The present work reports the synthesis and evaluation of the antitumour and immunomodulatory properties of new phthalimides derivatives designed to explore molecular hybridization and bioisosterism approaches between thalidomide, thiosemicarbazone, thiazolidinone and thiazole series. Twenty-seve...

A wide variety of 2-amino-4H-chromene derivatives with diverse substituents on the 4H-chromene ring were efficiently prepared via one-pot, three-component reaction of an aromatic aldehyde, malononitrile (or ethyl cyanoacetate), and diverse enolizable C–H activated acidic compounds in the presen...

A simple, green and environmentally benign procedure was developed for the one pot synthesis of 3-methyl-1,4-diphenyl-1,4,5,7-tetrahydro-pyrazolo[3,4-d]pyrimidine-6-one/thiones using catalytic amount of phthalimide-N-sulfonic acid (PISA) in 1-butyl-3-methylimidazolium bromide ([Bmim][Br]) ionic ...

A facile and environmentally benign synthesis of some 2-(2-oxo-2H-chromen-3-yl)-4-aryl-indeno[1,2-b]pyridine-5-one derivatives from the reaction of aromatic aldehydes, 3-acetylcoumarin, 1,3-indandione and ammonium acetate using phthalimide-N-sulfonic acid (PISA) as a catalyst is described. The p...

Ruthenium-catalyzed intermolecular [3 + 2] annulation pathway for aromatic acids with isocyanates to afford N-substituted phthalimide in one step is demonstrated, which provides an efficient process to direct preparation of phthalimide from commercially available starting materials and environme...

A novel series of phthalimide-1,2,3-trizole hybrids linked to benzyl ring containing different substituents were synthesized and evaluated for their tyrosinase inhibitory activity (inhibitory activity and inhibition kinetic). It was found that compounds 2-((1-(2-nitrobenzyl)-1H-1,2,3-triazol-4-y...

AimsIn this study, we synthesized a novel chemical, (E)-2-(3,4-dimethoxyphenyl)-4-oxo-4H-chromen-7-yl-3-(3,4-dimethoxyphenyl) acrylate (CSH) and investigated the effect of CSH on atopic dermatitis (AD) by evaluating the anti-inflammatory effect of CSH on immune cells in vitro and on atopic derma...

5-Chlorovaleroyl chloride (5-CVC) is commonly used as an alkylating agent in the synthesis of pharmaceutical intermediates, active ingredients, as well as other specialty chemicals. It is critical to monitor the impurities present in 5-CVC as they may have a direct impact on the impurity profile...

A new synthesis of 2-isoxazoline 2-oxides starting from unsaturated nitro compounds is described. A facile and convenient preparation of β-alkyl substituted β-nitroenones and their conversion to β-nitrosulfides are recorded. Treatment of these compounds with potassium tert-butoxide at −78°C ...

A concise, metal-free protocol has been established for the preparation of 2-arylbenzoxazoles from 2-nitrophenols and arylacetic acids via a sulfur-mediated redox decarboxylative cyclization reaction. The reactions proceeded in moderate to good yields, and gram-scale is suitable.

A series of novel β2-adrenoceptor agonists with a 5-(2-amino-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one moiety was designed, synthesized and evaluated for biological activity in human embryonic kidney 293 cells and isolated guinea pig trachea. Compounds 9g and (R)-18c exhibited the most excell...

The crystal and molecular structure of 1,3-dimethyl-8-azaxanthine (HDAX) monohydrate has been determined by X-ray diffraction. The compound exhibits the N8-H tautomer in the solid state and hydrogen-bonded dimers are formed.Molecular orbital calculations have been performed for this compound, it...

Bacterial strain Enterobacter aerogenes TJ-D capable of utilizing 2-methylquinoline as the sole carbon and energy source was isolated from acclimated activated sludge under denitrifying conditions. The ability to degrade 2-methylquinoline by E. aerogenes TJ-D was investigated under denitrifying ...

2-Methylquinoline is a common organic contaminant in environment. Its degradation in wastewater treatment system has not been fully explored. In this study, batch experiments were conducted to investigate the biodegradation of 2-methylquinoline by activated sludge under both aerobic and denitrif...

A solution for the limited fossil oil resources could be biodiesel. However, the future of biodiesel is threatened by the use of vegetable oil as biodiesel feedstock and the low economic value of the byproduct glycerol.The use of algal oil as feedstock and triacetin instead of glycerol as byprod...

The aim of this work was to evaluate the plasticizing effect of triacetin on the structure and properties of starch ester film and further establish the structure–property relationships. The presence of triacetin resulted in multiple structure changes of the film. The mobility of macromolecular...

The efficient and selective acetylation of glycerol to produce triacetin is achieved using magnetic solid acids as catalysts. The Fe-based materials including Fe-Sn-Ti (OH)x, Fe-Sn-Ti(SO42−) and Fe-Sn-Ti(SO42−)-t (t represents the temperature for the heating treatment) were successfully prepared...

By a continuous-flow apparatus, quaternary solubility of acetic acid, diacetin, and triacetin in supercritical CO2 was measured at constant flow rate of 180 mL min−1 and temperatures of 313 K, 333 K and 348 K in a pressure range of 70–180 bar. Acetic acid had the highest solubility in scCO2. Th...

The viscoelastic behaviour of cellulose acetate with a degree of substitution (DS) of 245 plasticized by triacetin was studied at short times by dynamic oscillatory measurements. Two distinct regimes and unexpected scaling behaviour according to plasticizer content were highlighted. The dynamics...

Global application of biodiesel in the transport sector has rapidly expanded over the last decade, however, efforts to overcome its main shortcoming, i.e., increase in NOx emissions compared with diesel, are still underway. In light of that, parameters/strategies capable of mitigating biodiesel ...