Acidic dissociation and homoconjugation constants were determined for a number of substituted pyridine N-oxides in nitrobenzene. The acidic dissociation constants of acids conjugated with the N-oxides studied turned out to be in the range of 4

A very large set of one-bond spin–spin carbon–carbon coupling constants, 1JCC, has been measured for 32 variously mono- and disubstituted pyridine N-oxides and for 14 substituted pyridines. The N-oxides studied were 2-, 3- and 4-monosubstituted isomers, and a series of disubstituted compounds....

Two new 2-methoxy -4-chromanones were synthesized from 3-formylchromone and 2-aminopyridine/2-amino-5-nitropyridine in methanolic media and was characterised using various spectral and analytical techniques. Reactions of these ligands with copper (II), zinc (II) and nickel (II) acetates lead to ...

Nitriles and esters of 2-(o-nitroaryl)crotonic acids are converted under basic conditions into substituted quinoline N-oxides, N-hydroxyindoles and N-hydroxy-2-hydroxymethyl indoles. Factors governing the reaction course and mechanistic pathways are discussed.

Nitrogen compounds in crude oil are known to cause several problems during refining including catalyst deactivation and gum formation. Industrially, nitrogen is removed by hydro-treating, which requires ring saturation prior to denitrogenation and makes hydro-treating an expensive process for he...

Di(hetero)arylamines were prepared in moderate to high yields by Buchwald–Hartwig C–N coupling of bromobenzenes bearing electron-withdrawing groups and of a bromobiphenyl with several methyl 3-aminobenzo[b]thiophene-2-carboxylates, using the coupling conditions for heteroaromatic amines [Pd(OA...

STAT3 has been extensively studied as a potential antitumor target. Though studies on regulating STAT3 mainly focus on the inhibition of STAT3 phosphorylation at Tyr705 residue, the phosphorylation at Ser727 residue of STAT3 protein is also closely associated with the mitochondrial import of STA...

Several novel 3-(aryl)benzothieno[2,3-c]pyran-1-ones (tricyclic lactones) were prepared either by a tandem one-pot Sonogashira coupling and intramolecular cyclization, reacting the 3-bromobenzo[b]thiophene-2-carboxylic acid with arylacetylenes, or by Sonogashira coupling of the methyl 3-bromoben...

Poly(8-quinolyl acrylate) and the polymers of the complexes of 8-quinolyl acrylate with some transition metal bromides and uranyl acetate have been prepared and characterized by elemental analyses, electronic and vibration spectroscopic studies and magnetic moments. The thermal stabilities of th...

Formyl peptide receptor2 (FPR2) is a G-protein coupled receptor that plays critical roles in inflammatory reactions. FPR2-specific interaction can be possibly used to facilitate the resolution of pathological inflammatory responses by enhancing endogenous anti-inflammation systems. Starting from...

In the search for new antifungal compounds and to explore structure activity relationships, a series of 24 chiral benzyl amine type antifungals was synthesised and characterised. In vitro testing against the human pathogen Cryptococcus neoformans revealed that several derivatives had MIC50 value...

Multitargeted therapy is considered a successful approach to cancer treatment. The development of small molecule multikinase inhibitors through hybridization strategy can provide highly potent and selective anticancer agents. A library of N-alkyl-2-[(4-oxo-3-(4-sulfamoylphenyl)-3,4-dihydroquinaz...

The medicinal value of the monoterpenoid indole alkaloids (MIAs) such as 3′,4′-anhydrovinblastine, as well as their chemical complexity have stimulated extensive efforts to understand the biochemical and molecular pathways involved in their biosynthesis in plants such as Catharanthus roseus, R...

Direct hydroxylation α to sulphur was accomplished in singlet oxygenation of thiazolidine derivatives. Photo-oxidation of 4-substituted 3-benzoyl-2,2-dimethylthiazolidines in aprotic solvents below 0° gave the corresponding 5-hydroxy derivatives quantitatively by subsequent treatment of dimeth...

A peptide-like self-immolative molecular clip is required for release of active drugs from prodrugs by endopeptidases. Upon cleavage from the carrier, this clip must collapse and release the drug rapidly. A series of aminoacyl-5,5-dimethylthiaproline (Aaa-Dmt) N-(2-(4-nitrophenyl)ethyl)amides we...

Nine new and three earlier known 4-halogen (Cl and Br) substituted pyridine N-oxides have been prepared and their 1H, 13C and 15N NMR chemical shifts assigned based on PFG 1H, X (X=13C and 15N) HMQC and HMBC experiments as well as the comparison with our earlier results for substituted pyridine ...

(Acid + base) equilibrium constants, involving the acidity (pKaAC) and cationic homoconjugation constants (in the form of lgKBHB+AC), have been determined by the potentiometric method in 13 systems formed by substituted 4-nitropyridine N-oxides in the polar aprotic solvent, acetone (AC). The der...

The chelate complex [CuCl2(L)] where L = 2-methylamino-3-methyl-4-nitropyridine-N-oxide has been obtained and characterized, both physicochemically (by the X-ray structure analysis of the complex and the ligand, FTIR, EPR and electronic spectroscopy, and thermal analysis) and cytotoxically (MCF-...

Nitro compounds are widely used in military and industrial activities including explosives dyes, pesticides, polymers and other active species. The main goal of this work is to present an efficient nanosorbent to remove mg L− 1 of 4-nitroaniline (4NA) and 2-amino-3-nitropyridine (2A3NP) from aqu...

Seven 3-substituted (alkylamino, alkylnitramino and alkylnitrosoamino) derivatives of pyridine N-oxide have been prepared and their 1H, 13C and 15N NMR chemical shifts assigned based on PFG 1H, 13C HMQC and PFG 1H, X (X = 13C or 15N) HMBC experiments. In the sterically most crowded congener, 3-e...