The conformationally flexible title compounds were prepared and subjected to reduction with sodium borodeuteride. Deuteride ion attacks exclusively from the side opposite of the anomeric methoxyl group. However, the stereoselectivity of a similar reduction of the corresponding 4,6-O-benzylidene-...

In this study, the 2–ethoxythiazole molecule (C5H7NSO) which is a member of the five−membered heterocyles with one nitrogen atom group has been investigated by using the experimental UV–vis (in three different solvents) and FT−IR spectral results as well as some magnetic properties. Furthermor...

Thiazole is a valuable scaffold in the field of medicinal chemistry and has accounted to display a variety of biological activities. Thiazole and its derivatives have attracted continuing interest to design various novel CNS active agents. In the past few decades, thiazoles have been widely used...

Green corrosion inhibitors are of great benefit to the protection of pipes or tanks in seawater systems. The properties of the corrosion inhibitor such as toxicity and anticorrosion performance are closely related to its molecular structure. Some thiazole derivatives are commonly known as food f...

As part of our medicinal chemistry program’s ongoing search for compounds with antimalarial activity, we prepared a series of thiazole analogs and conducted a SAR study analyzing their in vitro activities against the chloroquine-sensitive Plasmodium falciparum 3D7 strain. The results indicate t...

Dehydrogenative alkenylation of imidazo[2,1-b]thiazoles via palladium(II)-catalyzed site-selective CH bond activation has been developed in moderate to good yields under aerobic conditions. This methodology provides a very efficient, direct, and atomeconomical strategies to construct an alkenyl-...

AbsractHuman 5-Lipoxygenase (5-LOX) is a key enzyme targeted for asthma and inflammation. Zileuton, the only drug against 5-LOX, was withdrawn from the market due to several problems. In the present study, the performance of rationally designed conjugates of thiazole (2) and thiourea (3) scaffol...

In the present study, ethyl-2-(2-(2-methylbenzylidene)hydrazinyl)thiazole-4-carboxylate (1) and ethyl-2-(2-(4-bromobenzylidene)hydrazinyl)thiazole-4-carboxylate (2) were synthesized. The characterization of synthesized compounds was accomplished by employing analytical techniques of spectroscopy...

The dormant and resistant form of Mycobacterium tuberculosis presents a challenge in developing new anti-tubercular drugs. Herein, we report the synthesis and evaluation of trisubstituted thiazoles as antituberculosis agents. The SAR study has identified a requirement of hydrophobic substituent ...

A metal-free and highly atom-economic synthesis of thiazole-substituted α-hydroxy carbonyl compounds has been developed. Catalyzed by 5 mol% of p-toluenesulfonic acid (TsOH), a variety of thiazole-substituted α-hydroxy carbonyl compounds were obtained in moderate to good yields via 1,3-dipolar...

To develop agents for the treatment of infections caused by Mycobacterium tuberculosis, a novel phenotypic screen was undertaken that identified a series of 2-N-aryl thiazole-based inhibitors of intracellular Mycobacterium tuberculosis. Analogs were optimized to improve potency against an attenu...

In the present study a series of 4-isopropylthiazole-2-carbohydrazide analogs, derived clubbed oxadiazole–thiazole and triazole–thiazole derivatives have been synthesized and characterized by IR, 1H NMR, 13C NMR, elemental and mass spectral analyses. The synthesized compounds were evaluated fo...

In the present study a series of 2-substituted-5-[isopropylthiazole] clubbed 1,2,4-triazole and 1,3,4-oxadiazole derivatives have been synthesized and characterized by IR, 1H NMR, 13C NMR and mass spectral analysis. Synthesized compounds were evaluated for their preliminary cytotoxicity, antimic...

A series of novel molecules containing thiazole ring structure were designed and synthesized. The structures of the synthesized compounds were elucidated and confirmed by 1H NMR, 13C NMR, Mass spectrum and the purity was checked through HPLC analysis. Among these synthesized compounds, 3a–3i an...

Two new analogues of a popular host material, meta-bis(N-carbazolyl)phenylene (mCP), bearing either methoxy- (mCP-OMe) or tert-butyl (mCP-t-Bu) substituents at C-3 and C-6 positions of carbazole moieties were synthesized and characterized. These materials exhibit higher glass-transition temperat...

A direct and convenient metal-free method to prepare sulfonyl amidines in the presence of aqueous tert-butyl hydroperoxide (T-HYDRO) has been developed. Different tertiary and secondary amines were tested for compatibility with the oxidative conditions and could be coupled with sulfonyl azides t...

Quenching with tert-butyl nitroso 2-lithio-4-tert-butyl toluene prepared by an exchange reaction with t-butyl-lithium, followed by acidic hydrolysis furnishes in good yields the corresponding aromatic hydroxylamine whose oxidation affords the nitroxide, N-(2-methyl-5-tert-butyl-phenyl)-N-tert-bu...

Isobaric vapor-liquid equilibria for the binary systems tert-butyl alcohol + water, and tert-butyl alcohol + 1-ethyl-3-methylimidazolium dicyanamide ([emim][DCA]), as well as the vapor-liquid equilibria for the tert-butyl alcohol + water + [emim][DCA] ternary system, have been obtained at 100 kP...

A ligand-free nickel-catalyzed Kumada cross-coupling of aryl bromides and tert-butyl Grignard reagents led to the formation of a series of tert-butyl aryls in moderate to good yields, excellent tBu/iBu ratios, and good functional group compatibility. A radical coupling process is indicated and a...

Background.The rubidium 81/krypton 81m method was suggested for assessment of myocardial blood flow (MBF) three decades ago. This study investigates the novel concept of using 81Rb-/81mKr-labeled coronary guide wires with wire-attached 81Rb activity and diffusable 81mKr gas for assessment of les...