A novel phenylenevinylene copolymer (JP) with 4,7-dithien-5-yl-2,1,3-benzodiathiazole (DTBT) moiety along the backbone and di(p-tolyl)phenylamine (p-TPA) unit as side groups was synthesized and applied in polymer solar cells (PSCs). Introduction of DTBT and p-TPA moieties is beneficial to loweri...

We have expressed four virulence-associated proteins encoded by the Salmonella typhimurium plasmid pEX102 in Escherichia coli. The genes coding for the proteins MkaA, MkaB, MkaC and MkaD subcloned in the vectors pUC19 or Bluescript KS+ directed substantial production of these proteins in E. coli...

Salmonella typhimurium, like many other Salmonella serovars, harbours a large plasmid required for mouse virulence and growth of bacteria in host cells. The nature of one virulence-abolishing Tn5 insertion (zzx-2556::Tn5) in the plasmid was characterized. A 3.7 kb insert harbouring this region w...

Background: Garcimultiflorone K is a novel polyprenylated polycyclic acylphloroglucinol isolated from the stems of Garcinia multiflora that exhibits promising anti-angiogenic activity in human endothelial progenitor cells (EPCs).

The in vivo effects of 4-(1-naphthylvinyl)-pyridine on the activities of choline acetyltransferase and acetylcholinesterase, the levels of acetylcholine and choline, the sodium-dependent high affinity choline uptake and the number of synaptic vesicles were investigated in the rat brain. Our resu...

The effect of 4-(1-naphthylvinyl)-pyridine (NVP), an inhibitor of choline acetyltransferase, was investigated on responses to several cholinomimetics and to nervous stimulation of the rat bladder. NVP antagonised responses to acetylcholine (ACh) as well as responses to nervous stimulation sugges...

Inhibition by juglone (5-hydroxy-l,4-naphthoquinone) of choline acetyltransferase [ChAt; acetyl-CoA: choline O-acetyltransferase (EC 2.3.1.6)] of rabbit brain was noncompetitive for choline and not reversible by dialysis. When acetyl-CoA and juglone were mixed together before the addition of ChA...

Two “double-headed” nucleosides, 5′-(adeni-9-yl)thymidine (3) and 5′-(adenin-9-yl)-2,5′-dideoxyadenosine (4) have been synthesized from a 5′-deoxy-5′-tosyl precursor through displacement of the tosyl group by adenine (sodium salt) in N,N-dimethylformamide. The site of attachment of the in...

Saturation molalities m(sat) in H2O(l) have been measured for the substances 2′-deoxyadenosine · H2O(cr), 2′-deoxycytidine · H2O(cr), 2′-deoxyguanosine · H2O(cr), 2′-deoxyinosine(cr), and 2′-deoxyuridine(cr) by using h.p.l.c. The states of hydration were established by performing Karl Fi...

The rate of oxygen uptake by exponential phase cultures of Neurospora crassa lys 3 was measured in the presence and absence of the respiratory uncoupler, carbonyl-cyanide-mchlorophenylhydrozone (CCCP). Addition of CCCP (2.45 μm) approximately doubled the organism's rate of oxygen uptake bu...

An improved procedure for the preparation of a versatile synthetic precursor, (+)-13, of carba-2'-deoxyribonucleosides and the first stereospecific way to enantiomerically pure carbocyclic 2'-deoxyadenosine, (+)-14, are presented from bicyclic lactone diol (+)-1. An unexpected formatio...

Nuclear magnetic resonance spectra of 2′-deoxyadenosine (dA) were measured at several solute concentrations in binary solvent mixture (D2Odimethyl sulphoxide) varying in composition from 0% to 100% by vol. D2O. One type of upfield shift of the C2 and C8 protons of the base moiety was found to b...

We have tested the possible genesis of kinetin from a 2′-deoxyadenylate unit of DNA by a chemical route involving a head-to-tail transfer of deoxyribose from the 9 to the 3 position of the adenine nucleus via a cyclonucleoside, with subsequent elimination of 1′- and 3′-polar groups and 3 → N...

The nucleoside 6-amino-2-chloro-7-(2-deoxy-β-d-erythro-pentofuranosyl)-7H-purine 7 is readily accessible in two steps from 2,6-dichloropurine. The crystal structure of this unusual nucleoside reveals a bifurcated intramolecular hydrogen bond from the amino group to the O-5′ with a weaker branc...

The physicochemical properties of theophylline monohydrate and anhydrous polymorphic form II were evaluated using crystallographic, calorimetric and computational methods. The heats of solution of theophylline monohydrate and its anhydrous form were 28.6 and 19.4 kJ/mol, respectively, and the he...

A previous study around adenine nucleotides afforded the reference N6-methyl-2′-deoxyadenosine-3′,5′-bisphosphate (1a, MRS 2179) as a selective human P2Y1 receptor antagonist (pA2=6.55±0.05) with antithrombotic properties. In the present paper, we have synthesized and tested in vitro various...

The electrochemical oxidation of 2′-deoxyadenosine has been investigated in phosphate containing supporting electrolytes in pH range 2–10 at a pyrolytic graphite electrode by cyclic sweep voltammetry, spectral studies, controlled potential electrolysis and related techniques. The oxidation of ...

A study has been made of the semi-synthesis of 1,3-diols (anacardic alcohols) from natural phenolic lipid resources from Anacardium occidentale and Anacardium giganteum which have given C15 and C11 derivatives, respectively. An isomeric 1,3-diol (isoanacardic alcohol) has been obtained from card...

Publisher SummaryThis chapter presents the reactions leading to the benzo[c]cinnoline ring system. The chapter discusses the cyclization reactions of biphenyl derivatives including 2-substituted biphenyls. In these reactions when certain derivatives of 2-aminobiphenyl, having activating substitu...

To help elucidate the mechanism of dechlorination of chlorinated triazines via metallic iron, terbutylazine (TBA: 2-chloro-4-ethylamino-6-terbutylamino-1,3,5-triazine), deisopropyl atrazine (DIA: 2-amino-4-chloro-6-ethylamino-1,3,5-triazine), and chlorinated dimethoxy triazine (CDMT: 2-chloro-4,...