• Name

  Benzaldehyde propylene glycol acetal

• EINECS 219-906-4
• CAS No. 2568-25-4
• Article Data38
• CAS DataBase
• Density 1.059 g/cm³
• Solubility
• Melting Point
• Formula C₁₀H₁₂O₂
• Boiling Point 242.4 °C at 760 mmHg
• Molecular Weight 164.204
• Flash Point 101.7 °C
• Transport Information
• Appearance Clear colorless to yellowish oily liquid
• Safety 26-36
• Risk Codes 36/37/38
• Molecular Structure
• Hazard Symbols Xi
• Synonyms 2-Phenyl-4-methyl-1,3-dioxolane;4-Methyl-2-phenyl-1,3-dioxolane;
• PSA 18.46000
• LogP 2.12050

Synthetic route

57-55-6

propylene glycol

100-52-7

benzaldehyde

2568-25-4

4-methyl-2-phenyl-1,3-dioxolane

Conditions

Conditions	Yield
With cyclohexane at 105℃; for 1h; Dean-Stark;	99.7%
With phosphorus modified SO4(2-)/TiO2 In cyclohexane for 2h; Dean-Stark; Reflux;	98%
With poly(styren-co-3-(1-vinyllimidazolium-3-yl)propane-1-sulfonate)-acid at 110℃; for 1.5h; Reagent/catalyst;	96.2%

28224-73-9

1,3:4,6-di-O-benzylidene-D-mannitol

A

2568-25-4

4-methyl-2-phenyl-1,3-dioxolane

B

69-65-8

mannitol

Conditions

Conditions	Yield
With propylene glycol; toluene-4-sulfonic acid In dichloromethane for 1h;	A n/a B 99%

100-52-7

benzaldehyde

122-51-0

orthoformic acid triethyl ester

2568-25-4

4-methyl-2-phenyl-1,3-dioxolane

Conditions

Conditions	Yield
With tetra-N-butylammonium tribromide In propylene glycol at 20℃; for 12h; Inert atmosphere;	9%

57-55-6

propylene glycol

1125-88-8

benzaldehyde dimethyl acetal

2568-25-4

4-methyl-2-phenyl-1,3-dioxolane

Conditions

Conditions	Yield
With 5-sulfosalicylic Acid

100-52-7

benzaldehyde

2568-25-4

4-methyl-2-phenyl-1,3-dioxolane

Conditions

Conditions	Yield
With tin(IV) chloride Anschliessend Behandeln mit (+/-)-1,2-Epoxy-propan.;

100-52-7

benzaldehyde

75-56-9, 16033-71-9

methyloxirane

2568-25-4

4-methyl-2-phenyl-1,3-dioxolane

Conditions

Conditions	Yield
With N-(4-methyoxybenzyl)-2-cyanopyridinium hexafluoroantimonate for 0.5h; Ambient temperature;	100 % Spectr.

57-55-6

propylene glycol

103-67-3

benzyl-methyl-amine

2568-25-4

4-methyl-2-phenyl-1,3-dioxolane

Conditions

Conditions	Yield
With iodine In acetonitrile for 6h; Heating;	14 % Spectr.

57-55-6

propylene glycol

100-51-6

benzyl alcohol

A

2568-25-4

4-methyl-2-phenyl-1,3-dioxolane

B

100-52-7

benzaldehyde

Conditions

Conditions	Yield
With oxygen; palladium diacetate In neat (no solvent) at 150℃; under 3000.3 Torr; Catalytic behavior; Solvent;

...Expand

2568-25-4

4-methyl-2-phenyl-1,3-dioxolane

105-34-0

methyl 2-cyanoacetate

3695-84-9, 14533-85-8, 14533-86-9

methyl benzylidenecyanoacetate

Conditions

Conditions	Yield
With sulfuric acid; ethylenediamine at 80℃; for 12h;	85.5%

120-72-9

indole

2568-25-4

4-methyl-2-phenyl-1,3-dioxolane

35173-74-1

3,3'-bis-indolyl(phenyl)methane

Conditions

Conditions	Yield
With molecular iodine-loaded Cu4I4-MOF In neat (no solvent) at 20℃; for 10h; Friedel-Crafts Alkylation;	85%

2568-25-4

4-methyl-2-phenyl-1,3-dioxolane

6065-70-9

2-benzoyloxy-1-bromopropane

Conditions

Conditions	Yield
With N-Bromosuccinimide	82%

2568-25-4

4-methyl-2-phenyl-1,3-dioxolane

98-86-2

acetophenone

3-(2-hydroxy-1-methyl-ethoxy)-1,3-diphenyl-propan-1-one

Conditions

Conditions	Yield
Stage #1: acetophenone With di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine In dichloromethane at -78℃; for 0.5h; Stage #2: 4-methyl-2-phenyl-1,3-dioxolane In dichloromethane at -78℃; for 0.5h;	78%

2568-25-4

4-methyl-2-phenyl-1,3-dioxolane

7677-24-9

trimethylsilyl cyanide

62-53-3

aniline

4553-59-7

2-anilino-2-phenylacetonitrile

Conditions

Conditions	Yield
With hafnium tetrachloride In acetonitrile at 20℃; for 0.5h; Strecker Aminoacid Synthesis; Inert atmosphere;	76%

...Expand

2568-25-4

4-methyl-2-phenyl-1,3-dioxolane

62-53-3

aniline

758640-21-0

N-Benzylaniline

Conditions

Conditions	Yield
With triethylsilane; iodine In acetonitrile at 20℃; for 11h; Inert atmosphere; chemoselective reaction;	74%

67-56-1

methanol

2568-25-4

4-methyl-2-phenyl-1,3-dioxolane

2-methoxy-2-phenyl-4-methyl-1,3-dioxolane

Conditions

Conditions	Yield
With palladium 10% on activated carbon; oxygen; N-ethyl-N,N-diisopropylamine at 80℃; for 24h;	70%

2568-25-4

4-methyl-2-phenyl-1,3-dioxolane

6399-81-1

triphenylphosphine hydrobromide

A

3020-30-2

(2-hydroxypropyl)triphenylphosphonium bromide

B

100-52-7

benzaldehyde

Conditions

Conditions	Yield
In dichloromethane at 50℃; for 0.0833333h; Microwave irradiation; Sealed tube;	A 69% B n/a

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2568-25-4

4-methyl-2-phenyl-1,3-dioxolane

60011-15-6

2-(benzoyloxy)propanoic acid

Conditions

Conditions	Yield
With sodium periodate; ruthenium (III) chloride trihydrate In tetrachloromethane; water; acetonitrile at 20℃; for 2h; regioselective reaction;	68%

2568-25-4

4-methyl-2-phenyl-1,3-dioxolane

536-74-3

phenylacetylene

62-53-3

aniline

1039-51-6

2,4-diphenylquinoline

Conditions

Conditions	Yield
With bismuth(lll) trifluoromethanesulfonate In acetonitrile at 82℃; for 8h; regioselective reaction;	61%

...Expand

2568-25-4

4-methyl-2-phenyl-1,3-dioxolane

128796-45-2

2,4,6-tris-(4-trifluoromethylphenyl)boroxine

C17H17F3O2

Conditions

Conditions	Yield
With bis(1,5-cyclooctadiene)nickel (0); C46H67P In toluene at 85℃; for 16h; Suzuki Coupling;	60%

2568-25-4

4-methyl-2-phenyl-1,3-dioxolane

A

6656-60-6

2-oxopropyl benzoate

B

51591-52-7

1-hydroxyprop-2-yl benzoate

C

37086-84-3

2-hydroxypropyl benzoate

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; potassium carbonate; 1-(tert-butylperoxy)-1,2-benziodoxol-3(1H)-one In benzene at 20℃; for 36h;	A 2% B 54% C 39%

...Expand

2568-25-4

4-methyl-2-phenyl-1,3-dioxolane

103-49-1

dibenzylamine

766-97-2

4-n-methylphenylacetylene

α-[(4-methylphenyl)ethynyl]-N,N-bis(phenylmethyl)benzenemethanamine

Conditions

Conditions	Yield
With indium(III) chloride In toluene Inert atmosphere; Reflux;	50%

...Expand

2568-25-4

4-methyl-2-phenyl-1,3-dioxolane

A

51591-52-7

1-hydroxyprop-2-yl benzoate

B

37086-84-3

2-hydroxypropyl benzoate

Conditions

Conditions	Yield
With palladium 10% on activated carbon; oxygen In ethylene glycol at 80℃; for 6h; chemoselective reaction;	A 41% B 49%
With potassium permanganate; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane; water for 4h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With water; Iodine monochloride for 0.0833333h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

766-98-3

1-ethynyl-4-fluorobenzene

2568-25-4

4-methyl-2-phenyl-1,3-dioxolane

103-49-1

dibenzylamine

N,N-dibenzyl-3-(4-fluorophenyl)-1-phenylprop-2-yn-1-amine

Conditions

Conditions	Yield
With indium(III) chloride In toluene Inert atmosphere; Reflux;	47%

...Expand

2568-25-4

4-methyl-2-phenyl-1,3-dioxolane

536-74-3

phenylacetylene

103-49-1

dibenzylamine

dibenzyl-(1,3-diphenyl-2-propynyl)amine

Conditions

Conditions	Yield
With indium(III) chloride In toluene Inert atmosphere; Reflux;	46%

...Expand

2568-25-4

4-methyl-2-phenyl-1,3-dioxolane

67-66-3

chloroform

C11H12Cl2O2

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 0℃; Green chemistry;	45%

2568-25-4

4-methyl-2-phenyl-1,3-dioxolane

A

13807-91-5

benzyloxy-2-propanol

B

33106-26-2, 33106-64-8, 70448-03-2, 87037-69-2

2-benzyloxypropanol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; zirconium(IV) chloride In diethyl ether at 30℃; for 12h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With diisobutylaluminium hydride In toluene for 5h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With lithium aluminium tetrahydride; zirconium(IV) chloride In diethyl ether at 30℃; for 12h; Yield given. Yields of byproduct given;

2568-25-4

4-methyl-2-phenyl-1,3-dioxolane

A

36220-92-5

1-chloro-2-benzoyloxypropane

B

51591-52-7

1-hydroxyprop-2-yl benzoate

C

7022-98-2

2-chloropropyl benzoate

D

37086-84-3

2-hydroxypropyl benzoate

Conditions

Conditions	Yield
With Iodine monochloride; sodium thiosulfate 1.) 1 h, room temperature; Yield given. Multistep reaction. Yields of byproduct given;

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2568-25-4

4-methyl-2-phenyl-1,3-dioxolane

A

36220-92-5

1-chloro-2-benzoyloxypropane

B

7022-98-2

2-chloropropyl benzoate

Conditions

Conditions	Yield
With Iodine monochloride In chloroform for 1h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With 2,2'-azobis(isobutyronitrile); chloroform In benzene for 5h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

2568-25-4

4-methyl-2-phenyl-1,3-dioxolane

A

13807-91-5

benzyloxy-2-propanol

B

33106-26-2, 33106-64-8, 70448-03-2, 87037-69-2

2-benzyloxypropanol

C

108-88-3

toluene

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; cyclopentadienyl titanium(IV) trichloride In diethyl ether for 12h; Heating; Title compound not separated from byproducts;	A 5 % Spectr. B 41 % Spectr. C 53 % Spectr.

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2568-25-4

4-methyl-2-phenyl-1,3-dioxolane

A

6065-71-0

Benzoesaeure-(2-brom-propylester)

B

6065-70-9

2-benzoyloxy-1-bromopropane

Conditions

Conditions	Yield
With 2,2'-azobis(isobutyronitrile); Bromoform In benzene for 5h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

2568-25-4

4-methyl-2-phenyl-1,3-dioxolane

A

4799-68-2

3-benzyloxypropan-1-ol

B

13807-91-5

benzyloxy-2-propanol

C

33106-26-2, 33106-64-8, 70448-03-2, 87037-69-2

2-benzyloxypropanol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; zirconium(IV) chloride In diethyl ether at 30℃; for 12h; Reduction;

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Benzaldehyde propylene glycol acetal Chemical Properties

Benzaldehyde propylene glycol acetal Uses

Benzaldehyde propylene glycol acetal Toxicity Data With Reference

Benzaldehyde propylene glycol acetal Consensus Reports

Benzaldehyde propylene glycol acetal Safety Profile