This study investigated the accumulation of esters in three hybrid grape cultivars during berry development under two vintages to elucidate the differentiation on their esters biosynthesis. Results showed ‘Moldova’ showed lower esters content than ‘Campbell Early’ and ‘Catawba’ resulting f...

Continuous processing enables the use of non-standard reaction conditions such as high temperatures and pressures while in the liquid phase. This expands the chemist’s toolbox and can enable previously unthinkable chemistry to proceed with ease. For a series of amphoteric amino acid derivatives...

BackgroundFlexion-extension radiographs are often used to assess for removal of the cervical collar in the setting of trauma. The objective of this study was to evaluate their adequacy. We hypothesized that a significant proportion is inadequate.

BackgroundMicroprocessor knees have improved the gait and functional abilities of persons with transfemoral amputation. The Genium prosthetic knee offers an advanced sensor and control system designed to decrease impairment by: allowing greater stance phase flexion, easing transitions between ga...

(RS)-2-Amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid (ACPA), which is a potent and selective agonist at (RS)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptors, has previously been shown to desensitize AMPA receptors to a much lower degree than AMPA itself. We n...

The new multicomponent reaction of salicylaldehydes, 2-aminoprop-1-ene-1,1,3-tricarbonitrile and 3-phenylisoxazol-5(4H)-one gives substituted 2,4-diamino-5-(5-oxo-3-aryl-2,5-dihydroisoxazol-4-yl)-5H-chromeno[2,3-b]pyridine-3-carbonitriles (50–74% yields), which are promising for biomedical appl...

LF-3-88 (2-[5-[5-(2(S)-azetidinylmethoxyl)-3-pyridyl]-3-isoxazolyl]ethanol) was identified as a highly selective α4β2-nAChRs partial agonist, with a Ki value of 0.4 nM and EC50 value of 110 nM. A sensitive and selective ultra high pressure liquid chromatography–tandem mass spectrometry (UHPLC...

Novel tricyclic FPT inhibitors with submicromolar FPT activity are described. Greatly enhanced FPT activity is realized with phthaloyl derivatized amino compound 2k, which showed FPT inhibitory activity of IC50 = 0.66 μM. Sulfonamides 5g and 50 were also found to be potent FPT inhibitor. SAR re...

Methyl 2‐bromoacetyl‐4,5‐dimethoxyphenylacetate was prepared by reacting cupric bromide with methyl 2‐acetyl‐4,5‐dimethoxyphenylacetate. Aminoacetyl derivatives formed on condensation of substituted p‐aminobenzoic esters with the bromoacetyl derivative. Some prepared compounds were tested...

A surface plasmon resonance (SPR) assay for the specific recognition of a single guanine (G) bulge in DNA using an SPR sensor with an immobilized small-molecule ligand was developed. The synthesized ligand, 2-(2-aminoacetyl)amino-5,6,7-trimethyl-1,8 naphthyridine, can selectively binds to a G bu...

New cyanopyridine derivatives bearing different alkoxy substituents were designed and synthesized to study their optical and electrochemical properties. All the synthesized compounds were characterized using various spectroscopic techniques like IR, NMR, and Mass spectrometry. Their optical and ...

Prediabetes is the preclinical stage of type 2 diabetes mellitus (T2DM) with intermediate state of hyperglycemia. Hyperglycemia results in a state of oxidative stress, which may contribute to the production of insulin resistance, β-cell dysfunction and long-term complications of diabetes. Novel...

Recent successful synthesis of human glicentin prompted us to establish an immunoassay method for determination of human glicentin in plasma. Human glicentin in plasma was measured using a newly developed sandwich ELISA. The mean fasting levels of human glicentin were 18.6±2.4 and 19.7±2.1 pM ...

BackgroundPost-bypass postprandial hypoglycemia (PPH) is a frequent complication of Roux-en-Y Gastric Bypass (RYGB) but predictors remain poorly identified and are needed to assess individual risk. After RYGB, exaggerated secretion of glucagon-like peptide-1 (GLP-1) and insulin could lead to PPH...

BackgroundSideroxylon obtusifolium (Roem. & Schult.) T.D. Penn., Sapotaceae family, is a medicinal species native to the Brazilian Northeastern region. The plant is popularly used as an anti-inflammatory and hypoglycemic.

A series of square-planar palladium(II) benzisothiazolinate (bit) of the general type [Pd(bit)2L2] have been prepared and characterized by analytical and spectroscopic methods. Two synthetic routes have been employed, namely reactions of [Pd(bit)2]·H2O with two equivalents of ligands (L = amine...

Palladium-catalysed reactions of aryl iodides/vinyl triflates with 2,2,2-trifluoro-N-(2-(4-[2,2,2-trifluoro-acetylamino)-phenyl]-buta-1,3-diynyl)-phenyl)-acetamide provide a straightforward entry into 3,3′-disubstituted-2,2′-biindolyls. Subsequent application of the procedure to homochiral ary...

The enantioselective hydrogenation of 1,3-diarylpropane-1,3-diones with chiral Ru(II)-diphosphine catalyst has been studied. In a first approach it was found, that Tol-BINAP together with Ru(COD)methallyl2 formed the most selective catalyst. One of the C2-symmetric enantiopure 1,3-diols obtained...

High level (CASSCF-MRCI) ab initio calculations are used to investigate the structural, electronic and vibrational properties of the electronic ground state of thiazyl chloride (NSCl) and of the low-lying electronic states of NSCl+. A new high resolution HeI photoelectron spectrum of NSCl has be...

Chlorine monofluoride reacts with tetrasulphur tetranitride to give thiazyl chloride (monomer and trimer) and thiazyl fluoride; with further ClF, NSCl reacts to form NSF then ClNSF2, and finally N2, Cl2 and SF4. The reaction NSCl/ClF to give NSF/Cl2 reverses in SO2 solvent due to removal of ClF ...