DNA variants of the proteolipid protein 1 gene (PLP1) that shift PLP1/DM20 alternative splicing away from the PLP1 form toward DM20 cause the allelic X-linked leukodystrophies Pelizaeus-Merzbacher disease (PMD), spastic paraplegia 2 (SPG2), and hypomyelination of early myelinating structures (HE...

The Hem/Kette/Nap1 protein is involved in many biological processes. We have recently reported that Hem is required for the normal migration of neurons in the Drosophila embryo. In this paper, we report that Hem regulates the asymmetric division of neural precursor cells. We find that a well-stu...

In the nervous system, neurons form in different regions, then they migrate and occupy specific positions. We have previously shown that RP2/sib, a well-studied neuronal pair in the Drosophila ventral nerve cord (VNC), has a complex migration route. Here, we show that the Hem protein, via the WA...

SummaryLong-range (>10 μm) transport of electrons along networks of Geobacter sulfurreducens protein filaments, known as microbial nanowires, has been invoked to explain a wide range of globally important redox phenomena. These nanowires were previously thought to be type IV pili composed of Pi...

The selective conversion of 2,2,2-trifluoro-1-furan-2-yl-ethanone into (E)- and (Z)-oximes and oxime ethers and subsequent oxazaborolidine-catalyzed enantioselective reduction using different amino alcohols furnished both enantiomers of the important chiral building block 2,2,2-trifluoro-1-furan...

N-Substituted-3(10H)-acridones have been established as visible-light organic photocatalyst. These photosensitizers are efficient for oxidative coupling reaction of N-aryl tetrahydroisoquinolines with various nucleophiles. Notably, N-methyl-3(10H)-acridone (Ia) is stable and can be effectively p...

The aim of the present study was to screen the antiviral activity of the secondary metabolite 9(10H)-Acridanone extracted from Streptomyces fradiae strain VITMK2 in Litopenaeus vannamei shrimp infected with white spot syndrome virus (WSSV). The strain was isolated from marine soil sediment sampl...

Type 2 diabetes mellitus (T2DM) is one of the major global metabolic disorders characterized by insulin resistance and chronic hyperglycemia. Inhibition of the enzyme, dipeptidyl peptidase-4 (DPP-4) has been proved as successful and safe therapy for the treatment of T2DM since last decade. In or...

New fluorinated 7-benzylamino-2-phenyl-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amines were designed as potential anticancer agents and a practical method for their preparation was developed. The reaction of benzhydrazide with cyanoguanidine followed by intramolecular cyclocondensation resulted in ...

A novel electroanalytical approach is used to get insight into scavenger kinetics and mechanism of methylglyoxal (MG) by biguanides metformin, phenformin and 1-phenylbiguanide under the physiological conditions (pH 7.41 and 37 °C). The approach is based on monitoring the time profiles of concen...

Submicron, nonporous silica powders were prepared by vaporization of powdered quartz in a plasma-arc apparatus. Physical and surface chemical properties were measured for silica powders prepared by rapidly cooling the hot N2SiO2 plasma with either (a) dry N2, (b) N2—water vapor, or (c) N2—O2...

The degassing of 2014 aluminium powder has been studied using a range of techniques. Bulk degassing studies in a vacuum hot press show water evolution from 100° to 400°C coupled with hydrogen evolution above 300°C. Powder thermal conductivity and degassing rates at 450°C may be enhanced by u...

In this work, two novel amino-substituted derivatives of saccharin, N-(1,1-dioxo-1,2-benzisothiazol-3-yl)-N-methyl amine (MBAD) and N-(1,1-dioxo-1,2-benzisothiazol-3-yl)-N,N-dimethyl amine (DMBAD), were synthesized and characterized, and their molecular structure and vibrational properties were ...

Replacement of the 5-oxopyrrolidin-3-yl fragment in the previously reported lead structure with a 1-acetylpiperidin-4-yl group led to the discovery of a novel series of potent CCR5 antagonists. Introduction of small hydrophobic substituents on the central phenyl ring increased the binding affini...

A novel Vilsmeier-type methylenation for synthesis of dipyrazolylmethanes was developed by reacting pyrazolones with formamide or N-methylformamide in the presence of phosphorous oxychloride POCl3 coupling agent. This method can efficiently provide a series of dipyrazolylmethane derivatives as t...

Chemo selectivity of some N-aryl formamides with pentafluoropyridine under basic conditions in dry THF was investigated. The aromatic nucleophilic substitution of pentafluoropyridine with enol–imines derived from N-aryl formamides occurs at the 4-position of pyridine ring by both oxygen and nit...

HIV-1 integrase is one of the three most important enzymes required for viral replication and is therefore an attractive target for anti retroviral therapy. We herein report the design and synthesis of 3-keto salicylic acid chalcone derivatives as novel HIV-1 integrase inhibitors. The most activ...

An enantioselective baker’s yeast mediated approach to the pharmacologically active (R)-enantiomer of Tamsulosin hydrochloride is reported.

We observed the decomposition of the hydrochloride salt of α-pyrrolidinoheptanophenone (α-PHPP-HCl), a newly distributed pyrrolidine-type cathinone derivative when 2.5 ng of this substance was placed in glass test tubes and stored in a refrigerator for 3 days. To further investigate this pheno...

Fluorescence excitation and resonant two-photon ionization spectra were measured for 9-ethylfluorene (EFR) molecule cooled in pulsed supersonic expansion of He in the range of 286.5 ∼ 300 nm. The structures and energies of the global and local minima and the transition states separating them ar...