Capreomycin has good clinical utility to treat multidrug resistant tuberculosis, but it is only used as a second line drug due to its adverse reactions. Literature has demonstrated that the toxicity of capreomycin product is significantly influenced by the impurities in it. Unfortunately, so far...

AimTo discover anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) microbial natural products or their derivatives.

Azalomycins F5a (1), F4a (2) and F3a (3) are three 36-membered polyhydroxyl macrolides with remarkable antifungal activity. By comparing the NMR spectral data of 1 and its degradation products with those of several universal NMR databases and identical fragments of known compounds, the relative ...

Azalomycin F5a was a polyhydroxy macrolide produced by streptomycete strains. Our preliminary researches indicated that it could kill methicillin-resistant Staphylococcus aureus (MRSA) likely by increasing the permeability of cell membrane, and that cell-membrane phospholipids were likely import...

SummaryDespite the central role PSD-95 plays in anchoring postsynaptic AMPARs, how PSD-95 itself is tethered to postsynaptic sites is not well understood. Here we show that the F-actin binding protein α-actinin binds to the very N terminus of PSD-95. Knockdown (KD) of α-actinin phenocopies KD ...

The reaction of salmon sperm apurinic acid and the model compound barium (2-deoxy-d-ribose-3,5) diphosphate with a number of compounds containing the 1bNH2 group has been studied. Two different types of reaction are apparent.In one case, with compounds containing an oxygen atom adjacent to the 1...

Human apurinic/apyrimidinic (AP) endonuclease APE1 is a crucial enzyme of the base excision repair (BER) pathway, which is in charge of recognition and initiation of removal of AP-sites in DNA. It is known that some single-nucleotide polymorphism (SNP) variants of APE1 have a reduced activity as...

SummaryA reaction scheme based on polarographic, controlled-potential electrolysis and cyclic voltammetric data has been proposed for the electrochemical reduction of the triphenylsulfonium ion in aqueous solution. Comparison of the reduction process with those of other analogus “onium” compou...

A new photoacid generator (PAG) bound polymer containing triphenylsulfonium salt methacrylate (TPSMA) was synthesized and characterized. The PAG bound polymer was employed to improve electron beam lithographic performance, including sensitivity and resolution. The PAG bound polymer resist exhibi...

Cu-Zn alloy deposition processes from glucoheptonate baths have been studied by analysing the composition of deposits, measuring the current density-potential curves and measuring the absorption spectra of the bath. Alloying interactions during codeposition were discussed on the basis of partial...

The surface morphology, phase structure and colour of Cu-Zn deposits from pH 10.0 glucoheptonate baths have been studied as a function of current density. Smooth and dense deposits were obtained at 2.0 A dm−2 or below, whereas granular deposits were obtained at higher current densities. The depo...

Previous studies have shown that secretin and secretin receptors are expressed in central amygdala neurons. By using both in vivo extracellular recording as well as behavioral test, we investigated the direct electrophysiological effects of secretin in the central amygdala and its involvement in...

A concise synthesis of some new classes of heterocycles (4-aryl-11-oxo-1,2,3,11-tetrahydro-1,3a-diaza-cyclopenta[a]anthracen-6-carbonitriles and 5-aryl-12-oxo-1,3,4,12-tetrahydro-2H-1,4a-diazabenzo[a]anthracene-7-carbonitriles) has been developed by the ring transformation of suitably functional...

Although 3- and 4-cyanopyridine-N-oxides hydrogenate readily over Adam's platinum catalyst to form the corresponding aminomethylpyridines, complexes of these ligands with CuCl2 and Cu(ClO4)2 behave differently toward hydrogenation. In the CuCl2 case, Cu(II) is reduced to Cu(I) with only neg...

The contamination of pesticide residues in Oolong tea has raised much concern in recent years. The objective of this study was to synthesize gold nanoparticles (AuNPs) and develop surface-enhanced Raman spectroscopy (SERS) methods for detection and quantification of pesticides in Oolong tea. Fac...

The solubility of carbendazim in the lower alcohols (Methanol, Ethanol, n-Propanol, n-Butanol, and n-Pentanol) at temperatures from 278.15 K to 323.15 K was measured by a dynamic thermodynamic equilibrium method. The solubility of carbendazim increased with the increasing temperature in each sol...

Carbendazim is a fungicide commonly used as active substance in plant protection products and biocidal products, for instance to protect facades of buildings against fungi. However, the subsequent occurrence of this fungicide and potential endocrine disruptor in the aqueous environment is a majo...

The fungicide Carbendazim is widely used in agriculture and preservation of films and fibers. In mammals, it can promote germ cell mutagenicity, carcinogenicity, and reproductive toxicity. However, few data about the effects of this toxicant upon the respiratory system are available. In this wor...

Three-dimensional nanoporous copper (NP-Cu) for the first time has been used as an enhanced material for ultrasensitive detection of carbendazim by electrochemistry method. The NP-Cu was fabricated by dealloying AlCu alloy ribbons, which was characterized by scanning electron microscopy, high-re...

Indoleacetic acid (IAA)-carbendazim was synthesized to assess whether this conjugate could retain the fungicidal activity of carbendazim and gain root-inducing properties upon the addition of an indoleacetic acid group. An indoor virulence test demonstrated that the conjugate retained the fungic...