High levels of homocysteine (Hcy) have neurotoxic effects. Homocysteine thiolactone (HcyT), a thioester of Hcy, plays a role in Hcy-induced toxicity. In this study, effects of HcyT treatment (500 mg/kg body weight/day in drinking water) for 6 weeks on serum Hcy levels and brain prooxidant-antiox...

It is well established that homocysteine thiolactone (HTL) is associated with some health disorders, including cardiovascular diseases. HTL is a by-product of sulfur metabolic cycle. So far, its presence has been confirmed in human plasma and urine. It has been also shown that a vast majority of...

SummaryA sensitive system for d,l-amino acid analysis has been developed, using fluorescence derivatization with o-phthaldialdehyde in the presence of sodium salt of 1-thio-β-d-glucose. The reagents rapidly form fluorescent diastereoisomeric derivatives with primary amino acids. These derivativ...

99mTc-labeled 1-thio-β-d-glucose (99mTc-1-TG) was synthesized under different ligand concentrations. 1-Thio-β-d-glucose (1-TG) showed different chemical properties and higher stability at acid pH as compared to neutral and basic pH. Under different ligand concentrations, 99mTc-1-TG was obtaine...

AimThe aim of this study was to evaluate early detection of temporomandibular joint (TMJ) inflammatory changes based on 1-thio-β-d-glucose radiolabeled with technetium-99m.

A contaminant compound has been isolated from commercial samples of CTP by ion-exchange chromatography on a Dowex-1 column. It has been characterized as cytidine 5′-tetraphosphate from its ultraviolet spectrum, labile and total phosphate content, and periodate consumption. It is present in prop...

The results of several studies have shown favourable results with a once-a-month pill containing 2.5 mg quingestanol acetate and 2 mg quinestrol. In a multicentre study, 666 women were investigated for 3,130 woman months. Data analyzed using life-table method indicated a net cumulative continuat...

A clinical study of a long-acting oral steroid formulation, containing 2.0 mg quinestrol and 2.5 mg quingestanol acetate, was undertaken during a 31-month period. A total of 212 women were enrolled in the study and 2,781 women-months experience was accumulated. Life-table analysis of event rates...

Four hundred patients completed 4,370 cycles of treatment using quingestanol acetate, 300 mcg daily. Twelve pregnancies occurred resulting in a failure rate of 3.3 per 100 woman years. Seven of these pregnancies were considered drug failures giving a rate of 1.9 per 100 woman years. Cycle length...

Quingestanol acetate, an oral progestin, was administered in a continuous daily dose of 0.3 mg to 382 healthy women for a total of 3,208 woman-months, for contraceptive purposes. There was a cumulative pregnancy rate of 2.9 percent and a cumulative continuation rate of only 50 percent at the end...

A previous report based on investigations in Mexico suggested that quingestanol acetate might have potential as a postcoital oral contraceptive at a 800 mcg dose. This concept was based on some 1,000 cycles of therapy with no pregnancies in patients preselected to have 2 to 4 coital acts per wee...

A combination of quinestrol, a long-acting estrogen, and quingestanol acetate, a progestin, given by mouth once every four weeks was found to be an effective contraceptive in 303 healthy, fertile women for 2,493 cycles. Menstrual cycle control was good with normal amount of flow and normal or sl...

Quingestanol acetate, norethindrone acetate 3-cyclopentyl enol ether, was not separable from its sesame oil dosage form vehicle as the intact compound using chromatography procedures that depend on differences in polarity. The steroid can be retained quantitatively on a Florisil column treated w...

Quingestanol acetate is a potent progestogen which significantly alters the histology and histochemistry of the endometrium when studied by light and electron microscopy. The steroid did not alter transport mechanisms across the cell surfaces but, probably because of competition with estrogen fo...

A novel series of 6-substituted pyrrolo[2,3-d]pyrimidines with reversed amide moieties from the lead compound 1a were designed and synthesized as nonclassical antifolates and as potential antitumor agents. Target compounds 1–9 were successfully obtained through two sequential condensation react...

An efficient route to novel 4,7-dihydro-1H-pyrrolo[2,3-b]pyridines with incorporated tetrahedral fragment in the position-4 via three-component reaction of N-substituted 5-amino-3-cyanopyrroles, various carbonyl and active methylene compounds has been developed. In the same time, by using develo...

Polyalcohol is one of the important medium temperature phase change materials (PCMs) for thermal energy storage, in which liquid-free solid–solid PCMs are more promising although sublimation can hardly be avoided when crystals transform to the “plastic phase”. We reported here the preparation...

A new synthetic approach toward 2-C-methyl-d-erythritol 4-phosphate (MEP), a key intermediate in the mevalonate-independent biosynthetic pathway for isoprenoids, and deuterated analogues of its precursor, 2-C-methyl-d-erythritol acetonide, is described. This procedure uses 2-C-methyl-d-erythrose...

1.1.|The competitive inhibition and barley malt α-glucosidase (α-d-glucoside glucohydrolase, EC 2.3.1.20) with Tris and erythritol has been studied in the pH interval 3–7 with maltose as substrate.2.2.|At pH 4.6, Tris and erythritol compete with each other and with maltose for the enzyme.3.3....

The effect of erythritol, xylitol and sorbitol on monomeric collagen solution was evaluated with melting temperature, fluorescence studies, conformational stability and binding energy. The emission intensity and the melting temperature increase as the chain length of polyols increases. Circular ...