A novel drug delivery system, loaded the drug cephalexin on the basil seed mucilage coated magnetic nanoparticles (Fe3O4@BSM-CPX) was prepared and characterized by means of X-ray diffraction (XRD), Furier Transform Infrared (FTIR), Field Emission Scanning Electron Microscope (FESEM), Vibrating S...

Developing of new antibiotics with synergistic properties is of great importance. Herein, the synthesis of cephalexin nanoparticles (CPNPs) is reported through ball milling method for the first time. Cephalexin powders had an initial size in the range of 10–100 μm. The average particle size, h...

In this study, a newly-designed Z-scheme g-C3N4@ZnO heterostructure was synthesized by 3D ZnO controllable deposition on 2D g-C3N4 nanosheets using thermal atomic layer deposition. The activity of 2D/3D g-C3N4@ZnO was evaluated by photocatalytic degradation of cephalexin under simulated sunlight...

Effects of Fe3O4 NPs heterogeneous Fenton-like pretreatment on the physicochemical properties and microbial community structure of anaerobic granular sludge (AGS) and activated sludge (AS) with cephalexin were investigated. Results showed that the average removal rate of chemical oxygen demand (...

Polymer-metal nanocomposites have recently been employed for various analytical and biomedical applications. In this study, a highly stable silver nanoparticles (AgNPs) conjugated with four arm poly(ethylene oxide‑block‑caprolactone), P(EO-b-CL), were synthesized using two-phase one-pot protocol...

Cephalexin is extensively used as an antibiotic for treatment a number of bacterial infections. The data of possible adsorption mechanism and isotherm of Cephalexin on the synthesized adsorbent are depicted in this data article. The data obtained showed that the adsorption trend follows the pseu...

An optosensor based on the fluorescence quenching of two different nanocomposite fluorescence probes was developed for simultaneous detection of cephalexin and ceftriaxone. The nanocomposite fluorescence probes were synthesized by incorporating graphene quantum dots (GQDs) and cadmium telluride ...

Due to their ability to treat infections, antibiotics are being used in large quantities for human, animals and plants. Although they treat diseases well, they pose serious environmental risk as a result of non-consumption of a large fraction in metabolism. These unmodified antibiotics have been...

An ultra-high-performance liquid chromatography-tandem mass spectrometry method was developed to analyze cephalexin in swine tissues, urine, and feces. Samples were extracted with 1% sulfuric acid, followed by purification using MCX cartridges. Mean recoveries were 95.4%–100.7% with inter-day r...

In this study, optimized cephalexin-loaded niosomal formulations based on span 60 and tween 60 were prepared as a promising drug carrier system. The niosomal formulations were characterized using a series of techniques such as scanning electron microscopy, Fourier transformed infrared spectrosco...

Obesity is a chronic disease of multiple etiologies, including genetic, metabolic, environmental, social, and other factors. Pharmaceutical strategies in the treatment of obesity include drugs that regulate food intake, thermo genesis, fat absorption, and fat metabolism. Fenproporex is the secon...

BackgroundAllergic rhinitis afflicts more than 40 million people in the United States and is a leading cause of reduced productivity at work and in school. Patients with allergic rhinitis have a wide range of symptoms that are often treated with oral combination products that contain antihistami...

BackgroundClemastine (1 mg) is currently available over-the-counter for the treatment of allergic rhinitis.

Human ether-à-go-go-related gene (HERG) encodes the α-subunit of channels carrying the cardiac rapid delayed K+ current (IKr), which is a major determinant of the duration of ventricular action potentials (APs) and of the QT interval. This study investigated the effects on HERG channel current...

A highly sensitive high-performance liquid chromatographic-tandem mass spectrometric method (HPLC–MS–MS) has been developed to quantitate clemastine in human plasma for the purpose of pharmacokinetic studies. Sample preparation was carried out by liquid–liquid extraction using deuterated clem...

A sensitive high-performance liquid chromatography–tandem mass spectrometry (LC/MS/MS) method was developed and validated for the determination of clemastine in human plasma. After having been extracted from plasma samples by ethyl acetate, clemastine and internal standard, diphenhydramine, wer...

A method for the quantitative determination of clemastine in human plasma has been developed and validated. The assay uses gas chromatography with nitrogen–phosphorus detection and a HP-1 capillary column (25 m×0.22 mm, film thickness 0.33 mm) coated with dimethylpolysiloxane. Clemastine (with...

A simple and sensitive spectrophotometric method has been established for the determination of clemastine hydrogen fumarate (I), desloratadine (II), losartan potassium(III) and moxepril HCl(IV) based on binary complex formation with eosin. The method does not involve solvent extraction through t...

SummaryBackgroundMultiple sclerosis is a degenerative inflammatory disease of the CNS characterised by immune-mediated destruction of myelin and progressive neuroaxonal loss. Myelin in the CNS is a specialised extension of the oligodendrocyte plasma membrane and clemastine fumarate can stimulate...

We report a sensitive and specific method for the determination of butriptyline concentrations in serum by gas-liquid chromatography with a nitrogen phosphorus detector. The detection limit is 2 ng/ml, based on 3 ml of serum or plasma. The method has been validated in human volunteers receiving ...