Krypton-81m, a radionuclide emitting a 190 kev gamma ray, has a half-life of 13 seconds. It is a radioisotope of an inert water-soluble noble gas and is produced at a constant rate by spontaneous decay of rubidium-81 in an 81Rb-81mKr generator-delivery system. Delivery is through a minibore Tefl...

Fifteen patients with frequent anginal chest pain underwent diagnostic cardiac catheterization. After coronary arteriography a specially designed cardiac catheter was seated in the aortic root, permitting the continuous infusion of krypton-81m into the right and left aortic sinuses. A gamma came...

Study of the effects of various diseases and therapeutic manipulation of pulmonary vascular resistance on the right ventricle has been restricted by methodologic limitations. The radioactive gas in solution, krypton-81m was used to study the right ventricle and the technique was compared with a ...

Pacing-induced changes in regional coronary flow were studied continuously with krypton-81m by intracoronary infusion in 25 patients: 21 with 50% or greater diameter narrowing of 1 or more left coronary arteries (group I) and 4 with less than 50% diameter reduction of a left coronary artery (gro...

Rationale and ObjectiveCoregistered SPECT and CT imaging (SPECT-CT) has potential for more precise evaluation of regional pulmonary function and may be useful for prediction of postoperative lung function in non−small cell lung cancer (NSCLC) patients. The purpose of the present study was to pro...

Fifteen patients with intractable angina pectoris underwent coronary angiography and coronary arterial bypass graft surgery. After the operation, a continuous infusion of krypton-81m was delivered into each graft. A gamma camera and multichannel analyzer were used to record the regional myocardi...

A fully automated system was developed to produce rubidium-81 (81Rb), based on the natKr (p, n) 81Rb reaction. The energy incident on the target was 26 MeV. Only 6 MeV was stopped inside the gas and the remainder was stopped by a specially designed flange. The target body was characterized by it...

(Z)-7-(3,5-Di-tert-butyl-6-oxocyclohexa-2,4-dien-1-ylidene)-1,3-dimethyl-3a,9a-diphenyl-1,3a,4,9a-tetrahydroimidazo[4,5-e]thiazolo[2,3-c][1,2,4]triazine-2,8(3H,7H)-dione was obtained by aldol condensation of 3,5-di-tert-butyl-1,2-benzoquinone with 1,3-dimethyl-3a,9a-diphenyl-3,3a,9,9a-tetrahydro...

N-Substituted 2-amino-4-pentenoic acid derivatives employed for the protection of racemic amino acids were shown to be capable of permitting the chromatographic separation of R and S isomers. When Nα was disubstituted with benzyl and phenylfluorenyl groups, the racemic amino acids could be sepa...

The studies on the enzymatic kinetic resolution of 3-phenyl-4-pentenoic acid with various trialkyl orthoesters as alkoxy group donors are presented. The obtained results indicate that enantioselectivity of presented reaction is closely related to the alkoxy group donor structure. Based on critic...

We synthesized [11C]sulpiride as a positron emission tomography probe for investigating the drug distribution in the human body. [11C]Sulpiride was injected to healthy male subjects in either tracer dose of [11C]sulpiride (approximately 222 MBq) or with therapeutic dose of sulpiride (500 mg, per...

Twenty-three seasonally anovulatory mares, housed at two separate farms, were treated with 50 mg of estradiol cypionate (ECP) and 3 g of sulpiride in January to study factors that contributed to success of the treatment (response = ovulation within 28 days). Every other day, blood samples and pr...

Sixteen estrous cycles from 10 cyclic mares were randomly assigned to a control or sulpiride group (n = 8 each). All mares received 1,500 IU of human chorionic gonadotropin (hCG) (hour 0) during estrus with a follicular diameter ≥32 mm. Mares were scanned every 12 hours until ovulation. In the ...

Dopaminergic drugs, such as those used to treat pituitary pars intermedia dysfunction (PPID) in horses, have been shown to improve insulin sensitivity in other species. It has been suggested that pergolide, used to treat PPID, may enhance insulin sensitivity in resistant horses, although evidenc...

This experiment assessed the hormonal production, secretory aspects, and changes in luteinizing hormone (LH) receptor gene expression of early induced ovulatory-sized follicles relative to the first ovulatory-sized follicles occurring naturally in the spring. Anovulatory mares were treated on Ja...

The present study aimed to develop microemulsion (ME) formulae for nasal delivery of sulpiride with high drug concentration to overcome sulpiride low oral bioavailability. Different oils, surfactants (S) and co-surfactants (CoS) were screened for the highest sulpiride solubilizing capacity. Glyc...

The aim of this study was to verify the effect of deslorelin and sulpiride association on double ovulation induction in mares. Ten mares were used for this study. Eight days after ovulation, luteolysis was induced and mares were submitted a daily ultrasonographic evaluation until observation of ...

Four experiments assessed factors affecting prolactin responses to sulpiride administration in horses. Experiment 1 compared the efficacy of the (−) enantiomer of sulpiride to that of the commonly used (+/−) racemic mixture. Mares were used in an 8 × 8 Latin square to compare the prolactin resp...

New polyaza ferrocene macrocyclic ligands 4–7 have been synthesised and with 4, copper(II) and nickel(II) transition metal complexes isolated. Electrochemical investigations reveal these redox-active ligands can electrochemically sense various transition metal cations in polar organic solvents ...

We have studied the protonation equilibria of a dicopper(II) complex [Cu2(μ-OH)(C21H33ON6)](ClO4)2·H2O, (1), in aqueous solution, its interactions with DNA, its cytotoxic activity, and its uptake in tumoral cells. C21H33ON6 corresponds to the ligand 4-methyl-2,6-bis[(6-methyl-1,4-diazepan-6-yl...