Pregnane X receptor (PXR; NR1I2) is a member of the superfamily of nuclear receptors that regulates the expression of genes involved in various biological processes, including drug transport and biotransformation. In the present study, we investigated the effect of 3-hydroxyflavone and its struc...

Photopolymerization process of the photo-reactive acrylate-based E-Shell 300 biocompatible polymers doped with 3-hydroxyflavone (3-HF) molecules have been studied. It was found that the spectra of these complexes manifest two intensive fluorescence bands, the short-wavelength band of the E-Shell...

A fully water soluble 3-hydroxyflavone (3HF) derivative, N-(3-hydroxy-4′-flavonyl)-N,N,N-trimethylammonium sulfate (3HFNMe3) was synthesized. Investigation of its emissions at varying wavelengths revealed that it had three emission bands of normal (N⁎), anionic (A⁎) and tautomeric (T⁎), in ultr...

The modulation of photophysical behaviour of small organic molecules in the presence of macrocycles is one of the most interesting areas of research. In this work we reported the interaction of two biologically active molecules 3-hydroxyflavone and 7-hydroxyflavone with macrocyclic host cucurbit...

The interactions of bio-active flavonoids, 7-hydroxyflavone (7HF) and 3-hydroxyflavone (3HF) with hen egg white lysozyme (HEWL) have been established using differential spectroscopic techniques along with the help of molecular docking method. The characteristic dual fluorescence of 3HF due to th...

3-hydroxyflavone (3HF) is a widely studied molecule that acts as a simplified prototype of biological, more complex flavonoids. Its solvation mechanism is still under investigation. Here we report a joint experimental and simulation study of the vibrational properties of 3HF in gas phase and in ...

Two 3-hydroxyflavone derivatives as one- and two-photon fluorescent chemosensors for cysteine (Cys) and homocysteine (Hcy) were synthesized. The recognition properties and mechanism of the chemosensors for Cys and Hcy were investigated systematically. The experiment results indicate that 3-hydro...

We report spectroscopic properties of 3-hydroxyflavone (3-HF) and 4′-N,N-dimethylamino-3-hydroxyflavone (DMA3HF) in acetonitrile and ethyl acetate at different temperatures in the range from 10 °C to about 67 °C. These compounds are characterized by excited-state intramolecular proton transfe...

Two types of the carbapenem key intermediates (4 and 6) have been efficiently synthesized from inexpensive (S)-ethyl lactate (7). Thus, (S)-2-benzyloxypropanal readily obtainable from 7 was condensed with di-p-anisylmethylamine to give the chiral imine. The [2+2]-cycloaddition reaction of dikete...

Formation of ubiquinone precursors, polyprenylpyrophosphate, and 3-polyprenyl-4-hydroxybenzoic acid is greatly inhibited by bacitracin. The antibiotic prevents the transfer of polyprenylpyrophosphate to p-hydroxybenzoic acid in rat liver mitochondria and in cell-free extracts of Rhodospirillum r...

Polyprenylpyrophosphate: 4-hydroxybenzoate-polyprenyltransferase activity is highest in aerobically grown yeast cells and lowest in anaerobically grown cells. Its production is subject to catabolite repression in aerobic cells and the increase in its activity in anaerobic cells undergoing respir...

Transcription factor (TF) genes play a critical role in plant abiotic and biotic stress responses. In this study, we cloned a poplar TF NAC13 gene (Potri.001G404100.1), which is significantly up-regulated to salt stress. Then we developed gene overexpression and antisense suppression constructio...

A general method for the synthesis of the mitotic kinesin Eg5 inhibitor HR22C16 1 and its analogues based on protecting group (PG)-modulated highly diastereoselective Pictet–Spengler reaction of l-tryptophan methyl ester hydrochloride with meta-(RO)-benzaldehyde is described. By using the enant...

A series of new BODIPYs/aza-BODIPYs with a methylthio group were Herein prepared. Introduction of the electron-donating methylthio substituent into such dyes could reduce the fluorescence quantum yield, red-shift its emission spectra, provide higher extinction coefficients and larger Stokes'...

Internal rotations of pyridine fragment around single bond of isomeric 5-(2′, 3′ and 4′-pyridyl)-1,3,4-oxadiazol-2-thiones and 2-methylthio-5-(2′, 3′ and 4′-pyridyl)-1,3,4-oxadiazoles have been performed by DFT (B3LYP) and MP2 methods with RHF/6-31G(d,p) basis set. It was found that the MP...

Organometallic molybdenum compounds bearing poly[(methylthio)methyl]borates, [(η3-C3H5)Mo(CO)2(κ3-PhTt)] and [Bu4N][{(η3-C3H5)Mo(CO)2Cl}2(κ2:κ2-RTt)], where PhTt = phenyltris[(methylthio)methyl]borate and RTt = tetrakis[(methylthio)methyl]borate, have been obtained by ligand exchange reacti...

Pictet–Spengler condensation of 2-(aryl)-2-(1H-pyrrol-2-yl)ethanamines using conventional acid catalysts like TMSCl or TFA resulted in the formation of substituted 5-azaindoles involving a tandem one pot four steps reaction sequence. By contrast use of glacial acetic acid furnished the targeted...

Strophasterols E (1) and F (2) were isolated from the fruiting bodies of Pleurotus eryngii, together with four new ergostane-type sterols (3–6). Single-crystal X-ray diffraction analysis performed on the tris-p-bromobenzoate derivatives of compounds 1 and 2 allowed these two compounds to be ide...

Alfalfa and other seed sprouts have been implicated in several Escherichia coli O157:H7 and Salmonella spp. human illness outbreaks in the U.S. Continuing food safety issues with alfalfa seeds necessitate the need for discovery and use of novel and effective antimicrobials. The potential use of ...

The Differential Scanning Calorimetry (DSC) technique is used for measuring isobaric (vapour + liquid) equilibria for two binary mixtures: {monocaprylin + palmitic acid (system 1) or methyl stearate (system 2)} at two different pressures P = (1.20 and 2.50) kPa. The obtained PTx data are correla...