The syntheses of NH-3-phenylsulfanyl- and NH-3-benzylsulfanyl-azetidinones, starting from 1-phenylsulfanyl- or 1-benzylsulfanyl-2-trimethylsilyloxy-3-aza-1,3-dienes are reported.

4-Chloro-2-carboxyphenoxyacetic acid (CCPA) residues have occasionally been observed in crops treated with 4-chloro-2-methylphenoxyacetic acid (MCPA). The oral toxicity of MCPA and CCPA was compared in a 4-week rat study at a dietary concentration of 2000 ppm. CCPA was also given at 12,000 ppm (...

Chemiluminescence is observed in the thermal reaction of phenylchlorocarbene or (2-chlorophenyl)carbene and O2, matrix-isolated in Ar. The chemiluminescence spectra closely match the phosphorescence of the corresponding carbonyl compounds. The reactivity of both carbenes towards O2 is very diffe...

A general five-step synthesis of a short library of benzo[7,8]indolizinoquinolinine analogues of the topoisomerase-1 (topo-1) poison rosettacin and 22-hydroxyacuminatine alkaloids from DMAD and ortho-ketoanilines is reported. This consists on successively, the tandem aza-Michael addition/cyclode...

In higher vertebrates, in response to stress, the hypothalamus produces corticotropin-releasing hormone (CRH), which stimulates cells in the anterior pituitary to produce adrenocorticotropic hormone (ACTH), which in turn stimulates production of either cortisol (F) or corticosterone (B) by the a...

Cerium(IV) ammonium nitrate was found to be a versatile reagent for the oxidative functionalization of styrenes using N-hydroxyphthalimide and iodine affording three different types of products with oxyphthalimide, nitrate and iodide groups. It was shown that reaction of styrenes with N-hydroxyp...

In continuation of our previous study, a series of phenacyl esters of N-phthaloyl amino acids were synthesized and screened for their in vitro pancreatic lipase inhibitory activity. N-phthloylation of amino acids and subsequent esterification with different phenacyl bromides in presence of N,N-D...

Phthalimide monolayers were prepared on silicon (1 1 1) by the reaction of hydrogen–terminated silicon surfaces with vinylphthalimide. The hydrolysis reaction of phthalimide on silicon surfaces was performed in a methylamine solution to prepare amino-terminated monolayers. A series of reactions...

Literature reports that isatin as well as C5- and C6-substituted isatin analogues are reversible inhibitors of human monoamine oxidase (MAO) A and B. In general, C5- and C6-substitution of isatin leads to enhanced binding affinity to both MAO isozymes compared to isatin and in most instances res...

We found that N-acyl phthalimides and several N-acylated azoles are capable of reacting with aldehydes to form O-acyl-N,O-acetals in an apparent amide CN bond insertion. In the context of N-acyl phthalimides, the reaction is mediated by substoichiometric amounts of sodium iodide and potassium ph...

The multicomponent Amine-Aldehyde-Dienophile reaction is optimized employing benzyl or 4-methoxybenzylamine. The interest of the transformation consist in the synthesis of polysubstituted cyclohex-2-enylamines. The study of the scope of this AAD process is carried out, as well as the diastereose...

Two fatty acid hydroperoxide lyases (HPO lyase I and II) were purified to apparent homogeneity from etiolated hypocotyls of sunflower (Helianthus annuus L.) by a combination of ion-exchange, hydrophobic interaction, and gel filtration chromatography. The two HPO lyases were separated during the ...

The membrane bound hydroperoxide lyase (E″2) which catalyses the cleavage of 13-l-hydroperoxides (18:3-OOH and1 8:2-OOH) of linolenic and lin

An activity of homolytic hydroperoxide lyase (HPLS) catalyzing the specific cleavage of 13-hydroperoxylinolenic acid to form a volatile compound and 13-oxo acid was found in the enzyme extract from soybean cotyledons. 2-Penten-l-ol was characterized as a volatile metabolite by gas chromatography...

Enantioselective, homogeneous hydrogenation of 3-phenyl-3-butenoic acid (1) has extensively been examined in the presence of the rhodium(I)/4,5-bis[(diphenylphosphino)methyl]-2,2-dimethyldioxolane (DIOP) catalyst systems. Optimization of the reaction conditions was undertaken mainly by controlli...

Hydrolase catalysed kinetic resolutions leading to a series of 3-aryl alkanoic acids (⩾94% ee) are described. Hydrolysis of the ethyl esters with a series of hydrolases was undertaken to identify biocatalysts that yield the corresponding acids with excellent enantiopurity in each case. Steric an...

New method for the synthesis of the mononuclear anionic iron dinitrosyl complexes (DNICs) as prospective agents for nitric oxide (NO) chemotherapy of oncological diseases has been developed. Mononuclear anionic DNIC of the composition (N2H5)+[Fe(SR)2(NO)2]- with R = 5-nitropyridinyl (I) has been...

The method of comparison of the capacity of polar non-aqueous solvents to differentiate between the strengths of cationic acids, based on the magnitude of slope in correlations of the non-aqueous and aqueous pKa values, has been found inapplicable to acids obtained by protonation of substituted ...

The following crystalline complexes of trimethylamine N–oxide (TMAO) with pentachlorophenol (PCP): TMAO·PCP, TMAO·PCP·H2O and TMAO·2PCP have been prepared and characterized by FTIR spectroscopy, quantum–mechanical calculations with DFT and semiempirical methods and X–ray diffraction (two ...

Simple and, if formed, semiperchlorates of substituted pyridine N-oxides have been synthesised and the spectra of N-oxides and salts have been recorded in acetonitrile solution. For basic enough N-oxides homoconjugated cations are observed spectrophotometrically while for the remaining ones such...