Conditions | Yield |
---|---|
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; | 100% |
With thionyl chloride for 2h; Reflux; | 100% |
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 2h; Reflux; | 100% |
3-chlorophthalic anhydride
4-chlorotrichloromethylbenzene
A
3-chloro-phthaloyl dichloride
B
4-chloro-benzoyl chloride
Conditions | Yield |
---|---|
zirconium(IV) chloride at 160℃; for 16h; | A 61% B 95% |
phthalic anhydride
4-chlorotrichloromethylbenzene
A
4-chloro-benzoyl chloride
B
Phthaloyl dichloride
Conditions | Yield |
---|---|
zirconium(IV) chloride at 160℃; for 6h; | A 93% B 70% |
1-Chloro-4-iodobenzene
4-nitro-benzoyl chloride
A
p-nitrobenzene iodide
B
4-chloro-benzoyl chloride
Conditions | Yield |
---|---|
With (Xantphos)Pd(4-C6H4NO2)(I) In benzene at 90℃; for 20h; Sealed tube; Inert atmosphere; | A n/a B 93% |
Conditions | Yield |
---|---|
With phosphorus trichloride In acetonitrile at 80℃; for 3h; Schlenk technique; | 89% |
Conditions | Yield |
---|---|
Stage #1: oxalyl dichloride With aluminum (III) chloride In dichloromethane for 0.0833333h; Stage #2: chlorobenzene In dichloromethane at 20 - 25℃; for 1h; | 77.7% |
With aluminium trichloride; lithium perchlorate In nitromethane at 20℃; for 10h; | |
With aluminium trichloride In dichloromethane at 20℃; for 14h; chlorocarbonylation; Friedel-Crafts reaction; |
Conditions | Yield |
---|---|
With dioxochloro(trimethylsiloxy)chromate(VI) In 1,2-dichloro-ethane for 4.5h; Heating; Yields of byproduct given; | A 55% B n/a |
Conditions | Yield |
---|---|
Stage #1: 1-(pyridin-2-ylethynyl)-3-azabicyclo[3.1.0]hexane With triethylamine In tetrahydrofuran; N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: Cyclopentanecarboxylic acid chloride In tetrahydrofuran; N,N-dimethyl-formamide at 0 - 25℃; for 2h; | 18% |
Conditions | Yield |
---|---|
With chlorine; iron(III) chloride at 35℃; |
Conditions | Yield |
---|---|
With tetrachloromethane; tungsten(IV) oxide | |
With tetrachloromethane; tungsten(IV) oxide |
Conditions | Yield |
---|---|
With thionyl chloride at 240℃; |
1-(p-chlorobenzoyl)-3-methylimidazolium chloride
A
1-methyl-1H-imidazole
B
4-chloro-benzoyl chloride
Conditions | Yield |
---|---|
In dichloromethane at 25℃; Rate constant; Equilibrium constant; |
4-chloro-benzoyl chloride
Conditions | Yield |
---|---|
With water; iron(III) chloride at 100 - 120℃; |
Conditions | Yield |
---|---|
With benzene |
Conditions | Yield |
---|---|
With Petroleum ether |
1-methyl-4-nitrobenzene
phosphorus pentachloride
A
4-chloro-benzoyl chloride
B
4-nitro-benzoyl chloride
Conditions | Yield |
---|---|
at 180℃; Einleiten von Chlor; |
1-methyl-4-nitrobenzene
A
4-chloro-benzoyl chloride
B
4-nitro-benzoyl chloride
Conditions | Yield |
---|---|
at 180℃; Einleiten von Chlor; |
phosphorus pentachloride
4-dichlorophosphoryl-benzoyl chloride
A
4-chloro-benzoyl chloride
B
trichlorophosphate
C
phosphorus trichloride
Conditions | Yield |
---|---|
at 200℃; |
phosphorus pentachloride
4-dichlorophosphoryloxy-benzoyl chloride
A
4-chloro-benzoyl chloride
Conditions | Yield |
---|---|
at 170 - 180℃; |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: diluted permanganate 2: PCl5 View Scheme | |
Multi-step reaction with 2 steps 1: chlorine / 80 - 180 °C / Irradiation 2: iron(III) chloride; para-chlorobenzoic acid / melt / 100 - 110 °C View Scheme |
methyl 5-(4-aminobenzyl)-1-(4-tert-butoxycarbonylaminomethylphenyl)-2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-3-acetate
A
N-(2-fluorobenzyl)-1-(4-aminomethylphenyl)-5-[4-(4-chlorobenzoylamino)benzyl]-2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-3-acetamide hydrochloride
B
4-chloro-benzoyl chloride
Conditions | Yield |
---|---|
With FeCl3 In water | |
With sulfuric acid; acetic anhydride | |
With iron(III) chloride; para-chlorobenzoic acid In melt at 100 - 110℃; |
4-chloro-cyclohex-3-enecarbonyl chloride
4-chloro-benzoyl chloride
Conditions | Yield |
---|---|
With bromine |
Conditions | Yield |
---|---|
In water |
Conditions | Yield |
---|---|
In water |
2-(4,5-Dihydro-1,3-oxazol-2-yl)aniline
para-chlorobenzoic acid
4-chloro-benzoyl chloride
Conditions | Yield |
---|---|
With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide |
Conditions | Yield |
---|---|
With trichloroisocyanuric acid In dichloromethane at 20℃; for 120h; Inert atmosphere; | |
With tert.-butylhydroperoxide; N-chloro-succinimide; tris(2,2'-bipyridyl)ruthenium dichloride In acetonitrile at 20℃; for 24h; Sealed tube; Irradiation; | |
With trichloroisocyanuric acid In dichloromethane at 20℃; Inert atmosphere; |
Conditions | Yield |
---|---|
With trichloroisocyanuric acid In dichloromethane at 20℃; for 120h; Inert atmosphere; | |
With trichloroisocyanuric acid In dichloromethane at 20℃; Inert atmosphere; | |
With trichloroisocyanuric acid In dichloromethane at 20℃; Inert atmosphere; |
4-chloro-benzoyl chloride
anthranilic acid
N-(4-chlorobenzoyl)anthranilic acid
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 20℃; | 100% |
With triethylamine In dichloromethane at 0℃; | 95% |
With sodium hydroxide |
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; for 6h; | 100% |
With sodium carbonate In tert-butyl methyl ether; water at 15 - 25℃; for 1h; Schotten-Baumann Reaction; Inert atmosphere; | 98.7% |
In toluene at 50℃; | 90% |
4-chloro-benzoyl chloride
phenylhydrazine
2-(4-Chlorbenzoyl)-1-phenylhydrazid
Conditions | Yield |
---|---|
With pyridine In tetrahydrofuran at 5 - 20℃; for 2h; | 100% |
With pyridine for 20h; | 70% |
With pyridine |
silver trifluoromethanesulfonate
4-chloro-benzoyl chloride
4-Chlorbenzoesaeure-trifluormethansulfonsaeure-anhydrid
Conditions | Yield |
---|---|
100% | |
at 20℃; for 3h; | 90% |
Conditions | Yield |
---|---|
With triethylamine In benzene | 100% |
N-phenylsulfonylpyrrole
4-chloro-benzoyl chloride
(1-benzenesulfonyl-1H-pyrrol-3-yl)-(4-chlorophenyl)methanone
Conditions | Yield |
---|---|
With aluminium trichloride In dichloromethane for 0.5h; Ambient temperature; | 100% |
Stage #1: 4-chloro-benzoyl chloride With aluminum (III) chloride In 1,2-dichloro-ethane at 25℃; for 0.166667h; Inert atmosphere; Stage #2: N-phenylsulfonylpyrrole In 1,2-dichloro-ethane at 25℃; for 5h; Inert atmosphere; regioselective reaction; | 100% |
With aluminium trichloride In 1,2-dichloro-ethane at 25℃; for 1.5h; | 89% |
4-Aminobutanol
4-chloro-benzoyl chloride
4-chloro-N-(4-hydroxybutyl)benzamide
Conditions | Yield |
---|---|
With sodium hydroxide In chloroform; water for 0.75h; Cooling with ice; | 100% |
Stage #1: 4-chloro-benzoyl chloride With pyridine; Merrifield's resin-bound 6-methyl-2-thiouracil In dichloromethane at 80℃; for 0.0833333h; microwave irradiation; Stage #2: 4-Aminobutanol In dichloromethane at 80℃; for 0.0833333h; microwave irradiation; | 70% |
With triethylamine at 0℃; |
2-(4-aminophenoxy)-2-methyl propionic acid
4-chloro-benzoyl chloride
2-<4-(4-chlorobenzamido)phenoxy>-2-methylpropionic acid
Conditions | Yield |
---|---|
With pyridine at 0℃; | 100% |
With sodium hydroxide In tetrahydrofuran for 1h; | 90% |
2-aminoacetophenone hydrochloride
4-chloro-benzoyl chloride
4-Chloro-N-[1-(2-oxo-2-phenylethyl)]benzamide
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In ethyl acetate Ambient temperature; | 100% |
With pyridine Acylation; Heating; | 78.5% |
With sodium acetate for 4h; | 42% |
ammonium thiocyanate
4-chloro-benzoyl chloride
p-chlorobenzoyl isothiocyanate
Conditions | Yield |
---|---|
With PEG-400 In ethyl acetate at 20℃; | 100% |
In acetone for 1h; Heating; | |
In acetone |
2,3,4,6-tetra-O-acetyl-5-thio-D-glucopyranose
4-chloro-benzoyl chloride
Conditions | Yield |
---|---|
With pyridine for 2h; Ambient temperature; | 100% |
2-ethoxycarbonyethylzinc iodide
4-chloro-benzoyl chloride
ethyl 4-(4-chlorophenyl)-4-oxobutanoate
Conditions | Yield |
---|---|
tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl acetamide; benzene at 60℃; for 0.5h; various co-solvents; | 100% |
tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl acetamide; benzene at 60℃; for 0.5h; | 100% |
4-chloro-benzoyl chloride
1-(2-oxazolinyl)indole
Conditions | Yield |
---|---|
In benzene for 12h; Heating; | 100% |
4-chloro-benzoyl chloride
2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaphospholane
(4-Chloro-phenyl)-(4,4,5,5-tetramethyl-2-oxo-2λ5-[1,3,2]dioxaphospholan-2-yl)-methanone
Conditions | Yield |
---|---|
at 0℃; | 100% |
4-chloro-benzoyl chloride
N-[(thien-3-ylcarbonyl)methyl]amine hydrochloride
N-(4-chlorobenzoyl)aminomethyl(3-thienyl)ketone
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In ethyl acetate Ambient temperature; | 100% |
With sodium hydrogencarbonate |
4-chloro-benzoyl chloride
aminomethyl 3-furyl ketone hydrochloride
N-<(4-chlorobenzoyl)amino>methyl 3-furyl ketone
Conditions | Yield |
---|---|
With sodium hydrogencarbonate | 100% |
With sodium hydrogencarbonate In water; ethyl acetate Ambient temperature; Yield given; |
Conditions | Yield |
---|---|
With hydroxylamine hydrochloride; sodium hydrogencarbonate In water; ethyl acetate at 20℃; for 0.0833333h; | 100% |
With hydroxylamine hydrochloride; sodium hydrogencarbonate In water; ethyl acetate at 20℃; for 0.0833333h; | 95% |
With hydroxylamine hydrochloride; potassium carbonate In water; ethyl acetate at 0 - 20℃; for 16h; | 55% |
Conditions | Yield |
---|---|
With N-methylpyrrolidine zinc borohydride In tetrahydrofuran at 20℃; for 1.16667h; | 100% |
With Zr(BH4)2Cl2(dabco)2 In tetrahydrofuran for 1.7h; Heating; | 98% |
With sodium tetrahydroborate; lithium perchlorate In acetonitrile for 0.666667h; | 95% |
3-amino-2-methyl-4-oxoquinazoline
4-chloro-benzoyl chloride
4-Chloro-N-(2-methyl-4-oxo-4H-quinazolin-3-yl)-benzamide
Conditions | Yield |
---|---|
With pyridine In benzene for 2h; Heating; | 100% |
In toluene Heating; |
Conditions | Yield |
---|---|
With pyridine; dmap In chloroform | 100% |
N,O-dimethylhydroxylamine*hydrochloride
4-chloro-benzoyl chloride
4-chloro-N-methoxy-N-methylbenzamide
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 100% |
Stage #1: N,O-dimethylhydroxylamine*hydrochloride With triethylamine In dichloromethane at 0℃; Inert atmosphere; Stage #2: 4-chloro-benzoyl chloride In dichloromethane at 0 - 20℃; Inert atmosphere; | 96% |
With triethylamine In dichloromethane at 0 - 20℃; | 92% |
4-chloro-benzoyl chloride
4-(3-hydroxyphenyl)piperidine
1-(4-chlorobenzoyl)-4-(3-hydroxyphenyl)piperidine
Conditions | Yield |
---|---|
With sodium hydroxide In isopropyl alcohol at 40 - 50℃; for 2h; | 100% |
4-chloro-benzoyl chloride
t-butyl 5-benzyloxy-2-methyl indole acetate
Conditions | Yield |
---|---|
Stage #1: t-butyl 5-benzyloxy-2-methyl indole acetate With potassium tert-butylate In tetrahydrofuran for 0.333333h; Stage #2: 4-chloro-benzoyl chloride In tetrahydrofuran for 11h; Further stages.; | 100% |
4-chloro-benzoyl chloride
Conditions | Yield |
---|---|
With triethylamine; benzene | 100% |
4-chloro-benzoyl chloride
2-Methylaziridine
(4-chlorophenyl)(2-methylaziridin-1-yl)methanone
Conditions | Yield |
---|---|
With sodium hydroxide In diethyl ether at 0℃; | 100% |
With sodium hydroxide In tetrahydrofuran | 89% |
With sodium hydroxide In tetrahydrofuran | 89% |
amino-4 hydroxy-2 toluene
4-chloro-benzoyl chloride
4-chloro-benzoic acid 5-(4-chloro-benzoylamino)-2-methyl-phenyl ester
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 0 - 20℃; for 16h; | 100% |
trifluorormethanesulfonic acid
4-chloro-benzoyl chloride
4-Chlorbenzoesaeure-trifluormethansulfonsaeure-anhydrid
Conditions | Yield |
---|---|
100% |
4-chloro-benzoyl chloride
diisopropylamine
4-chloro-N,N-diisopropylbenzamide
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; for 6h; | 100% |
With dmap; triethylamine In tetrahydrofuran; dichloromethane at 0 - 20℃; for 12h; | 89% |
With triethylamine In dichloromethane at 20℃; Inert atmosphere; | 84% |
4-chloro-benzoyl chloride
p-aminoiodobenzene
4-chloro-N-(4-iodo-phenyl)-benzamide
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 20℃; for 4h; | 100% |
With triethylamine In tetrahydrofuran at 20℃; for 4h; | 100% |
Product Name: Benzoylchloride, 4-chloro- (CAS NO.122-01-0)
IUPAC Name: 4-chlorobenzoyl chloride
Molecular Formula: C7H4Cl2O
Molecular Weight: 175.012060 g/mol
Appearance: clear colorless to slight colored clear liquid
Melting Point: 12 °C
Boiling Point: 222 °C
Flash Point: 221 °F
Solubility: ethanol, ether and acetone
Insolubility: water
density: 1.37
refractive index: n20/D 1.578(lit.)
FreezingPoint: 12-14 °C
Sensitive: Moisture
BRN: 471606
EINECS: 204-515-3
Categories: ACIDHALIDE; Absolute Configuration Determination (Exciton Chirality CD Method); Analytical Chemistry; Enantiomer Excess & Absolute Configuration Determination; Exciton Chirality CD Method (for Hydroxyl Groups); Acid Halides; Carbonyl Compounds; Organic Building Blocks
Benzoylchloride, 4-chloro-(CAS NO.122-01-0) is used as an intermediate for medicine and dye,also used in the pharmaceutical industry and in organic synthesis.
Safety Information of Benzoylchloride, 4-chloro- (CAS NO.122-01-0):
Hazard Codes:C
Risk Statements:34-36/37
34:Causes burns
36/37:Irritating to eyes and respiratory system
Safety Statements:26-36/37/39-45-28A
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39:Wear suitable protective clothing, gloves and eye/face protection
45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
RIDADR:UN 3265 8/PG 2
WGK Germany:1
RTECS:DM6635510
F:10-19-21
HazardClass:8
PackingGroup:II
HS Code:29163900
Benzoylchloride, 4-chloro- , its CAS NO. is 122-01-0, the synonyms are 4-chloro-benzoylchlorid ; Benzoyl chloride, 4-chloro- ; Benzoyl chloride, p-chloro- ; Benzoylchloride,4-chloro- ; para-Chlorobenzoyl chloride .
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View