Conditions | Yield |
---|---|
With hydrogenchloride; sodium hydroxide; sodium perchlorate; chlorine at 24.9℃; Mechanism; Rate constant; Equilibrium constant; multistep reaction: 1.) water, 298 deg K, 2.) water, 298 deg K; reactions under var. conditions; | A 100% B n/a C n/a |
Conditions | Yield |
---|---|
In water at 24.9℃; Rate constant; Mechanism; Thermodynamic data; Irradiation; I=0.5 mol-1 L-1; various pH; ΔH(excit.), ΔS(excit.); | A 100% B n/a |
With water In 1,4-dioxane at 25℃; | |
With water In 1,4-dioxane at 25℃; Kinetics; Mechanism; |
acetamide
4,5-diethyl-2,5-dihydro-1,2,2,3-tetramethyl-1H-1,2,5-azasilaborole
A
ethylbis(dimethyl(2-penten-2-yl)silyloxy)borane
B
methylamine
Conditions | Yield |
---|---|
In 1,2,5-trimethyl-benzene dropwise addn. of acetamide to boron compd. soln., 160°C, 3.5h; heating (reflux), 10h; evapn.; all under Ar; distn.; elem. anal.; | A 100% B 98% |
Conditions | Yield |
---|---|
With borane-ammonia complex In methanol; water at 20℃; for 0.0833333h; | 99% |
With ammonia borane; Pd/MIL-101 In methanol; water at 20℃; for 0.025h; | 99% |
With sodium tetrahydroborate In methanol; water at 20℃; for 0.0666667h; Sealed tube; Green chemistry; | 99% |
piperidine
N-n-butyl-N-methylamine
A
1-butyl-piperidine
B
methylamine
Conditions | Yield |
---|---|
palladium at 160℃; for 5h; | A 98% B n/a |
piperidine
benzyl-methyl-amine
A
N-Benzylpiperidine
B
methylamine
Conditions | Yield |
---|---|
palladium at 130℃; for 10h; | A 97% B n/a |
A
1-methyl-1,3,5-triazine-2,4,6(1H,3H,5H)-trione
B
N,N'-dimethyl-guanidine
C
methylamine
Conditions | Yield |
---|---|
With hydrogenchloride for 10h; Heating; | A 15% B 96% C 4% |
N,N'-Dimethylurea
sodium p-toluenesulfonamide
A
N-Methyl-N'-toluene-p-sulfonylurea
B
methylamine
Conditions | Yield |
---|---|
at 160℃; for 3h; Product distribution; Rate constant; Equilibrium constant; Other temperature, other time, other ratio of reactants, activation energy, ΔH, ΔS;; | A 95.5% B n/a |
at 160℃; for 3h; | A 95.5% B n/a |
ethylenediamine
benzyl-methyl-amine
A
methylamine
B
N-benzylethylenediamine
Conditions | Yield |
---|---|
palladium at 120℃; for 10h; | A n/a B 95% |
4-Aminobutanol
4,5-diethyl-2,5-dihydro-1,2,2,3-tetramethyl-1H-1,2,5-azasilaborole
A
4,5-diethyl-2,2,3-trimethyl-6-oxa-1-azonia-2-sila-5-boratabicyclo{5.3.0}dec-3-ene
B
4,5-diethyl-2,2,3-trimethyl-1-oxa-6-aza-2-sila-5-bora-3-cyclodecene
C
methylamine
Conditions | Yield |
---|---|
In neat (no solvent) addn. of boron compd. to equimolar amt. of aminoalkanol, room temp.; driving out CH3NH2 in a stream of Ar, 20-80°C, 4h;; distn. (vac.); elem. anal.; monocyclic : bicyclic isomer = 95:5; | A n/a B n/a C 95% |
6-methyl-8-nitro-1,6-naphthyridin-5(6H)-one
A
8-methylpyrido<2,3-d>pyridazin-5-one
B
methylamine
Conditions | Yield |
---|---|
With hydrazine hydrate at 130 - 140℃; for 5h; | A 94% B n/a C n/a |
4,5-diethyl-2,5-dihydro-1,2,2,3-tetramethyl-1H-1,2,5-azasilaborole
ethanolamine
A
4,5-diethyl-2,2,3-trimethyl-1-oxa-6-aza-2-sila-5-bora-3-cyclooctene
B
methylamine
Conditions | Yield |
---|---|
In 1,2,5-trimethyl-benzene heating under Ar, 40-70°C, 4h; | A 93% B 93% |
In neat (no solvent) addn. of boron compd. to equimolar amt. of aminoalkanol, room temp.; driving out CH3NH2 in a stream of Ar, 20°C, 24h;; distn. (vac.); elem. anal.; | A 82% B 87% |
(2R)-2-aminobutan-1-ol
4,5-diethyl-2,5-dihydro-1,2,2,3-tetramethyl-1H-1,2,5-azasilaborole
A
(R)-4,5,7-triethyl-2,2,3-trimethyl-6-oxa-1-azonia-2-sila-5-boratabicyclo{3.3.0}oct-3-ene
B
(R)-4,5,7-triethyl-2,2,3-trimethyl-1-oxa-6-aza-2-sila-5-bora-3-cyclooctene
C
methylamine
Conditions | Yield |
---|---|
In neat (no solvent) addn. of boron compd. to equimolar amt. of aminoalkanol, room temp.; driving out CH3NH2 in a stream of Ar, 20-25°C, 18h; distn. (vac.); elem. anal.; monocyclic : bicyclic isomer = 95:5; | A n/a B n/a C 91% |
pyrrolidine
benzyl-methyl-amine
A
N-benzylcyclohexylamine
B
N-phenyl(methylidene)cyclohexanamine
C
methylamine
Conditions | Yield |
---|---|
palladium at 120℃; for 10h; | A 10% B 90% C n/a |
2-aminobutanol
4,5-diethyl-2,5-dihydro-1,2,2,3-tetramethyl-1H-1,2,5-azasilaborole
A
4,5,7-triethyl-2,2,3-trimethyl-6-oxa-1-azonia-2-sila-5-boratabicyclo{3.3.0}oct-3-ene
B
4,5,7-triethyl-2,2,3-trimethyl-1-oxa-6-aza-2-sila-5-bora-3-cyclooctene
C
methylamine
Conditions | Yield |
---|---|
In neat (no solvent) addn. of boron compd. to equimolar amt. of aminoalkanol, room temp.; driving out CH3NH2 in a stream of Ar, 20-25°C, 22h; distn. (vac.); elem. anal.; monocyclic: bicyclic isomer = 95:5; | A n/a B n/a C 89% |
N-methylisoephedrine
A
2-hydroxy-1-phenylpropylamine
B
formaldehyd
C
benzaldehyde
D
acetaldehyde
E
dimethyl amine
F
methylamine
Conditions | Yield |
---|---|
With water at 25℃; Product distribution; Mechanism; anodic oxidation, carbonate buffer, pH 10; effect of substituents investigated with different types of β-alkanolamines; | A 1.3% B 28% C 82% D 88% E 38% F 33% |
4,5-diethyl-2,5-dihydro-1,2,2,3-tetramethyl-1H-1,2,5-azasilaborole
m-Hydroxyaniline
A
C30H48B2N2O2Si2
B
methylamine
Conditions | Yield |
---|---|
In 1,2,5-trimethyl-benzene at 125-150°C, 26h under Ar; evapn.; elem. anal.; | A n/a B 88% |
Conditions | Yield |
---|---|
With hydrogenchloride; sodium hydroxide; sodium perchlorate; chlorine at 24.9℃; Mechanism; Rate constant; Equilibrium constant; multistep reaction: 1.) water, 298 deg K, 2.) water, 298 deg K; reactions under var. conditions; | A n/a B 87% C n/a |
2-methylamino-1-phenylpropanol
A
formaldehyd
B
benzaldehyde
C
acetaldehyde
D
benzoic acid
E
methylamine
Conditions | Yield |
---|---|
Mechanism; Product distribution; anodic oxidation; | A 12% B 65% C 68% D 12% E 87% |
4,5-diethyl-2,5-dihydro-3-isopropenyl-1,2,2-trimethyl-1,2,5-azasilaborole
ethanolamine
A
4,5-diethyl-3-isopropenyl-2,2-dimethyl-1-oxa-6-aza-2-sila-5-bora-3-cyclooctene
B
4,5-diethyl-3-isopropenyl-2,2-dimethyl-6-oxa-1-azonia-2-sila-5-boratabicyclo{3.3.0}oct-3-ene
C
methylamine
Conditions | Yield |
---|---|
In neat (no solvent) addn. of boron compd. to equimolar amt. of aminoalkanol, room temp.; driving out CH3NH2 in a stream of Ar, 20-25°C, 22h;; distn. (vac.); standing at room temp.; crystn. of bicyclic isomer; elem. anal.; | A 57% B n/a C 87% |
4,5-diethyl-2,5-dihydro-1,2,2,3-tetramethyl-1H-1,2,5-azasilaborole
propan-1-ol-3-amine
A
4,5-diethyl-2,2,3-trimethyl-6-oxa-1-azonia-2-sila-5-boratabicyclo{4.3.0}non-3-ene
B
4,5-Diethyl-2,2,3-trimethyl-1-oxa-6-aza-2-sila-5-bora-3-cyclononene
C
methylamine
Conditions | Yield |
---|---|
In neat (no solvent) addn. of boron compd. to equimolar amt. of aminoalkanol, room temp.; driving out CH3NH2 in a stream of Ar, 20-80°C, 24h;; distn. (vac.); elem. anal.; monocyclic : bicyclic isomer = 95:5; | A n/a B n/a C 87% |
pseudoephedrine
4,5-diethyl-2,5-dihydro-1,2,2,3-tetramethyl-1H-1,2,5-azasilaborole
A
(4S,5S)-2-Ethyl-4-methyl-5-phenyl-1,3,2-oxazaborolan
B
{(1S,2S)-2-[Dimethyl-((E)-1-methyl-but-1-enyl)-silanyloxy]-1-methyl-2-phenyl-ethyl}-methyl-amine
C
(7S,8S)-4,5-Diethyl-2,2,3,6,7-pentamethyl-8-phenyl-1-oxa-6-aza-2-sila-5-bora-3-cycloocten
D
methylamine
Conditions | Yield |
---|---|
In 1,2,5-trimethyl-benzene dropwise addn. of boron compd. to aminoalkanol soln. under Ar, 0.5h; heating to 140-150°C, 12h; evapn.; distn. (vac.); elem. anal.; | A n/a B n/a C 75% D 86% |
Conditions | Yield |
---|---|
With sodium hydroxide; benzyltrimethylazanium tribroman-2-uide In water at 70℃; for 2h; | 85% |
With potassium hydroxide; bromine ueber mehrere Stufen; | |
With potassium hydroxide; bromine | |
With water; bromine; calcium carbonate ueber mehrere Stufen; | |
With sodium hydroxide; sodium bromite In water at 70℃; for 0.5h; Yield given; |
Conditions | Yield |
---|---|
palladium at 120℃; for 20h; | A 85% B n/a |
2-(N,N-dimethylamino)ethanol
4,5-diethyl-2,5-dihydro-1,2,2,3-tetramethyl-1H-1,2,5-azasilaborole
A
(E)-3-<<2-(Dimethylamino)ethoxy>ethylboryl>-2-<<2-(dimethylamino)ethoxy>dimethylsilyl>-2-penten
B
methylamine
Conditions | Yield |
---|---|
In neat (no solvent) stirring under Ar, 0-20°C, 1-2h; heating to a maximum of 140°C, 10h; distn. (vac.); elem. anal.; | A 82% B 76% |
(2-hydroxyethyl)(methyl)amine
4,5-diethyl-2,5-dihydro-1,2,2,3-tetramethyl-1H-1,2,5-azasilaborole
A
4,5-diethyl-2,2,3,6-tetramethyl-1-oxa-6-aza-2-sila-5-bora-3-cyclooctene
B
methylamine
Conditions | Yield |
---|---|
In neat (no solvent) dropwise addn. of boron compd. to aminoalkanol, 10 min; stirring in a stream of Ar, 20°C, 24h;; distn. (vac.); elem. anal.; | A 81% B 82% |
trimethyl-borane; compound with methylamine
A
trimethylborane
B
methylamine
Conditions | Yield |
---|---|
at 130.0°C, 77.4 Torr equilibrium; | A 81.95% B 81.95% |
at 130.0°C, 77.4 Torr equilibrium; | A 81.95% B 81.95% |
at 85.4°C, 52.5 Torr equilibrium; | A 38.86% B 38.86% |
at 85.4°C, 52.5 Torr equilibrium; | A 38.86% B 38.86% |
L(-)-ephedrine hemihydrate
4,5-diethyl-2,5-dihydro-1,2,2,3-tetramethyl-1H-1,2,5-azasilaborole
A
(7S,8R)-4,5-diethyl-2,2,3,6,7-pentamethyl-1-oxa-6-aza-2-sila-5-bora-3-cyclooctene
B
methylamine
Conditions | Yield |
---|---|
In neat (no solvent) dropwise addn. of boron compd. to aminoalkanol under Ar, 5 min; heating to 110-150°C, 8.5h;; distn. (vac.); elem. anal.; | A 73% B 80.5% |
N-n-butyl-N-methylamine
benzyl-methyl-amine
A
N-Butyl-N-methylbenzenemethanamine
B
methylamine
Conditions | Yield |
---|---|
palladium at 120℃; for 10h; | A 80% B n/a |
Conditions | Yield |
---|---|
at 20℃; under 600.048 - 750.06 Torr; Addition; soid-gas reaction; ring cleavage; | 100% |
With water | |
In water for 1h; Ambient temperature; |
Conditions | Yield |
---|---|
With magnesium sulfate In methanol; dichloromethane for 7h; Heating; | 100% |
With water | |
In water 1.) 40 - 45 deg C, 15 min, 2.) room temp., 4 h; Yield given; |
Conditions | Yield |
---|---|
In water at 220℃; under 114000 Torr; for 4h; | 100% |
With ethanol at 220℃; | |
In 5,5-dimethyl-1,3-cyclohexadiene |
Conditions | Yield |
---|---|
at -20℃; under 75.006 Torr; Addition; solid-gas reaction; ring cleavage; | 100% |
In ethanol | 55% |
Conditions | Yield |
---|---|
In ethanol; water at 20℃; for 72h; Inert atmosphere; | 100% |
In water for 72h; Reflux; | 100% |
In water | 100% |
Conditions | Yield |
---|---|
In ethanol at 120℃; for 7h; Sealed tube; Microwave irradiation; | 100% |
With ethanol at 120℃; | |
With phenol at 190℃; |
4-methyl-benzaldehyde
methylamine
p-methylbenzylidene-methylamine
Conditions | Yield |
---|---|
at 20℃; for 12h; | 100% |
In methanol; dichloromethane for 18h; Molecular sieve; | 86% |
Conditions | Yield |
---|---|
With triethylamine In ethanol for 4h; Reflux; | 100% |
In ethanol; water Sealed tube; Reflux; | 94% |
In ethanol; water at 100℃; for 72h; Sealed tube; | 54% |
Conditions | Yield |
---|---|
at 20℃; for 12h; | 100% |
In water for 1h; Ambient temperature; | 95% |
at 20℃; for 15h; | 95% |
Conditions | Yield |
---|---|
at 0℃; under 187.515 Torr; Solid phase reaction; gas-solid reaction; | 100% |
at 20℃; for 12h; | 100% |
With ethanol; water at 40℃; |
Conditions | Yield |
---|---|
In ethanol; water at 40℃; for 2h; | 100% |
In ethanol at 0 - 40℃; | 90% |
In water for 10h; Ambient temperature; | 80% |
Conditions | Yield |
---|---|
In ethanol at 20℃; for 8h; | 100% |
In ethanol at 20℃; for 8h; | 100% |
With molecular sieve In ethanol; water for 0.5h; | 96% |
N,N,N',N'-Tetramethylphosphorodiamidic chloride
methylamine
Pentamethylphosphoramide
Conditions | Yield |
---|---|
at 20℃; for 48h; | 100% |
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane at 0℃; for 1h; | 83% |
64% |
3,4-dimethoxy-benzaldehyde
methylamine
N-(3,4-dimethoxybenzylidene)methanamine
Conditions | Yield |
---|---|
With 4 A molecular sieve In toluene at 0℃; | 100% |
With benzene | |
In methanol at 40℃; for 5h; | |
In ethanol at 50℃; | |
In benzene for 2h; Reflux; |
Conditions | Yield |
---|---|
In ethanol at 0 - 5℃; for 2h; | 100% |
at 20℃; for 12h; | 100% |
With benzene zuletzt unter Abdestillieren des gebildeten Wassers; |
Conditions | Yield |
---|---|
at 0℃; under 375.03 Torr; Addition; solid-gas reaction; | 100% |
acrylic acid methyl ester
methylamine
methyl 3-(methylamino)propanoate
Conditions | Yield |
---|---|
In diethyl ether at 4℃; Addition; | 100% |
With C12H18NO3S(1+)*HO4S(1-) at 25℃; for 0.0833333h; Ionic liquid; Neat (no solvent); chemoselective reaction; | 99% |
In ethanol at -10℃; | 86% |
Conditions | Yield |
---|---|
In ethanol at 20℃; for 48h; Molecular sieve; Inert atmosphere; | 100% |
In ethanol at 20℃; for 48h; Molecular sieve; Inert atmosphere; | 100% |
With triethylamine In ethanol for 1h; Molecular sieve; | 97% |
Conditions | Yield |
---|---|
at 20℃; for 12h; | 100% |
In ethanol at 0 - 40℃; | 90% |
In water for 10h; Ambient temperature; | 86% |
Conditions | Yield |
---|---|
In ethanol at 0 - 40℃; | 100% |
In water for 10h; Ambient temperature; | 80% |
With water |
4-dimethylamino-benzaldehyde
methylamine
4-(dimethylamino)-N-methylbenzylimine
Conditions | Yield |
---|---|
at 20℃; under 750.06 Torr; Solid phase reaction; gas-solid reaction; | 100% |
at 20℃; for 12h; | 100% |
With benzene |
Conditions | Yield |
---|---|
In ethanol; water Reflux; | 100% |
In methanol; water Heating; | 98% |
In water at 20℃; for 2h; Inert atmosphere; | 93% |
Conditions | Yield |
---|---|
In ethanol at 20℃; for 15h; | 100% |
In ethanol; water at 20℃; for 1h; | 100% |
In ethanol at 0 - 20℃; for 15h; | 95% |
1-isothiocyanatonaphthalene
methylamine
1-methyl-3-naphthalene-1-yl-thiourea
Conditions | Yield |
---|---|
at 20℃; under 750.06 Torr; Addition; solid-gas reaction; | 100% |
With ethanol |
p-nitrophenyl isothiocyanate
methylamine
1-(4-nitrophenyl)-3-methyl-thiourea
Conditions | Yield |
---|---|
at 20℃; under 750.06 Torr; Addition; solid-gas reaction; | 100% |
Conditions | Yield |
---|---|
With ammonium chloride In ethanol at 200℃; for 20h; | 100% |
With water at 200 - 220℃; unter Druck; | |
With sodium hydrogensulfite In water Bucherer reaction; Autoclave; |
methylamine
3-(bromomethyl)benzonitrile
3-((methylamino)methyl)benzonitrile
Conditions | Yield |
---|---|
In THjfF (tetrahydrofuran) at 20℃; for 3h; Inert atmosphere; | 100% |
In tetrahydrofuran at 20℃; for 24h; | 96% |
In water at 0 - 20℃; for 3.16h; | 82% |
methylamine
4-Bromophenyl isothiocyanate
1-(4-bromophenyl)-3-methyl-thiourea
Conditions | Yield |
---|---|
at 20℃; under 750.06 Torr; Addition; solid-gas reaction; | 100% |
With ethanol |
methylamine
2,3-dimethyoxybenzaldehyde
(2,3-dimethoxy-benzylidene)-methyl-amine
Conditions | Yield |
---|---|
at 20℃; for 12h; | 100% |
In ethanol at 0 - 40℃; | 90% |
With benzene zuletzt unter Erwaermen und Entfernen des gebildeten Wassers; | |
In benzene for 2h; Reflux; | |
In ethanol; water |
methylamine
2,4-Dichloro-5-nitropyrimidine
2-chloro-4-(methylamino)-5-nitropyrimidine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; methanol at -78 - 20℃; for 3h; | 100% |
With N-ethyl-N,N-diisopropylamine In dichloromethane at -60℃; for 1h; | 85% |
With N-ethyl-N,N-diisopropylamine In ethanol; dichloromethane at 0℃; for 0.5h; | 85.4% |
The IUPAC name of this chemical is methanamine. With the CAS registry number 74-89-5, it is also named as Aminomethane. The product's categories are Refrigerants; Alkylamines; Biochemistry; Monofunctional & alpha,omega-Bifunctional Alkanes; Monofunctional Alkanes; Reagents for Oligosaccharide Synthesis. It is colourless gas which is soluble in water, ethanol and ether. In addition, it is the simplest primary amine. It is sold as a solution in methanol, ethanol, THF, and water, or as the anhydrous gas in pressurized metal containers. It is flammable by fire and heat. When heated to decomposition it emits toxic fumes of NOx. So the storage environment should be ventilate, low-temperature and dry.
The other characteristics of Methylamine can be summarized as:
(1)ACD/LogP: -0.66; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -3.76; (4)ACD/LogD (pH 7.4): -3.54; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 1; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 0; (12)Index of Refraction: 1.34; (13)Molar Refractivity: 10.21 cm3; (14)Molar Volume: 48.7 cm3; (15)Polarizability: 4.05×10-24 cm3; (16)Surface Tension: 18.4 dyne/cm; (17)Enthalpy of Vaporization: 25.6 kJ/mol; (18)Vapour Pressure: 3970 mmHg at 25°C; (19)Exact Mass: 31.042199; (20)MonoIsotopic Mass: 31.042199; (21)Topological Polar Surface Area: 26; (22)Heavy Atom Count: 2; (23)Complexity: 2.
Preparation of Methylamine:
It can be obtained by many methods. For example: it is produced by the reaction of ammonia with methanol in the presence of a silicoaluminate catalyst. Dimethylamine and trimethylamine are coproduced. CH3OH + NH3 → CH3NH2 + H2O
2CH3OH+NH3→(CH3)2NH+2H2O
3CH3OH+NH3→(CH3)3N+3H2O
Uses of Methylamine:
It is widely used in manufacturing of pharmaceuticals, pesticides, explosives, dyes, photographic developer, vulcanization accelerators, surfactants, preservatives, etc. And it is a good nucleophile as it is highly basic and unhindered, though, as an amine it is considered a weak base. Its use in organic chemistry is pervasive. Liquid methylamine can be used as a solvent analogous to liquid ammonia. Methylamine can also be used for scavenging H2S from hydrocarbon in refining applications. Furthermore, it is used as a building block for the synthesis of many other commercially available compounds.
When you are using Methylamine, please be cautious about it as the following:
It is extremely flammable and can cause burns, so people should keep it away from sources of ignition. And it is not only toxic by inhalation, in contact with skin and if swallowed, but also irritating to eyes, respiratory system and skin. So it must not empty into drains. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
People can use the following data to convert to the molecule structure.
1. SMILES:NC
2. InChI:InChI=1/CH5N/c1-2/h2H2,1H3
3. InChIKey:BAVYZALUXZFZLV-UHFFFAOYAN
The following are the toxicity data of Methylamine:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LDLo | subcutaneous | 200mg/kg (200mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. | |
mammal (species unspecified) | LC50 | inhalation | 2400mg/m3 (2400mg/m3) | Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 80, 1975. | |
mouse | LC50 | inhalation | 2400mg/m3/2H (2400mg/m3) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 81, 1982. | |
mouse | LDLo | subcutaneous | 2500mg/kg (2500mg/kg) | "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 949, 1989. | |
rat | LC50 | inhalation | 448ppm/2.5H (448ppm) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA SKIN AND APPENDAGES (SKIN): "DERMATITIS, IRRITATIVE: AFTER SYSTEMIC EXPOSURE" | Journal of Environmental Biology. Vol. 13, Pg. 273, 1992. |
rat | LD50 | oral | 100mg/kg (100mg/kg) | Inhalation Toxicology. Vol. 2, Pg. 29, 1990. | |
rat | LDLo | subcutaneous | 200mg/kg (200mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. |
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