The cis and trans isomers of 2,3-piperidine dicarboxylic acids were obtained in enantiopure forms from the same chiral inductor: 2-phenylglycinol. This synthesis was mainly based on a δ-lactam formation via Stille's aza-annulation/hydrogenation procedure which includes here an asymmetric i...

(Z,Z)-6,9-cis-3S,4R-Epoxynonadecadiene has been identified as the major sex pheromone component of the Geometrid Boarmia selenaria. A short and efficient synthesis of the chiral methylene-interrupted diene-epoxide has been developed for both enantiomers.

A series of novel cisplatin-type platinum complexes with (1S,3S)-1,2,3,4-tetrahydroisoquinolines as the ligands were synthesized as potential anticancer agents in several steps starting from commercially available l-DOPA. The cytotoxicities of these compounds were tested against HCT-8, BEL-7402,...

Allyltrimethylsilane (5) reacted with N-carbobenzoxy-O-tert-butyldimethylsilyl-L serinal (4) to give with high diastereoselectivity syn-adduct 3 which was subsequently transformed into cis-(2R,3S)-3-hydroxyproline (1).

Publisher SummarySulfones are sulfur derivatives of the general formula RSO2R' in which the sulfur atom is at an oxidation level between that of sulfoxides (RSOR') and sulfonic acids (RSO3H). This chapter describes the synthesis of S-benzyl-DL-α-methylcysteine sulfone from the corresp...

PurposeCytosine arabinoside (AraC) remains the backbone of most treatment regimens for acute myeloid leukemia (AML). Incorporation of AraC into DNA activates checkpoint kinase 1 (Chk1), leading to cell-cycle arrest and diminished AraC cytotoxicity, which can be reversed by the selective Chk1 inh...

Clinical studies suggest that chemotherapy is associated with long-term cognitive impairment in some patients. A number of underlying mechanisms have been proposed, however, the etiology of chemotherapy-related cognitive dysfunction remains relatively unknown. As part of a multifaceted approach,...

The central nervous system toxicity of high-dose cytosine arabinoside is well recognized, but the toxicity of cytosine arabinoside in the peripheral nervous system has been infrequently reported. A 49-year-old Japanese man was diagnosed with acute myeloid leukemia. After he achieved complete rem...

Two benzophenone O-arabinosides, annulatophenonoside (1) and acetylannulatophenonoside (2) were isolated from the methanol extract of the herb of Hypericum annulatum. The structures of the benzophenones were established as 2-O-α-l-arabinofuranosyl-3′,5′,6-trihydroxy-4-methoxybenzophenone (1) ...

A method for simultaneous bioanalysis of the three cytotoxic drugs cytosine arabinoside, daunorubicin and etoposide in human plasma was developed and validated. A HPLC method with ultra-violet and fluorescence detection, preceded by mixed-mode cation-exchange solid phase extraction sample prepar...

Cytosine arabinoside (Ara-C) is widely used to induce remission in adult granulocytic leukemia. High doses can be infused in refractory leukemia or in relapse. After injection, Ara-C is quickly metabolized to uracil arabinoside (Ara-U), the main inactive metabolite. We here described a micellar ...

PurposeTo assess cervical tumor hypoxia using the hypoxia tracer 18F-fluoroazomycin arabinoside (18F-FAZA) and compare different reference tissues and thresholds for quantifying tumor hypoxia.

A number of neurotoxic agents could potentially exert their action by degrading or modifying cytoskeleton components like neurofilaments (NF). Cytosine arabinoside (AraC) is an anticancer drug commonly used in leukemia treatment. Its side effects include neuronal cell death in the cerebellum and...

The chemical synthesis of Guanine arabinoside (ara-G) is extremely complex, time-consuming, and seriously polluted. A two-step enzymatic synthesis process was developed to acquire ara-G easily. 2,6-Diaminopurine arabinoside (ara-DA) was first synthesized with purine nucleoside phosphorylase and ...

Eight new C19-diterpenoid alkaloid arabinosides, named aconicarmichosides E–L (1–8), were isolated from an aqueous extract of the lateral roots of Aconitum carmichaelii (Fu Zi). Their structures were determined by spectroscopic and chemical methods including 2D NMR experiments and acid hydroly...

K2Zn3[Fe(CN)6]2 @ Ni-P (KNiP) composites with high cesium selectivity were synthesized for the first time. Nickel phosphorus (NiP) was used as a solid base for the adsorption of K2Zn3[Fe(CN)6]2 (KZnHCF). The synthesized KNiP composites were characterized by SEM, TEM, XRD, VSM and BET. The charac...

A series of N-substituted rac-cis-4a-ethyl-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-8-ols have been prepared using a simple synthetic route previously designed for synthesis of related cis-2-methyl-4a-alkyl-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols. The new phenolic compounds, w...

We demonstrate that the properties of the transient photoconductivity such as its life time and its dependence on light intensity and electric field (E) in crystal 8T are radically different from those in 8T oriented polycrystalline film. Our observations indicate a bimolecular carrier recombina...

Scanning tunneling microscopy and spectroscopy as well as photoemission spectroscopy have been employed to study the adsorption behavior and electronic structure of α-octithiophene (8T) on Au(1 1 1). At a monolayer (ML) and bilayer coverage well-ordered molecular rows forming closely packed fil...

UV-Vis absorption spectra of polycrystalline thin films of three conjugated oligothiophenes (quaterthiophene (α-4T), sexithiophene (α-6T) and octithiophene (α-8T)) have been studied over the temperature range 14–300 K. The fundamental π-π∗ band exhibits a succession of equally spaced side ...