The absorption of propoxyphene napsylate from tablets, capsules, and a suspension formulation, as measured by concentrations in the plasma of 10 human male subjects, reveals that the tablet and capsule are equivalent solid dosage forms. The suspension affords a significantly higher plasma concen...

A sensitive and specific GLC assay method was developed for the determination of propoxyphene, its major metabolite norpropoxyphene, and lesser known metabolites cyclic dinorpropoxyphene and/or dinorpropoxyphene in plasma of heroin addicts administered up to 800 mg of propoxyphene napsylate. The...

Propoxyphene napsylate was studied in reproduction and teratology experiments in rats and in a teratology experiment in rabbits. Rats were given daily oral doses of 0, 100, 200, or 400 mg/kg, while rabbits were treated with oral doses of 0, 32, or 80 mg/kg/day. In neither species were there any ...

This paper serves as an introduction for the succeeding papers of this issue and discusses the chemistry of propoxyphene napsylate and the designs of the experiments.

Calcium gluceptate (calcium α-glucoheptonate, CaC14H26O16) is commercially available as a crystalline hydrate containing 3.5 molecules of water per atom of calcium. A crystalline anhydrate was prepared by dehydration. The transition between the hydrate and the anhydrous phases is reversible, an...

SummaryThe pituitary TSH cell structure of middle-aged (14-month-old) female Wistar rats chronically treated with estradiol dipropionate (EDP), calcium glucoheptonate (Ca) or with the combination of both was studied. TSH-producing cells were examined in the pituitary pars distalis using rabbit a...

This study determined the effect of feeding a combination of zinc amino acid (AA), manganese AA and copper AA complexes, and cobalt glucoheptonate on productive and reproductive performance of early lactation high producing dairy cows. The product used as a source of the organic trace mineral co...

Recent advances in understanding of the pathophyslology of myocardial necrosis indicate the need for a noninvaslve method that will allow detection and quantification of infarcts in the first few hours after the onset of infarction. Myocardial infarct scintigraphy using technetium-99m glucohepto...

Prophylactic Ca supplementation immediately after calving is a common strategy to prevent clinical and subclinical hypocalcemia in parturient dairy cows. The objective of this study was to evaluate the effect of prophylactic administration of an injected Ca supplement on blood Ca concentration a...

ABSTRACTOur objectives were to measure serum Ca concentrations in the first 48 h postpartum in cows supplemented with oral Ca or subcutaneous Ca and nonsupplemented cows and evaluate the effect of these treatments on the incidence of metritis, displaced abomasum, mastitis, and early lactation di...

The purpose of this study was to investigate the influence of chronic calcium treatment on the structure and function of thyroid C cells in ovariectomzed adult female rats. Eighteen 3-month-old, female Wistar rats were divided into three groups. The first group was used as the sham-operated cont...

ABSTRACTLow total blood calcium concentration after calving has been demonstrated to be a risk factor for reduced neutrophil function. The objective of this study was to evaluate whether administration of an injectable calcium supplement product soon after calving increased neutrophil oxidative ...

Radiopharmaceuticals are useful to evaluate effectiveness of cancer treatments as well as diagnosis of diseases. 99mTc-Glucoheptonate has high sensitivity for imaging lung cancer tissues. In this study, the potential use of 99mTc-glucoheptonate for monitoring apoptosis related to chemotherapeuti...

Calcium gluconate glucoheptonate (GGCa) is known to interact with glass containers, leading to the leaching of aluminum from the glass into the solution at toxic level. Therefore, plastic containers seem to be a preferable packaging alternative. Nevertheless, plastics contain potentially toxic a...

We have synthesized a novel derivative of oxymorphone, oxymorphone-6α-spirohdantoin. The derivative was less toxic in mice than the parent compound and it showed a significant anticonvulsive activity. It exerted agonist effects in doses lower than those of morphine and its agonist effects were ...

Efficient but reversible aldol condensations of 2-azido-5-formyl-1,5-lactones provide short routes to precursors for α-cyclopentane amino acids, some aminopseudosugars and spirohydantoins of cyclopentanes with control of the stereochemistry at all 5 carbons bearing functional groups. The effect...

Routes from both γ- and δ-glucoheptonolactones to spirohydantoins of glucofuranose are described, affording further analogues of hydantocidin. It may be that the glucofuranose isomers are more stable than the glucopyranose forms.

Bromine-induced oxidative ring contraction of an α-amino-δ-lactone gave a mixture of α-aminotetrahydrofurancarboxylic esters which may allow the preparation of stable amino acid derivatives at the anomeric position of mannofuranose. The synthesis of N-phenylhydantoins at the anomeric position...

An efficient and versatile method was used for the diastereoselective synthesis of achiral and racemic spirohydantoins based on ketones 4, 5, 7 and 10.

Four Δ8(14)-sterols, 5α-cholest-8(14)-en-3β-ol, (24R)-α- and (24S)-β-epimers of 24-methyl-5α-cholest-8(14)-en-3β-ol, and (24R)-α-ethyl-5α-cholest-8(14)-en-3β-ol, in addition to 24-methylene-25-methylcholest-5-en-3β-ol and 13 other sterols were isolated and identified from the bulbils ...