We report herein a straightforward and efficient one-step reaction to prepare new nor-β-lapachone derivatives tethered with phenylthio groups at position 3 of the furan ring. We have screened the compounds on bloodstream trypomastigotes of Trypanosoma cruzi, the causative agent of Chagas diseas...

Norfloxacin (NOR), a well-known antibacterial agent is also known to have potential antitumor activity. In this study, NOR was immobilized into poly(3-hydroxybutyrate/polyethylene glycol‑nickel oxide (PHB/PEG-NiO) nanocomposites using different NiO contents. The NiO nanoparticles were prepared b...

In a continuing study of novel anti-HIV agents with drug-like structures and properties, 30 1′-O-, 1′-S-, 4′-O- and 4′-substituted-2′,3′-seco-3′-nor DCP and DCK analogues (8-37) were designed and synthesized. All newly synthesized seco-compounds were screened against HIV-1NL4-3 and a mult...

Penioxalicin (1), the first 3-nor-2,3-seco-labdane type diterpene featuring the fission between C-2 and C-3 in the ring A and the decarboxylation at C-3, was isolated from the fungus Penicillium oxalicum TW01-1. Its planar structure and absolute configuration were elucidated mainly by analysis o...

In recent years, experimental research on lysergic acid diethylamide (LSD) in humans has gained new momentum. In humans, LSD is metabolized rapidly into several metabolites but knowledge of the involved metabolizing enzymes is limited. The aim of the current study was to identify the cytochrome ...

Gurmarin (Gur) is a peptide that selectively suppresses sweet taste responses in rodents. The inhibitory effect of Gur differs among tongue regions and mouse strains. Recent studies demonstrated that co-expression levels of genes controlling sweet receptors (T1r2/T1r3 heterodimer) versus Gα-pro...

The effect of an anti-sweet peptide, gurmarin purified from the leaves of Gymnema sylvestre, was studied electrophysiologically on taste responses of the rat chorda tympani. The action of gurmarin was highly specific to sweet taste so that responses to various sweeteners including sugars, sweet ...

Gymnema sylvestre (gymnema) contains gurmarin that selectively inhibits responses to sweet substances in rodents. The present study investigated possible interaction between gurmarin and the submandibular saliva in rats fed diet containing gymnema. Electrophoretic analyses demonstrated that rela...

Gurmarin is a 35 amino acid peptide with three disulfide bridges in an inhibitor cystine knot. It is found in the plant Gymnema sylvestre, and has been identified as a sweet taste inhibitor in rodents. In this article we provide an efficient route for the synthesis of gurmarin by a controlled ra...

The nutrient-type distribution of dissolved cadmium concentrations (dCd) reflects a biological control in the global ocean, with uptake of dissolved Cd into biogenic particles in surface waters and regeneration of particulate Cd at depth. Depth profiles of dissolved Cd stable isotope composition...

The adsorption behavior of polyamidoamine (PAMAM) dendrimers functionalized silica (SG-G0∼SG-G4.0) for Cd(II) from aqueous solution was investigated by combining experimental and theoretical method. The influences of dendrimer generation, terminal functional group, solution pH, contact time, te...

Suspended microbes gradually lost advantages in practical applications of PAHs and heavy metals bioremediation. Therefore this study investigated the effect of immobilization on phenanthrene degradation by Bacillus sp. P1 in the presence of different Cd(II) concentrations. Condensed Bacillus sp....

Porous coordination compounds, commonly known as metal–organic frameworks (MOFs), exhibit many unique characteristics (e.g., high surface area, high porosity, and tunability). The corresponding naturally occurring counterparts, CD-MOFs have opened a new avenue of research in light of its non-to...

A pot experiment was conducted to evaluate how nitrogen (N) availability influences cadmium (Cd) absorption, translocation and stress tolerance in roots of Populus euramericana. Seedling growth was sensitive to N deficiency, but it was unaltered by Cd exposure. Cadmium absorption by roots was pr...

Ubiquitous calcium carbonate (biogenic or abiotic) exerted an important impact on the migration and transformation of heavy metal in the environment. Cd(II) pollution, common in China, has attracted much attention due to its critical toxicity. The purpose of this study is to compare the differen...

In this research, un- and Cd-doped ZnS nanostructures were synthesized using an electrodeposition method. The electrolyte contained 20 mM ZnCl2, 20 mM Na2S2O3 and the various amounts of CdCl2 solution. The X-ray diffraction (XRD) patterns of the as-deposited samples exhibited that Cd doping lead...

The identification of hyperaccumulators is a key step for the phytoextraction of contaminated soils. However, few cadmium (Cd) hyperaccumulators have been identified in the plant kingdom. In our previous field investigations, Lantana camara L. plants exhibited some traits of hyperaccumulators. T...

High grain-Cd-accumulating rice variety Yongyou 9 was planted in Cd-contaminated farmland in Taizhou City, Zhejiang Province, China to study the effects of 5-aminolevulinic acid (ALA) and 24-epibrassinolide (EBR) on Cd accumulation in brown rice. Results showed that the exogenous ALA and EBR had...

The plant cell wall acts as a barrier to prevent heavy metal ions from entering the plant cytoplasm. To study the mechanism of Cd fixation by tomato (Solanum lycopersicum) cell wall pectin, the expression levels of pectin synthesis and pectin-modifying enzyme-related genes were determined in thi...

Ab initio MP2/aug’-cc-pVTZ calculations were carried out to investigate HN(CH)SX:OCS potential energy surfaces. Bound equilibrium complexes stabilized by N…C tetrel bonds and O…S chalcogen bonds have been found on all HN(CH)SX:OCS surfaces, but HN(CH)SF:OCS is the only bound molecule. Charge-...