It has been demonstrated that hyperproduction of nitric oxide (NO) plays a major role in the vasodilatation of cirrhosis; thus, the vasodilatation might be reversed by an inhibition of NO production. Experimental studies in isolated aortic rings showed that naftazone inhibits the effects of NO p...

In the present study, the potential involvement of lipid peroxidation and disruption of lysosomal integrity in the pathogenesis of different experimental models of inflammation was examined. The chosen models were carrageenan-induced paw oedema, carrageenan granuloma pouch (acute phase) and Freu...

The fungus Mucor plumbeus catalyzes the enzymatic cyclization of Naftazone to naphtho-(1,2-e)-(1,2,4)-triazine-(3H)-one. This compound inhibits the induction and the activity of NO synthase by activated murine peritoneal macrophages.

It is well known that an excessive release of glutamate in the mammalian brain plays a major role in several neurological diseases. Naftazone (Etioven®) is a currently used vasoprotectant drug that is metabolized in humans by reduction and glucuronidation. In the present study naftazone was foun...

A chromatographic method involving a single run was validated for the quantification of clanobutin, dichlorvos, and naftazone in products of animal origin. Pork, beef, chicken, milk, and egg samples were extracted with a solution of 0.1% formic acid in acetonitrile, defatted with n-hexane, centr...

IntroductionThere is an unmet need to better control motor complications in Parkinson's disease (PD). Naftazone, which exhibits glutamate release inhibition properties, has shown antiparkinsonian and antidyskinetic activity in preclinical models of PD and in a clinical proof of concept study.

NiFe2O4/activated carbon magnetic composite (NiAC) was produced by hydrothermal method, characterized and applied to adsorb the emerging contaminants ibuprofen and ketoprofen from diluted solutions. The study of the adsorption process was focused on the evaluation of pH effect, kinetic behavior,...

Ibuprofen (IBP), a widely used anti-inflammatory drug, has been detected in many rivers and lake waters. This study was aimed to degrade the ibuprofen from synthetic wastewater by using UV-LED/catalytic and UV-LED/oxidants advanced oxidation process. The degradation of IBP was investigated with ...

The goals of this work were to prepare and characterize two functional materials, a natural montmorillonite (Mt) and a synthetic mica (Na-mica-4) were modified with the cationic octadecylamine by a cation-exchange reaction between obtained C18-Mt and C18-mica-4, and to explore their potential us...

BackgroundAcute mountain sickness is a common occurrence for travel to high altitudes. Although previous studies of ibuprofen have shown efficacy for the prevention of acute mountain sickness, recommendations have been limited, as ibuprofen has not been compared directly with acetazolamide until...

ObjectivesThe aim was to investigate if offering symptomatic therapy (Uva-ursi or ibuprofen) alongside a delayed prescription would relieve symptoms and reduce the consumption of antibiotics for adult women presenting with acute uncomplicated urinary tract infection (UTI).

Pharmaceuticals are often discharged into the environment and later detected in drinking water, plants, and soil. Thus, the decomposition or biodegradability of these compounds is a constant concern. The objective of this work was to show the decomposition of pharmaceutical ionic liquids (IL-API...

Drug repurposing arises as an interesting alternative to overcome the limited efficacy of current available antibiotics by reducing time, cost and risk associated with drug innovation. In this study, the activity of ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), was evaluated on the ...

ObjectiveThe aim of this animal study was to investigate the short and long-term local histomorphologic effects and the utility of intra-articular application of ibuprofen.

Human serum albumin (HSA) is the binding cargo in blood plasma. The binding of drugs to HSA determines the pharmacokinetics and pharmacodynamics of the drugs. There are 67 natural genetic variants of HSA were reported in literature. Studying the effect of albumin modifications on drug binding he...

The ability of bean husk, an agricultural waste, as a promising adsorbent for sequestering Ibuprofen from aqueous solution was investigated. Bean husk waste was modified using ortho-phosphoric acid. The prepared adsorbent was further characterized using FTIR, SEM, EDX and pHpzc techniques respec...

Embutramide is a general anesthetic having a strong narcotic effect on the central nervous system where it paralyzes the brain center that controls respiration. It is a constituent of T61, a veterinary euthanasia drug. This paper describes a gas chromatographic procedure using nitrogen—phosphor...

The results of a Raman and an i.r. investigation show that the tetrabamate molecule is formed by the hydrogen bonded constituants phenobarbital, febarbamate. Detailed spectroscopic results are given on these four molecules.

Drug hepatotoxicity is partially determined by genetic factors involved in drug metabolism, which may involve the debrisoquine oxidation polymorphism mediated by cytochrome (CYP) 2D6. The purpose of this study was to assess the relationship between drug hepatotoxicity and another genetic polymor...

Propiram bioavailability was determined in 10 healthy volunteers after a single oral administration of 50 mg (base equivalent) of propiram fumarate in tablet or solution dosage form in a randomized crossover design. The plasma drug concentration-time curve revealed a one-compartment open model w...