The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:139756-22-2
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inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:139756-22-2
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
Cas:139756-22-2
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:139756-22-2
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inquiry5-(5-Chlorosulfonyl-2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one CAS:139756-22-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, productio
Cas:139756-22-2
Min.Order:1 Gram
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:139756-22-2
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquirySuperiority We can customize and synthesize products that other suppliers may not be able to provide. Advantage cof, mof ligand manufacturer Product Detail
Cas:139756-22-2
Min.Order:100 Kilogram
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:139756-22-2
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:139756-22-2
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:139756-22-2
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryWhy Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu
Cas:139756-22-2
Min.Order:1 Gram
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inquiryOur service We have our own research and development team, laboratory, pilot workshop and production plant. Factory produc
Cas:139756-22-2
Min.Order:1 Kilogram
FOB Price: $15.0
Type:Trading Company
inquiryfactory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
Cas:139756-22-2
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:139756-22-2
Min.Order:10 Gram
FOB Price: $100.0
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inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:139756-22-2
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:139756-22-2
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inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:139756-22-2
Min.Order:1 Metric Ton
FOB Price: $7.0 / 8.0
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inquiryAppearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea
Cas:139756-22-2
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inquirySAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in
Cas:139756-22-2
Min.Order:0 Metric Ton
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inquiryWe are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
Cas:139756-22-2
Min.Order:1 Metric Ton
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Type:Trading Company
inquiryLower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe
Cas:139756-22-2
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Type:Lab/Research institutions
inquiryR & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates
Cas:139756-22-2
Min.Order:0
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Type:Manufacturers
inquiryTAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp
Cas:139756-22-2
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Type:Manufacturers
inquiry1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.
Cas:139756-22-2
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Type:Lab/Research institutions
inquirybest seller Application:API
Cas:139756-22-2
Min.Order:0
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Type:Manufacturers
inquiryAnsciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
Cas:139756-22-2
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Type:Lab/Research institutions
inquirySAGECHEM/ 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-sulfonyl chloride /Manufacturer in China Application:SAGECHEM/ 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benz
Cas:139756-22-2
Min.Order:0
Negotiable
Type:Other
inquiryWe product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Pharm intermediate
Cas:139756-22-2
Min.Order:0
Negotiable
Type:Trading Company
inquiryAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China
Cas:139756-22-2
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inquiry5-(2-ethoxy)-phenyl-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidine-7-one
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Conditions | Yield |
---|---|
With chlorosulfonic acid at 0 - 25℃; for 2h; | 97% |
With chlorosulfonic acid In neat (no solvent) at 0 - 20℃; for 12h; | 95% |
With chlorosulfonic acid; thionyl chloride at 0 - 20℃; Sealed tube; | 92% |
ethyl 3-butyrylpyruvate
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1: hydrazine hydrate / acetic acid; 2-methoxy-ethanol / 100 °C 2: caesium carbonate / N,N-dimethyl-formamide / 20 °C 3: hydrogenchloride / water / 100 °C 4: nitric acid; sulfuric acid / 50 °C 5: thionyl chloride / Reflux 6: ammonium hydroxide / tetrahydrofuran / 2 h / Cooling with ice 7: palladium on activated charcoal; hydrogen / methanol / 30 °C / 2585.81 Torr 8: triethylamine / dichloromethane / 20 °C 9: sodium hydroxide; dihydrogen peroxide / ethanol; water / 100 °C 10: chlorosulfonic acid / 2 h / 20 °C / Cooling with ice View Scheme | |
Multi-step reaction with 10 steps 1: acetic acid; hydrazine hydrate / 2-methoxy-ethanol / 100 °C 2: caesium carbonate / N,N-dimethyl-formamide / 20 °C 3: hydrogenchloride; water / 100 °C 4: sulfuric acid; nitric acid / 50 °C 5: thionyl chloride / Reflux 6: ammonium hydroxide / tetrahydrofuran / 2 h / Cooling with ice 7: palladium on activated charcoal; hydrogen / methanol / 30 °C / 2585.81 Torr 8: triethylamine / dichloromethane / 20 °C 9: sodium hydroxide; dihydrogen peroxide / water; ethanol / 100 °C 10: chlorosulfonic acid / 2 h / 20 °C / Cooling with ice View Scheme |
2-Pentanone
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Conditions | Yield |
---|---|
Multi-step reaction with 11 steps 1.1: sodium / ethanol / 1 h / 20 °C 1.2: 20 °C 2.1: hydrazine hydrate / acetic acid; 2-methoxy-ethanol / 100 °C 3.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C 4.1: hydrogenchloride / water / 100 °C 5.1: nitric acid; sulfuric acid / 50 °C 6.1: thionyl chloride / Reflux 7.1: ammonium hydroxide / tetrahydrofuran / 2 h / Cooling with ice 8.1: palladium on activated charcoal; hydrogen / methanol / 30 °C / 2585.81 Torr 9.1: triethylamine / dichloromethane / 20 °C 10.1: sodium hydroxide; dihydrogen peroxide / ethanol; water / 100 °C 11.1: chlorosulfonic acid / 2 h / 20 °C / Cooling with ice View Scheme | |
Multi-step reaction with 11 steps 1.1: sodium / ethanol / 1 h / 20 °C 1.2: 20 °C 2.1: acetic acid; hydrazine hydrate / 2-methoxy-ethanol / 100 °C 3.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C 4.1: hydrogenchloride; water / 100 °C 5.1: sulfuric acid; nitric acid / 50 °C 6.1: thionyl chloride / Reflux 7.1: ammonium hydroxide / tetrahydrofuran / 2 h / Cooling with ice 8.1: palladium on activated charcoal; hydrogen / methanol / 30 °C / 2585.81 Torr 9.1: triethylamine / dichloromethane / 20 °C 10.1: sodium hydroxide; dihydrogen peroxide / water; ethanol / 100 °C 11.1: chlorosulfonic acid / 2 h / 20 °C / Cooling with ice View Scheme |
ethyl 3-propyl-1H-pyrazole-5-carboxylate
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: caesium carbonate / N,N-dimethyl-formamide / 20 °C 2: hydrogenchloride / water / 100 °C 3: nitric acid; sulfuric acid / 50 °C 4: thionyl chloride / Reflux 5: ammonium hydroxide / tetrahydrofuran / 2 h / Cooling with ice 6: palladium on activated charcoal; hydrogen / methanol / 30 °C / 2585.81 Torr 7: triethylamine / dichloromethane / 20 °C 8: sodium hydroxide; dihydrogen peroxide / ethanol; water / 100 °C 9: chlorosulfonic acid / 2 h / 20 °C / Cooling with ice View Scheme | |
Multi-step reaction with 7 steps 1.1: 9 h / 5 - 25 °C 2.1: sodium hydroxide / 3 h / 75 °C 3.1: sulfuric acid; nitric acid / 8 h / 50 °C 4.1: thionyl chloride / 5 h / Reflux 5.1: iron; ammonium chloride / ethanol; water / 4.5 h / 80 °C 6.1: ethanol / 1.5 h / 70 °C 6.2: 1.5 h / 70 °C 7.1: chlorosulfonic acid / 0 - 5 °C View Scheme | |
Multi-step reaction with 9 steps 1: caesium carbonate / N,N-dimethyl-formamide / 20 °C 2: hydrogenchloride; water / 100 °C 3: sulfuric acid; nitric acid / 50 °C 4: thionyl chloride / Reflux 5: ammonium hydroxide / tetrahydrofuran / 2 h / Cooling with ice 6: palladium on activated charcoal; hydrogen / methanol / 30 °C / 2585.81 Torr 7: triethylamine / dichloromethane / 20 °C 8: sodium hydroxide; dihydrogen peroxide / water; ethanol / 100 °C 9: chlorosulfonic acid / 2 h / 20 °C / Cooling with ice View Scheme |
1-Methyl-3-n-propylpyrazole-5-carboxylic acid ethyl ester
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: hydrogenchloride / water / 100 °C 2: nitric acid; sulfuric acid / 50 °C 3: thionyl chloride / Reflux 4: ammonium hydroxide / tetrahydrofuran / 2 h / Cooling with ice 5: palladium on activated charcoal; hydrogen / methanol / 30 °C / 2585.81 Torr 6: triethylamine / dichloromethane / 20 °C 7: sodium hydroxide; dihydrogen peroxide / ethanol; water / 100 °C 8: chlorosulfonic acid / 2 h / 20 °C / Cooling with ice View Scheme | |
Multi-step reaction with 6 steps 1.1: sodium hydroxide / 3 h / 75 °C 2.1: sulfuric acid; nitric acid / 8 h / 50 °C 3.1: thionyl chloride / 5 h / Reflux 4.1: iron; ammonium chloride / ethanol; water / 4.5 h / 80 °C 5.1: ethanol / 1.5 h / 70 °C 5.2: 1.5 h / 70 °C 6.1: chlorosulfonic acid / 0 - 5 °C View Scheme | |
Multi-step reaction with 8 steps 1: hydrogenchloride; water / 100 °C 2: sulfuric acid; nitric acid / 50 °C 3: thionyl chloride / Reflux 4: ammonium hydroxide / tetrahydrofuran / 2 h / Cooling with ice 5: palladium on activated charcoal; hydrogen / methanol / 30 °C / 2585.81 Torr 6: triethylamine / dichloromethane / 20 °C 7: sodium hydroxide; dihydrogen peroxide / water; ethanol / 100 °C 8: chlorosulfonic acid / 2 h / 20 °C / Cooling with ice View Scheme |
1-methyl-3-propyl-1 H-pyrazole-5-carboxylic acid
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: nitric acid; sulfuric acid / 50 °C 2: thionyl chloride / Reflux 3: ammonium hydroxide / tetrahydrofuran / 2 h / Cooling with ice 4: palladium on activated charcoal; hydrogen / methanol / 30 °C / 2585.81 Torr 5: triethylamine / dichloromethane / 20 °C 6: sodium hydroxide; dihydrogen peroxide / ethanol; water / 100 °C 7: chlorosulfonic acid / 2 h / 20 °C / Cooling with ice View Scheme | |
Multi-step reaction with 5 steps 1.1: sulfuric acid; nitric acid / 8 h / 50 °C 2.1: thionyl chloride / 5 h / Reflux 3.1: iron; ammonium chloride / ethanol; water / 4.5 h / 80 °C 4.1: ethanol / 1.5 h / 70 °C 4.2: 1.5 h / 70 °C 5.1: chlorosulfonic acid / 0 - 5 °C View Scheme | |
Multi-step reaction with 7 steps 1: sulfuric acid; nitric acid / 50 °C 2: thionyl chloride / Reflux 3: ammonium hydroxide / tetrahydrofuran / 2 h / Cooling with ice 4: palladium on activated charcoal; hydrogen / methanol / 30 °C / 2585.81 Torr 5: triethylamine / dichloromethane / 20 °C 6: sodium hydroxide; dihydrogen peroxide / water; ethanol / 100 °C 7: chlorosulfonic acid / 2 h / 20 °C / Cooling with ice View Scheme |
1-methyl-2-nitro-3-propyl-1H-pyrazole-5-carboxylic acid
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: thionyl chloride / Reflux 2: ammonium hydroxide / tetrahydrofuran / 2 h / Cooling with ice 3: palladium on activated charcoal; hydrogen / methanol / 30 °C / 2585.81 Torr 4: triethylamine / dichloromethane / 20 °C 5: sodium hydroxide; dihydrogen peroxide / ethanol; water / 100 °C 6: chlorosulfonic acid / 2 h / 20 °C / Cooling with ice View Scheme | |
Multi-step reaction with 4 steps 1.1: thionyl chloride / 5 h / Reflux 2.1: iron; ammonium chloride / ethanol; water / 4.5 h / 80 °C 3.1: ethanol / 1.5 h / 70 °C 3.2: 1.5 h / 70 °C 4.1: chlorosulfonic acid / 0 - 5 °C View Scheme | |
Multi-step reaction with 6 steps 1: thionyl chloride / Reflux 2: ammonium hydroxide / tetrahydrofuran / 2 h / Cooling with ice 3: palladium on activated charcoal; hydrogen / methanol / 30 °C / 2585.81 Torr 4: triethylamine / dichloromethane / 20 °C 5: sodium hydroxide; dihydrogen peroxide / water; ethanol / 100 °C 6: chlorosulfonic acid / 2 h / 20 °C / Cooling with ice View Scheme |
1-methyl-4-nitro-3-propyl-1H-pyrazole-5 carboxamide
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: palladium on activated charcoal; hydrogen / methanol / 30 °C / 2585.81 Torr 2: triethylamine / dichloromethane / 20 °C 3: sodium hydroxide; dihydrogen peroxide / ethanol; water / 100 °C 4: chlorosulfonic acid / 2 h / 20 °C / Cooling with ice View Scheme | |
Multi-step reaction with 3 steps 1.1: iron; ammonium chloride / ethanol; water / 4.5 h / 80 °C 2.1: ethanol / 1.5 h / 70 °C 2.2: 1.5 h / 70 °C 3.1: chlorosulfonic acid / 0 - 5 °C View Scheme | |
Multi-step reaction with 4 steps 1: palladium on activated charcoal; hydrogen / methanol / 30 °C / 2585.81 Torr 2: triethylamine / dichloromethane / 20 °C 3: sodium hydroxide; dihydrogen peroxide / water; ethanol / 100 °C 4: chlorosulfonic acid / 2 h / 20 °C / Cooling with ice View Scheme |
1-methyl-4-nitro-3-propyl-1H-pyrazole-5-carbonyl chloride
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: ammonium hydroxide / tetrahydrofuran / 2 h / Cooling with ice 2: palladium on activated charcoal; hydrogen / methanol / 30 °C / 2585.81 Torr 3: triethylamine / dichloromethane / 20 °C 4: sodium hydroxide; dihydrogen peroxide / ethanol; water / 100 °C 5: chlorosulfonic acid / 2 h / 20 °C / Cooling with ice View Scheme | |
Multi-step reaction with 5 steps 1: ammonium hydroxide / tetrahydrofuran / 2 h / Cooling with ice 2: palladium on activated charcoal; hydrogen / methanol / 30 °C / 2585.81 Torr 3: triethylamine / dichloromethane / 20 °C 4: sodium hydroxide; dihydrogen peroxide / water; ethanol / 100 °C 5: chlorosulfonic acid / 2 h / 20 °C / Cooling with ice View Scheme |
4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 20 °C 2: sodium hydroxide; dihydrogen peroxide / ethanol; water / 100 °C 3: chlorosulfonic acid / 2 h / 20 °C / Cooling with ice View Scheme | |
Multi-step reaction with 2 steps 1.1: ethanol / 1.5 h / 70 °C 1.2: 1.5 h / 70 °C 2.1: chlorosulfonic acid / 0 - 5 °C View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 20 °C 2: sodium hydroxide; dihydrogen peroxide / water; ethanol / 100 °C 3: chlorosulfonic acid / 2 h / 20 °C / Cooling with ice View Scheme |
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydroxide; dihydrogen peroxide / ethanol; water / 100 °C 2: chlorosulfonic acid / 2 h / 20 °C / Cooling with ice View Scheme | |
Multi-step reaction with 2 steps 1: sodium hydroxide; dihydrogen peroxide / water; ethanol / 100 °C 2: chlorosulfonic acid / 2 h / 20 °C / Cooling with ice View Scheme |
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: dipotassium peroxodisulfate / acetonitrile / 8 h / 80 °C / Sealed tube; Inert atmosphere 2: chlorosulfonic acid / 0 - 20 °C / Sealed tube View Scheme |
2-ethoxylbenzaldehyde
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: ethanol / 1.5 h / 70 °C 2: copper dichloride; oxygen / ethanol / 1.5 h / 70 °C 3: chlorosulfonic acid / 0 - 5 °C View Scheme |
C17H22N4O2
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: copper dichloride; oxygen / ethanol / 1.5 h / 70 °C 2: chlorosulfonic acid / 0 - 5 °C View Scheme |
2-ethoxybenzoyl chloride
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 1.5 h / 20 °C 2: sodium hydroxide / tert-butyl alcohol / 35 h / 80 - 90 °C 3: chlorosulfonic acid / 12 h / 20 - 30 °C View Scheme |
4-[(2-ethoxybenzoyl)amino]-1-methyl-3-propyl-1H-pyrazole-5-carboxamide
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydroxide / tert-butyl alcohol / 35 h / 80 - 90 °C 2: chlorosulfonic acid / 12 h / 20 - 30 °C View Scheme |
4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonic acid
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Conditions | Yield |
---|---|
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0℃; for 5h; Inert atmosphere; |
viagra
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sulfuric acid; water / 41 h / 20 - 100 °C 2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 5 h / 0 °C / Inert atmosphere View Scheme |
2-(2-ethoxyphenyl)acetic acid
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: dipotassium peroxodisulfate / water / 12 h / 80 °C / Sealed tube 2: chlorosulfonic acid; thionyl chloride / 0 - 20 °C / Sealed tube View Scheme |
2-Hydroxyphenylacetic acid
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium carbonate / acetonitrile / 4 h / 80 °C / Sealed tube 2: dipotassium peroxodisulfate / water / 12 h / 80 °C / Sealed tube 3: chlorosulfonic acid; thionyl chloride / 0 - 20 °C / Sealed tube View Scheme |
1,4-Diazacycloheptane
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
5-(5-(1,4-diazepane-1-ylsulfonyl)-2-ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one
Conditions | Yield |
---|---|
With triethylamine In ethanol at 0 - 10℃; for 1h; Concentration; Inert atmosphere; | 98% |
1-Methylhomopiperazine
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
5-[2-ethoxy-5-(4-methyl-1-homopiperazinylsulfonyl)]-phenyl-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo [4,3-d]pyrimidine-7-one
Conditions | Yield |
---|---|
With triethylamine In ethanol at 20℃; for 1h; Concentration; Solvent; Inert atmosphere; | 97.5% |
With N-ethyl-N,N-diisopropylamine In chloroform for 12h; pH=9; Cooling with ice; | 92.2% |
With N-ethyl-N,N-diisopropylamine In chloroform for 12h; pH=9; Cooling with ice; | 92.2% |
2-Ketopiperazine
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Conditions | Yield |
---|---|
Stage #1: 2-Ketopiperazine With triethylamine In chloroform at 10℃; for 0.166667h; Stage #2: 5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one In chloroform at 25℃; for 6h; | 95% |
With N-ethyl-N,N-diisopropylamine In dichloromethane at 15 - 25℃; | 70% |
1-methyl-piperazine
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
viagra
Conditions | Yield |
---|---|
With pyridine In water at 50℃; Reagent/catalyst; Temperature; | 93.9% |
With triethylamine In methanol at 20℃; for 0.75h; Product distribution / selectivity; | 91% |
In acetone at 20℃; for 3h; Sealed tube; | 90% |
piperazine
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 2h; | 93% |
In ethanol at 100℃; for 1h; Microwave irradiation; | 87% |
In ethanol at 100℃; for 1h; Microwave irradiation; | 86.8% |
In ethanol at 100℃; for 1h; Microwave irradiation; | 86.8% |
In ethanol at 20℃; for 3h; | 72.3% |
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
N-acetylhomopiperizine
5-(5-(4-acetyl-1,4-diazepan-1-ylsulfonyl)-2-ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one
Conditions | Yield |
---|---|
With triethylamine In ethanol at 20℃; for 1h; Inert atmosphere; | 93% |
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
4-(piperazin-1-yl)pyridine
Conditions | Yield |
---|---|
Stage #1: 4-(piperazin-1-yl)pyridine With triethylamine In chloroform at 10℃; for 0.166667h; Stage #2: 5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one In chloroform at 25℃; for 6h; | 93% |
With N-ethyl-N,N-diisopropylamine In dichloromethane at 15 - 25℃; | 70% |
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
7-chloro-1-methyl-5-[2-ethoxy-5-(chlorosulfonyl)phenyl]-3-n-propyl-1H-pyrazolo[4,3-d]pyrimidine
Conditions | Yield |
---|---|
With trichlorophosphate at 70 - 80℃; for 2h; Product distribution / selectivity; | 92% |
With trichlorophosphate at 80℃; for 2h; Product distribution / selectivity; | 92% |
With phosphorus pentachloride In benzene at 0 - 90℃; for 2.5h; Product distribution / selectivity; | 67% |
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
N-(2-aminoethyl)benzeneamine
C25H30N6O4S
Conditions | Yield |
---|---|
With triethylamine In ethanol at 30℃; for 0.0833333h; microwave irradiation; | 92% |
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
N-(2-pyridinyl)piperazine
Conditions | Yield |
---|---|
Stage #1: N-(2-pyridinyl)piperazine With trimethylamine In 1,4-dioxane at 15℃; for 0.166667h; Stage #2: 5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one In 1,4-dioxane at 27℃; for 6h; | 92% |
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
azetion-3-ol hydrochloride
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 25℃; for 16h; | 91.81% |
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
1-methylpiperazine hydrochloride
viagra
Conditions | Yield |
---|---|
With triethylamine; N-ethyl-N,N-diisopropylamine In water at 60℃; for 1.2h; | 91.8% |
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
1-(2-pyridyl)piperazine
Conditions | Yield |
---|---|
Stage #1: 1-(2-pyridyl)piperazine With caesium carbonate In N,N-dimethyl-formamide at 15℃; for 0.166667h; Stage #2: 5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one In N,N-dimethyl-formamide at 35℃; for 4h; | 91% |
4-benzylpyperidine
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Conditions | Yield |
---|---|
Stage #1: 4-benzylpyperidine With triethylamine In dichloromethane at 20℃; for 0.166667h; Stage #2: 5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one In dichloromethane at 30℃; for 6h; | 91% |
With N-ethyl-N,N-diisopropylamine In dichloromethane at 15 - 25℃; | 70% |
cyclohexylpiperazine
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
C27H38N6O4S
Conditions | Yield |
---|---|
With triethylamine In ethanol at 30℃; for 0.0833333h; microwave irradiation; | 90% |
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
1-(o-toluyl)piperazine
C28H34N6O4S
Conditions | Yield |
---|---|
With triethylamine In ethanol at 30℃; for 0.0833333h; microwave irradiation; | 90% |
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
1-(2-Methoxyphenyl)piperazine
C28H34N6O5S
Conditions | Yield |
---|---|
With triethylamine In ethanol at 30℃; for 0.0833333h; microwave irradiation; | 90% |
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
1-(4-Nitrophenyl)piperazine
C27H31N7O6S
Conditions | Yield |
---|---|
With triethylamine In ethanol at 30℃; for 0.0833333h; microwave irradiation; | 90% |
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
1-(o-fluorophenyl)piperazine
C27H31FN6O4S
Conditions | Yield |
---|---|
With triethylamine In ethanol at 30℃; for 0.0833333h; microwave irradiation; | 90% |
piperidin-4-one
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Conditions | Yield |
---|---|
Stage #1: piperidin-4-one With N-ethyl-N,N-diisopropylamine In dichloromethane at 15℃; for 0.166667h; Stage #2: 5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one In dichloromethane at 25℃; for 6h; | 90% |
With N-ethyl-N,N-diisopropylamine In dichloromethane at 15 - 25℃; for 6h; | 90% |
4-methoxypiperidine
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Conditions | Yield |
---|---|
Stage #1: 4-methoxypiperidine With potassium carbonate In acetone at 20℃; for 0.166667h; Stage #2: 5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one In acetone at 35℃; for 5h; | 90% |
With N-ethyl-N,N-diisopropylamine In dichloromethane at 15 - 25℃; | 80% |
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
4'-piperazinoacetophenone
Conditions | Yield |
---|---|
Stage #1: 4'-piperazinoacetophenone With potassium carbonate In acetonitrile at 20℃; for 0.166667h; Stage #2: 5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one In acetonitrile at 35℃; for 5h; | 90% |
With N-ethyl-N,N-diisopropylamine In dichloromethane at 15 - 25℃; | 65% |
4-piperidinopiperidin
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Conditions | Yield |
---|---|
Stage #1: 4-piperidinopiperidin With potassium carbonate In acetone at 25℃; for 0.166667h; Stage #2: 5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one In acetone at 25℃; for 4.5h; | 90% |
With N-ethyl-N,N-diisopropylamine In dichloromethane at 15 - 25℃; | 65% |
4-methylpiperidin
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Conditions | Yield |
---|---|
Stage #1: 4-methylpiperidin With N-ethyl-N,N-diisopropylamine In 1,2-dichloro-ethane at 20℃; for 0.166667h; Stage #2: 5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one In 1,2-dichloro-ethane at 30℃; for 6h; | 90% |
With N-ethyl-N,N-diisopropylamine In dichloromethane at 15 - 25℃; | 80% |
With triethylamine In chloroform | |
With triethylamine In chloroform |
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
(piperidin-4-yl)carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Stage #1: (piperidin-4-yl)carbamic acid tert-butyl ester With N-ethyl-N,N-diisopropylamine In dichloromethane at 15℃; for 0.166667h; Stage #2: 5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one In dichloromethane at 30℃; for 6h; | 90% |
With N-ethyl-N,N-diisopropylamine In dichloromethane at 15 - 25℃; | 75% |
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonic acid
Conditions | Yield |
---|---|
With ethanol for 5h; Reagent/catalyst; Reflux; | 90% |
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
1-naphtylpiperazine
C31H34N6O4S
Conditions | Yield |
---|---|
With triethylamine In ethanol at 30℃; for 0.0833333h; microwave irradiation; | 89% |
4-HYDROXYPIPERIDINE
5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Conditions | Yield |
---|---|
Stage #1: 4-HYDROXYPIPERIDINE With N-ethyl-N,N-diisopropylamine In dichloromethane at 15℃; for 0.166667h; Stage #2: 5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one In dichloromethane at 25℃; for 4h; | 88% |
With N-ethyl-N,N-diisopropylamine In dichloromethane at 15 - 25℃; | 85% |
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