaction with 2 steps 1: aqueous NaOH 2: lithium alanate; diethyl ether View Scheme

: 201230-82-2
carbon monoxide

: 287477-27-4
2-[3-(tetrahydro-2H-pyran-2-yloxy)prop-1-yn-1-yl]aniline

A: 13137-14-9
acetic acid 2-(1H-indol-3-yl)ethyl ester

B: 526-55-6
2-(3-indole)-ethanol

C: 156049-44-4
3-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-1H-indole

Conditions

Conditions	Yield
With carbonylhydridetris(triphenylphosphine)rhodium(I); hydrogen; 1,2-bis-(diphenylphosphino)ethane In toluene at 100℃; under 18751.9 Torr; for 8h; regioselective reaction;	A n/a B n/a C 78%

...Expand

: 201230-82-2
carbon monoxide

: 195191-58-3
(E)-3-(2-aminophenyl)prop-2-en-1-ol

: 526-55-6
2-(3-indole)-ethanol

Conditions

Conditions	Yield
With carbonylhydridetris(triphenylphosphine)rhodium(I); hydrogen; triphenylphosphine In toluene at 70℃; under 15514.4 Torr; for 70h;	73%

: 61-54-1
tryptamine

: 526-55-6
2-(3-indole)-ethanol

Conditions

Conditions	Yield
With carbonylchloro[4,5-bis(diisopropylphosphinomethyl)acridine]hydridoruthenium(II); water In 1,4-dioxane at 135℃; for 48h; Pressure; Schlenk technique; Inert atmosphere;	62%

: 2,2-dimethyl-propionic acid 2-(1H-indol-3-yl)-ethyl ester

: 526-55-6
2-(3-indole)-ethanol

Conditions

Conditions	Yield
With polymer-supported potassium thiophenolate In tetrahydrofuran; ethylene glycol at 140℃;	50%

: 3-(2-(allyloxy)ethyl)-1-methyl-1H-indole

A: 526-55-6
2-(3-indole)-ethanol

B: 3-(2-(allyloxy)ethyl)-1H-indole

Conditions

Conditions	Yield
With ammonia; sodium In tetrahydrofuran at -78 - -50℃; for 4h;	A 22% B 50%

: 67-56-1
methanol

: 141972-15-8
2-(Indol-3'-yl)ethyl Trichloroacetate

A: 526-55-6
2-(3-indole)-ethanol

B: 141972-21-6
1,3,4,7-tetrahydro-7,7-dimethoxyoxocino<4,5,6-cd>indol-6-one

Conditions

Conditions	Yield
With acetonitrile for 0.416667h; Irradiation;	A 48% B 42%

...Expand

: 103-25-3
3-phenylpropanoic acid methyl ester

: 91-56-5
indole-2,3-dione

: 4111-54-0
lithium diisopropyl amide

A: 526-55-6
2-(3-indole)-ethanol

B: 178665-43-5
β-(phenylmethyl)-1H-indole-ethanol

Conditions

Conditions	Yield
In tetrahydrofuran; cyclohexane; water; 3-Phenylpropionic acid	A 46.9% B n/a

...Expand

: 1191-99-7
2,3-dihydro-2H-furan

: 100-63-0
phenylhydrazine

: 526-55-6
2-(3-indole)-ethanol

Conditions

Conditions	Yield
With acetic acid In water Reflux;	46%

: S-methyl tryptophol dithiocarbonate

: 526-55-6
2-(3-indole)-ethanol

Conditions

Conditions	Yield
With Leptosphaeria maculans In acetonitrile for 24h; Enzymatic reaction;	32%

: 91566-04-0
2-(1H-indol-3-yl)-N,N-dimethylacetamide

: 526-55-6
2-(3-indole)-ethanol

Conditions

Conditions	Yield
With ethanol; sodium In hexane; paraffin oil at 0℃; for 0.0833333h;	32%

: 13436-46-9
2-ethoxytetrahydrofuran

: 59-88-1
phenylhydrazine hydrochloride

: 526-55-6
2-(3-indole)-ethanol

Conditions

Conditions	Yield
In ethanol Heating;	21.5%

: 120-72-9
indole

: 142-26-7
2-acetylaminoethanol

A: 526-55-6
2-(3-indole)-ethanol

B: 1016-47-3
N-Acetyltryptamine

C: N-(2,2-bis(1H-indol-3-yl)ethyl)acetamide

Conditions

Conditions	Yield
With dichloro(pentamethylcyclopentadienyl) iridium; potassium acetate at 150℃; for 48h; Reagent/catalyst; Inert atmosphere; Sealed tube;	A 10% B 12% C 21%

...Expand

: 201230-82-2
carbon monoxide

: 107-18-6
allyl alcohol

: 100-63-0
phenylhydrazine

: 526-55-6
2-(3-indole)-ethanol

Conditions

Conditions	Yield
With hydrogen; toluene-4-sulfonic acid; 6,6′-[(3,3′-di-tert-butyl-5,5′-dimethoxy-1,1′-biphenyl-2,2′-diyl)bis(oxy)]bis(di-benzo[d,f][1,3,2]dioxaphosphepin); acetylacetonatodicarbonylrhodium(l) In 1,4-dioxane at 60 - 100℃; under 15001.2 Torr; for 43h;	17%

...Expand

: 181780-88-1
2-(1-Triisopropylsilanyl-1H-indol-3-yl)-ethanol

: 526-55-6
2-(3-indole)-ethanol

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride In tetrahydrofuran at 25℃; for 0.166667h; Yield given;

: 2117-12-6
4-(trimethylsilyl)but-3-yn-1-ol

: 615-43-0
2-iodophenylamine

A: 526-55-6
2-(3-indole)-ethanol

B: trifluoro-acetic acid 2-(1H-indol-3-yl)-ethyl ester

Conditions

Conditions	Yield
Yield given; Multistep reaction;

...Expand

: trifluoro-acetic acid 2-(1H-indol-3-yl)-ethyl ester

: 526-55-6
2-(3-indole)-ethanol

Conditions

Conditions	Yield
With sodium methylate In methanol

: 75-21-8
oxirane

indolyl magnesium bromide: indolyl magnesium bromide

: 526-55-6
2-(3-indole)-ethanol

Conditions

Conditions	Yield
With diethyl ether; benzene und folgenden Erhitzen des Reaktionsgemisches auf ca. 100grad nach Abdestillieren des Aethers.;

: 120-72-9
indole

fluorobenzene*Cr(CO)3 complex: fluorobenzene*Cr(CO)3 complex

: 526-55-6
2-(3-indole)-ethanol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: diethyl ether 2: diethyl ether / 12 h / 20 °C 3: 100 percent / LiAlH4 / tetrahydrofuran / 12 h / 20 °C View Scheme

: 22980-09-2
indolyl-3-glyoxylyl chloride

: 526-55-6
2-(3-indole)-ethanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: diethyl ether / 12 h / 20 °C 2: 100 percent / LiAlH4 / tetrahydrofuran / 12 h / 20 °C View Scheme
With sodium borohydrid In diethylene glycol dimethyl ether
Multi-step reaction with 2 steps 1: diethyl ether / 0 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 20 °C View Scheme
Multi-step reaction with 2 steps 1: triethylamine / 0.5 h / Reflux; Inert atmosphere 2: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere; Reflux View Scheme
Multi-step reaction with 2 steps 1: diethyl ether / 0 °C / Inert atmosphere 2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 80 °C / Inert atmosphere View Scheme

: 615-43-0
2-iodophenylamine

: 526-55-6
2-(3-indole)-ethanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 2: NaOMe / methanol View Scheme
Multi-step reaction with 2 steps 2: NaOMe / methanol View Scheme

: 79-36-7
dichloroacethyl chloride

: 526-55-6
2-(3-indole)-ethanol

: 141972-14-7
2-(Indol-3'-yl)ethyl Dichloroacetate

Conditions

Conditions	Yield
With pyridine In dichloromethane for 18h; kept in the dark;	100%

: 526-55-6
2-(3-indole)-ethanol

: 108-24-7
acetic anhydride

: 13137-14-9
acetic acid 2-(1H-indol-3-yl)ethyl ester

Conditions

Conditions	Yield
With pyridine; dmap In dichloromethane for 24h; Ambient temperature;	100%
With pyridine at 20℃; for 15h; Inert atmosphere;	99%
With pyridine for 1h; Ambient temperature;	55.3 g
With pyridine at 20℃; for 15h; Inert atmosphere;

: 526-55-6
2-(3-indole)-ethanol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 101079-48-5
3-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1H-indole

Conditions

Conditions	Yield
With 1H-imidazole In tetrahydrofuran at 0 - 20℃; for 0.5h; Inert atmosphere;	100%
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃; for 0.5h;	100%
With 1H-imidazole In N,N-dimethyl-formamide for 16h; Ambient temperature;	99%

: 526-55-6
2-(3-indole)-ethanol

: 13154-24-0
triisopropylsilyl chloride

: 242806-12-8
3-(2-((triisopropylsilyl)oxy)ethyl)-1H-indole

Conditions

Conditions	Yield
With 1H-imidazole In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;	100%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; Substitution;	99%

: 526-55-6
2-(3-indole)-ethanol

: 40118-09-0
2,3-dihydro-1H-indole-3-ethanol

Conditions

Conditions	Yield
With sodium cyanoborohydride; acetic acid at 0 - 20℃; for 3.5h;	100%
With sodium cyanoborohydride; acetic acid at 0 - 20℃; for 5h;	38%
With sodium cyanoborohydride; acetic acid at 0 - 20℃; for 3.5h; Inert atmosphere;	37.4%

: 526-55-6
2-(3-indole)-ethanol

: 876932-36-4
3-dimethylaminomethyl-4-(3-fluorophenyl)-4-hydroxy-cyclohexanone

: 1,1-(2-(dimethylaminomethyl)-3-hydroxy-3-(3-fluorophenyl)-pentamethylene)-1,3,4,9-tetrahydro-pyrano[3,4-b]indol

Conditions

Conditions	Yield
Stage #1: 2-(3-indole)-ethanol; 3-dimethylaminomethyl-4-(3-fluorophenyl)-4-hydroxy-cyclohexanone With methanesulfonic acid In dichloromethane at 20℃; for 24h; Stage #2: With sodium hydroxide In water Stage #3: With sodium hydroxide In water	100%

: 526-55-6
2-(3-indole)-ethanol

: 2591-98-2
indole-3-acetaldehyde

Conditions

Conditions	Yield
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In acetonitrile at 80℃; for 2h;	99%
With 2-iodoxybenzoic acid In acetonitrile at 80℃; for 3h;	91%
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In dimethyl sulfoxide	87%

: 288-32-4
1H-imidazole

: 526-55-6
2-(3-indole)-ethanol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1-O-tert-Butyldimethylsilyl-2-(3-indolyl)ethanol

Conditions

Conditions	Yield
In N,N-dimethyl-formamide	99%
In N,N-dimethyl-formamide	99%

...Expand

: 526-55-6
2-(3-indole)-ethanol

: 943002-80-0
4-(Dimethylamino-phenyl-methyl)-cyclohexanone

: 954420-64-5
1,1-[3-(dimethylamino-(phenyl)-methyl)-pentamethylene]-1,3,4,9-tetrahydropyrano[3,4-b]indole

Conditions

Conditions	Yield
Stage #1: 2-(3-indole)-ethanol; 4-(Dimethylamino-phenyl-methyl)-cyclohexanone With trifluorormethanesulfonic acid In dichloromethane at 20℃; for 6h; Stage #2: With sodium hydroxide; water In dichloromethane	99%

: 526-55-6
2-(3-indole)-ethanol

: 943002-86-6
4-[(4-Chloro-phenyl)-dimethylamino-methyl]-cyclohexanone

: 954420-68-9
1,1-[3-(dimethylamino-(4-chlorophenyl)-methyl)-pentamethylene]-1,3,4,9-tetrahydro-pyrano[3,4-b]indole

Conditions

Conditions	Yield
Stage #1: 2-(3-indole)-ethanol; 4-[(4-Chloro-phenyl)-dimethylamino-methyl]-cyclohexanone With trifluorormethanesulfonic acid In dichloromethane at 20℃; Stage #2: With sodium hydroxide; water In dichloromethane	99%

: 526-55-6
2-(3-indole)-ethanol

: 75-75-2
methanesulfonic acid

: C17H24N2O

: 4',9'-dihydro-4-(4-methylpiperazin-1-yl)-4-phenyl-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indole] methanesulfonate

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 4h;	99%

...Expand

: 526-55-6
2-(3-indole)-ethanol

: 106501-78-4
tert-butyl (4,4-dimethoxycyclohexa-2,5-dien-1-ylidene)carbamate

: di-tert-butyl (((3aS,8aS)-2,3-dihydro-8H-furo[2,3-b]indole-3a,8(8aH)-diyl)bis(4-methoxy-3,1-phenylene))dicarbamate

Conditions

Conditions	Yield
With (R)-6,6'-bis(9-phenanthryl)-1,1'-spirobiindanyl-7,7'-diyl hydrogen phosphate In toluene at 30℃; for 12h; Molecular sieve; stereoselective reaction;	99%

: 526-55-6
2-(3-indole)-ethanol

: tert-butyl (4,4-diethoxycyclohexa-2,5-dien-1-ylidene)carbamate

: di-tert-butyl (((3aR,8aR)-2,3-dihydro-8H-furo[2,3-b]indole-3a,8(8aH)-diyl)bis(4-ethoxy-3,1-phenylene))dicarbamate

Conditions

Conditions	Yield
With (R)-6,6'-bis(9-phenanthryl)-1,1'-spirobiindanyl-7,7'-diyl hydrogen phosphate In toluene at 30℃; for 12h; Molecular sieve; stereoselective reaction;	99%

: 526-55-6
2-(3-indole)-ethanol

: (E)-(1-methyl-3-styryl-1H-indol-2-yl)diphenylmethanol

: 2-(2-(4-methyl-2,3,3-triphenyl-1,2,3,4-tetrahydrocyclopenta[b]indol-1-yl)-1H-indol-3-yl)ethanol

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In chloroform at 40℃; for 8h; chemoselective reaction;	99%

: 526-55-6
2-(3-indole)-ethanol

: (E)-(5-methyl-3-styryl-1H-indol-2-yl)diphenylmethanol

: 2-(1-(7-methyl-2,3,3-triphenyl-1,2,3,4-tetrahydrocyclopenta[b]-indol-1-yl)-1H-indol-3-yl)ethanol

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In chloroform at 30℃; for 3h; Molecular sieve; diastereoselective reaction;	99%

: 526-55-6
2-(3-indole)-ethanol

: (E)-(5-methyl-3-styryl-1H-indol-2-yl)diphenylmethanol

: 2-(2-(7-methyl-2,3,3-triphenyl-1,2,3,4-tetrahydrocyclopenta[b]indol-1-yl)-1H-indol-3-yl)ethanol

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In chloroform at 40℃; for 8h; chemoselective reaction;	99%

: 526-55-6
2-(3-indole)-ethanol

: (E)-(3-(4-fluorostyryl)-1H-indol-2-yl)diphenylmethanol

: 2-(2-(2-(4-fluorophenyl)-3,3-diphenyl-1,2,3,4-tetrahydrocyclopenta[b]indol-1-yl)-1H-indol-3-yl)ethanol

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In chloroform at 40℃; for 8h; chemoselective reaction;	99%

: 526-55-6
2-(3-indole)-ethanol

: (E)-(3-(3-chlorostyryl)-1H-indol-2-yl)diphenylmethanol

: 2-(2-(2-(3-chlorophenyl)-3,3-diphenyl-1,2,3,4 -tetrahydrocyclopenta[b]indol-1-yl)-1H-indol-3-yl)ethanol

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In chloroform at 40℃; for 8h; chemoselective reaction;	99%

: 526-55-6
2-(3-indole)-ethanol

: C10H10N4O

Conditions

Conditions	Yield
With 5,11,17,23,29,35-hexakis(tert-butyl)-37,38,39,40,41-hexakis(hydroxy)calix[6]arene; copper diacetate; 1-azido-1λ3-benzo[d][1,2]iodaoxol-3(1H)-one; 1-butyl-2,3-methylimidazolium tetrafluoroborate In dimethyl sulfoxide at 45℃; for 1.5h; Solvent; Reagent/catalyst; Inert atmosphere;	98.5%

: 526-55-6
2-(3-indole)-ethanol

: 77-76-9
2,2-dimethoxy-propane

: 42821-17-0
1,1-dimethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole

Conditions

Conditions	Yield
With bismuth(lll) trifluoromethanesulfonate; water In toluene at 80℃; oxa Pictet-Spengler reaction;	98%
With iron(II) triflate In toluene at 70℃; for 24h; Pictet-Spengler Synthesis; Green chemistry;	98%

: 526-55-6
2-(3-indole)-ethanol

: 106-99-0
buta-1,3-diene

: 3,3a,8,8a-tetrahydro-3a-(2,7-octadienyl)-2H-furo[2,3-b]indole

Conditions

Conditions	Yield
With 1,1'-bis-(diphenylphosphino)ferrocene; triethyl borane; palladium diacetate In tetrahydrofuran at 20℃; for 48h; Inert atmosphere; diastereoselective reaction;	98%

: 526-55-6
2-(3-indole)-ethanol

: 75-75-2
methanesulfonic acid

: 1004548-07-5
4-morpholino-4-phenylcyclohexanone

: 4',9'-dihydro-4-morpholino-4-phenyl-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indole] methanesulfonate

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 16h;	98%

...Expand

: 526-55-6
2-(3-indole)-ethanol

: 53578-01-1
4-methylacetophenone dimethyl acetal

: (R)-1-methyl-1-(p-tolyl)-1,3,4,9-tetrahydropyrano[3,4-b]indole

Conditions

Conditions	Yield
With 2,3,4,5-tetrabromo-6-(((1R,2R)-2-(3-(4-nitro-3-(trifluoromethyl)phenyl)thioureido)-cyclohexyl)carbamoyl)benzoic acid In toluene at -30℃; for 18h; Pictet-Spengler Synthesis; Molecular sieve; Inert atmosphere; enantioselective reaction;	98%

: 526-55-6
2-(3-indole)-ethanol

: 104-54-1
3-Phenylpropenol

: C28H27NO

Conditions

Conditions	Yield
With iron(II) triflate; (S)-(+)-N-(3,5-dioxa-4-phosphacyclohepta-[2,1-a;3,4-a′]dinaphthalen-4-yl)dibenz[b,f]azepine; bis(1,5-cyclooctadiene)diiridium(I) dichloride In diethyl ether at 20℃; for 8h; Reagent/catalyst; Time; Temperature; Solvent; enantioselective reaction;	97%

: 526-55-6
2-(3-indole)-ethanol

: (2-(3-bromophenyl)-3-oxocycloprop-1-enyl)methyl acetate

: C20H16BrNO2

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane In tetrahydrofuran at 25℃; for 5h; Molecular sieve; Inert atmosphere;	97%

: 526-55-6
2-(3-indole)-ethanol

: 115262-01-6
[bromo(difluoro)methyl](trimethyl)silane

: 3-(2-(difluoromethoxy)ethyl)-1H-indole

Conditions

Conditions	Yield
With potassium hydrogenfluoride In dichloromethane at 20℃; for 2h;	97%
With potassium hydrogen difluoride In dichloromethane; water at 20℃; for 10h; Reagent/catalyst;	93%

: 526-55-6
2-(3-indole)-ethanol

: (E)-diphenyl(3-styryl-1H-indol-2-yl)methanol

: 2-(1-(2,3,3-triphenyl-1,2,3,4-tetrahydrocyclopenta[b]indol-1-yl)-1H-indol-3-yl)ethanol

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In chloroform at 30℃; for 3h; Catalytic behavior; Reagent/catalyst; Temperature; Solvent; Molecular sieve; diastereoselective reaction;	97%

Tryptophol Chemical Properties

Product Name: Tryptophol (CAS NO.526-55-6)

Molecular Formula: C₁₀H₁₁NO
Molecular Weight: 161.2g/mol
Mol File: 526-55-6.mol
Einecs: 208-393-2
Melting Point: 56-59 °C(lit.)
Boiling point: 357.8 °C at 760 mmHg
Storage Temperature: 2-8°C
Flash Point: 170.2 °C
Density: 1.219 g/cm³
Water Solubility: 10 g/L (20 ºC)
Surface Tension: 57.5 dyne/cm
Enthalpy of Vaporization: 63.65 kJ/mol
Vapour Pressure: 9.66E-06 mmHg at 25°C
XLogP3-AA: 1.8
H-Bond Donor: 2
H-Bond Acceptor: 1
Structure Descriptors of Tryptophol (CAS NO.526-55-6):
IUPAC Name: 2-(1H-indol-3-yl)ethanol
Canonical SMILES: C1=CC=C2C(=C1)C(=CN2)CCO
InChI: InChI=1S/C10H11NO/c12-6-5-8-7-11-10-4-2-1-3-9(8)10/h1-4,7,11-12H,5-6H2
InChIKey: MBBOMCVGYCRMEA-UHFFFAOYSA-N
Product Categories: Heterocyclic Compounds; Indoles; Simple Indoles

Tryptophol Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	351mg/kg (351mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Journal of Toxicology and Environmental Health. Vol. 1, Pg. 515, 1976.
mouse	LD50	intravenous	180mg/kg (180mg/kg)		U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00777,

Tryptophol Safety Profile

Safety Information of Tryptophol (CAS NO.526-55-6):
Hazard Codes: Xi Irritant
Safety Statements: 24/25
24: Avoid contact with skin
25: Avoid contact with eyes

Tryptophol Specification

Tryptophol ,its CAS NO. is 526-55-6,the synonyms is 1H-Indole-3-ethanol ; 2-(3-Indolyl)ethanol ; 3-(2-Hydroxyethyl)indole ; 3-(beta-Hydroxyethyl)indole ; 3-Indolylethanol ; 5-21-03-00061 (Beilstein Handbook Reference) ; BRN 0125553 ; EINECS 208-393-2 ; Ethanol, 2-indol-3-yl- ; Ethanol, 3-indolyl- ; IEA ; Indole ethanol ; NSC 3884 .

Product Name

Tryptophol

Synthetic route

Tryptophol Chemical Properties

Tryptophol Toxicity Data With Reference

Tryptophol Safety Profile

Tryptophol Specification

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