Searching for hit compounds within the huge chemical space resembles the attempt to find a needle in a haystack. Cheminformatics-guided selection of few representative molecules of a rationally designed virtual combinatorial library is a powerful tool to confront this challenge, speed up hit ide...

Involved in the tyrosine degradation pathway, 4-hydroxyphenylpyruvate dioxygenase (HPPD) is an important target for treating type I tyrosinemia. To discover novel HPPD inhibitors, we proposed a hydrophobicity-oriented drug design (HODD) strategy based on the interactions between HPPD and the com...

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) participates in diverse cancer-associated signaling pathways, playing an oncogenic role in multiple human cancers, including hepatocellular carcinoma (HCC). Our recent works clarify that Pin1 modulates miRNAs biogenesis by interacting...

We report here the synthesis, the biological evaluation and the molecular modeling studies of new imidazo[1,2-a]pyridines derivatives designed as potent kinase inhibitors. This collection was obtained from 2-aminopyridines and 2-bromoacetophenone which afforded final compound in only one step. T...

Four series of tetracyclic benzo[b]carbazolone compounds possessing more rotatable bonds and higher molecular flexibility were designed by either inserting a linker within the C8-side chain or by opening the middle ketone ring on the basis of compound 5 (Alectinib, CH5424802). Compound 15b was i...

Based on the unusual reactivity of trifluoromethyl groups in nitrogen containing heterocycles, we synthesized the appropriate porphyrin mono-, di-, tri- or tetra-carboxylic ester derivatives by treatment of the precursor meso-tetrakis(trifluoromethyl)porphyrin with an excess of sodium- or potass...

BackgroundPreparation of a new series of Michael adducts as an 1-(4-acetylphenyl)-3-aryloxypyrrolidine-2,5-dione derivates using cellulose sulfuric acid catalyst with objective of obtaining lead compounds for future development as anticonvulsants.

4-[(3-Acetylphenyl)amino]-2-methylidene-4-oxobutanoic acid is synthesized and the structure of the compound was confirmed by IR, 1H NMR and single crystal X-ray diffraction studies. FT-IR spectrum of 4-[(3-acetylphenyl)amino]-2-methylidene-4-oxobutanoic acid was recorded and analyzed. The crysta...

A series of bivalent metal complexes having compositions [Co(L)2Cl2] (1), [Zn(L)2Cl2] (2), [Co(L)2(H2O)4](NO3)2·2H2O (3), [Zn(L)2(H2O)4](NO3)2·2H2O (4), [Co(L)2(OAc)2(H2O)]·3H2O (5), [Mn(L)2(OAc)2(H2O)]·3H2O (6) [Co(L)4(NCS)2] (7), {[Co(L)2(Fum)(H2O)2]·2H2O}n (8) and {[Mn(L)2(Fum)]}n (9) we...

SummaryTwenty five analogues of uridine 5′-diphosphate glucose were screened against herpes simplex type 2, vaccinia virus, Sindbis virus and African swine fever virus. After screening, the compound 5′-[[[[(2″,3″,4″,6″-tetra-O-benzoyl-α-d-glucopyranosyl) oxi]carbonyl]amino]sulfonyl]uridin...

The relevance of the linker tethering site in haptens was investigated for antibody generation and immunoassay development. Three derivatives of the strobilurin fungicide picoxystrobin were synthesized with the same functionalized spacer arm located at three different positions. Protein conjugat...

This paper describes the original synthesis of a functionalized derivative of the fungicide picoxystrobin and the generation of the first reported monoclonal antibodies against this strobilurin pesticide. The synthetic hapten was prepared by total synthesis from commercial chemicals and incorpor...

Picoxystrobin is a new generation fungicide primarily developed to be used in cereal crops. In the present study a novel collection of specific monoclonal antibodies has been produced using different immunizing haptens based on a carboxy-functionalized identical spacer arm attached to alternativ...

This article reports and compares the performance of two new electrochemical methods for the determination of picoxystrobin (a strobilurin-class fungicide). The methods were square-wave voltammetry (SWV) and batch-injection analysis (BIA) with multiple-pulse amperometric detection, both employin...

Fluorescence polarisation immunoassays (FPIAs) based on monoclonal antibodies for detection of three strobilurin fungicides - kresoxim-methyl (KM), trifloxystrobin (TF) and picoxystrobin (PC), were developed and optimised. Fluorescein-labelled derivatives of target antigens (tracers) were synthe...

Differential pulse anodic stripping voltammetry was used for trace determination of picoxystrobin in urine and water samples. Experimental conditions have been optimized and the measurement cycle started with the application of a deposition potential at −700 mV, during 60 s, for the in situ form...

Apis mellifera perform important pollination roles in agroecosystems. However, there is often intensive use of systemic pesticides in crops, which can be carried to the colony by forage bees through the collection of contaminated pollen and nectar. Inside the colony, pollen loads are stored by b...

The effect of Picoxystrobin 25% SC on soil microorganisms (carbon transformation) was assessed in a test that measured induced respiration rate following the application of Picoxystrobin 25% SC to soil. Picoxystrobin 25% SC was incubated in loamy sand soil over a period of 28 days for the carbon...

Strobilurins is the most widely used class of fungicides, but is reported highly toxic to some aquatic organisms. In this study, zebrafish embryos were exposed to a range concentrations of three strobilurins (pyraclostrobin, trifloxystrobin and picoxystrobin) for 96 h post-fertilization (hpf) to...

Azoxystrobin and picoxystrobin are two primary strobilurin fungicides used worldwide. This study was conducted to test their effects on embryonic development and the activity of several enzyme in the zebrafish (Danio rerio). After fish eggs were separately exposed to azoxystrobin and picoxystrob...