ObjectivesThe prognosis of high-risk patients might be greatly ameliorated using genetic predisposition risk factors. Sympathetic activity and innate immunity related to neuropeptide Y function may be related to dyslipidemia and atherosclerosis. The aim of this study is to detect the correlation...

SummarySleep is an essential and evolutionarily conserved behavioral state whose regulation remains poorly understood. To identify genes that regulate vertebrate sleep, we recently performed a genetic screen in zebrafish, and here we report the identification of neuropeptide Y (NPY) as both nece...

The present study was designed to identify immunomodulatory components from the leech salivary gland of Haemadipsa sylvestris. The Sephadex G-50, ResourceTM S column chromatography and reverse-phase high performance liquid chromatography (RP-HPLC) were used to isolate and purify the salivary gla...

Resilience to traumatic stress is a complex psychobiological process that protects individuals from developing posttraumatic stress disorder (PTSD) or other untoward consequences of exposure to extreme stress, including depression. Progress in translational research points toward the neuropeptid...

We synthesized a series of pyrrolo[3,2-d]pyrimidine derivatives and evaluated their application as type-II inhibitors of vascular endothelial growth factor receptor 2 (VEGFR2) kinase. Incorporation of a diphenylurea moiety at the C4-position of the pyrrolo[3,2-d]pyrimidine core via an oxygen lin...

This paper focuses on the study of thermomechanical properties of polyester acrylate (PEA) resins based on poly(butylene succinate) (PBS) and isosorbide with incorporation of 1/ diacid chains ranging from succinic acid (C4) to azelaic acid (C9) and 2/ diols with various structures such as butane...

Aliphatic polyesters are thermoplastic and biodegradable polymers with promising potentials to substitute synthetic polymers derived from petrochemicals. In particular, polylactides (PLAs) and other polylactones can be renewable and biocompatible. A more benign approach for polyester synthesis i...

For the potential application of functional polyesters in biomedical field, a series of side-chain functional fluorescent polyesters have been designed and prepared through the polymerization of AIE-functionalized carbonate monomer TPETC. The controllable nature of TPETC’s ROP and ROCP using di...

Small interfering RNA (siRNA) has potential as therapeutic agents against various diseases because it can reversibly silence any gene with high efficiency and specificity. Unmodified siRNA is a hydrophilic molecule with negative charge, which is unstable in the bloodstream and cannot freely cros...

The study and development of new biocompatible materials to be applied as UV-curable adhesives is extremely important to grant the preparation of matrices with suitable mechanical, biological and thermal properties with a fast curing rate. Herein, photocrosslinkable biodegradable copolymers comp...

Enzymatic polymerization is an environmentally benign process for the synthesis of biodegradable and biocompatible polymers. The regioselectivity of lipase B from Candida Antarctica (CAL-B) produces linear functional polyesters without protection-deprotection steps. In this work, two different m...

As concerns increase regarding sustainable industries and environmental pollutions caused by the accumulation of non-degradable plastic wastes, bio-based polymers, particularly biodegradable plastics, have attracted considerable attention as potential candidates for solving these problems by sub...

In order to utilize biodegradable polymers as a functional material, it is important to make the best use of their biodegradability. Biodegradation of aliphatic polyesters, such as PCL, PBSA and P3HB, in seawater was investigated. BOD test using seawater and field test were carried out. As for B...

Non-toxic coating formulations, i.e. without isocyanate, formaldehyde and toxic amines are a topic in the coating industries since decades. The replacement of cross-linking agents or functional groups to non-toxic compounds reduced often the mechanical properties of the coating film or just one ...

The rate and severity of polyurethane (PU) coating degradation is due to a combination of both abiotic and biotic factors. The contribution of biotic factors to the degradation process has not been fully realized, in part, because it is assumed that microorganisms cannot survive exclusively on p...

N-Acetyl-S-(1,2-dichlorovinyl)-l-cysteine (NA-DCVC) has been detected in the urine of humans exposed to trichloroethylene and its related sulfoxide, N-acetyl-S-(1,2-dichlorovinyl)-l-cysteine sulfoxide (NA-DCVCS), has been detected as hemoglobin adducts in blood of rats dosed with S-(1,2-dichloro...

A spin-labelled analogue (sl-glutathione) has been used in order to characterize the active site of human placenta glutathione transferase π. The sl-glutathione shows a competitive inhibition towards glutathione ( Ki = 14 μM). Binding of sl-glutathione to the enzyme, followed by electron param...

Microsomal glutathione transferase 1 (MGST1) is an abundant membrane‐bound glutathione transferase and peroxidase constituting 3% of the endoplasmic reticulum protein in rat liver (and 5% of the outer mitochondrial membrane). The enzyme is most well studied in mammals and belongs to a large and...

A novel fluorescent compound, 4-(trimethyl ammonium chloride)acetamide-2-(1H-naphtho[2,3-d]imidazol-2-yl)phenol (TMACA-NIP), was synthesized and used as a fluorescent probe for detecting glutathione reduced (GSH). The new NIP-based probe exhibited high fluorescence in water, which was quenched d...

The anesthetic halothane is bioactivated by the liver cytochrome P450 system to the reactive intermediate, trifluoroacetyl chloride, which can acylate liver protein. Cytosolic glutathione-S-transferase (GST) was identified as a major target for protein adduct formation in guinea pig liver slices...