BackgroundThe discovery of N‑acylethanolamines (NAEs) has prompted an increase in research aimed at understanding their biological roles including regulation of appetite and energy metabolism. However, a knowledge gap remains to understand the effect of dietary components on NAE levels, in parti...

Spiramycin is a widely used macrolide antibiotic and exists at high concentration in production wastewater. A thermal-acid hydrolytic pretreatment using silicotungstic acid (STA) under microwave (MW) irradiation was suggested to mitigate spiramycin from production wastewater. Positive correlatio...

An efficient sequential chromatographic process for the production of pure individual hydroxy acids (HAs) or simple mixtures of these HAs from black liquor (BL)-based HA mixtures was developed. The method enabled the production of 99 wt% pure isosaccharinic, glycolic, lactic, and 2-hydroxybutano...

The objective of the study was to evaluate ruminal biohydrogenation (BH) and apparent transfer of long-chain (FA) from duodenum into milk in dairy goats fed Ca salts of palm oil (CaS, 45 g/d) or lipid-encapsulated conjugated linoleic acids (LE-CLA, 45 g/d providing 4.5 g trans-10, cis-12 C18:2/d...

Elymus nutans Griseb. was planted in three locations on Qinghai-Tibetan Plateau of China to test if geographic differences would impact fatty acid (FA) and amino acid (AA) metabolism. It was found that lipid and crude protein content of E. nutans differed among locations, both highest in Haibei ...

Fatty acids (g/100 g total fatty acids) in M. longissimus thoracis et lumborum (LTL) and total branched chain fatty acids (μg/g fat) in subcutaneous adipose tissue (SAT) of rams and castrates from Scottish Blackface (SB) or Texel × Scottish Blackface (T × SB) lambs, slaughtered at mean ages o...

Two new sterically hindered salicylaldimines, N-(2,2,6,6-tetramethyl-piperidine-4)-3,5-Bu2t-salicylaldimine (I) and N-(1-carboxyethyl piperidine-4)-3,5-Bu2t-salicylaldimine (II), have been prepared and characterized by IR, UV–vis, 1H NMR, 13C NMR techniques and the structure of II has been exam...

The method of enantioselective hydrolysis of 3-hydroxy-7-bromo-5-phenyl-1,2-dihydro-3H-1,4-benzodiazepin-2-one esters using pig liver microsomal fraction was developed. The S-enantiomers of three substrates were obtained with ees >97% and yields 44–49%, their absolute configurations were determ...

The Fourier Transform Raman and infrared spectra of the crystallized herbicide (2-methylphenoxy)acetic acid (MPA) have been recorded in the region 4000–400 cm−1. The geometry, intermolecular hydrogen bond, and harmonic vibrational frequencies of MPA have been investigated with the help of B3LYP...

A method is described for the synthesis and purification of the photoaffinity label Se-(8-azidoadenosyl)[75Se]selenomethionine. This photoaffinity label can be used to specifically and covalently label the S-adenosylmethionine binding site of proteins that use this cofactor, as exemplified by la...

Acetochlorglucosamine was reacted with the presence of potassium t-butoxide in dimethyl-formamide with salicylaldehyde, salicyclic acid, methyl salicylate, methyl 3-methylsalicylate, salicylamide and 4-acetamidophenol to give, after de-O-acetylation, a series of aryl 2-acetamido-2-deoxy-β-d-glu...

Di-Calciphor is a synthetic derivative of prostaglandin B1 that protects against cerebral and cardiac ischemia apparently by preserving mitochondrial function. To determine whether di-Calciphor specifically protects against mitochondrial failure, we studied its effects on mitochondrial functions...

Following 20 min occlusion of both carotid arteries, female gerbils were subjected to treatment with di- or tri-Calciphor (dimer or trimer of 16,16′-dimethyl prostaglandin B1). Dimer was injected i.p. at 5 and 10 mg/kg at 5 min and again at 24 h, 30 min and 24 h, 60 min and 24 h or 180 min and ...

Post-ischemic treatment of di-Calciphor (16,16′-dimethyl-15-dehydroprostaglandin B1) significantly improves animal survival and prevents ischemia-induced neurodegeneration of vulnerable forebrain regions assessed with histochemical and biochemical techniques in gerbils. Neuronal degeneration se...

All-trans retinoic acid analogues such as N-(4-hydroxyphenyl)retinamide (4-HPR) are effective chemopreventive and chemotherapeutic agents but their utility has been hampered by dose-limiting side effects. The glucuronide derivatives of 4-HPR, the oxygen-linked 4-HPROG and the carbon-linked 4-HPR...

1-(2-C-Cyano-2-deoxy-β-d-arabino-pentofuranosyl)cytosine (CNDAC, 1) is a potent antitumor nucleoside developed by us. A series of 5′-phosphatidyl derivatives of CNDAC bearing various fatty acyl residues, namely dimyristoyl derivative 3a, dipalmitoyl derivative 3b, distearoyl 3c, dioleoyl deriv...

The antitumor effects of 2′-C-cyano-2′-deoxy-1-β-d-arabinofuranosylcytosine (CNDAC), a synthetic 1-β-d-arabinofuranosylcytosine (ara-C) derivative, were examined and compared with that of ara-C in murine tumors and in various human tumors using three different chemosensitivity tests. CNDAC e...

2′-C-Cyano-2′-deoxy-1-β-d-arabino-pentofuranosylcytosine (CNDAC) is an antitumor nucleoside with a novel chemical structure that exerts potent antitumor activity against various human tumor cells in vitro and in vivo. In order to be active it needs to be phosphorylated by deoxycytidine (dCyd)...

The pharmacokinetics and pharmacodynamics of the novel clinical candidate 2′-C-cyano-2′-deoxy-1-β-d-arabino-pentofuranosylcytosine (CNDAC) were investigated in human lymphoblastoid CCRF-CEM cells and human myeloblastic leukemia ML-1 cells. Formation of CNDAC 5′-mono-, di-, and triphosphate (...

We previously reported that liposomalized 5′-O-dipalmitoylphosphatidyl 2′-C-cyano-2′-deoxy-1-β-D-arabino-pentofuranosylcytosine (DPP-CNDAC), a hydrophobized derivative of the novel antitumor nucleoside CNDAC, is quite useful for cancer therapy. On the other hand, for anti-neovascular therapy...