The chemical syntheses of 4,4′-dimethylcholest-5-en-3β-ol-7-one, 4,4′-dimethylcholest-5-ene-3β,7β-diol and 4,4′-dimethylcholest-5-ene-3β-7α-diol are described. All of these compounds were found to be potent inhibitors of 3-hydroxy-3-methylglutaryl (HMG-CoA) reductase activity in cultured...

The stereochemistry of 5α-cholest-8-en-3β-ol to 5α-cholest-7-en-3β-ol isomerization was studied in rat liver homogenates incubated in the presence of either 3(±)-2R-[2-3H1]- or 3(±)-2S-[2-3H1]-mevalonic acid lactone. The isolated radioactive 5α-cholest-7-en-3β-ol and cholesta-5,7-dien-3β...

Cholest-4α-methyl-7-en-3β-ol (1) has potent inhibitory activity against pc 12 tumor with 0.5043 ratio (10 μg/mL). This paper describes a series of structural modification of this compound, which focus on 3β-hydroxyl group and 7(8)-double bond. The synthesized derivatives of 1 were tested for...

Inhibitors for NorA efflux pump of Staphylococcus aureus have attracted the attention of many researchers towards the discovery and development of novel efflux pump inhibitors (EPIs). In an attempt to find specific potent inhibitors of NorA efflux pump of S. aureus, a total of 15 amino acid conj...

This work offers construction and comparative evaluation the performance characteristics of conventional polymer (I), carbon paste (II) and carbon nanotubes chemically modified carbon paste ion selective electrodes (III) for meclofenoxate hydrochloride are described. These electrodes depend main...

Boc-Asp-βAla-Gly-Ser-βAla-Gly-His-βAla-Gly-OEt, Boc-Asp-βAla-Gly-Ser-βAla-Gly-Ser-βAla-Gly-His-βAla-Gly-OH, cyclo(Asp-βAla-Gly-Ser-βAla-Gly-His-βAla-Gly) and poly(Asp-βAla-Gly-Ser-βAla-Gly-His-βAla-Gly) were synthesized as catalysts in hydrolytic reactions. Asp and Ser residues were...

The oligopeptide transporter, which contributes to the absorption of di-/tri-peptides and various peptidomimetic compounds across intestinal epithelia, is expressed in mature Caco-2 monolayers. It was shown in our previous report that β-esterified d-Asp(OBzl)-Ala is efficiently transported acro...

β-Carboline derivatives are known as the lead compounds for anti-tumor agents. To examine an optimal structure for anti-tumor activity, we synthesized a variety of β-carboline derivatives, possessing a variety of substituents on the nitrogen atom of the amino group of 3-amino-β-carboline, and...

The mechanism of anticonvulsant action was evaluated for the benzylamino enaminones. The most potent enaminone in this series was the unsubstituted benzylamine analog (30; methyl 4-benzylamino-6-methyl-2-oxocyclohex-3-en-1-oate) which had an oral effective dose (ED50) in rats of 27 mg/kg against...

Two solid derivatives of dichlone (2,3-dichloronaphthalene-1,4-dione), 2-(benzylamino)-3-chloronaphthalene-1,4-dione and 2-chloro-3-(phenethylamino)naphthalene-1,4-dione were synthetized by replacing the chlorine atom with the amine substituent by means of a substitution reaction, with a purity ...

In some inhibitor-resistant TEM-derived β-lactamases, Met-69 is substituted by Leu, Ile or Val. Residue 69 is located in a region of strong structural constraints, at the beginning of H2 α-helix, and in the vicinity of B3 and B4 β-strands. Analysis of the three-dimensional structure of TEM-1 ...

Removal of hexavalent chromium was accomplished by using photocatalyst materials of TiO2 doped with tungsten oxide, environmental air as oxygen supply and white light as irradiation source. Dichromate anions in concentration ranges of 50 to 1000 μg/L were removed by means of aqueous dispersions...

Chromium doped mesoporous CeO2 catalysts were synthesized via a simple nanocasting route by using silica SBA-15 as the template and metal nitrates as precursors. The effect of Cr doping concentration (5%, 10%, 15% and 20% of the initial Cr/(Cr + Ce) molar percentage) on the structures of these c...

The current study is an attempt to utilize the waste algal biomass of Spirulina platensis obtained after biodiesel production. The research specifically focuses on employing these biomasses for carrying out the adsorption studies on chromium. The algal samples used in the study were subjected to...

The present work aims at evaluating the effect of cerium nitrate on corrosion resistance of mild carbon steel coated by Dacromet in 3.5% NaCl solution. The scanning electron microscope (SEM) and energy dispersive X ray spectroscope (EDX) analysis were carried out to compare the surface structure...

The implementation of Anammox process in wastewater has been a growing concern, but chromium toxicity, created by the coexistence of chromium and ammonium, is a challenge, In this study, the acute toxicity of two typical chromium ions (i.e., Cr(III) and Cr(VI)) on Anammox process as well as the ...

Chromium is a common heavy metal widely present in aquatic environments. Cost-effective remediation of chromium-contaminated environment can be realized by microbial reduction of Cr(VI) to Cr(III). The genus Aeromonas species is one of such Cr(VI) reducers, whose reduction mechanism remains unre...

Chromium (Cr) pollution affects plant growth and biochemical processes, so, the relative uptake of glycine, nitrate, and ammonium by pak choi (Brassica chinensis) seedlings in treatments with 0 mg L−1 and 10 mg L−1 Cr (VI) were detected by substrate-specific 15N-labelling in a sterile environmen...

The synthesis and exploration of novel butyrophenones have led to the identification of a diazepane analogue of haloperidol, 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one (compound 13) with an interesting multireceptor binding profile. Compound 13 was evaluated for its b...

We have previously synthesized a series of 1,8-naphthyridine-3-carboxamide derivatives to identify potential anti-cancer/anti-inflammatory compounds. Three derivatives, 7-chloro-N-(3-(cyclopentylamino)-3-oxo-1-phenylpropyl)-6-fluoro-4-oxo-1-(prop-2-yn-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carbox...