A novel binuclear copper(II) complex [Cu2L(μ-SO4)](PF6)2 (1) (L = 3,5-bis (bis(pyridine-2-ylmethyl)amino)methyl)-4H-1,2,4-triazol-4-amine) has been synthesized and structurally characterized. X-ray structure shows that the two copper(II) atoms are bridged by one bidentate sulfate ion and the 1,...

Due to their aerobic lifestyle, eukaryotic organisms have evolved different strategies to overcome oxidative stress. The recruitment of some specific metalloenzymes such as superoxide dismutases (SODs) and catalases (CATs) is of great importance for eliminating harmful reactive oxygen species (h...

A series of hetero-dinuclear CuII–ZnII complexes, [CuZnCl2L1] (1), [CuZnCl2L2] (2), [CuZnBr2L3] (3), [CuZnBr2L4(DMF)] (4), [CuZnCl2L4] (5), [CuZnCl2L5] (6), [CuZnCl2L3] (7) and [CuZnBr2L1] (8), where L1, L2, L3, L4 and L5 are the deprotonated forms of N,N′-bis(3-ethoxysalicylidene)-1,3-propane...

In this work, guided by a pyridoxal derived Schiff base ligand, H2PydChda [5-Hydroxymethyl-4-({2-[5-hydroxymethyl-2-methylpyridin-3-hydroxy-4-ylethylene)-amino]-cyclohexylimino}-methyl)-2-methylpyridin-3-ol], a new copper(II) complex, [Cu(PydChda-2H+)]2·4ClO4·2H2O was constructed and structura...

Copper(II) complexes with diamino-diamido-type ligands were tested as catalysts of O2− dismutation. ESR spectra of these systems showed that, in consequence of the O2− interaction, all the bis complexes of formula [Cu(L)2H−2] (where L = L-valylamide, L-phenylalanylamide, L-prolylamide) transform...

Hydrolyses of lithium 2,4-dinitrophenyl ethyl phosphate (7) and 2,4-dinitrophenyl diethyl phosphate (8) catalyzed by copper(II)—triamine complexes (triamine = cis,cis-triaminocyclohexane (1), 1,5,9-triazacyclododecane (2), 1,4,7-triazacyclononane (3), dipropylenetriamine (4), N-(2-aminoethyl)-1...

Two dinuclear complexes, µ-phenoxo, µ1,1-azido bridged [Ni2(L)2(µ1,1-N3)(N3)(CH3OH)] (1) and µ-phenoxo, µ1,1-azido bridged [Cu2(L)2(µ1,1-N3)(N3)] (2) bearing HL as a blocking co-ligand produced by the 1:1 condensation of N-methyl 1,3 propanediamine with o-vanillin have been synthesized and...

In this paper we report the synthesis of the new multidentate N,O-donor ligand H3L_2pyald = (N,N′-bis-(2-pyridylmethyl)-(2-hydroxy-3-carbonyl-5-methylbenzyl)-1,3-propanediamine-2-ol) and its first trinuclear copper(II) complex, [Cu3(L_2pyald)(μ-OAc)](ClO4)2 (1). The structure of 1 was determin...

As an extension of previous methods for enantiomer analyses of diacylglycerols, a highly sensitive HPLC method was developed for the determination of the absolute configuration and optical purity of monoacylglycerols. Chiral derivatization by a fluorescent (S)-TBMB carboxylic acid followed by a ...

The reaction of n-butyllithium with 1,3-benzodioxole, 1,3-benzoxathiole, and their 2,2-dimethyl derivatives has been investigated. Except with 1,3- benzoxathiole there is competition between metalation and cleavage of the ether bond. Metalation occurs ortho to the oxygen, while cleavage gives su...

Carbon monoxide is a minor product formed during the cytochrome P-450-catalyzed oxidation of 1,3-benzodioxoles. Studies with [2-13C]methylene 1,3-benzodioxoles established that the methylenic carbon of the 1,3-benzodioxole ring is the source of the carbon atom in the carbon monoxide, and an isot...

Dialyzed supernatant from sonic-treated cells of a puromycin-producing strain of Streptomyces alboniger has been shown to catalyze the synthesis of two new amino pentose phosphates from d-ribose 5-phosphate and NH4+ at pH 7.5. The amino pentose phosphates, after isolation and separation by ion-e...

Mammalian tissue slices under anaerobic conditions utilized more ribose 5-phosphate than with oxygen due to greater leakage of the enzymes from the cell into the incubation medium. Apparently cytolysis is not the mechanism, for no obvious morphological differences were observed between cells inc...

Publisher SummaryThis chapter discusses the preparation and analysis of ribose-5-phosphate. Two methods of preparation of ribose-5-phosphate are presented in this chapter. One of these is based on the hydrolysis of adenylic acid; the other involves the esterification of free ribose with ATP in t...

Publisher SummaryThis chapter discusses the preparation of d-altro-heptulose (d-sedoheptulose) 7-phosphate. The important metabolite d-sedoheptulose (d-altro-heptulose) 7-phosphate has been prepared by biological and chemical procedures. In general, the biological syntheses are comparatively len...

The facile formation of glycosylamines suggests that a base liberated by depurination might react at the free C1 position of the sugar phosphate from which it had been hydrolyzed, effectively repurinating the site. Model experiments testing this hypothesis demonstrate that such a reaction does t...

Marine environments are an enormous source of materials with biological interest, such as sulphated polysaccharides, which have relevant biological activities. In this study the potential of salt pan brine water as an easily accessible source of sulphated polysaccharides was evaluated. This wate...

This paper reports the synthesis of new 4-phospho-d-erythronic acid derivatives, namely 4-phospho-d-erythronohydroxamic acid (1), 4-phospho-d-erythronohydrazide (2), and 4-phospho-d-erythronamide (3), and their kinetic evaluation as new competitive inhibitors of the isomerization reaction betwee...

4-deoxy-4-Phosphonomethyl-d-erythronate, an isosteric and hydrolytically stable analogue of the known ribose-5-phosphate isomerase inhibitor 4-deoxy-4-phospho-d-erythronate, was obtained by a 14-step synthesis from d-arabinose through an highly improved synthesis of the precursor 5-deoxy-5-phosp...

The crystal of the 1:1 complex of 3,3-dimethylbutylamine with cyclomaltoheptaose (βCD, β-cyclodextrin) is monoclinic C2 with a = 19.187(9), b = 24.56(1), c = 15.893(7) Å, β = 108.77(4)°, V = 7091 Å3, and Z = 4. Two βCD molecules, held together by intermolecular hydrogen bonds involving HO-3...