Plasma quinolone concentrations are not routinely measured in clinical practice. However, in order to optimize quinolone treatment, monitoring of plasma concentrations could sometimes be useful particularly in critically ill patients. In this study, anti-sparfloxacin antibody was obtained by imm...
The cobalt(II) complexes with the quinolone sparfloxacin (Hsf) in the absence or presence of the nitrogen-donor heterocyclic ligands 2,2′-bipyridine (bipy), 1,10-phenanthroline (phen) or 2,2′-bipyridylamine (bipyam) were prepared and characterized physicochemically and spectroscopically. The c...
Water-soluble CdSe/CdS quantum dots (QDs) modified with thioglycolic acid (TGA) were synthesized. A novel method for determination of sparfloxacin (SPFX) has been developed based on quenching of the fluorescence of QDs at 556 nm wavelength. The optimum fluorescence intensity was found in 0.067 m...
BackgroundFluoroquinolones are a group of broad spectrum bactericidal antibiotics used to treat various infections of urinary and respiratory systems, as well as in ophthalmology and dermatology. This class of antibiotics causes toxic effects directed to pigmented tissues, what introduces a seri...
To create more active adsorption sites on biochar, the Fe3O4/GO/citrus peel-derived magnetic bio-nanocomposite (mGOCP) with hierarchically porous architectures was synthesized by a facile one-pot hydrothermal approach for efficient removal of fluoroquinolone antibiotics ciprofloxacin (CIP) and s...
We synthesized two derivatives of sparfloxacin (HSf): aminomethyl(diphenyl)phosphine (PSf) and its oxide (OPSf). The compounds were characterized by NMR spectroscopy, MS and elemental analysis. In addition, the molecular structures of the compounds were determined using DFT and X-ray (OPSf) anal...
New diorganotin(IV) derivatives of sparfloxacin having general formula R2SnCl(L), (where L = monoanion of sparfloxacin (HL) and R = n-Bu (1)/Ph (2)) have been synthesized and structurally characterized by elemental analysis, IR, NMR (1H, 13C, 119Sn), HMQC, ESI-MS, UV–Vis and emission spectrosco...
Sparfloxacin is a third generation, broad spectrum fluoroquinolone antibiotic. Its main advantages over older fluoroquinolones are improved activity against gram-positive pathogens and a long half-life that allows for once a day dosing. In comparison to other fluoroquinolones, sparfloxacin has e...
20(R)-25-methoxyl-dammarane-3β,12β,20-triol (AD-1, CN Patent: 201010107476.7) is a novel derivative of dammarane-type ginsenoside. AD-1 has been shown to inhibit cancer cell proliferation without significant host toxicity in vivo, and has excellent development potential as a new anti-cancer ag...
As an irreparable brain disease, Alzheimer's disease (AD) seriously impairs human thinking and memory. The accurate diagnosis of AD plays an important role in the treatment of patients. Many machine learning methods have been widely used in classification of AD and its early stage. An incre...
The rapid spread of ad blockers potentially threatens the sustainability of the hitherto dominant business model of ad-supported websites, in which users get web content free in return for allowing themselves to be exposed to advertising. Focusing on the users’ perspective, this study proposes ...
Despite the large body of research that has investigated the effect of ad appeals of television advertisements on consumers' internal responses and behavior, our understanding of how different ad appeals are processed remains limited. Complementing existing literature with novel insights fr...
BackgroundNoise is one of the most important environmental health hazards for humans. Environmental noise or apolipoprotein ε4 (ApoE4) can cause typical Alzheimer's disease (AD)-like pathological changes, which is characterized by progressive cognitive decline and neurodegenerative lesions...
Modern tactical operations have complex communication and computing requirements that cannot be supported by today’s mobile ad hoc networks. The emerging Software Defined Networking (SDN) paradigm has the potential to enable the redesign and successful deployment of these systems. An SDN-based ...
Recent developments have shown that entity-based models that rely on information from the knowledge graph can improve document retrieval performance. However, given the non-transitive nature of relatedness between entities on the knowledge graph, the use of semantic relatedness measures can lead...
This study explores the effects of ad-task relevance and ad salience on ad avoidance. Through structural equation modeling (N = 555), significant effects of ad-task relevance and ad salience on ad avoidance were found, and these relationships were mediated by ad engagement and perceived goal imp...
Identified in 1993, APOE4 is the greatest genetic risk factor for Alzheimer’s disease (AD), increasing risk up to 15-fold compared to the common variant APOE3. Since the mid 1990’s, transgenic (Tg) mice have been developed to model AD pathology and progression, primarily via expression of the ...
Does a timer—displayed during an in-stream commercial to show viewers how long they need to wait—help relieve the ad irritation that viewers experience when they have to wait for a video to play? Likewise, does the skip-ad button that allows viewers to skip an ad after several seconds help les...
3-(4-hydroxy-3,5-dimethoxyphenyl)-Propanal (dihydrosinapic aldehyde) has been isolated from the sapwood of Sorbus aucuparia in a yield of 2 × 10−4%. Its structure has been elucidated spectroscopically.
A recently developed column packing material, 3-morpholinopropylsilyl-modified silica gel (MPS), was succesfully applied to the separation of many kinds of sugars (rhamnose, xylose, arabitol, glucose, mannose, maltose, melibiose, raffinose and maltotriose) and the determination of glucose or/and...
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