In humans, deleterious mutations in the sterile α motif domain protein 9 (SAMD9) gene are associated with cancer, inflammation, weakening of the immune response, and developmental arrest. However, the biological function of SAMD9 and its sequence-structure relationships remain to be characteriz...

A therapeutic approach to improve treatment outcome of ovarian cancer (OC) in patients is urgently needed. Myxoma virus (MYXV) is a candidate oncolytic virus that infects to eliminate OC cells. We found that in vitro MYXV treatment enhances cisplatin or gemcitabine treatment by allowing lower do...

Aberrant activation of the receptor tyrosine kinase-mediated RAS signaling cascade is the primary driver of embryonal rhabdomyosarcoma (ERMS), a pediatric cancer characterized by a block in myogenic differentiation. To investigate the cellular function of activated RAS signaling in regulating th...

Many common neoplasms are still noncurative with current standards of cancer therapy. More therapeutic modalities need to be developed to significantly prolong the lives of patients and eventually cure a wider spectrum of cancers. Oncolytic virotherapy is one of the promising new additions to cl...

The pathogenesis of South American and North American myxoma viruses was examined in two species of North American lagomorphs, Sylvilagus nuttallii (mountain cottontail) and Sylvilagus audubonii (desert cottontail) both of which have been shown to have the potential to transmit the South America...

The epidemiology of myxoma virus was studied by serology and molecular analysis of restriction fragment length polymorphisms (RFLPs) in genomic DNA. 159 isolates of myxoma virus were made over a period of 5 spring/summer epidemics from 12 field sites in south-eastern Australia. Virus isolates we...

Primary cardiac tumors are extremely rare and constitute only about 5% of all cardiac tumors. Cardiac myxomas are noncancerous primary tumors of the heart and constitute about of 50% of all primary heart tumors. Left-sided atrial myxomas are more common than right-sided atrial myxomas. Atrial my...

Myxoma virus (MYXV) is a poxvirus with a strict rabbit-specific host-tropism for pathogenesis. The immunoregulatory factors encoded by MYXV can suppress some functions of immune effectors from other species. We review their mechanisms of action, implications in therapeutics and the potential to ...

Guazatine (1-17-diguanidino-9-aza-heptadecane acetate) was compared with sodium orthophenylphenate (SOPP), sec-butylamine (2-AB), benomyl and tridemorph for the control of citrus sour rot (Geotrichum candidum) under local marketing, export, and ethylene (C2H4) degreening storage conditions. Guaz...

Guazatine is a non-systemic contact fungicide, a mixture of reaction products from polyamines, comprising mainly octa-methylenediamine, iminodi(octamethylene)diamine, octamethylenebis(imino-octamethylene) diamine and carbamonitrile. In this work, the analysis of guazatine mixture by LC and LC–M...

Zero-VOC technologies combining ecological and economic efficiency are destined to occupy a growing place in the polymer economy. Today, Polymerization in dispersed systems and Photopolymerization are the two major key players. The hybrid technology based on photopolymerization in dispersed syst...

Development of benign and efficient approaches towards abatement of industrial grade toxic organic dyes from the fresh water resources is an evolving challenge. To this end, current study was focused on the removal of reactive yellow 186 dye (RY-186) dye using green synthesized SnO2 nanoparticle...

The composition of the products formed by the thermal degradation of PS is modified by the presence of a fire retardant chloroparaffin. In particular, chain fragments with more than one phenyl group are evolved in larger yield from polystyrene in the mixtures than from the pure polymer, whereas ...

The thermal degradation behaviour of bismuth carbonate-chloroparaffin-polypropylene ternary mixtures can mostly be accounted for on the basis of that of bismuth carbonate-chloroparaffin and of chloroparaffin-polypropylene binary mixtures. For example, polypropylene volatilises in the ternary mix...

The main characteristics of the evolution of HCl and SbCl3 during the thermal degradation of chloroparaffin-Sb2O3 mixtures, which are typical fire retardant additives for polymers, have been studied.Sb2O3 reacts with HCl evolved from the chloroparaffin without any apparent effect on the dehydroc...

The mechanisms of reactions which occur on heating mixtures of Bi compounds and a chloroparaffin, which are suitable fire retardant additives for polymers, have been studied.BiCl3, which is evolved at a high initial rate by reaction of Bi compounds with HCl eliminated by the chloroparaffin, has ...

In mixtures of polystyrene with a fire retardant chloroparaffin, the rate of volatilisation of the polymer is initially increased during the thermal dehydrochlorination of the additive. In the residue which results, the volatilisation of polystyrene occurs at a lower rate than when it is heated ...

Congener group patterns of technical short chain and medium chain chloroparaffins (SCCP and MCCP) were determined by electron capture negative ionization (ECNI) and chloride attachment chemical ionization (CACI) mass spectrometry (MS). In contrast to CACI–MS, congener patterns obtained by ECNI ...

Antimony trioxide and bismuth compounds added to chloroparaffin-polypropylene mixtures display different fire retardant ‘synergistic’ mechanisms. Antimony-chlorine ‘synergism’ depends on SbCl3 evolved from the mixtures on heating, which is a much more efficient flame poison than HCl evolved ...

The mechanism by which a typical fire retardant chloroparaffin imparts fire retardant characteristics to high density polyethylene, polypropylene and polystyrene is studied by comparing the oxygen indices of these mixtures measured before and after dehydrochlorination. It is shown that flame poi...