Objective: To investigate the therapeutic efficacy of fexofenadine hydrochloride (Allegra® tablets), an antihistaminic launched in 2001, in patients with cedar pollinosis by dividing them into two groups for comparison, i.e. the early-treatment group in which treatment was started before the ini...

Publisher SummaryThis chapter describes fexofenadine hydrochloride (FEX), its nomenclature, formulae, methods of preparation, physical properties, and methods of analysis, stability, drug metabolism, and pharmacokinetics. FEX is obtained as a white to off-white crystalline powder. FEX is a nonse...

A novel sensitive fluorimetric method was investigated for the assay of fexofenadine hydrochloride (FEX) using silver nanoparticles (NPs) as a fluorescence probe. The NPs, which were prepared by chemical reduction of silver nitrate with sodium borohydride (reducing agent) in aqueous solution (wi...

A simple, fast and precise reverse phase high performance liquid chromatographic method has been developed for the simultaneous determination of Montelukast Sodium (MONT) and Fexofenadine hydrochloride (FEXO). The chromatographic separation was achieved on X-bridge C18 column (250 mm × 4.6 mm, ...

Allergic rhinitis is a common disease in children which has considerable negative effects on the quality of life. Fexofenadine hydrochloride (FFH) is a second-generation oral antihistamine which has been widely perscribed for alleviating symptoms of AR in children. The aim of this study was to t...

High-throughput measurements of ciprofloxacin, clomipramine and fexofenadine hydrochlorides were performed by employing an automatic 8-channel electrical titrator. Silver nitrate (AgNO3) and sodium tetraphenylborate (NaTPB) were used as titrants. When AgNO3 was used for measuring the drugs in pu...

The interactions of serum albumins with a variety of drugs have expected immense interest currently owing to their considerable achieve in the biomedical area. In the current study, we have accounted the interactions between clomipramine hydrochloride (CLP) drug and human serum albumin (HSA) usi...

A convergent synthesis of the nonacyclic BCDEFGHIJ-ring polyether core of gambieric acids, potent antifungal polycyclic ether marine natural products, has been achieved. The present synthesis involved as key features: (i) convergent union of the BCD- and GHIJ-ring fragments through esterificatio...

The J ring segment 2 of gambieric acid was synthesized stereoselectively by the coupling between the cyclic ether component 3 and the alkenyl iodide 4. The tetrahydropyran 3 was stereoselectively synthesized by the 6-endo-cyclization of a hydroxyepoxide prepared from deoxy-d-ribose. The side cha...

The absolute configurations of potent antifungal polyether compounds, gambieric acids A–D, isolated from the marine dinoflagellate Gambierdiscus toxicus were determined by combining the modified Mosher method, NMR analysis, and chiral fluorimetric HPLC.

Brevetoxins (BTXs) and ciguatoxins (CTXs) bind to site 5 of the voltage-gated sodium channel of excitable membranes. In the present study, we performed a competitive inhibition assay with other structurally distinct naturally occurring polyethers using isotope-labeled dihydro BTX-B ([3H]PbTx-3),...

A stereocontrolled synthesis of a fully elaborated GHIJ-ring fragment of gambieric acids, which are potent antifungal polycyclic ether natural products, has been accomplished. The synthesis features convergent assembly of the tetracyclic polyether skeleton through aldol coupling/cyclodehydration...

The A ring fragment of gambieric acids was stereoselectively synthesized based on an Evans’ asymmetric alkylation, Brown's asymmetric crotyl-, allylboration and an intramolecular SN2 reaction.

A stereocontrolled synthesis of the GHIJ-ring fragment having a side chain of gambieric acids, which are potent antifungal polycyclic ether natural products, has been achieved. The synthesis features convergent assembly of the tetracyclic polyether skeleton by using aldol coupling and stereosele...

o-Tolyloxy acetic acid (1H-indol-3-yl-methylene)-hydrazide was synthesized by treating 2-methyl phenoxy acetic acid hydrazide with indole carboxaldehyde. It was characterized by NMR, IR studies and mass spectral studies and finally, the structure was confirmed by single crystal X-ray diffraction...

The deformylation of indole and azaindole-3-carboxaldehydes was achieved in the presence of anthranilamide and a solid acid heterogeneous catalyst under reflux conditions in 25–90% yield. The reaction proceeds via quinazolinone intermediate, which undergoes acid catalyzed cleavage to form defor...

A stereoselective and scalable synthesis of (1R,3S,5R)-2-(tert-butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic acid (3a) is described. Key to the success of the devised route was the realization that the stereoselectivity of a cyclopropanation step could be controlled by the composition o...

A very mild, one-step esterification using nearly equimolar amounts of N-protected amino acids and alcohols, in conjunction with 1-tert-butoxy-2-tert-butoxycarbonyl-1,2-dihydroisoquinoline (BBDI) as a novel condensing reagent is described.

The objective of this study was to determine the effect of dietary supplementation with calcium salts of n-3 and n-6 fatty acids (FA) during the last 3 weeks of gestation on colostrum composition and productive and reproductive performance of nulliparous and parous Holstein cows during the entir...

The aim of this work was to study whether the dietary supplementation with soluble fibre (SF) and the reduction of the n-6/n-3 fatty acid ratio or the combination of both influence the growth performance and digestible nitrogen and energy (DN and DE) retention efficiency in rabbits from 27 to 62...