AimsTo analyze the correlation between neck circumference (NC) and non-alcoholic fatty liver disease (NAFLD) and compare the predictive value of NC for NAFLD with that of other simple anthropometric measures and other biochemical profiles.

2-Ethylhexyl nitrate (EHN) and nitrocellulose (NC) are commonly used energetic materials that have caused many thermal runaway reactions and explosions worldwide, and their thermal stabilities have always been an important issue. Based on the results of Roduit et al. (2013), differential scannin...

In the present study, the dehydration process of caffeine hydrate (CAH) was investigated by calibrating the moisture content in the caffeine tablet using backscattering Raman spectroscopy (BRS) and transmission Raman spectroscopy (TRS). The detectable depth of BRS is limited by its shallow laser...

Iron chelation has already been proposed to be a feasible strategy for cancer therapeutics in that reinforced iron demand is demonstrated in cancer cells, and quite a few iron chelators have been developed for this purpose. Desferrioxamine (DFO), an iron chelator approved by the U.S. Food and Dr...

The production of β-Lg nanoparticles by a simple heat-induced denaturation method without the need to add chemicals was performed at different conditions of pH, and temperature of denaturation. Optimum conditions were set as 0.2% β-Lg, pH 6 and simply heating at 75 °C for 45 min. At these con...

Caffeine has been shown to be a robust uncompetitive inhibitor of glucose uptake in erythrocytes. It preferentially binds to the nucleotide-binding site on GLUT1 in its tetrameric form and mimics the inhibitory action of ATP. Here we demonstrate that caffeine is also a dose-dependent, uncompetit...

Coffee is a drink prepared from roasted coffee beans and is lauded for its aroma and flavour. It is the third most popular beverage in the world. This beverage is known by its stimulant effect associated with the presence of methylxanthines. Caffeine, a purine-like molecule (1,3,7 trymetylxantin...

Three Pt(II) complexes containing the natural ligands curcumin and caffeine, namely [Pt(curc)(PPh3)2]Cl (1), [PtCl(curc)(DMSO)] (2) (curc = deprotonated curcumin) and trans-[Pt(caffeine)Cl2(DMSO)] (3), were synthesized and fully characterized. The data obtained suggest that, for both 1 and 2, th...

BackgroundAlthough epidemiologic studies in populations of European descent suggest a possible chemoprotective effect of caffeine against nonmelanoma skin cancer (NMSC), data in Asian populations are lacking.

The present study reports a DSC investigation of solid–liquid equilibria in the o-acetylsalicylic acid–caffeine binary system revealing a simple eutectic behaviour. The eutectic temperature and temperatures of liquidus were determined. Further, assessed eutectic and liquidus temperatures toget...

Here, we use single molecule force spectroscopy performed with optical tweezers in order to investigate the interaction between Caffeine and the DNA molecule for various different concentrations of the alkaloid and under two distinct ionic strengths of the surrounding buffer. We were able to det...

Stability of caffeine dimers in the presence of surrounding water molecules was investigated by performing ab initio calculations at B3LYP/CBSB7 level of theory. Dimers were constructed by placing geometry optimized monomers at different relative orientations. These dimers were then fully geomet...

Pd(II) is a noble metal in the platinum group metals (PGMs) and has been used extensively in automobile catalysts. However, its resources are strictly limited; thus, the recovery of Pd(II) from wastes or secondary sources currently has great importance. A new ligand, namely, 11,17,23-tetrakis-[(...

A new functionalised calixarene, para-tert-octylcalix[4]arene, fitted with phosphinoyl pendant arms (B4boctL4) 1, was synthesised and fully characterised. The procedure using xylene via a Williamson reaction between the tetra sodium derivative of the calixarene and dimethyl-chloromethyl-phosphin...

Removal of Pb(II) ion over several other metal ions with 25,26,27,28-tetrakis(N,N-diethylaminocarbonylmethoxy)-5,11,17,23-tetrakis(1,1,3,3-tetramethylbutyl)calix[4]arene (EATOC) from nitric acid media was investigated in a solvent extraction system. Pb(II) ion was selectively extracted over Fe(I...

Various p-tert-octylcalix[4]arene derivatives as hydrophobic extractants have been prepared to investigate Ag(I) extraction efficiency in a batch-wise process in nitric acid media. The influence of the functional groups of the hydrophobic extractants on the interfacial behavior and Ag(I) extract...

The photostability of the antihistamine fexofenadine hydrochloride is described. The stress studies revealed the photostability of the drug as the most adverse stability factor. The main photodegradation products were isolated and its structures were elucidated by 1H, 13C, COSY, HSQC, HMBC NMR a...

Hyaluronic acid (HA)-based microspheres containing PEG 6000 and/or sodium taurocholate (NaTC) were prepared by the spray-drying method for nasal delivery of fexofenadine hydrochloride (HCl). Their physicochemical properties including particle size and drug contents were determined, while their m...

BackgroundAntihistamines are an established first-line treatment for allergic rhinitis and are widely prescribed in infants for allergic symptoms.

ABSTRACTTo enhance permeation and solubility of an intranasal delivery system of fexofenadine hydrochloride (FXD HCl), a new formulation using poloxamer 407 (P407)/hydroxypropyl-β-cyclodextrin (HP-β-CD)-based thermoreversible gels with chitosan, was developed. Prepared gels were characterized ...