Fluorine chemistry has represented a hot topic in drug research over the last decade. Because of their pharmaceutical potential, fluorine-containing amino acids and related derivatives have acquired high importance among medicinal chemists. Therefore their synthesis and the development of variou...

Quinazolinediones were obtained from 2-iodobenzoic acids and carbodiimide derivatives under mild reaction conditions via a copper-catalyzed domino reaction. The absence of an external base was essential to avoid the generation of amide by-products. Both alkyl- and aryl-substituted carbodiimides ...

Pullulan is a non-ionic, linear, water-soluble and a neutral polysaccharide. It is composed of α-(1,6) repeated maltotriose units via α-(1,4) glycosidic bond having chemical formula (C6H10O5)n. It shows non-immunogenic, non-toxic, non-carcinogenic and non-mutagenic properties. It is used in fo...

Lipids are key components of biosystems. Their use is also widespread in industry, consumer products, personal care, and in the food and pharmaceutical industries. We find natural waxes such as carnauba wax in car polishes, in lipsticks and eyeliners, as waterproof for leather products, as relea...

The development of viable alternatives to petroleum-based polymeric materials is a compelling contemporary challenge attributable to environmental concerns and the effects of fluctuating oil prices. Triglycerides, the primary components of vegetable oils, are an abundant, renewable, and widely i...

Lactic acid is an important organic acid used in the chemical, pharmaceutical, and food industries. Its production by biotechnological routes is preferable to chemical processes mainly because of the possibility of obtaining pure isomers (d- or l-lactic acid). l-Lactic acid is easily assimilated...

Interest in the use of wastewaters of different origins for the industrial production of microalgal biomass for biofuels and bioproducts has stimulated studies on the influence of a variety of compounds in wastewaters on algal physiology. Following the previously published work on the impact of ...

MicroRNA-31 (miR-31) is an evolutionarily conserved microRNA, and its biological function in colorectal cancer and other cancers is controversial. In this study, we identified the host gene of mouse miR-31 and found that miR-31 was over-expressed in both human colorectal cancer and mouse colon c...

MicroRNAs have been proposed as novel biomarkers for the diagnosis and treatment of many types of cancer. The levels of five candidate microRNAs (miRNAs) (miR-99a-5p, miR-31-5p, miR-138-5p, miR-21-5p, and miR-375-3p) in sera from oral cancer patients and paired tumor and normal tissues were dete...

Recently, microRNAs (miRNAs) have emerged as crucial regulators of lipid metabolism. However, the miRNA-mediated regulatory mechanism on long-chain (≥C20) polyunsaturated fatty acids (LC-PUFA) biosynthesis in vertebrates remains largely unknown. Here, we address a potentially important role of ...

Phytohormones have shown great potential as natural anticancer compounds, being interesting in cancer prevention and therapy. Strigolactones are a class of plant hormones involved in the inhibition of root branching and sprouting. The antiproliferative capacity of the synthetic strigolactone ana...

The analysis of triacylglycerols and phospholipids - phosphatidylcholines allowed the use of shotgun lipidomics to identify very long-chain fatty acids and very long-chain polyunsaturated fatty acids in microalgae. These fatty acids were determined in triacylglycerols by positive electrospray io...

Oxidative stress is an important pathological mechanism for acute kidney injury (AKI). SS-31, as a mitochondria-targeted peptide with strong antioxidant activity, is a good candidate for the treatment of AKI. However, an efficient treatment of AKI requires frequent administration of SS-31, which...

MicroRNA miR-31 is implicated in the neoplastic process of various malignancies including oral squamous cell carcinoma (OSCC). Silent information regulator 3 (Sirtuin3 or SIRT3) is a NAD-dependent deacetylase that regulates metabolic process. Suppressor role of SIRT3 has been found in neoplasms....

In this report, environmental and energy issues were deal with a Z-scheme photocatalytic system toward the synthetic ammonia by N2 photofixation. Different from traditional double-charge-transfer model, a direct all-solid-state Z-scheme system of modified TiO2 (MT) loaded with ZnFe2O4 (ZFO) was ...

Rational construction of Z-scheme photocatalysts and deep exploration of Z-scheme transfer mechanism are highly desirable for improving the activity of CO2 reduction photocatalysts but remains a significant challenge. Herein, we synthesized a series of heterostructured CdS/CdWO4 materials by sel...

A new cohesive damage model was proposed to analyze the Mode I, Mode II, and mixed-mode bridging micromechanisms of a single Z-pin in the quasi-isotropic laminate. One zero-thickness cohesive element was embedded into each pair of adjacent elements in the damage zone to model the multi-direction...

Recently much endeavor has been devoted to improving pervaporation performances of polydimethylsiloxane (PDMS) membranes for organic aqueous solutions by doping hydrophobic porous particles. However, the strategy generally promotes water permeation as well, which is contrary to the separation pu...

Artificial Z-scheme photocatalysis has become a potential solution for resisting environmental degradation and to the worldwide energy shortage because they can effectively promote the separation of photogenerated electron-hole pairs and optimize the oxidation and reduction ability of the photoc...

According to the characteristics of realized volatility existing in Shanghai and Shenzhen 300 index (China Securities Index 300, CSI 300), the GARCH family model is introduced to describe the ARCH effect of error sequences in HAR, ARFIMA, and ARFIMAX models. Then, the HAR-GARCH family, the ARFIM...