As a leading and professional manufacturer of APIs and API intermediates in China,Anhui Dexinjia Biopharm Co., Ltd founded in 2006, Except for the R&D center, our company has built a close cooperation relation with Chinese Academy of Sciences,
he company has a professional R & D team, mature technology, very competitive prices and stable high quality products for customers to order high quality and low price product efforts! Appearance:White or off-white Solid Storage:Sealed, dry
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:123855-51-6
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inquiryHigh quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours. 2.Best quality in your requirement. 3.We pay more attention on delivery time, and usually ship on time. 4.Free samples will be provided. 5.Ensure specifications an
Cas:123855-51-6
Min.Order:1 Kilogram
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Type:Trading Company
inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:123855-51-6
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis
Cas:123855-51-6
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:123855-51-6
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:123855-51-6
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
Cas:123855-51-6
Min.Order:1 Gram
FOB Price: $1000.0 / 1300.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:123855-51-6
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryProduct name N-Boc-4-piperidinemethanol Synonyms n-tert-butyloxycarbonyl-4-piperidinemethanol;N-BOC-4-HYDROXYLMETHYLENE-PIPERIDINE;N-BOC-4-HYDROXYMETHYLPIPERIDINE;N-BOC-4-PIPERIDINEMETHANOL;1-N-Boc-4
Cas:123855-51-6
Min.Order:5 Metric Ton
FOB Price: $1.0 / 2.0
Type:Other
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
Cas:123855-51-6
Min.Order:10 Gram
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Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:123855-51-6
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryN-Boc-4-piperidinemethanol CAS: 123855-51-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality orga
Cas:123855-51-6
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:123855-51-6
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryProduct Name: N-Boc-4-piperidinemethanol Synonyms: 123855-51-6;n-tert-butyloxycarbonyl-4-piperidinemethanol;N-BOC-4-HYDROXYLMETHYLENE-PIPERIDINE;N-BOC-4-HYDROXYMETHYLPIPERIDINE;N-BOC-4-PIPERIDINEMETHANOL;1-N-Boc-4-piperidinemethanol;tert-Butyl 4
Cas:123855-51-6
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryProduct Name:N-Boc-4-piperidinemethanol Appearance: White to brown powder CAS No.:123855-51-6 MF:C11H21NO3 MW:215.29 Assay : 98% Shipping: Timely delivery after your payment Advantages:Good quality, favorable price, factory sales directly
Cas:123855-51-6
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:123855-51-6
Min.Order:0 Metric Ton
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Type:Lab/Research institutions
inquiryN-Boc-4-piperidinemethanol is one of the most competitive products in our company, we can supply it with good quality and best price. Appearance:white to brown solid Storage:Room temperature, Keep in Dark Place. Package:Kilograms/MT Application:Pharm
Cas:123855-51-6
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:123855-51-6
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Type:Lab/Research institutions
inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:123855-51-6
Min.Order:4 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHot Sale 123855-51-6 Good Supplier N-Boc-4-piperidinemethanol Piperidine is a very important six-membered nitrogen heterocyclic compound. Many natural products contain piperidine structural units. Piperidine ring is the most common type of heterocyc
Cas:123855-51-6
Min.Order:1 Gram
Negotiable
Type:Other
inquiryN-Boc-4-piperidinemethanol CAS 123855-51-6 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict qual
Cas:123855-51-6
Min.Order:1 Kilogram
FOB Price: $10.0 / 50.0
Type:Trading Company
inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:123855-51-6
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiry1. A strong scientific research team . 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch of products). 3. Rich export experience (with practical experience in exporting to m
Cas:123855-51-6
Min.Order:1 Kilogram
FOB Price: $8.2 / 8.8
Type:Trading Company
inquiryProduct name: N-Boc-4-Piperidinemethanol CAS No.: 123855-51-6 Molecule Formula:C11H21NO3 Molecule Weight:215.29 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS
Cas:123855-51-6
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and develop
Cas:123855-51-6
Min.Order:1 Kilogram
FOB Price: $2.0 / 6.0
Type:Trading Company
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:123855-51-6
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryWe are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED
Cas:123855-51-6
Min.Order:1 Gram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryN-Boc-4-piperidinemethanol Basic information Product Name: N-Boc-4-piperidinemethanol Synonyms: 1-N-BOC-4-HYDROXYMETHYL-PIPERIDINE;1-(TERT-BUTOXYCARBONYL)-4-(HYDROXYMETHYL)PIPERIDINE;1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINEMETHANOL;TERT-BUTYL 4-(H
Cas:123855-51-6
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry4-piperidinemethanol
di-tert-butyl dicarbonate
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
In dichloromethane | 100% |
In tetrahydrofuran; ethyl acetate at 20℃; for 14h; | 100% |
With sodium carbonate In tetrahydrofuran; water at 95℃; for 2.5h; | 100% |
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
With borane-THF In tetrahydrofuran | 100% |
Stage #1: N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid With borane-THF In tetrahydrofuran at 0℃; for 0.5h; Stage #2: With methanol | 96% |
With borane-THF In tetrahydrofuran at 0℃; for 0.666667h; Inert atmosphere; | 89% |
tert butyl 4-formylpiperidine-1-carboxylate
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
With methanol; sodium tetrahydroborate at 0 - 25℃; for 1h; | 100% |
With sodium tetrahydroborate In ethanol for 1h; Inert atmosphere; | 53% |
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate With diisobutylaluminium hydride In tetrahydrofuran at -78 - 20℃; for 0.833333h; Stage #2: With ammonium chloride In tetrahydrofuran; water at 20℃; for 0.75h; | 97% |
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 2h; | 96% |
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; | 94% |
tert-butyl 4-(iodomethyl)piperidine-1-carboxylate
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate In tetrahydrofuran | 93% |
chloroformic acid ethyl ester
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
With 4-methyl-morpholine; sodium borohydrid In tetrahydrofuran; methanol; ethyl acetate | 90% |
With 4-methyl-morpholine; sodium borohydrid In tetrahydrofuran; methanol; ethyl acetate | 90% |
potassium carbonate
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
In tetrahydrofuran; water | 84% |
potassium carbonate
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
In tetrahydrofuran; water | 84% |
1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: 1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate With lithium borohydride In tetrahydrofuran at 0℃; Reflux; Stage #2: With water In tetrahydrofuran Product distribution / selectivity; | 82% |
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; | |
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; | |
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; | |
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; Inert atmosphere; |
4-piperidinemethanol
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
Acylation; |
isonipecotic acid
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 92 percent / aq. NaOH, Et3N / dioxane / 20 h / Ambient temperature 2: BH3*THF / tetrahydrofuran / 1 h / 0 °C View Scheme | |
Multi-step reaction with 2 steps 1: 100 percent / CH2Cl2 2: 100 percent / BH3*THF / tetrahydrofuran View Scheme | |
Multi-step reaction with 2 steps 1: 91 percent / NaHCO3 / dioxane; H2O / 24 h 2: 84 percent / BH3*THF / tetrahydrofuran / 0 - 25 °C View Scheme |
di-tert-butyl dicarbonate
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 92 percent / aq. NaOH, Et3N / dioxane / 20 h / Ambient temperature 2: BH3*THF / tetrahydrofuran / 1 h / 0 °C View Scheme | |
Multi-step reaction with 2 steps 1: 100 percent / CH2Cl2 2: 100 percent / BH3*THF / tetrahydrofuran View Scheme | |
Multi-step reaction with 2 steps 1: 91 percent / NaHCO3 / dioxane; H2O / 24 h 2: 84 percent / BH3*THF / tetrahydrofuran / 0 - 25 °C View Scheme |
4-carbethoxypiperidine
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 98 percent / Et3N; DMAP / CH2Cl2 2: 94 percent / LiAlH4 / tetrahydrofuran / 0 °C View Scheme | |
Multi-step reaction with 2 steps 1: 99 percent / ethyl acetate / 20 h / Ambient temperature 2: 84 percent / LAH / tetrahydrofuran / 2 h / 0 °C View Scheme | |
Multi-step reaction with 2 steps 1: 94 percent / Et3N / dioxane; H2O / 16 h / 0 - 20 °C 2: 93 percent / LiAlH4 / tetrahydrofuran / 16 h / 0 - 20 °C View Scheme |
di-tert-butyl dicarbonate
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 98 percent / Et3N; DMAP / CH2Cl2 2: 94 percent / LiAlH4 / tetrahydrofuran / 0 °C View Scheme |
isonipecotic acid
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 91 percent / NaHCO3 / dioxane; H2O / 24 h 2: 84 percent / BH3*THF / 0 - 25 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: aq. NaOH / 1,2-dimethoxy-ethane 2.1: isobutyl chloroformate; N-methylmorpholine / 1,2-dimethoxy-ethane / 0 °C 2.2: aq. NaBH4 View Scheme |
di-tert-butyl dicarbonate
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 91 percent / NaHCO3 / dioxane; H2O / 24 h 2: 84 percent / BH3*THF / 0 - 25 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: aq. NaOH / 1,2-dimethoxy-ethane 2.1: isobutyl chloroformate; N-methylmorpholine / 1,2-dimethoxy-ethane / 0 °C 2.2: aq. NaBH4 View Scheme |
4-piperidinemethanol
tert-butyldicarbonate
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 12h; | |
In dichloromethane at 0 - 20℃; |
borane-THF
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
In tetrahydrofuran |
4-carbethoxypiperidine
di-tert-butyl dicarbonate
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
With sodium carbonate In 1,4-dioxane; diethyl ether; ethyl acetate | 11.7 gm (36%) |
isonipecotic acid
1-hydroxy-pyrrolidine-2,5-dione
ethyl acetate
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
With sodium hydroxide; sodium tetrahydroborate; triethylamine In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane |
tert butyl 4-formylpiperidine-1-carboxylate
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
In tetrahydrofuran; hexane |
tert-butyl 4-((4-(benzyloxy)phenoxy)methyl)piperidine-1-carboxylate
A
tert-butyl 4-((4-hydroxycyclohexyloxy)methyl)piperidine-1-carboxylate
B
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogen / palladium 10% on activated carbon / ethanol; water / 15 h / 23 °C / 760.05 Torr 2: hydrogen; sodium hydroxide / rhodium contaminated with carbon / water / 21 h / 60 - 70 °C / 7500.75 - 9750.98 Torr View Scheme |
tert-butyl 4-[(4-hydroxyphenoxy)methyl]piperidine-1-carboxylate
A
tert-butyl 4-((4-hydroxycyclohexyloxy)methyl)piperidine-1-carboxylate
B
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
With hydrogen; sodium hydroxide; rhodium contaminated with carbon In water at 60 - 70℃; under 7500.75 - 9750.98 Torr; for 21h; |
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 16 h / 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 0 - 45 °C View Scheme |
N-tert-butyloxycarbonylpiperidin-4-one
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 °C 1.2: 12 h / 0 - 25 °C 2.1: cerium(III) chloride; sodium iodide / acetonitrile / 12 h / Reflux 3.1: sodium tetrahydroborate; methanol / 1 h / 0 - 25 °C View Scheme |
tert-butyl 4-(methoxymethylene)piperidine-1-carboxylate
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: cerium(III) chloride; sodium iodide / acetonitrile / 12 h / Reflux 2: sodium tetrahydroborate; methanol / 1 h / 0 - 25 °C View Scheme |
isonipecotic acid methyl ester
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 12 h / 25 °C 2: lithium borohydride / tetrahydrofuran / 0 °C / Reflux View Scheme |
pyridine-4-carboxylic acid
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrogen / water / 1.5 h / 80 - 95 °C 2: potassium hydroxide; water / ethanol 3: sodium tetrahydroborate / tetrahydrofuran / 3.5 h / -5 - 0 °C View Scheme |
methanesulfonyl chloride
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
tert-butyl 4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 5℃; for 1.5h; | 100% |
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 1.33333h; | 100% |
With triethylamine In dichloromethane at 0 - 20℃; for 2h; | 100% |
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
tert butyl 4-formylpiperidine-1-carboxylate
Conditions | Yield |
---|---|
With oxalyl dichloride; dimethyl sulfoxide; triethylamine In dichloromethane Swern oxidation; | 100% |
Stage #1: tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate With oxalyl dichloride; dimethyl sulfoxide In dichloromethane for 0.25h; Cooling with acetone-dry ice; Stage #2: With triethylamine In dichloromethane at 20℃; | 100% |
Stage #1: tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate With oxalyl dichloride; dimethyl sulfoxide In dichloromethane at -20℃; for 0.333333h; Swern oxidation; Inert atmosphere; Stage #2: With triethylamine In dichloromethane at -50 - 20℃; Swern oxidation; Inert atmosphere; | 100% |
benzyl bromide
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
tert-butyl 4-((benzyloxy)methyl)piperidine-1-carboxylate
Conditions | Yield |
---|---|
With sodium hydride In DMF (N,N-dimethyl-formamide) at 0 - 20℃; for 23h; | 100% |
Stage #1: tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.25h; Inert atmosphere; Stage #2: benzyl bromide In tetrahydrofuran; mineral oil at 0 - 80℃; for 3h; Inert atmosphere; | 76% |
Stage #1: tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate With sodium hydride In DMF (N,N-dimethyl-formamide) at 0 - 20℃; for 0.75h; Stage #2: benzyl bromide In DMF (N,N-dimethyl-formamide) at 0 - 60℃; | |
With NaH In hexane; N,N-dimethyl-formamide |
Conditions | Yield |
---|---|
Stage #1: C13H12N4O3; tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate With PS-triphenylphosphine In dichloromethane for 0.0833333h; Stage #2: With di-tert-butyl-diazodicarboxylate In dichloromethane at 20℃; for 3h; Stage #3: With trifluoroacetic acid In dichloromethane | 100% |
methanesulfonyl chloride
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran; water | 100% |
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
tert-butyl 4-(chloromethyl)piperidine-1-carboxylate
Conditions | Yield |
---|---|
With tetrachloromethane In dichloromethane at 20℃; | 100% |
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
With hydrogenchloride In 1,4-dioxane at 20℃; for 3h; | 100% |
With hydrogenchloride In 1,4-dioxane; dichloromethane at 20℃; for 6h; | 77% |
With hydrogenchloride In methanol; diethyl ether for 1h; | |
With hydrogenchloride In 1,4-dioxane; water for 1h; |
methanesulfonyl chloride
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
4-(methylsulfonylmethyl)piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; for 12.5h; | 100% |
p-toluenesulfonyl chloride
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
N-tert-butoxycarbonyl-4-(4-toluenesulphonyloxymethyl)piperidine
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane at 0 - 17℃; for 2h; Inert atmosphere; | 99% |
With triethylamine In dichloromethane at 10 - 20℃; for 12h; | 92.1% |
With pyridine at 0 - 20℃; for 16h; | 91% |
1-methyl-4-nitro-5-chloro-1H-pyrazole
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
tert-butyl 4-((4-amino-1-methyl-1H-pyrazol-5-yloxy)methyl)piperidine-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: 5-chloro-1-methyl-4-nitro-1H-pyrazole; tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate With sodium hydride In N,N-dimethyl-formamide for 1h; Stage #2: With iron; ammonium chloride In ethanol; water at 60℃; for 1h; | 99% |
2,5-dibromopyridine
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
tert-butyl 4-((5-bromopyridin-2-yloxy)methyl)piperidine-1-carboxylate
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 3h; Temperature; Concentration; | 98% |
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 80℃; for 5h; | 87% |
Stage #1: tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate With sodium hydride In dimethyl sulfoxide; mineral oil at 20 - 50℃; for 1.5h; Stage #2: 2,5-dibromopyridine In dimethyl sulfoxide; mineral oil at 20℃; | 84% |
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 3h; | 78% |
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In dichloromethane at 20℃; for 18h; Inert atmosphere; | 98% |
4,6-dichloro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate With sodium hydride In dimethyl sulfoxide; mineral oil at 20℃; for 0.5h; Stage #2: 4,6-dichloro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine In dimethyl sulfoxide; mineral oil at 20℃; for 2h; | 98% |
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
tert-butyl 4-(iodomethyl)piperidine-1-carboxylate
Conditions | Yield |
---|---|
With 1H-imidazole; iodine; triphenylphosphine In tetrahydrofuran at 20℃; | 97% |
With pyridine; iodine; triphenylphosphine In benzene for 1.5h; Heating; | 92% |
With 1H-imidazole; iodine; triphenylphosphine In tetrahydrofuran at 20℃; for 14h; | 92% |
(4-chlorophenyl)(3-hydroxyphenyl)methanone
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
tert-butyl 4-{[3-(4-chlorobenzoyl)phenoxy]methyl}-piperidine-1-carboxylate
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran for 3h; Mitsunobu reaction; | 97% |
4-Nitrophenyl chloroformate
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
(1-(tert-Butoxycarbonyl)piperidin-4-yl)methyl 4-nitrophenyl carbonate
Conditions | Yield |
---|---|
With 4-methyl-morpholine In DCM at 0 - 20℃; | 96% |
2,2'-dihydroxybiphenyl
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 6h; Inert atmosphere; | 96% |
5-bromo-6-chloropyridin-3-ol
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 5h; | 96% |
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
tert-butyl 4-(bromomethyl)piperidine-1-carboxylate
Conditions | Yield |
---|---|
With carbon tetrabromide; triphenylphosphine In dichloromethane at 20℃; for 1h; | 95% |
With carbon tetrabromide; triphenylphosphine In dichloromethane for 0.166667h; | 95% |
With carbon tetrabromide; triphenylphosphine In dichloromethane at 0 - 20℃; for 22h; | 94% |
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In dichloromethane at 0 - 20℃; for 28h; Inert atmosphere; | 95% |
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
In dimethylsulfoxide-d6; [D3]acetonitrile at 40℃; for 15h; Inert atmosphere; | 95% |
N-(3-methoxybenzyl)-6-methyl-4-(2H-tetrazol-5-yl)picolinamide
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
With di-tert-butyl-diazodicarboxylate In tetrahydrofuran at 0 - 20℃; for 15h; | 94% |
N-hydroxyphthalimide
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
N-(N-Boc-piperidin-4-yl)methoxyphthalimide
Conditions | Yield |
---|---|
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0 - 20℃; for 4h; Inert atmosphere; | 94% |
3-bromo-4-chloropyridine
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide | 94% |
tert-butyl 3-chloro-4-fluorobenzoate
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
Conditions | Yield |
---|---|
With caesium carbonate In dimethyl sulfoxide at 80℃; for 18h; Inert atmosphere; | 94% |
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