When α,α-dibromomethyl ketones are treated with sodium thiolates only the α-monosulfenylated ketones are formed. Evidence is put forward that the reaction mechanism proceeds by an initial nucleophilic substitution of one bromo atom and reduction by single electron transfer (SET) - hydrogen at...

A new series of thirty-six dihydroxylated 2,6-diphenyl-4-aryl pyridines containing hydroxyl groups at the ortho, meta, or para position of 2- and 6-phenyl rings attached to the central pyridine were designed and synthesized. They were evaluated for topoisomerase I and II inhibitory activity and ...

Four coordination polymers, {[Co2(4-DPSS)4(DMF)4](ClO4)4}n (1), {[Mn2(4-DPSS)4(DMF)4](ClO4)4}n (2), {[Co(4-DPSS)2(H2O)(NO3)]NO3·3H2O}n (3) and [Co(4-DPSS)2(NCS)2]n (4) have been synthesized to study the reactivity of cobalt(II) and manganese(II) salts (perchlorate, thiocyanate and nitrate) with...

Different rhodium(I)/(III) diphenyl-2-pyridylphosphine complexes were isolated and successfully characterized. The [Rh(acac)(CO)(DPP)] (DPP = diphenyl-2-pyridylphosphine) complex crystallizes in the P1¯ space group with four molecules per unit cell. The results clearly show that the differences...

Hydrogen sulfide (H2S) is a colorless toxic gas which can be found as HS− in rivers and waste waters especially in the occupational susceptible environment. Herein we synthesized a lophine analogue, 2-(4-hydroxyphenyl)-4,5-di(2-pyridyl)imidazole (HPI), which fluoresces at 410 nm after excitation...

Uranyl complexes containing diphenyl(2-pyridyl)phosphine oxide, with the formulae [UO2(NO3)2({C6H5}2POC5H4N)2] (1) and [UO2(DBM)2({C6H5}2POC5H4N)] (2) (where DBM = C6H5COCHCOC6H5), were prepared and characterized by IR, NMR spectroscopic and elemental analysis methods. The structures of the comp...

We report a combined experimental and computational investigation on the structure and photophysics of 4-[(4-pyridinylmethylene)amino]-benzoic acid, a functional molecule bearing two anchoring groups for attachment onto a TiO2 surface and perovskite surface, for potential solar cell application....

As a part of our investigations on weak interactions involving organic fluorine, we have analyzed two representative compounds, (4-chlorophenyl)-(4-fluorophenyl)-(4-pyridyl) methanol and bis-(4-fluorophenyl)-(4-pyridyl) methanol. In these structures the molecules are linked by strong O–H⋯N hydr...

Background. The methyl-branched free fatty acid analog 15-(p-iodophenyl)-9-(R,S)-methylpentadecanoic acid (9MPA) is metabolized more rapidly than 15-(p-iodophenyl)-3(β)-(R,S)-methylpentadecanoic acid. This study investigates whether myocardial ischemic injury to β-oxidation and viable myocardi...

A major challenge associated with the oral delivery of anti-hypertensive drugs is their poor water solubility and low oral bioavailability. Carvedilol (CAR), a potential beta-blocker is hydrophobic drug that exhibit limited therapeutic effect through oral conventional drug delivery systems. For ...

Self-(micro)emulsifying drug delivery systems (S(M)EDDS) have emerged as effective vehicles for enhancing bioavailability of poorly water soluble drugs, however solidification of the systems represents a major challenge. Objective of this study was development of carvedilol loaded liquid SMEDDS ...

ObjectiveDeterioration in ventricular function is often observed in patients treated with anthracyclines for cancer. There is a paucity of evidence on interventions that might provide cardio-protection. We investigated whether prophylactic use of carvedilol can prevent doxorubicin-induced cardio...

Silicosis is a well acknowledged occupational lung disorder with considerable negative impact on the patients' quality of life. Various signaling pathways have been reported to interplay in the pathogenesis of pulmonary fibro-proliferative disorders; of which, P-AKT/mTOR signaling pathway. ...

After acute myocardial infarction (AMI), reactive oxygen species and oxidative stress have important roles in the progression to heart failure. As a therapeutic alternative, thyroid hormones (TH) revealed cardioprotective effects after AMI, including decreasing oxidative stress. Carvedilol beta-...

The inhibition of transient outward potassium current (Ito) is the major ionic mechanism for quinidine to treat Brugada syndrome; however, quinidine is inaccessible in many countries. The present study compared the inhibitory effect of the nonselective β-adrenergic blocker carvedilol with quini...

The present work is aimed towards designing advanced materials by means of sustainable processes. In that sense, the utilization of supercritical CO2 (scCO2) for processing of pharmaceutical polymers (Soluplus®, Eudragit®, and hydroxypropyl methylcellulose acetate succinate), alone and with an a...

Carvedilol, a third generation beta blocker, is in clinical use for heart failure patients. However, besides adrenergic receptor blockade, the pharmacological effects of carvedilol on cardiomyocytes remain unknown. AMP-activated protein kinase (AMPK) is an emerging target recognized for heart fa...

Previous studies indicated that one of the action targets of carvedilol is the voltage-gated potassium (Kv) channel, which has a fundamental role in the control of electrical properties in excitable cells. It is not clear whether this compound exerts any actions specifically on delayed rectifier...

There is increasing support for the potential clinical use of compounds that interact with serotonin 2A (5-HT2A) receptors. It is therefore of interest to discover novel compounds that interact with 5-HT2A receptors. In the present study, we used computational chemistry to identify critical liga...

Utilizing 2-vinylthiophene as the starting material, the thienyl-containing aza-BODIPY 1 was successfully prepared. Aza-BODIPY 1 absorbs at 760 nm and emits at 782 nm in CHCl3 in NIR region. Aza-BODIPY 1 as a NIR turn-off chemosensor was highly selective to Hg2+. The fluorescence quenching is du...