A rare aldotetrose, l-erythrose, was produced from erythritol via a two-step reaction. In the first step, complete oxidation of erythritol to l-erythrulose was achieved by using Gluconobacter frateurii IFO 3254. Washed cell suspension of the strain grown on tryptic soy broth (TSB) supplemented w...

2-C-Methyl-d-erythritol-4-phosphate (MEP) is a key chemical intermediate of the non-mevalonate pathway for isoprenoid biosynthesis employed by many pathogenic microbes. MEP is also the precursor for the synthesis of 4-diphosphocytidyl-2-C-methyl d-erythritol (CDP-ME), another key intermediate of...

We have identified the enzyme responsible for erythritol utilization and its reaction product in the yeast Lipomyces starkeyi CBS 1807. The enzyme, a polyol dehydrogenase requiring NAD+ as a coenzyme, was induced by erythritol in this yeast. We confirmed that the enzyme product was l-erythrulose...

Here, the erythritol-xylitol binary system was thermodynamically optimized based on available experimental phase equilibrium data, to explore compositions suitable as phase change materials (PCMs) for thermal energy storage (TES). A previous experimental study revealed that erythritol-xylitol wa...

3-C-(Hydroxymethyl)erythritol was prepared from 3-C-(hydroxymethyl)-2,3-O-isopropylidene-d-erythro-tetrofuranose (4) by hydrolysis followed by reduction, or by reduction followed by hydrolysis. Monotosylation of 4, followed by reduction with lithium aluminum hydride and hydrolysis, afforded 3-C-...

The enzymatic oxidations of [α-14C]hematohemin IX and 2,4-diacetyl[α-14C]-deuterohemin IX were carried out by using a microsomal heme oxygenase system from rat liver in combination with the biliverdin reductase from the same origin. In every case the bilirubins formed were devoid of radioactiv...

Triterpene hexahydroxydiphenoyl (HHDP) esters have only been isolated from Castanopsis species, and the distribution of these esters in nature is of chemotaxonomical interest. In this study, the chemical constituents of the leaves of Castanopsis fissa were examined in detail to identify and isol...

In a screening for antifungal metabolites, two indole compounds of mixed biogenesis, 1H-indole-3-carboxylic acid, 1-(1,1-dimethyl-2-propenyl) methyl ester and 1H-indole-3-carboxylic acid, 1-(2,3-dihydroxy-1,1-dimethylpropyl) methyl ester were isolated from a culture of the basidiomycete Aporpium...

Seven new bismuth(III) complexes derived from indole-carboxylic acids have been synthesised: five are homoleptic; [Bi(IAA)3] B1, [Bi(IPA)3] B2, [Bi(IBA)3] B3, [Bi(MICA)3] B4, [Bi(IGA)3] B6, and two are heteroleptic [BiPh(MICA)2] B5 (where IAA-H = 2-(1H-indol-3-yl)acetic acid, IPA-H = 3-(1H-indol...

2,3-Aziridino-γ-lactones are versatile synthons for the preparation of polysubstituted α- or β-amino acids. With the intention of preparing α,α-disubstituted α- or β-amino acids, regioselective electrophilic substitution of aziridino-γ-lactones at C2 was realized using two different meth...

The reaction of C,O,O-tris(trimethylsilyl)ketene acetal 1 with saturated, cyclic and aromatic ketones 2 proceeds smoothly in the presence of titanium chloride to give (E)-α,β-unsaturated carboxylic acids 3 with fairly good stereoselectivity. With α,β-unsaturated ketones 4, α-trimethylsilyl ...

SummaryThe 3-alkoxy-1-N-toluenesulfonyl azopropene structural motif has been known in the context of the Eschenmoser-Tanabe fragmentation for over 50 years. It is derived from α-epoxy N-toluenesulfonyl hydrazones by deprotonation and epoxide ring opening. A very interesting yet unreported featu...

A new diol glucoside, 2-β-d-glucopyranosyloxy-2-methylpropanol, the first reported naturally occurring monoglucoside of an aliphatic dihydric alcohol, was isolated from pods of Acacia sieberana var. woodii. Structure elucidation was based on 1 H and 13C NMR spectroscopy, and enzymatic analyses....

α-Deamino-3-(β-d-glucopyranosyloxy)kynurenine, a yellow, fluorescent compound isolated from human lens, was synthesized in 8 steps (10% overall yield) from commercially available 3-methoxy-2-nitrobenzaldehyde. Key events included preparation and glucosylation of methyl 4-(3-hydroxy-2-nitrophen...

This research communication is toward the investigation of the antibacterial, antifungal and antioxidant activities of the synthesized compounds 1-(4′-O-β-d-glucopyranosyloxy-2′-hydroxyphenyl)-3-aryl-propane-1,3-diones (5a)–(5h). These compounds have been obtained by the interaction of α-ac...

Z-2-(β-d-glucopyranosyloxy)-3-phenylpropenoic acid (PPAG), a compound postulated to contribute to the taste and mouthfeel of fermented rooibos tea (Aspalathus linearis), was isolated from unfermented rooibos plant material. Its structure was unequivocally confirmed by LC–MS, –MS2, FT-IR and N...

The microwave spectrum of methyl isobutyl ketone was recorded using a molecular beam Fourier transform microwave spectrometer and analyzed to determine the rotational constants A = 4.7517(17) GHz, B = 1.496 115(79) GHz, C = 1.324 364(39) GHz, and centrifugal distortion constants. A–E splittings...

The occurrence of enantiomorphism and the frequency of occurrence of different planes in contact with the growth vessel are investigated for potassium bichromate crystals grown from aqueous solution by solvent evaporation and temperature difference methods. It was found that left- and right-hand...

A study was made of oxidation of polysulphide oligomers using sodium bichromate. Kinetics of oxidation were investigated by the chronovolt-amperometric method using a PO-5122 oscillopolarograph (TsLA-02A model) with linear voltage scan under monocyclic conditions. It was established that during ...

Angiotensin-converting enzyme (ACE) plays diverse roles in the animal kingdom. However, whether ACE plays an immune function against viral infection in vector insects is unclear. In this study, an ACE gene (LsACE) from the small brown planthopper was found to respond to Rice stripe virus (RSV) i...