The impairment of the serotonergic system contributes to nicotine and ethanol effects on mood, suggesting that this system is targeted by each of these drugs and that co-exposure possibly worsens the disruption. Here, we tested this hypothesis in an adolescent mice model of tobacco smoke and/or ...

New analogues of 2-[2-substituted-3-(3,4-dichlorobenzylamino)propylamino]quinolin-4-ones, 26a, 26b, 31a–e, 34, 35, 38 and 40, have been synthesized and evaluated against Staphylococcus aureus methionyl-tRNA synthetase. All of the synthesized compounds were less active than the reference compoun...

The solubility of CO2 was measured in aqueous solutions of 2-(isopropylamino)ethanol (IPAE) and 2-(propylamino)ethanol (PAE) at 313 K, 373 K and 393 K and CO2 partial pressures ranging from 5 kPa to 0.2 MPa. With different CO2 loadings, speciation analyses were conducted by accurate quantitative...

Behavioral effects induced by 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT; i.e., lower lip retraction, flat body posture, and forepaw treading) were examined in rats during ethanol withdrawal following a 2-week period of access to a liquid diet containing 9% (v/v) ethanol. After an 18 h wi...

Regioselective ring-opening reactions of a set of representative 1,2-cyclic sulfamidates with lithium triethylorthopropiolate proceeded efficiently to deliver the corresponding δ-amino-α,β-unsaturated esters after acidic hydrolysis. Hydrogenation of the unsaturated esters and subsequent therm...

The first enantioselective synthesis of (2R,13R,8Z)-2,13-diacetoxy-8-heptadecene 1, the major component of the sex pheromone of the pear leaf midge, Dasineura pyri, has been achieved. The key steps include the (R,R)-BINOL/Ti(OiPr)4 catalyzed alkynylzinc addition to an unsaturated aldehyde, the r...

Tris(2-ethylhexyl)phosphate is proposed as an extractant for scandium(III) and yttrium(III) from salicylate media. The optimum extraction conditions are evaluated and described. The method permits mutual separation of scandium(III) and yttrium(III) and can be used for the separation and determin...

While monomeric aryl organophosphate flame retardants (m-aryl-OPFRs) are used worldwide in a variety of consumer products, specific biomarkers for epidemiologic studies are lacking. To explore the potential of urinary hydroxylated metabolites of m-aryl-OPFRs as the biomarkers, we detected triphe...

Several regulatory offices called for the phase-out of di (2-ethylhexyl) phthalate (DEHP) in medical devices if safer alternatives are available. In medical devices, the occurrence of alternative plasticizers (APs) is widely variable among types of devices. However, plasticizer use is constantly...

A series of solvent mediators containing a phosphoryl (PO) group, such as tris(2-ethylhexyl)phosphate, bis(2-ethylhexyl) 2-ethylhexylphosphonate, 2-ethylhexyl bis(2-ethylhexyl)phosphinate, and tris(2-ethylhexyl)phosphine oxide, were used to construct serotonin-selective membrane electrodes. We f...

Tris(2-ethylhexyl) phosphate was an effective solvent mediator for constructing a poly(vinyl chloride) (PVC) membrane electrode responsive to a stimulant, phentermine, in combination with an ion-exchanger, sodium tetrakis[3,5-bis(2-methoxyhexafluoro-2-propyl)phenyl]borate (NaHFPB). This electrod...

Liquid-liquid extraction of light lanthanides (La(III) and Nd(III)) from 5.0 M phosphoric acid and U(IV) from 8.0 M phosphoric acid by Octyl Phenyl Acid Phosphate (OPAP) in benzene and kerosene at ratio 1:4, respectively, has been studied. The effects of several parameters such as shaking time, ...

A novel Plutonium (Pu) (IV) selective ligand, bis-(2-ethylhexyl) carbamoyl methoxy phenoxy-bis-(2-ethylhexyl) acetamide (BenzoDODA) was studied for its Pu(IV) extraction behavior in presence of 1-alkyl-3-methylimidazolium bis[(trifluoromethyl)sulfonyl] imide {[Cnmim][Tf2N]}ionic liquids. BenzoDO...

We investigated the epoxidase activity of a class mu glutathione S-transferase (cGSTM1-1), using 1,2-epoxy-3-(p-nitrophenoxy)propane (EPNP) as substrate. Trp209 on the C-terminal tail, Arg107 on the α4 helix, Asp161 and Gln165 on the α6 helix of cGSTM1-1 were selected for mutagenesis and kinet...

Racemic methyl, ethyl and cyanomethyl 3-(2′-nitrophenoxy) butanoates 4–10, chiral precursors of 2,3-dihydro-1,5-benzoxazepin-4(5H)-ones with ACE inhibitory activity, were prepared and submitted to kinetic resolution, by a series of commercially available lipases. Best results (e.e.'s ⪢99%...

Asymmetric dihydroxylation of mono nitrophenyl allyl ethers leads to the corresponding non-racemic 3-(nitrophenoxy)-propane-1,2-diols 1a–c. As this takes place, regardless of the reagent used (AD-mix-α or AD-mix-β), the configuration of the predominant enantiomer for the para- and meta-nitros...

The major radioactive component (84%) of a commercial sample of [G-3H]dibenz[a, h]anthracene was not this compound but was identified as [G-3H]-5,6-dihydrodibenz[a, h]anthracene and could be efficiently transformed by dehydrogenation into the tritiated parent hydrocarbon.

The synthesis of 3β-hydroxy-5-azacholestane (10a) from cholesterol (1) is described. B-norcholest-4-ene-3-one (2) obtained from 1, was reduced to carbinol 3a. The aeetyl derivative (3b) of the latter, after ozonolysis and methylation, afforded the methyl ester of 3β-acetoxy-4,5-seco-5-keto-B-n...

Leukotrienes (LTs) and prostaglandin (PG)E2, produced by 5-lipoxygenase (5-LO) and microsomal prostaglandin E2 synthase-1 (mPGES-1), respectively, are key players in inflammation, and pharmacological suppression of these lipid mediators (LM) represents a strategy to intervene with inflammatory d...

Co(II), Ni(II), Cu(II) and Pd(II) complexes of 4-amino-5-pyrimidinecarbonitrile (APC) have been synthesized and characterized using elemental analysis, magnetic susceptibility, mass spectrometry, infrared (4000–200 cm−1), UV–Visible (200–1100 nm), 1H NMR and ESR spectroscopy as well as TGA an...