ObjectivesThe purpose of the present study was to evaluate the association between pre-eclampsia and blood groups in a group of pregnant women hospitalized in a University Hospital in Porto Alegre, Brazil – Hospital São Lucas (HSL)/PUCRS.

Catalytic oxidation of chlorobenzene over noble metal catalysts Pd/TiO2, Pt/TiO2, Ru/TiO2, and Rh/TiO2 was evaluated, and Ru/TiO2 contributed the highest catalytic activity and CO2 selectivity. During the oxidation, polychlorinated benzenes PhClx (x ≥ 2) were observed, and Ru/TiO2 showed appare...

β-Keto carboxylic acids are key intermediates in organic syntheses, used for the development of fine chemicals, natural products, and various biologically relevant molecules. Their utilities stem from the structural features and facile bond formations, e.g., asymmetric reduction of carbonyl gro...

The esters of 4-hydroxy-cyclohexanone and a series of carboxylic acids R–COOH with R of different electronic and steric influence (R=Me, Et, n-Pr, i-Pr, n-Bu, i-Bu, sec-Bu, t-Bu, CF3, CH2Cl, CHCl2, CCl3, CH2Br, CHBr2, and CBr3) were synthesized and the conformational equilibria studied by 1H an...

We herein present an efficient method for the construction of α,α-difluoro-β-hydroxy ketones. The La(OTf)3-catalyzed aldol reaction between difluoroenol O-Boc (Boc = tert-butyloxycarbonyl) esters and carbonyl compounds affords α,α-difluoro-β-hydroxy ketones in good yield. The key reagents ...

Isostructural molecular sieves based upon AlPO4 and SiO2 chemistry were made for comparison of catalytic selectivity. The AFI and CHA structures were compared with B and Al substitution of SiO2 and Mg and Si substitution in the AlPO4 case. The conversion of methanol to hydrocarbons was studied. ...

Bioassay-directed fractionation of the stems of Rollinia mucosa led to the isolation of new N-methoxycarbonyl aporphine alkaloids, romucosine A (1), romucosine B (2), romucosine C (3), and romucosine D (4), along with the known alkaloid, N-methoxylcarbonyl-nornuciferine (5). Alkaloids 1 and 4 ex...

Four l-Lysine(Lys)-l-glutamic acid(Glu) dipeptide derivatives (1–4) and their precursor–a single fluorenyl-9-methoxycarbonyl(Fmoc)-l-Lys(Fmoc)-OH amino acid (5) were demonstrated as gelators to gelate a variety of alcohols and aromatic solvents under the sonication conditions. Compared to the ...

A new type of rearrangement of an unsaturated seven-membered cycle into substituted ethenylcyclopentadienyl derivatives is described. This process proceeds via a cascade reaction of 1,2,3,4,5,6,7-hepta(methoxycarbonyl)cycloheptatrienyl potassium with organic azides (sulfonyl and carbonyl azides)...

A new hydrazone ligand (2-(Methoxycarbonyl-hydrazono)-pentanedioic acid, H2L), derived from methyl carbazate and α-ketoglutaric acid, and its Ag(I) complex [Ag(HL)(H2L)] were synthesised and characterised by elemental, spectral and thermal analyses. The X-ray structures of the ligand and comple...

Novel drugs are urgently needed to combat hepatitis B virus (HBV) infection due to drug-resistant virus. In this paper, a series of novel 4-monosubstituted 2′-deoxy-2′-β-fluoro-4′-azido-β-d-arabinofuranosyl 1,2,3-triazole nucleoside analogues (1a-g) were designed, synthesized and screened f...

Myclobutanil (CAS 88671-89-0) is a broad-spectrum systemic foliar-applied fungicide of the substituted triazole chemical class of compounds. Exposure may occur at workplaces where it is used or produced and the general population may be exposed via ingestion of contaminated food. The predominate...

Both 25-epimers of (22E)-22-dehydro-1α,25-dihydroxy-26-methylvitamin D3 [22-dehydro-26-methyl-1, 25-(OH)2D3] were synthesized. The biological activity of these compounds was tested in binding affinity to chick intestinal receptor protein of 1α,25-dihydroxy-vitamin D3 [1,25-(OH)2D3] and in stim...

Monocylic differentiation-inducing activity of steroidal side chain-lengthened 26,27-dialkyl analogs of 1α,25-dihydroxyvitamin D3 was examined in human promyelocytic leukemia (HL-60) cells in serumsupplemented or serum-free culture. The order of in vitro potency for reducing nitroblue tetrazoli...

Novel vitamin D receptor (VDR) antagonists, 24,24-dimethyl-1α-hydroxyvitamin D3-26,23-lactones (8 and 9) and their C2α functionalized analogues (8a–c and 9a–c) were efficiently synthesized and their biological activities were evaluated. The construction of vitamin D3 triene skeleton was achi...

The syntheses 1α-hydroxy-25-oxo-25-phosphavitamin D3, 25-oxo-25-phospha-26,27-dioxa-26,27-dimethylvitamin D3, and 1α-hydroxy-25-oxo-25-phospha-26,27-dioxa-26,27-dimethylvitamin D3 are reported. The biological activity of 25-oxo-25-phosphavitamin D3 and the above compounds are reported.

A [Cu(maloNHC)]-catalyzed synthesis of 2-aryl pyrazolo[5,1-a]isoquinolines via annulation of N′-(2-((trimethylsilyl)ethynyl)benzylidene)hydrazides with terminal aromatic alkynes was developed.

The pyridine scaffold is present in a number of natural products, biologically active materials, as well as in materials with interesting physical–chemical properties. As such, their preparation and properties continue to be ubiquitously examined. Several reviews point to interesting approaches...

This review covers the carbon-nitrogen (C–N) bond forming reactions of pyridines that include both electrophilic as well as nucleophilic substitution reactions. The electrophilic reactions, such as nitration and nitrosation, include both the classical methods and their recent modifications. Nuc...

Total stereoselective synthesis of 2,3-dideoxy-3-fluoro- and 2,3-dideoxy-3-azido-d-glycero-pentose and their condensation with 5-fluorouracil is described. The key step in this synthesis is nucleophilic cleavage of a chiral epoxyalcohol, prepared from commercially available 2-methyl-2-butenal.