To date, the main source for phycocyanin production is the thermophilic cyanobacterium Spirulina platensis, although latest researches are exploring the possibility to exploit the thermoacidophilic Cyanidiophyceae (Rhodophyta) to this purpose. Galdieria phlegrea is a polyextremophilic red alga b...

Commercial paints are produced using components that can be harmful to the environment. In light of this, our study aimed to reduce these drawbacks by investigating water-based paints in which the latex resin (polyvinyl acetate [PVA]) was replaced with poly(3-hydroxybutyrate) (PHB) extracted fro...

This paper assesses the application of pulsed electric fields (PEF) to the fresh biomass of Artrhospira platensis in order to enhance the extraction of C-phycocyanin into aqueous media.Electroporation of A. platensis depended on both electric field strength and treatment duration. The minimum el...

The demand for natural colorants and the potential biopolymer applications of polyhydroxyalkanoates (PHA) have attracted special attention of the cosmetic and food industry. The purpose of the present work was to analyze the co-production of total carotenoids, C-phycocyanin (C-PC) and PHA by Art...

This study describes characterisation of three thermophilic strains of cyanobacteria belonging to Thermosynechococcaceae and their utilisation as a source of thermostable C-phycocyanin. Three strains NIES 2133, NIES 2134 and PCC 6715 have been cultivated in two types of growth media and two temp...

In this work, a chitosan-modified nanofiber membrane was fabricated and used to examine the permeation characteristics of C-phycocyanin (CPC) obtained from Spirulina platensis. The effects of NaCl concentration (0.1–1.0 M), chitosan coupling pH (6–8), chitosan coupling concentration (0.1–3.0%...

In this study, the intensification of C-phycocyanin protein extraction from the green microalgae Spirulina maxima was successfully achieved using aqueous two-phase systems coupled to different continuous-operation extractors. Three systems with different total concentrations of Polyethylene glyc...

C-phycocyanin (C-PC) is a blue photosynthetic pigment and the major phycobiliprotein in many blue-green algae with high nutritional values and antioxidant, antivirus, anti-cancer, and anti-inflammatory properties. It also boosts the immune system in various organisms and can be used in immunoass...

Liquid biphasic flotation (LBF), an integrated process of liquid biphasic system (LBS) and adsorptive bubbles flotation, was used for the purification of C-phycocyanin from S. platensis microalgae. Various experimental parameters such as type of phase forming polymer and salt, concentration of p...

The ionophoric and hemolytic activities of two antifungal aromatic heptaenes: vacidin A and perimycin A, were studied on human red blood cells. Measurements of hemolysis, K+ influx and efflux, H+ movement and potential difference across the cell membrane, show that the hemolytic activity, being ...

Retro-aldolization and methanolysis of the polyene antibiotic perimycin yield N-methyl-p-aminoacetophenone and methyl perosaminide, respectively. Their structural elucidation, mainly by spectroscopic techniques, is presented.

The sensitivities of wild-type, rough, deep-rough and antibiotic-hypersensitive strains of Escherichia coli and Pseudomonas aeruginosa to avoparcin, flavomycin and virginiamycin are described. Avoparcin was least active against these strains. Overall, the results suggested that resistance of wil...

This study focused on the effects of three additives given together with a hay/concentrate-based diet on nutrient digestibility, rumen fermentation, and methane emission from sheep. The basal diet consisted of 1.29 kg mixed hay and 0.43 kg concentrate mixture based on dry matter (DM). Treatments...

Trace levels of veterinary antibiotics that reside in livestock products may disturb the balance of human intestinal microbiota and impair the colonized barrier function, which is critical to protect against the invasion or overgrowth of exogenous pathogens. We investigated the colonization barr...

SummaryThe enzymatic deacetylation of 15′-O-acetylated cardenolides was investigated. A partially purified enzyme extract prepared from suspension-cultured Digitalis lanata cells (line K 3 OHD) showed high levels of lanatoside-hydrolysing activity. The enzyme responsible is located in the cell ...

Lanatoside C standard samples had their partition coefficients (K) determined in dichloromethane-methanol-water (4:4:3), (5:6:4) and (7:13:8), by the shake flask method and the obtained values were similar. On the other hand, K for lanatoside C accomplished by calculation from rotation locular c...

Glioblastoma (GBM) is the most common malignant brain tumor in adults. We designed an adeno-associated virus (AAV) vector for intracranial delivery of secreted, soluble tumor necrosis factor-related apoptosis-inducing ligand (sTRAIL) to GBM tumors in mice and combined it with the TRAIL-sensitizi...

BackgroundHepatocellular carcinoma is the second deadliest cancer with limited treatment options. Loss of PTEN causes the P13K/Akt pathway to be hyperactive which contributes to cell survival and resistance to therapeutics in various cancers, including the liver cancer. Hence molecules targeting...

Dengue infection poses a serious threat globally due to its recent rapid spread and rise in incidence. Currently, there is no approved vaccine or effective antiviral drug for dengue virus infection. In response to the urgent need for the development of an effective antiviral for dengue virus, th...

Gastric cancer is the third common cause of cancer mortality in the world with poor prognosis and high recurrence due to lack of effective medicines. Our studies revealed that lanatoside C, a FDA-approved cardiac glycoside, had an anti-proliferation effect on different human cancer cell lines (M...