Treatment of N-(2-arylcyclohex-1-en-1-yl)-α-(methylthio)acetamides with N-chlorosuccinimide (NCS) gave 3a-aryl-2,3,3a,4,5,6-hexahydro-3-(methylthio)indol-2-ones. Desulfurization of the cyclization products followed by a catalytic hydrogenation of the resulting hexahydroindol-2-ones gave predomi...

Bis[bis(methylthio)lithiomethyl]dimethylsilane was generated from bis[bis(methylthio)methyl]dimethylsilane by deprotonation with t-BuLi in THF and allowed to react with various dichloro(poly)silanes to give the corresponding 4- to 7-membered polysilacarbacycles in moderate to good yields. The me...

SummaryThe polarographic behaviour of 4-cyanocinnamic acid in 50% ethanolic solution shows a marked dependence on pH. At low pH-values a single 4-electron wave is observed, the height of which decreases with increasing pH; the protonated undissociated acid is reduced to a primary amine. A mixed ...

Phosphatidylethanolamines (PEs) are abundant lipid constituents of the cellular membrane. The amino group of PEs exhibits high reactivity with hypochlorous acid that is generated under inflammatory conditions in vivo. The analysis of the resulting PE mono- and dichloramines is of significant int...

BackgroundCompounds acting on endocannabinoid system regulate different neuronal processes through the cannabinoid receptors activation. The main aim of this study was determining whether the 2-styrylquinazolin-4(3H)-one 5, a structural analogue of rimonabant, was able to counteract the behaviou...

The simple and direct synthesis in good yields of substituted pyrazoles and 4-triphenylphosphoranylidene-4,5-dihydropyrazol-5-ones is reported. These products have been prepared by heterocyclization under different reaction conditions of some 1,5-zwitterionic species obtained from the 1,4-conjug...

Bis(triphenylphosphoranylidene)ammonium iodide (PPN+I−) forms a 2:3 complex with TCNQ [(PPN)2(TCNQ)3(CH3CN)2] that provides an example of a TCNQ complex containing acetonitrile in the crystal lattice; the material is a semi-conductor with trimerised TCNQ stacks.

N-Triphenylphosphoranylidene nucleosides synthesized by Mitsunobu reaction can be utilized for protecting the amino groups bearing on the base moieties of nucleosides.

We describe here the dynamic 1H NMR studies of dimethyl 2-(triphenylphosphoranylidene) succinate (1). Phosphorane 1 has a bond presenting slow (in the 1H NMR time scale) rotation which results in spectra of two isomers at the same time. From the spectral data were calculated the rate constant an...

Several amino acid enantiomer derivatives were prepared with different chloroformates and analysed by gas chromatography (GC) on a Chirasil-L-Val GC column, at a temperature below 200°C. Among them the N(O,S)-ethoxycarbonyl heptafluorobutyl esters presented the best compromise between short ret...

The pyridylalanine 7a was synthesised in good yield from serine and 4-bromopyridine 3. The pyridylpropionates 12, 13 were synthesised in good yields by either Heckolefination or palladium catalysed cross coupling.

A nuclear magnetic resonance (1H NMR) method for the determination of β-N-methylamino-l-alanine (l-BMAA) in environmental aqueous samples was developed and validated. l-BMAA is a neurotoxic modified amino acid that can be produced by cyanobacteria in aqueous environments. This toxin was extract...

BackgroundPrior research demonstrates a protective role for oxytocin in ovarian cancer based on its anti-proliferative, anti-migratory, and anti-invasive effects in vitro and in vivo. However, the role of endogenous oxytocin has not been examined in ovarian cancer patients. Oxytocin also has ant...

SummaryThe aims of the present study were: (1) to investigate the presence of oxytocin receptors in benign and malignant canine mammary tumours (CMTs) and to evaluate the possible association between oxytocin receptor (OTR) expression and the expression of oestrogen receptor (OR) α and ORβ, an...

Oxytocin (OT) is presented in the male reproductive tract and has various physiological functions, such as stimulating contraction of the reproductive tract and aiding sperm transport. In this study we investigated seasonal expressions of OT and oxytocin receptor (OTR) in the epididymis of the m...

Ionic liquid 1-methyl-3-pentylimidazolium bromide have been synthesised and confirmed by characterisation techniques H1 NMR, C13 NMR, MASS and IR spectroscopy. Density and speed of sound of aqueous amino acids (L-cysteine and N-acetyl-l-cysteine) in aqueous ionic liquid (0.005, 0.01, 0.03, 0.05)...

N-Acetyl-S-(3-coumarinyl)cysteine, a metabolite of coumarin in rodents, has been synthesized as methyl ester. A new synthetic route to prepare N-acetyl-S-(3-coumarinyl)-d,l-cysteine methyl ester (1) comprises reaction of 3-mercaptocoumarin (3) with N-acetyl-3-chloro-d,l-alanine methyl ester (4)....

Isoprene, the 2-methyl analog of 1,3-butadiene, is identified as a possible human carcinogen by the International Agency for Research on Cancer (IARC). Isoprene is ubiquitous in the environment with numerous natural and anthropogenic sources. Tobacco smoke is the main exogenous source of isopren...

A sensitive spectrolfuorimetric method for the determination of catecholamines with 1,2-diphenylethylenediamine is described. The method is based on the reaction of catechol compounds in neutral medium with 1,2-diphenylethylenediamine in the presence of hexacyanoferrate(III) and glycine at ambie...

Highly enantioselective reduction of 1,2-bis(p-methoxyphenylimino)-1,2-diphenylethane was conducted even with 0.5 mol% of new oxazaborolidine derived form L-threonine and a stoichiometric amount of BH3·THF to give 1,2-diphenylethylenediamine derivative in excellent enantiomeric purity. The subs...