Laboratory scale experiments were conducted on the removal of metallic iron from reduced ilmenite. A mechanically stirred aeration vessel was used to determine the iron leaching ability of aerated water in the presence of ethylene diammonium chloride catalyst. The efficiency of the aeration cata...

The synthesis and evaluation of a series of N,N-bis-heterocyclic-methylamines 1 as isoazaerianin analogues are described. It was demonstrated that the replacement of the 3,4,5-trimethoxyphenyl A-ring present in CA-4, isoCA-4 and isoazaerianin by a quinoline or a quinazoline ring is possible and ...

2-(Perfluoroalkyl)ethanesulfinic acids of the formula RFCH2CH2SO2H (2, where RF = n-C6F13, or n-C8F17) are synthesized from the thiol, RFCH2CH2SH (1). These segmented acids 2 have sharp melting point (mp) and can be recrystallized. The C6 or C8 perfluoroalkyl group confers unusual “fluophilic”...

The regioselective synthesis of the title compounds was developed on the basis of condensation reactions of trifluoroacetylacetone and its methyl enacetal with cyanothioacetamide in the presence of bases. Thus, the condensation of trifluoroacetyl-acetone with cyanothioacetamide yields predominan...

The cyclization of acylated 4-amino-5-aryl-2-(trifluoromethyl)pyridines under the action of P2O5/POCl3 smoothly afforded 3-(trifluoromethyl)benzo[c][1,6]naphthyridines in good yields. Intermediate aminopyridines were synthesized in a two-step sequence from the corresponding 4H-pyran-4-ones, whic...

A facile synthetic approach to the direct preparation of 2-pyridyl and 3-pyridylzinc bromides has been demonstrated using Rieke zinc with 2-bromopyridine and 3-bromopyridine, respectively. A variety of different electrophiles have been coupled with the resulting organozinc reagents to give the c...

The effect of a phosphate surface treatment on dry-fermented sausages with co-extruded alginate casings was investigated to reduce or inhibit the formation of white efflorescences on the surface of the sausages. Furthermore, with the co-extrusion process a continuous sausage production is possib...

A microfluidic hydrodynamic sequential injection (μHSI) spectrophotometric system was designed and fabricated. The system was built by laser engraving a manifold pattern on an acrylic block and sealing with another flat acrylic plate to form a microfluidic channel platform. The platform was inc...

Endophytic microorganisms live inside the host plant and contribute in various biological processes, without causing any harmful effect. Inorganic phosphate solubilization, through microorganisms, is one of the major mechanisms involved in plant growth. The present study highlights the potential...

Injectable bone cement (IBC) such as those based on methacrylates and hydraulic calcium phosphate and calcium sulfate-based cements have been used extensively for filling bone defects with acceptable clinical outcomes. There is a need however for novel IBC materials that can address some of the ...

l-ascorbic acid 2-phosphate magnesium (APMg) salt is a vitamin C derivative frequently used in cell culture media for research purposes. It is also used as a raw material in the GMP-manufacturing of gene-, cell- and tissue advanced therapy medicinal products (ATMPs). However, quality methods are...

This in vitro study evaluated, for the first time, the safety and the biological activity of a novel urea-crosslinked hyaluronic acid component and sodium ascorbyl phosphate (HA-CL – SAP), singularly and/or in combination, intended for the treatment of inflammatory lung diseases. The aim was to...

Liquid microemulsions appropriate for topical application were obtained by increasing their viscosity through the addition of thickening agents. The present study first assessed the usefulness of ultrasound (US) plus US contrast agent, microbubbles (MBs), in agarose gel for enhancing transdermal...

In this study, a non-shell graphene-based monolith (GBM) with huge surface area was synthesized by chemical reduction of Graphene oxide (GO) using magnesium ascorbyl phosphate (MAP), and tested as an adsorbent for trace Bisphenol A (BPA) removal. The properties of MAP-GBM was characterized by sc...

The formation of hepatic DNA adducts in male Sprague-Dawley rats following i.p. administration of benzo[f]quinoline (BfQ) was examined using a 32P-post-labeling assay. BfQ exhibited a low binding (11–27 amol adducts/μg DNA) to liver DNA. Two BfQ-nucleoside adducts (one major and one minor) wer...

Chlorophyllin (CHL), the sodium and copper salt of chlorophyll, was tested for its chemopreventive activity against tumorigenesis induced by benzo[a]pyrene (B[a]P) and its ultimate electrophilic and carcinogenic metabolite, benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE). Administration of CH...

We determined the capacity of grapefruit juice (GJ) to inhibit the rate of micronucleated polychromatic erythrocytes (MNPE) in mice treated with benzo(a)pyrene (BaP), an environmental contaminant that is biotransformed by Cyp1a1 and is a strong genotoxic agent. For this study, we administered 4....

1. Liver microsomes from rats were considerably more active in metabolizing benzo[ƒ]quinoline (B ƒ Q) than those from brown bullheads (Ictalurus nebulosus).2. The main B ƒ Q metabolites formed by both rat and brown bullhead liver microsomes were qualitatively similar and included B ƒ Q-7,8-dihyd...

The metabolism of benzo[f]quinoline (BfQ) and its carbon analog phenanthrene has been compared in incubations with liver microsomes from control, 3-methylcholanthrene (3-MC)- and phenobarbital (PB)-pretreated rats. The rates of phenanthrene metabolism by the three types of microsomes were 0.7, 4...

This report describes the synthesis, and in vitro and in vivo antimalarial evaluations of certain ester-modified neocryptolepine (5-methyl-5H-indolo[2,3-b]quinoline) derivatives. The modifications were carried out by introducing ester groups at the C2 and/or C9 position on the neocryptolepine co...