N-Boc-4-piperidinemethanol supplier

Name
N-Boc-4-piperidinemethanol
EINECS
CAS No. 123855-51-6
Article Data165
CAS DataBase
Density 1.059 g/cm³
Solubility
Melting Point 78-82 °C
Formula C₁₁H₂₁NO₃
Boiling Point 308 °C at 760 mmHg
Molecular Weight 215.293
Flash Point 140.1 °C
Transport Information
Appearance
Safety 24/25
Risk Codes
Molecular Structure
Hazard Symbols Xi
Synonyms 4-(Hydroxymethyl)-1-piperidinecarboxylic acid1,1-dimethylethyl ester;4-(Hydroxymethyl)piperidine-1-carboxylic acidtert-butyl ester;4-Hydroxymethylpiperidine-1-carboxylic acid tert-butyl ester;N-(tert-Butoxycarbonyl)-4-piperidinemethanol;N-BOC-piperidine-4-methanol;1-(tert-Butoxycarbonyl)-4-(hydroxymethyl)piperidine;1-(tert-Butoxycarbonyl)-4-piperidinemethanol;1-Boc-4-Hydroxymethylpiperidine;
PSA 49.77000
LogP 1.56370

Synthetic route

: 6457-49-4
4-piperidinemethanol

: 24424-99-5
di-tert-butyl dicarbonate

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

Conditions

Conditions	Yield
In dichloromethane	100%
In tetrahydrofuran; ethyl acetate at 20℃; for 14h;	100%
With sodium carbonate In tetrahydrofuran; water at 95℃; for 2.5h;	100%

: 84358-13-4
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

Conditions

Conditions	Yield
With borane-THF In tetrahydrofuran	100%
Stage #1: N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid With borane-THF In tetrahydrofuran at 0℃; for 0.5h; Stage #2: With methanol	96%
With borane-THF In tetrahydrofuran at 0℃; for 0.666667h; Inert atmosphere;	89%

: 137076-22-3
tert butyl 4-formylpiperidine-1-carboxylate

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

Conditions

Conditions	Yield
With methanol; sodium tetrahydroborate at 0 - 25℃; for 1h;	100%
With sodium tetrahydroborate In ethanol for 1h; Inert atmosphere;	53%

: 142851-03-4
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

Conditions

Conditions	Yield
Stage #1: 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate With diisobutylaluminium hydride In tetrahydrofuran at -78 - 20℃; for 0.833333h; Stage #2: With ammonium chloride In tetrahydrofuran; water at 20℃; for 0.75h;	97%
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 2h;	96%
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃;	94%

: 145508-94-7
tert-butyl 4-(iodomethyl)piperidine-1-carboxylate

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In tetrahydrofuran	93%

: 541-41-3
chloroformic acid ethyl ester

: 84358-13-4
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

Conditions

Conditions	Yield
With 4-methyl-morpholine; sodium borohydrid In tetrahydrofuran; methanol; ethyl acetate	90%
With 4-methyl-morpholine; sodium borohydrid In tetrahydrofuran; methanol; ethyl acetate	90%

: borane tetrahydrofuran

: 584-08-7
potassium carbonate

: 84358-13-4
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

Conditions

Conditions	Yield
In tetrahydrofuran; water	84%

...Expand

: 584-08-7
potassium carbonate

: 84358-13-4
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

Conditions

Conditions	Yield
In tetrahydrofuran; water	84%

: 124443-68-1
1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

Conditions

Conditions	Yield
Stage #1: 1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate With lithium borohydride In tetrahydrofuran at 0℃; Reflux; Stage #2: With water In tetrahydrofuran Product distribution / selectivity;	82%
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃;
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃;
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃;
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; Inert atmosphere;

: 6457-49-4
4-piperidinemethanol

tBuOC(O)X: tBuOC(O)X

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

Conditions

Conditions	Yield
Acylation;

: 498-94-2
isonipecotic acid

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 92 percent / aq. NaOH, Et3N / dioxane / 20 h / Ambient temperature 2: BH3*THF / tetrahydrofuran / 1 h / 0 °C View Scheme
Multi-step reaction with 2 steps 1: 100 percent / CH2Cl2 2: 100 percent / BH3*THF / tetrahydrofuran View Scheme
Multi-step reaction with 2 steps 1: 91 percent / NaHCO3 / dioxane; H2O / 24 h 2: 84 percent / BH3*THF / tetrahydrofuran / 0 - 25 °C View Scheme

: 24424-99-5
di-tert-butyl dicarbonate

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 92 percent / aq. NaOH, Et3N / dioxane / 20 h / Ambient temperature 2: BH3*THF / tetrahydrofuran / 1 h / 0 °C View Scheme
Multi-step reaction with 2 steps 1: 100 percent / CH2Cl2 2: 100 percent / BH3*THF / tetrahydrofuran View Scheme
Multi-step reaction with 2 steps 1: 91 percent / NaHCO3 / dioxane; H2O / 24 h 2: 84 percent / BH3*THF / tetrahydrofuran / 0 - 25 °C View Scheme

: 1126-09-6
4-carbethoxypiperidine

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 98 percent / Et3N; DMAP / CH2Cl2 2: 94 percent / LiAlH4 / tetrahydrofuran / 0 °C View Scheme
Multi-step reaction with 2 steps 1: 99 percent / ethyl acetate / 20 h / Ambient temperature 2: 84 percent / LAH / tetrahydrofuran / 2 h / 0 °C View Scheme
Multi-step reaction with 2 steps 1: 94 percent / Et3N / dioxane; H2O / 16 h / 0 - 20 °C 2: 93 percent / LiAlH4 / tetrahydrofuran / 16 h / 0 - 20 °C View Scheme

: 24424-99-5
di-tert-butyl dicarbonate

1.) NaH; 2.) SOCl2: 1.) NaH; 2.) SOCl2

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 98 percent / Et3N; DMAP / CH2Cl2 2: 94 percent / LiAlH4 / tetrahydrofuran / 0 °C View Scheme

: 498-94-2
isonipecotic acid

paraformaldehyde: paraformaldehyde

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 91 percent / NaHCO3 / dioxane; H2O / 24 h 2: 84 percent / BH3*THF / 0 - 25 °C View Scheme
Multi-step reaction with 2 steps 1.1: aq. NaOH / 1,2-dimethoxy-ethane 2.1: isobutyl chloroformate; N-methylmorpholine / 1,2-dimethoxy-ethane / 0 °C 2.2: aq. NaBH4 View Scheme

: 24424-99-5
di-tert-butyl dicarbonate

pentacarbonyl<1-<<(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl>oxy>-(E)-3-phenyl-2-propenylidene>chromium: pentacarbonyl<1-<<(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl>oxy>-(E)-3-phenyl-2-propenylidene>chromium

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 91 percent / NaHCO3 / dioxane; H2O / 24 h 2: 84 percent / BH3*THF / 0 - 25 °C View Scheme
Multi-step reaction with 2 steps 1.1: aq. NaOH / 1,2-dimethoxy-ethane 2.1: isobutyl chloroformate; N-methylmorpholine / 1,2-dimethoxy-ethane / 0 °C 2.2: aq. NaBH4 View Scheme

: 6457-49-4
4-piperidinemethanol

: 34619-03-9
tert-butyldicarbonate

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 12h;
In dichloromethane at 0 - 20℃;

: 14044-65-6
borane-THF

: 84358-13-4
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

Conditions

Conditions	Yield
In tetrahydrofuran

: 1126-09-6
4-carbethoxypiperidine

aqueous sodium hydrogen sulfate: aqueous sodium hydrogen sulfate

: 24424-99-5
di-tert-butyl dicarbonate

: 142851-03-4
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

Conditions

Conditions	Yield
With sodium carbonate In 1,4-dioxane; diethyl ether; ethyl acetate	11.7 gm (36%)

...Expand

: 498-94-2
isonipecotic acid

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

(Boc)2 O: (Boc)2 O

: 141-78-6
ethyl acetate

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

Conditions

Conditions	Yield
With sodium hydroxide; sodium tetrahydroborate; triethylamine In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane

...Expand

: sodium borohydrid

: 137076-22-3
tert butyl 4-formylpiperidine-1-carboxylate

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

Conditions

Conditions	Yield
In tetrahydrofuran; hexane

: 1401098-21-2
tert-butyl 4-((4-(benzyloxy)phenoxy)methyl)piperidine-1-carboxylate

A: 1401098-22-3
tert-butyl 4-((4-hydroxycyclohexyloxy)methyl)piperidine-1-carboxylate

B: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogen / palladium 10% on activated carbon / ethanol; water / 15 h / 23 °C / 760.05 Torr 2: hydrogen; sodium hydroxide / rhodium contaminated with carbon / water / 21 h / 60 - 70 °C / 7500.75 - 9750.98 Torr View Scheme

: 1350060-40-0
tert-butyl 4-[(4-hydroxyphenoxy)methyl]piperidine-1-carboxylate

A: 1401098-22-3
tert-butyl 4-((4-hydroxycyclohexyloxy)methyl)piperidine-1-carboxylate

B: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

Conditions

Conditions	Yield
With hydrogen; sodium hydroxide; rhodium contaminated with carbon In water at 60 - 70℃; under 7500.75 - 9750.98 Torr; for 21h;

: piperidine-4-carboxylic acid ethyl ester hydrochloride

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 16 h / 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 0 - 45 °C View Scheme

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 °C 1.2: 12 h / 0 - 25 °C 2.1: cerium(III) chloride; sodium iodide / acetonitrile / 12 h / Reflux 3.1: sodium tetrahydroborate; methanol / 1 h / 0 - 25 °C View Scheme

: 138022-91-0
tert-butyl 4-(methoxymethylene)piperidine-1-carboxylate

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: cerium(III) chloride; sodium iodide / acetonitrile / 12 h / Reflux 2: sodium tetrahydroborate; methanol / 1 h / 0 - 25 °C View Scheme

: 2971-79-1
isonipecotic acid methyl ester

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 12 h / 25 °C 2: lithium borohydride / tetrahydrofuran / 0 °C / Reflux View Scheme

: 55-22-1
pyridine-4-carboxylic acid

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: hydrogen / water / 1.5 h / 80 - 95 °C 2: potassium hydroxide; water / ethanol 3: sodium tetrahydroborate / tetrahydrofuran / 3.5 h / -5 - 0 °C View Scheme

: 124-63-0
methanesulfonyl chloride

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: 161975-39-9
tert-butyl 4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 5℃; for 1.5h;	100%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 1.33333h;	100%
With triethylamine In dichloromethane at 0 - 20℃; for 2h;	100%

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: 137076-22-3
tert butyl 4-formylpiperidine-1-carboxylate

Conditions

Conditions	Yield
With oxalyl dichloride; dimethyl sulfoxide; triethylamine In dichloromethane Swern oxidation;	100%
Stage #1: tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate With oxalyl dichloride; dimethyl sulfoxide In dichloromethane for 0.25h; Cooling with acetone-dry ice; Stage #2: With triethylamine In dichloromethane at 20℃;	100%
Stage #1: tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate With oxalyl dichloride; dimethyl sulfoxide In dichloromethane at -20℃; for 0.333333h; Swern oxidation; Inert atmosphere; Stage #2: With triethylamine In dichloromethane at -50 - 20℃; Swern oxidation; Inert atmosphere;	100%

: 100-39-0
benzyl bromide

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: 301226-04-0
tert-butyl 4-((benzyloxy)methyl)piperidine-1-carboxylate

Conditions

Conditions	Yield
With sodium hydride In DMF (N,N-dimethyl-formamide) at 0 - 20℃; for 23h;	100%
Stage #1: tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.25h; Inert atmosphere; Stage #2: benzyl bromide In tetrahydrofuran; mineral oil at 0 - 80℃; for 3h; Inert atmosphere;	76%
Stage #1: tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate With sodium hydride In DMF (N,N-dimethyl-formamide) at 0 - 20℃; for 0.75h; Stage #2: benzyl bromide In DMF (N,N-dimethyl-formamide) at 0 - 60℃;
With NaH In hexane; N,N-dimethyl-formamide

: 895136-02-4
C13H12N4O3

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: C19H23N5O3

Conditions

Conditions	Yield
Stage #1: C13H12N4O3; tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate With PS-triphenylphosphine In dichloromethane for 0.0833333h; Stage #2: With di-tert-butyl-diazodicarboxylate In dichloromethane at 20℃; for 3h; Stage #3: With trifluoroacetic acid In dichloromethane	100%

: 124-63-0
methanesulfonyl chloride

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: (1-tert-butoxycarbonylpiperidin-4-ylmethyl)methanesulfonate

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran; water	100%

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: 479057-79-9
tert-butyl 4-(chloromethyl)piperidine-1-carboxylate

Conditions

Conditions	Yield
With tetrachloromethane In dichloromethane at 20℃;	100%

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: 4-piperidinemethanol hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In 1,4-dioxane at 20℃; for 3h;	100%
With hydrogenchloride In 1,4-dioxane; dichloromethane at 20℃; for 6h;	77%
With hydrogenchloride In methanol; diethyl ether for 1h;
With hydrogenchloride In 1,4-dioxane; water for 1h;

: 124-63-0
methanesulfonyl chloride

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: 194872-09-8
4-(methylsulfonylmethyl)piperidine-1-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 12.5h;	100%

: 98-59-9
p-toluenesulfonyl chloride

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: 166815-96-9
N-tert-butoxycarbonyl-4-(4-toluenesulphonyloxymethyl)piperidine

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 0 - 17℃; for 2h; Inert atmosphere;	99%
With triethylamine In dichloromethane at 10 - 20℃; for 12h;	92.1%
With pyridine at 0 - 20℃; for 16h;	91%

: 42098-25-9
1-methyl-4-nitro-5-chloro-1H-pyrazole

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: 1338717-88-6
tert-butyl 4-((4-amino-1-methyl-1H-pyrazol-5-yloxy)methyl)piperidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: 5-chloro-1-methyl-4-nitro-1H-pyrazole; tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate With sodium hydride In N,N-dimethyl-formamide for 1h; Stage #2: With iron; ammonium chloride In ethanol; water at 60℃; for 1h;	99%

: 624-28-2
2,5-dibromopyridine

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: 1010114-48-3
tert-butyl 4-((5-bromopyridin-2-yloxy)methyl)piperidine-1-carboxylate

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 3h; Temperature; Concentration;	98%
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 80℃; for 5h;	87%
Stage #1: tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate With sodium hydride In dimethyl sulfoxide; mineral oil at 20 - 50℃; for 1.5h; Stage #2: 2,5-dibromopyridine In dimethyl sulfoxide; mineral oil at 20℃;	84%
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 3h;	78%

: 4-((3-phenylpropyl)amino)-2-chloroquinazolin-7-ol

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: 4-((3-phenylpropyl)amino)-2-chloro-7-(O-((N-boc)piperidin-4-ylmethoxy))quinazoline

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In dichloromethane at 20℃; for 18h; Inert atmosphere;	98%

: 881902-80-3
4,6-dichloro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: tert-butyl 4-[[6-chloro-1-(2-trimethylsilylethoxymethyl)pyrrolo[2,3-b]pyridin-4-yl]oxymethyl] piperidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate With sodium hydride In dimethyl sulfoxide; mineral oil at 20℃; for 0.5h; Stage #2: 4,6-dichloro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine In dimethyl sulfoxide; mineral oil at 20℃; for 2h;	98%

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: 145508-94-7
tert-butyl 4-(iodomethyl)piperidine-1-carboxylate

Conditions

Conditions	Yield
With 1H-imidazole; iodine; triphenylphosphine In tetrahydrofuran at 20℃;	97%
With pyridine; iodine; triphenylphosphine In benzene for 1.5h; Heating;	92%
With 1H-imidazole; iodine; triphenylphosphine In tetrahydrofuran at 20℃; for 14h;	92%

: 62810-39-3
(4-chlorophenyl)(3-hydroxyphenyl)methanone

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: 1372526-57-2
tert-butyl 4-{[3-(4-chlorobenzoyl)phenoxy]methyl}-piperidine-1-carboxylate

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran for 3h; Mitsunobu reaction;	97%

: 7693-46-1
4-Nitrophenyl chloroformate

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: 1159928-33-2
(1-(tert-Butoxycarbonyl)piperidin-4-yl)methyl 4-nitrophenyl carbonate

Conditions

Conditions	Yield
With 4-methyl-morpholine In DCM at 0 - 20℃;	96%

: 1806-29-7
2,2'-dihydroxybiphenyl

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: tert-butyl 4-(((2'-hydroxy-[1,1'-biphenyl]-2-yl)oxy)methyl)piperidine-1-carboxylate

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 6h; Inert atmosphere;	96%

: 130115-85-4
5-bromo-6-chloropyridin-3-ol

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: C16H22BrClN2O3

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 5h;	96%

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: 158407-04-6
tert-butyl 4-(bromomethyl)piperidine-1-carboxylate

Conditions

Conditions	Yield
With carbon tetrabromide; triphenylphosphine In dichloromethane at 20℃; for 1h;	95%
With carbon tetrabromide; triphenylphosphine In dichloromethane for 0.166667h;	95%
With carbon tetrabromide; triphenylphosphine In dichloromethane at 0 - 20℃; for 22h;	94%

: 4-((1-benzylpiperidin-4-yl)amino)-6-methoxy-7-hydroxy-2-(4-phenylpiperazin-1-yl)quinazoline

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: 4-((1-benzylpiperidine-4-yl)amino)-6-methoxy-2-(4-phenylpiperazin-1-yl)-7-(O-((N-Boc)piperidin-4-ylmethoxy))quinazoline

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In dichloromethane at 0 - 20℃; for 28h; Inert atmosphere;	95%

: 2-fluoro-5-nitrophenyldiazonium tetrafluoroborate

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: 5-nitro-2-(piperidinium-4-ylmethoxy)benzenediazonium tetrafluoroborate fluoride

Conditions

Conditions	Yield
In dimethylsulfoxide-d6; [D3]acetonitrile at 40℃; for 15h; Inert atmosphere;	95%

: 1112181-71-1
N-(3-methoxybenzyl)-6-methyl-4-(2H-tetrazol-5-yl)picolinamide

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: tert-butyl 4-((5-(2-((3-methoxybenzyl)carbamoyl)-6-methylpyridin-4-yl)-2H-tetrazol-2-yl)methyl)piperidine-1-carboxylate

Conditions

Conditions	Yield
With di-tert-butyl-diazodicarboxylate In tetrahydrofuran at 0 - 20℃; for 15h;	94%

: 524-38-9
N-hydroxyphthalimide

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: 143540-03-8
N-(N-Boc-piperidin-4-yl)methoxyphthalimide

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0 - 20℃; for 4h; Inert atmosphere;	94%

: 36953-42-1
3-bromo-4-chloropyridine

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: tert-butyl 4-(((3-bromopyridin-4-yl)oxy)methyl)piperidine-1-carboxylate

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide	94%

: 570407-88-4
tert-butyl 3-chloro-4-fluorobenzoate

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: tert-butyl 4-((4-(tert-butoxycarbonyl)-2-chlorophenoxy)methyl)piperidine-1-carboxylate

Conditions

Conditions	Yield
With caesium carbonate In dimethyl sulfoxide at 80℃; for 18h; Inert atmosphere;	94%

N-Boc-4-piperidinemethanol Chemical Properties

IUPAC Name: tert-Butyl 4-(hydroxymethyl)piperidine-1-carboxylate
Synonyms of N-Boc-4-piperidinemethanol (CAS NO.123855-51-6): N-tert-Butyloxycarbonyl-4-piperidinemethanol
CAS NO: 123855-51-6
Molecular formula: C₁₁H₂₁NO₃
Molecular Weight: 215.29
Molecular Structure :
Melting point:78-82 °C(lit.)
H bond acceptors: 4
H bond donors: 1
Freely Rotating Bonds: 4
Polar Surface Area: 38.77 Å²
Index of Refraction: 1.479
Molar Refractivity: 57.66 cm³
Molar Volume: 203.2 cm³
Surface Tension: 37.8 dyne/cm
Density: 1.059 g/cm³
Flash Point: 140.1 °C
Enthalpy of Vaporization: 63.62 kJ/mol
Boiling Point: 308 °C at 760 mmHg
Vapour Pressure: 6.41E-05 mmHg at 25°C
Melting Point: 78-82 °C(lit.)
Product Categories of N-Boc-4-piperidinemethanol (CAS NO.123855-51-6): Amines;blocks;Piperidine;Piperazine

N-Boc-4-piperidinemethanol Safety Profile

Safety Information about N-Boc-4-piperidinemethanol (CAS NO.123855-51-6):
Hazard Codes: Xi
WGK Germany: 3
Hazard Note: Irritant

Product Name

N-Boc-4-piperidinemethanol

Synthetic route

N-Boc-4-piperidinemethanol Chemical Properties

N-Boc-4-piperidinemethanol Safety Profile

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