The trimethylsilylester of β-(4-acetoxyphenyl) propionic acid (APPA), which is easier to isolate than the free acid, was used as monomer for all polycondensations. Copolycondensations with small amounts of 4-tert-butylbenzoic acid or 4-tert-butylphenol acetate yielded oligo- and polyesters with...

Recent experimental studies and calculations have revealed that only two conformational isomers of racemic 2,4-dichloro- and dibromopentane are low enough in energy to be appreciably present at ordinary temperatures. Although the two stable conformers and their energy difference are known for ea...

IR spectra for 2,4-dibromopentane and 2,5-dibromohexane in the liquid and solid states, and liquid-state Raman spectra are reported. Conformational studies have been undertaken with the aid of normal coordinate calculations. The pentane exists in approximately equal concentrations of SHHSHH (mes...

A facile solid-state synthesis of 2-(2-acetamidophenyl)-2-oxo-N phenyl acetamide and N-(2-(2-oxo-2(phenylamino)acetyl)phenyl)propionamide six derivatives has been achieved by microwave promoted condensation of N-acylisatin or N-propionylisatin with various aniline derivatives. The six products w...

As an ongoing search for potent non-nucleoside anti-HBV agents with novel structures, we described a series of phenyl propionamide derivatives (3a-b, 4a-e, 7a-g, 8a-h and 9a-b) by pharmacophore fusion strategy in the present work. All the compounds exhibited an anti-HBV activity to some extent. ...

Effect of natural and modified cyclodextrins on the absorption and 2D, 3D fluorescence spectra of 7‑hydroxy‑4‑methyl coumarin (HMC) have been investigated in different buffer solutions (pHs – 1.0, 6.5 and 10.0). Both neutral and monoanion species were formed in the ground state, whereas three s...

A new compound named 7-hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde oxime (7-Oxime) was synthesized and characterized by FT-IR, FT-Raman, 1H NMR and 13C NMR techniques. The conformer possibilities were studied to find the most stable conformer and its molecular geometry. Then, the dimer for...

For the first time the antioxidant flavonoid of 7-hydroxy-4´-methoxy-isoflavon was extracted from the leaf of Commelina diffusa and used as reducing and stabilizing agent to biosynthesis of The Cu/ZrO2 nanocomposite (NCs). The extracted flavonoid was characterized using Uv–vis spectroscopy, 1H...

The apparent distribution coefficients of the potential bioactive compounds of the N-aryl-(3-sulfur-1-azabicyclo[3,3,1] non-2-ylidene) amine series in organic solvent/buffer pH 7.4 systems at five temperatures from 293.15 to 315.15 K have been determined by the shake-flask method. The logDO/B va...

The reaction of dl-1,3-butadiene diepoxide and of dl-1,4-dibromo-2,3-butanediol with aqueous alkaline sodium arsenite, “Na3AsO3”, gave mixtures of the title arsonic acids which can be separated by anion exchange resin. Characterization of by-products leads to a better understanding of these re...

In the southern corn blight fungus, Bipolaris maydis, five polyoxin-resistance genes (Pol1 to Pol5) have been reported. Pol2 and Pol5 are pleiotropic for not only polyoxin resistance but also reddish brown colonies. Here, we used a comparative genomics approach to identify Pol2 and Pol5 at a mol...

These studies showed that SC-19220 can act to reverse the antilipolytic action of PGE2. The compound does not produce the reversal by epinephrine potentiation and has no effect on the antilipolytic action of propranalol or insulin suggesting some degree of specificity. Spectral and chromatograph...

The effects of the cyclooxygenase inhibitors indomethacin and acetylsalicylic acid (ASA) and the prostaglandin (PG) antagonist 1-acetyl-2-[8-chloro-10, 11-dihydrodibenz (b, f)(1, 4) oxazepine-10-carbonyl]hydrazine (SC-19220) on smooth muscle strips from the rabbit renal pelvis were examined. Cir...

This study shows that SC-19220 can antagonize PGE2 inhibition of epinephrine stimulated lipolysis in the isolated fat cell. The antagonism appears direct and is not due to the stimulating effect of the compound on lipolysis or its potentiation of the lipolytic action of epinerphrine.

Prostaglandin E2 (PGE2) applied cumulatively (1 nM − 1 μM) induced concentration-dependent tonic contractions in the longitudinal muscle of isolated rat rectum. The PGE2 effects were not altered by guanethidine (50 μM), whereas atropine (3 μM), guanethidine plus atropine or tetrodotoxin (0.1 ...

Intravenous injection of SC-19220 (3–9 mg/kg) caused dose-related hypothermic responses in cats. Repeated administration of SC-19220 resulted in tolerance to its hypothermic action. During SC-19220-induced hypothermia, the hyperthermic activity of both prostaglandin E1 and leukocytic pyrogen wa...

The effects on guinea-pig tracheal muscle of a prostaglandin synthesis inhibitor, indomethacin, antagonist, SC-19220, and precursor, arachidonic acid have been studied in order to investigate the possible role of prostaglandins in the maintenance of respiratory smooth muscle tone. Indomethacin r...

The isolated perfused ear of the rabbit connected to the body only by its nerve was used to investigate the influence of some vasodilators (papaverine, aminophylline, NaNO2, verapamil) and a prostaglandin antagonist, SC-19220, on the algesic effect of bradykinin and acetylcholine. Infusion of SC...

SC-19220 has been shown to inhibit some actions of PGE1 on isolated intestinal muscle and intestinal motility. We studied the effects of this compound on PGE1-induced inhibition of gastric secretion in pylorus-ligated rats. In equimolar or twice molar amounts, SC-19220 did not affect PGE1 gastri...

SC-19220 (5–20 mg/kg i.v.), a competitive receptor antagonist of PGE, increased the bladder capacity and reduced the voiding efficiency of micturition (elicited by slow transvesical filling) of urethane-anesthetized rats. The effect of SC-19220 was prevented by indomethacin pretreatment, wherea...