A combined FTIR matrix isolation and theoretical B3LYP/6-311++G(2d,2p) study of 2-(tetrazol-5-yl)benzoic acid isolated in solid nitrogen was performed. Out of fifteen stable isomers of this molecule located on the singlet potential energy surface the most stable one, comprising the intramolecula...

1-(3,5-Diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives were synthesized and tested for their in vitro antifungal and antimycobacterial activities. These imidazole derivatives showed an excellent antifungal activity against a clinical strain of Candida albicans and an interesting ant...

A novel series of 3-(4, 5-dihydro-1-phenyl-5-substituted phenyl-1H-pyrazol-3-yl)-2H-chromen-2-one derivatives were synthesized. In the first step salicylaldehyde was reacted with ethylacetoacetate at room temperature by stirring which gives compound (I). Compound (I) when refluxed with substitut...

Nitric oxide (NO) is a physiological inhibitor of platelet function and has vaso-dilating effects. Therefore, synthesized NO releasing agents are used e.g. in cardiovascular medicine. The aim of this study was to characterise specific effects of the short living agent MAHMA/NONOate, a NO donor o...

Background and objectiveExcision of cutaneous scalp tumors results in surgical defects that are difficult to repair because of poor distensibility in this area of the body. The main aim of this study was to develop a structured algorithm to help choose the best technique for reconstructing scalp...

The [3 + 2] cycloaddition of two acetylacetylenes with ruthenium azido complex [Ru]−N3 (1, [Ru] = (η5-C5H5)(dppe)Ru, dppe = Ph2PCH2CH2PPh2) is reported. The metal-bound heterocyclic complexes produced are triazolato complexes [Ru]N3C2H(COCH3) (2) and [Ru]N3C2(Ph)(COCH3) (3) from 3-butyn-2-one a...

ObjectiveTo compare percutaneous nephrolithotomy (PCNL) and retrograde intrarenal surgery (RIRS) for the treatment of lower calyceal calculi with diameter of 2-3 cm in patients with solitary kidney.

ObjectivesTumor spread through air spaces (STAS) is a novel invasive pattern in lung adenocarcinoma (ADC). The effects of the combination of STAS and tumor size on survival have not been well studied.

Osteoarthritis (OA) is a common degenerative joint disease characterized by progressive deterioration of articular cartilage. There have been reports that small molecule inhibitors have anti-osteoarthritis effects; however, the effects of 3-(4-chloro-2-fluorophenyl)-6-(2,4-difluorophenyl)-2H-ben...

Both mucin 1 (MUC1) and trophoblast cell surface antigen 2 (Trop-2) are overexpressed in various epithelial tumor cells, and their high expression is correlated with a poor prognosis. Both proteins were expressed in a human breast cancer cell line, MCF-7 cells, but neither was in a human colon c...

SummaryIntroductionTo compare the effects of micropercutaneous nephrolithotomy (micro-PCNL) and retrograde intrarenal surgery (RIRS) in treating 1–2 cm solitary renal stones in pediatric patients aged less than 3 years.

We generalize the definition of CM cycles beyond the ‘small’ and ‘big’ CM ones studied by various authors, such as in [BY09] and [BKY12] and give a uniform formula for the CM values of Green functions associated to these special cycles in general using the idea of regularized theta lifts. Fi...

Electrospray-ionization mass spectrometry was used to identify a novel, highly polar metabolite of diflunisal isolated from Gunn rat urine. Negative ion spectra were obtained of the sulphate conjugate of diflunisal and the new metabolite, which was identified as a sulphate conjugate of 3-hydroxy...

Two new s-block metal-containing coordination polymers, viz. [M(ona)]n (M = Ba (1), Ca (2); ona = 2‑hydroxylnicotinic anion), have been synthesized under hydrothermal condition. Single crystal X-ray diffraction analysis discloses that both 1 and 2 display two-dimensional wave-like layer construc...

A concise synthesis of (S)-3-hydroxytetrahydropyran from natural l-glutamic acid has been developed. The intramolecular etherification starting from 1,5-diol was promoted by trifluoromethanesulfonic anhydride. The clinnamates of the alcohols were prepared for accurately determining the optical p...

AbstracrtOmeprazole (OM), a prototype proton pump inhibitor, oxidizes thiol groups and induces DNA damage. The aim of this study was to evaluate the oxidative effects of omeprazole and its interactions with ascorbic acid (AA, 50 μM) and retinol palmitate (RP) in proficient and deficient Sacchar...

Two preparative chemical methods for aromatization of 19-nor-Δ4-3-oxosteroids are described. The first method consist of an oxidative aromatization of 19-nor-Δ4-3-oxosteroids with iodine-ceric ammonium nitrate in methanol to give a mixture of 3-methoxy ring-A aromatized derivatives consisting ...

Four alkaloids comprising two vallesamine, one strychnan, and one pyranopyridine alkaloid, in addition to 32 other known alkaloids were isolated from two Malayan Alstonia species, Alstonia pneumatophora and Alstonia rostrata. The structures of these alkaloids were determined using NMR and MS ana...

An 8-level 3-bit cell programming technique is presented in NOR-type nano-scaled polycrystalline silicon-oxide–nitride-oxide-silicon (SONOS) memory devices. This new operating mode provides the double programming and sensing window over the traditional 4-level cell programming by using a double...

In this study, the cytotoxicity, genotoxicity and early ROS generation of 2,2-dimethyl-(3H)-3-(N-3′-nitrophenylamino)naphtho[1,2-b]furan-4,5-dione (QPhNO2) were investigated and compared with those of its precursor, nor-beta-lapachone (nor-beta), with the main goal of proposing a mechanism of a...