High molecular weight forms of adrenocorticotropin (ACTH) and endorphin were identified in extracts of guinea pig anterior and intermediate/posterior pituitary. Extracts of anterior pituitary contained ACTH immunoactive material with apparent molecular weights of 36,000, 24,000 and 4,500 daltons...

The present study was conducted to elucidate the effects of ACTH application during pregnancy on the female offsprings' endocrine status and behavior in a precocial animal, the guinea pig. We, therefore, studied daughters whose mothers were treated three times with either ACTH-depot or plac...

Analytical methods were developed and validated for the determination of enloplatin (an anticancer agent) in plasma by reversed-phase LC and for platinum (an elemental component of enloplatin) in plasma, plasma ultrafiltrate (PUF) and whole blood by flameless atomic absorption spectrometry (FAAS...

Interjectin, isolated from the rhizomes of H. interjecta and H. multiceps, is a diglucoside of a norlignan, nyasicol, plus an additional p-hydroxy cinnamoyl unit. The structure was correlated to that of tetramethylnyasicoside.

From the rhizome of Hypoxis nyasica a new monoglucoside, the 1-(3',4'-dihydroxyphenyl)-5-(3',4' -dihydroxyphenyl)-1-hydroxy-2-0-β -D-glucopyranoayl-pentan-4-yne named nyasicoside, was isolated and its structure elucidated by chemical and spectroscopic methods.

The (R) configuration at C-1 of nyasicoside and its derivatives was assigned by comparison of the Cotton effect with those of optically active phenylcarbinols, whereas the (S) configuration at C-2 was assigned by the application of the CD exciton chirality method for the diol bis p-bromobenzoates.

A stable high-temperature reaction site and the uniformity and speed of heating the feedstocks play a key role in pyrolysis processes. In this study, microwave-assisted heating coupled with atomization feeding was used to pyrolyze methyl ricinoleate (MR) for the efficient, continuous production ...

New sesquiterpene esters, triptofordins A, B, C-1 and C-2 have been isolated from the leaves ofTripterygium wilfordii Hook fil var.regelii and their structures established. The absolute structure of triptofordins B and C-1 were determined by using the CD dibenzoate chirality method.

The ability of acidic (AcW) and alkaline electrolyzed waters (AlW) to improve the flavour of persimmon (Diospyros kaki L.) wine was evaluated. Wines made with AcW (WAcW) were significantly better than wines made with AlW or pure water (PW) in aroma, taste, and colour. Volatile analysis showed th...

The relative ability of derivatives of 2-piperidinecarboxylic acid (2-PC; pipecolic acid) and 3-piperidinecarboxylic acid (3-PC; nipecotic acid) to block maximal electroshock (MES)-induced seizures, elevate the threshold for electroshock-induced seizures and be neurotoxic in mice was investigate...

(Z)-2-N-Acylamino-3-thienyl-acrylic acids and their esters were prepared by known procedures and hydrogenated to the corresponding optically active 2-N-acetyl(or benzoyl)-3-(2- or 3-thienyl)-alanines with optical yields up to 90% using the rhodium complexes of “PROPRAPHOS” 6a,b and O,N-bis(dip...

NMR spectral data of some (E)-α-phenyl-β-(2-thienyl) acrylic acids indicate that these compounds exist in the preferred s-trans conformation. In the case of (E)-α-phenyl-β-(2-furyl)acrylic acids and their methyl esters the presence of only s-cis rotamer has been established.

New derivatives of 5-aryl-2-[2-(2-furyl)ethenyl]-1,3,4-oxadiazoles and 5-aryl-2-[2-(2-thienyl)ethenyl]-1,3,4-oxadiazoles are synthesized in a stepwise procedure through intermediate acyclic N′-arylcarbonyl-N-[2-(2-heteroaryl)acryloyl]hydrazines, starting from 3-(2-heteroaryl)acrylic acid hydraz...

In this work, the molecular structures and vibrational spectral analyses of 3-(2-Theinyl)acrylic acid (3-2TAA) monomer and dimer structures have been reported by using density functional theory calculations at B3LYP/6-311++G(d,p) level of theory. The complete assignments of the fundamental vibra...

Oxyfedrine, a β-sympathomimetic drug, did not affect isolated rat and rabbit trachea in concentration from 2.86 × 10−8 to 2.86 × 10−4 M, but on the guinea-pig trachea, it caused a dose dependent relaxation of natural tone in lower concentrations (1.79 × 10−7 to 2.86 × 10−6 M. In higher conc...

The long-lasting sympathomimetic effects of oxyfedrine on the rat perfused heart, rat uterus and guinea-pig trachealis can be prevented or terminated by propranolol. Reserpine pretreatment did not affect the early peak cardiac responses or the responses of the other two tissues but abolished the...

Oxyfedrine, a new aminoketone of the phenylethylamine series, was studied in three cardiac preparations in the cat. Oxyfedrine (0.5 × 10−6 g/ml) exerted a positive inotropic effect while 5.0 × 10−5 g/ml exerted a negative inotropic effect in the cat papillary muscle preparation. Positive inotr...

1-3-methoxy-ω-(1-hydroxy-1-phenylisopropylamino)-propiophenone hydrochloride (oxyfedrine) (10−8–10−6 g/ml) produces a positive inotropic effect on electrically driven guinea-pig left atria which is prevented by propranolol; higher concentrations depress contractile force. Oxyfedrine (10−8–10−...

Oxyfedrine, 0.5 μg/ml, caused typical but long lasting sympathomimetic effects on guinea-pig atria and trachealis, rabbit atria and duodenum and rat uterus and perfused heart. These effects were antagonised by propranolol. The heart rate and blood pressure of the anaesthetised rat also showed s...

Quantitative determination of drugs by in situ spectrophotometry of chromatograms for pharmacokinetic studies. I. Sulpiride and other benzamides, vincamine, naftazone.Assays are proposed for sulpiride and other benzamides, vincamine and naftazone in plasma (or blood) and urine with direct UV ref...